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ALX-385-017 Revised 01-Apr-08
(+)-Catechin . monohydrate
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SYNONYMS (+)-3,3',4',5,7-Flavanpentol
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antioxidants
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ALX-385-017-G001   1 g 20.00 USD Add To Cart
Product Specification
FORMULA: C15H14O6 . H2O
MW: 290.3 . 18.0
CAS NUMBER: 88191-48-4, 225937-10-0
MERCK INDEX: 14: 1902
PURITY: ≥98% (TLC)
APPEARANCE: Off-white to yellow powder.
SOLUBILITY: Soluble in 100% ethanol (50mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: IRRITANT.

Product Description
Antioxidant flavonoid. Free radical scavenger. Has chemopreventive and antitumor properties.
Product Specific Literature References
Adjuvant chemoprevention of experimental cancer: catechin and dietary turmeric in forestomach and oral cancer models: M.A. Azuine & S.V. Bhide; J. Ethnopharmacol. 44, 211 (1994) Abstract
Chemoprevention of mammary tumor virus-induced and chemical carcinogen-induced rodent mammary tumors by natural plant products: S.V. Bhide, et al.; Breast Cancer Res. Treat. 30, 233 (1994) Abstract
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Flavonoids as anticancer agents: structure-activity relationship study: M. Lopez-Lazaro; Curr. Med. Chem. Anticancer Agents 2, 691 (2002), (Review) Abstract
In vitro biological properties of flavonoid conjugates found in vivo: G. Williamson, et al.; Free Radic. Res. 39, 457 (2005), (Review) Abstract
(+)-Catechin prevents ultraviolet B-induced human keratinocyte death via inhibition of JNK phosphorylation: W.B. Wu, et al.; Life Sci. 79, 801 (2006) Abstract
Antispasmodic, bronchodilator and vasodilator activities of (+)-catechin, a naturally occurring flavonoid: M.N. Ghayur, et al.; Arch. Pharm. Res. 30, 970 (2007) Abstract
Further Categories Containing This Product:
Flavonoids/Related Products • Natural Products - Antitumor Reagents • Free Radical Scavengers • Natural Products - Chemopreventive Agents • Active Substances from Fruit and Vegetables
 
 
ALX-385-002 Revised 19-Nov-07
(±)-Catechin
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SYNONYMS (±)-3,3',4',5,7-Flavanpentol
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antioxidants
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ALX-385-002-G001   1 g 80.00 USD Add To Cart
Product Specification
FORMULA: C15H14O6
MW: 290.3 (anhydrous basis)
CAS NUMBER: 7295-85-4
MERCK INDEX: 14: 1902
PURITY: ≥98% (HPLC)
APPEARANCE: White to yellow powder.
SOLUBILITY: Soluble in methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: IRRITANT.

Product Description
Antioxidant flavonoid. Free radical scavenger. Has chemopreventive and antitumor properties.
Product Specific Literature References
Adjuvant chemoprevention of experimental cancer: catechin and dietary turmeric in forestomach and oral cancer models: M.A. Azuine & S.V. Bhide; J. Ethnopharmacol. 44, 211 (1994) Abstract
Chemoprevention of mammary tumor virus-induced and chemical carcinogen-induced rodent mammary tumors by natural plant products: S.V. Bhide, et al.; Breast Cancer Res. Treat. 30, 233 (1994) Abstract
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Flavonoids as anticancer agents: structure-activity relationship study: M. Lopez-Lazaro; Curr. Med. Chem. Anticancer Agents 2, 691 (2002), (Review) Abstract
In vitro biological properties of flavonoid conjugates found in vivo: G. Williamson, et al.; Free Radic. Res. 39, 457 (2005), (Review) Abstract
(+)-Catechin prevents ultraviolet B-induced human keratinocyte death via inhibition of JNK phosphorylation: W.B. Wu, et al.; Life Sci. 79, 801 (2006) Abstract
Antispasmodic, bronchodilator and vasodilator activities of (+)-catechin, a naturally occurring flavonoid: M.N. Ghayur, et al.; Arch. Pharm. Res. 30, 970 (2007) Abstract
Further Categories Containing This Product:
Free Radical Scavengers • Natural Products - Antitumor Reagents • Natural Products - Chemopreventive Agents • Active Substances from Fruit and Vegetables • Flavonoids/Related Products
 
 
ALX-350-101 Revised 03-Apr-08
Catharanthine . tartrate
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SYNONYMS 3,4-Didehydroibogamine-18-carboxylic acid methyl ester . tartrate
7-Ethyl-9,10,12,13-tetrahydro-6,9-methano-5H-pyrido[1’,2’:1,2]azepino[4,5-b]indole-6(6aH)-carboxylic acid methyl ester . tartrate
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Cytoskeletal Research
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ALX-350-101-G001   1 g 430.00 USD Add To Cart
ALX-350-101-M100   100 mg 160.00 USD Add To Cart
Product Specification
FORMULA: C21H24N2O2 . C4H6O6
MW: 336.4 . 150.1
CAS NUMBER: 2648-21-5
MERCK INDEX: 14: 1904
SOURCE/HOST: Isolated from Catharanthus roseus.
PURITY: ≥90%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Very hygroscopic. Keep cool and dry.

Product Description

Starting material for the synