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Dyes / Stains / Fluorescent Probes / Fluorescent Labels
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ALX-350-238 Revised 03-Apr-08
Chlortetracycline . hydrochloride
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SYNONYMS Aureomycin . HCI
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
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ALX-350-238-G001   1 g 20.00 USD Add To Cart
ALX-350-238-G005   5 g 35.00 USD Add To Cart
Product Specification
FORMULA: C22H23ClN2O8. HCl
MW: 478.9 . 36.5
CAS NUMBER: 64-72-2
MERCK INDEX: 14: 2192
SOURCE/HOST: Isolated from Streptomyces aureofaciens.
PURITY: ~80%
APPEARANCE: Yellow powder.
SOLUBILITY: Soluble in water or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Antibiotic. Inhibits protein synthesis in prokaryotes and eukaryotes. Inhibits binding of aminoacyl-tRNA to ribosomes. Used as a fluorescent Ca2+ probe.
Product Specific Literature References
Inhibition of thrombin-induced secretion from platelets by chlortetracycline and its analogs: E.H. Murer and E. Siojo; Thromb. Haemost. 47, 62 (1982) Abstract
Characterization of chlortetracycline (aureomycin) as a calcium ionophore: J.R. White & F.L. Pearce; Biochemistry 21, 6309 (1982) Abstract
Effect of bile acids on intracellular calcium in isolated rat hepatocyte couplets: N. Thibault & F. Ballett; Biochem. Pharmacol. 45, 289 (1993) Abstract
Chlortetracycline, oxytetracycline, and tetracycline in edible animal tissues, liquid chromatographic method: collaborative study: J.D. MacNeil, et al.; J. AOAC Int. 79, 405 (1996) Abstract
The effect of chlortetracycline treatment and its subsequent withdrawal on multi-resistant Salmonella enterica serovar Typhimurium DT104 and commensal Escherichia coli in the pig: A.A. Delsol, et al.; J. Appl. Microbiol. 95, 1226 (2003) Abstract
Further Categories Containing This Product:
Dyes / Stains / Fluorescent Probes / Fluorescent Labels • Calcium Indicators / Probes • tRNA / Related Products
 
 
ALX-350-268 Revised 01-Jun-06
Phalloidin (FITC)
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SYNONYMS Fluoresceinyl-aminomethyldithiolano-phalloidin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Cytoskeletal Research
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ALX-350-268-MC01   0.1 mg 150.00 USD Add To Cart
Product Specification
FORMULA: C58H62N10O14S4
MW: 1251.4
SOURCE/HOST: Semisynthetic from aminomethyldithiolano-phalloidin.
PURITY: ≥90%
APPEARANCE: Amorphous solid.
SOLUBILITY: Soluble in DMSO, dimethyl formamide, methanol or water (warm).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Prepare fresh solutions for each application.
HANDLING: Protect from light and moisture.
HAZARD: VERY TOXIC.

Product Description
For detection of microfilaments in the light microscope. Mixture of 4 isomers with lower affinity to actin than phalloidin (Prod. No. ALX-350-265).
Product Specific Literature References
Fluorescent phallotoxin, a tool for the visualization of cellular actin: E. Wulf, et al.; PNAS 76, 4498 (1979) Abstract
Fluorescent phallotoxins as probes for filamentous actin: H. Faulstich, et al.; J. Muscle Res. Cell Motil. 9, 370 (1988) Abstract
Further Categories Containing This Product:
Dyes / Stains / Fluorescent Probes / Fluorescent Labels • Amanitins & Phalloidins / Related Products • Actin / Related Products
 
 
ALX-400-004 Revised 29-Aug-08
Griess Reagent
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PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY Nitric Oxide & NOS Detection / Related Products
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ALX-400-004-L050   50 ml 70.00 USD Add To Cart
Product Specification
APPEARANCE: Colorless to slightly pink liquid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: CORROSIVE.
Product Description
Reagent for the determination of nitrite (NO2-) in biological media. Consists of 1 part 0.1% naphthylethylenediamine dihydrochloride in distilled water plus 1 part 1% sulfanilamide (or sulfanilic acid) in 5% concentrated H3PO4.
Product Specific Literature References
Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids: L.C. Green, et al.; Anal. Biochem. 126, 131 (1982) Abstract
Measurement of nitrate and nitrite in biological samples using nitrate reductase and Griess reaction: D.L. Granger, et al.; Methods Enzymol. 268, 142 (1996) Abstract
Anticoagulants and other preanalytical factors interfere in plasma nitrate/nitrite quantification by the Griess method: D. Ricart-Jane, et al.; Nitric Oxide 6, 178 (2002) Abstract
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Dyes / Stains / Fluorescent Probes / Fluorescent Labels
 
 
ALX-400-034 Revised 02-Sep-08
Ellman's Reagent
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SYNONYMS 5,5-Dithio-bis(2-nitrobenzoic acid)
DTNB
PRODUCT LINE Other Products
PRODUCT CATEGORY Dyes / Stains / Fluorescent Probes / Fluorescent Labels
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ALX-400-034-G001   1 g 30.00 USD Add To Cart
ALX-400-034-G005   5 g 120.00 USD Add To Cart
Product Specification
FORMULA: C14H8N2O8S2
MW: 396.3
CAS NUMBER: 69-78-3
RTECS: DG9650000
PURITY: ≥98% (TLC)
APPEARANCE: Light yellow solid.
SOLUBILITY: Soluble in 100% ethanol or dioxane.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: IRRITANT.
IDENTITY: Identity determined by IR.

Product Description
A sensitive sulfhydryl reagent.
Product Specific Literature References
H. Deakin, et al.; Biochem. J. 89, 2996 (1963)
 
 
ALX-400-043 Revised 09-May-07
Propidium Iodide
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PRODUCT LINE Other Products
PRODUCT CATEGORY Dyes / Stains / Fluorescent Probes / Fluorescent Labels
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ALX-400-043-M001   1 mg 77.00 USD Add To Cart
Product Specification
FORMULA: C27H34N4I2
MW: 668.4
CAS NUMBER: 25535-16-4
RTECS: SF7949600
CONCENTRATION: 1mg/ml
FORMULATION: Liquid. Solution in PBS.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
DNA intercalator. Useful for differentiation between apoptotic cell death if used in combination with annexin V conjugates by flow cytometry. Ex(max): 536nm; Em(max): 617nm.
Product Specific Literature References
Propidium iodide staining correlates with the extent of DNA degradation in isolated nuclei: T. Crompton, et al.; BBRC 183, 532 (1992) Abstract
A flow cytometric method using Hoechst 33342 and propidium iodide for simultaneous cell cycle analysis and apoptosis determination in unfixed cells: F. Belloc, et al.; Cytometry 17, 59 (1994) Abstract
Assessment of secondary necrosis of Jurkat cells using a new microscopic system and double staining method with annexin V and propidium iodide: O. Honda, et al.; Int. J. Oncol. 16, 283 (2000) Abstract
Flow cytometric analysis of apoptotic subpopulations with a combination of annexin V-FITC, propidium iodide, and SYTO 17: M. Eray, et al.; Cytometry 43, 134 (2001) Abstract
A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V: I. Vermes, et al.; J. Immunol. Meth. 184, 39 (1995) Abstract
Distribution of the human intracellular serpin protease inhibitor 8 in human tissues: M.C. Strik, et al.; J. Histochem. Cytochem. 50, 1443 (2002) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION Dilute to 250µg/ml in PBS before use. Add 1µl per annexin V assay.
Related Products
Further Categories Containing This Product:
DNA Intercalators & Crosslinkers
 
 
ALX-430-140 Revised 08-Mar-07
F16
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SYNONYMS 4-[(E)-2-(Indol-3-yl)ethenyl]-N-methylpyridinium iodide
PRODUCT LINE Cancer
PRODUCT CATEGORY Antitumor Agents (Apoptosis Inducers)
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ALX-430-140-M005   5 mg 40.00 USD Add To Cart
ALX-430-140-M025   25 mg 160.00 USD Add To Cart
Product Specification
FORMULA: C16H15IN2
MW: 362.2
CAS NUMBER: 36098-33-6
PURITY: ≥98% (HPLC)
APPEARANCE: Orange solid.
SOLUBILITY: Soluble in 100% ethanol, DMSO or dimethyl formamide; also soluble in PBS, pH 7.2.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for 2 years after receipt when stored at -20°C. Organic stock solutions are stable for at least 6 months when stored at -20°C. We do not recommend storing the aqueous solutions for more than one day.
HANDLING: Protect from light. Hygroscopic.
HAZARD: MAY BE CARCINOGENIC. HARMFUL.

Product Description
Cell permeable, fluorogenic, delocalized lipophilic mitochondrial toxin. Induces apoptosis as well as necrosis in tumor cells.
Product Specific Literature References
A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth: V.R. Fantin, et al.; Cancer Cell 2, 29 (2002) Abstract
F16, a mitochondriotoxic compound, triggers apoptosis or necrosis depending on the genetic background of the target carcinoma cell: V.R. Fantin and P. Leder; Cancer Res. 64, 329 (2004) Abstract
A predictive model for the selective accumulation of chemicals in tumor cells: S. Trapp and R.W. Horobin; Eur. Biophys. 34, 959 (2005) Abstract
Further Categories Containing This Product:
Cell Structure and Organelle Markers • Dyes / Stains / Fluorescent Probes / Fluorescent Labels • Non-apoptotic Cell Death / Necrosis
 
 
ALX-445-047 Revised 18-Jan-08
Sapintoxin D (high purity)
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SYNONYMS Phorbol 12-N-methylanthranilate (high purity)
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Toxins
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ALX-445-047-M001   1 mg 55.00 USD Add To Cart
ALX-445-047-M005   5 mg 165.00 USD Add To Cart
Product Specification
FORMULA: C30H37NO8
MW: 539.6
CAS NUMBER: 80998-07-8
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in methanol, DMSO or chloroform.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: TUMOR PROMOTER. HIGHLY IRRITANT.

Product Description
Fluorescent, highly potent phorbol ester. Useful for membrane studies.
Product Specific Literature References
N.A. Morrice, et al.; J. Pharm. Pharmacol. 38, 30P (1986)
Effects of biologically active tumour-promoting and non-promoting phorbol esters on in vitro growth of melanocytic cells: G. Brooks, et al.; Pigment Cell. Res. 3, 98 (1990) Abstract
Effects of five phorbol esters on gap junctional intercellular communication, morphological transformation and epidermal growth factor binding in Syrian hamster embryo cells: T. Husoy, et al.; Carcinogenesis 14, 73 (1993) Abstract
Sapintoxin D is a weak tumour promoter in Sencar mouse skin: J.R. McLean, et al.; J. Pharm. Pharmacol. 47, 263 (1995) Abstract
Conformation of the C1 phorbol-ester-binding domain participates in the activating conformational change of protein kinase C: C. Ho, et al.; Biochem. J. 344, 451 (1999) Abstract; Full Text
Further Categories Containing This Product:
Phorbols / Phorbol Esters • Carcinogens & Tumor Promoters Other Products • Dyes / Stains / Fluorescent Probes / Fluorescent Labels
 
 
ALX-450-004 Revised 04-Feb-05
INDO 1 . pentapotassium salt
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SYNONYMS 1-[2-Amino-5-(6-carboxyindol-2-yl)phenoxy]-2-(2'-amino-5'-methylphenoxy)ethane-N,N,N',N'-tetraacetic acid . 5K
PRODUCT LINE Other Products
PRODUCT CATEGORY Dyes / Stains / Fluorescent Probes / Fluorescent Labels
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ALX-450-004-M001   1 mg 95.00 USD Add To Cart
Product Specification
FORMULA: C32H26N3O12 . 5K
MW: 644.6 . 195.5
CAS NUMBER: 132319-56-3
PURITY: ≥97%
APPEARANCE: Off-white solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Ca2+ chelator and indicator of intracellular and extracellular Ca2+.  Particularly useful in flow cytometry studies.
Product Specific Literature References
New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures: R.Y. Tsien; Biochemistry 19, 2396 (1980) Abstract
A new generation of Ca2+ indicators with greatly improved fluorescence properties: G. Grynkiewicz, et al.; J. Biol. Chem. 260, 3340 (1985) Abstract; Full Text
Heterogeneity among T cells in intracellular free calcium responses after mitogen stimulation with PHA or anti-CD3. Simultaneous use of indo-1 and immunofluorescence with flow cytometry: P.S. Rabinovitch, et al.; J. Immunol. 137, 952 (1986) Abstract
CD5 antibodies increase intracellular ionized calcium concentration in T cells: C.H. June, et al.; J. Immunol. 138, 2782 (1987) Abstract
Diminished calcium influx in lectin-stimulated T cells from old mice: R.A. Miller, et al.; J. Cell. Physiol. 132, 337 (1987) Abstract
Calcium mobilization in human platelets using indo-1 and flow cytometry: L.K. Jennings, et al.; Blood 74, 2674 (1989) Abstract
Analysis of cytosolic ionized calcium variation in polymorphonuclear leukocytes using flow cytometry and Indo-1 AM: M. Lopez, et al.; Cytometry 10, 165 (1989) Abstract
Cytosolic and vacuolar Ca2+ concentrations in yeast cells measured with the Ca2+-sensitive fluorescence dye indo-1: D. Halachmi & Y. Eilam; FEBS Lett. 256, 55 (1989) Abstract
Intracellular Ca2+ measurement with Indo-1 in substrate-attached cells: advantages and special considerations: M. Wahl, et al.; Cell Calcium 11, 487 (1990) Abstract
Calcium changes in immune complex-stimulated human neutrophils. Simultaneous measurement of receptor occupancy and activation reveals full population stimulus binding but subpopulation activation: B.A. Brunkhorst, et al.; J. Biol. Chem. 266, 13035 (1991) Abstract; Full Text
Further Categories Containing This Product:
Calcium Indicators / Probes • Calcium Chelators / Caged Calcium Chelators • MDR Other Products
 
 
ALX-450-005 Revised 04-Feb-05
INDO 1/AM
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SYNONYMS 1-[2-Amino-5-(6-carboxyindol-2-yl)phenoxy]-2-(2'-amino-5'-methylphenoxy)ethane-N,N,N',N'-tetraacetic acid, pentaacetoxymethylester
PRODUCT LINE Other Products
PRODUCT CATEGORY Dyes / Stains / Fluorescent Probes / Fluorescent Labels
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ALX-450-005-M001   1 mg 130.00 USD Add To Cart
ALX-450-005-M005   5 mg 520.00 USD Add To Cart
Product Specification
FORMULA: C47H51N3O22
MW: 1009.9
CAS NUMBER: 112926-02-0
PURITY: ≥97%
APPEARANCE: Off-white solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Cell permeable analog of INDO 1 (Prod. No. ALX-450-004). Fluorescent probe for Ca2+. After crossing the membrane, the product is rapidly hydrolyzed by cytoplasmic esterases to the membrane impermeant INDO 1.
Product Specific Literature References
New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures: R.Y. Tsien; Biochemistry 19, 2396 (1980) Abstract
A new generation of Ca2+ indicators with greatly improved fluorescence properties: G. Grynkiewicz, et al.; J. Biol. Chem. 260, 3440 (1985) Abstract; Full Text
Measuring cytosolic free calcium concentration in endothelial cells with indo-1: the pitfall of using the ratio of two fluorescence intensities recorded at different wavelengths: A. Luckhoff; Cell Calcium 7, 233 (1986) Abstract
Cross-linking of surface immunoglobulin on B lymphocytes induces both intracellular Ca2+ release and Ca2+ influx: analysis with indo-1: M.K. Bijsterbosch, et al.; BBRC 137, 500 (1986) Abstract
Heterogeneity among T cells in intracellular free calcium responses after mitogen stimulation with PHA or anti-CD3. Simultaneous use of indo-1 and immunofluorescence with flow cytometry: P.S. Rabinovitch, et al.; J. Immunol. 137, 952 (1986) Abstract
Cytosolic and vacuolar Ca2+ concentrations in yeast cells measured with the Ca2+-sensitive fluorescence dye indo-1: D. Halachmi & Y. Eilam; FEBS Lett. 256, 55 (1989) Abstract
Calcium mobilization in human platelets using indo-1 and flow cytometry: L.K. Jennings, et al.; Blood 74, 2674 (1989) Abstract
Analysis of cytosolic ionized calcium variation in polymorphonuclear leukocytes using flow cytometry and Indo-1 AM: M. Lopez, et al.; Cytometry 10, 165 (1989) Abstract
Intracellular Ca2+ measurement with Indo-1 in substrate-attached cells: advantages and special considerations: M. Wahl, et al.; Cell Calcium 11, 487 (1990) Abstract
Calcium homeostasis in dissociated embryonic neurons: a flow cytometric analysis: J.P. Grierson, et al.; J. Neurophysiol. 67, 704 (1992) Abstract
Further Categories Containing This Product:
Calcium Indicators / Probes • MDR Other Products • Calcium Chelators / Caged Calcium Chelators
 
 
ALX-450-011 Revised 26-Apr-07
TPEN
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SYNONYMS N,N,N',N'-Tetrakis-(2-pyridylmethyl)ethylenediamine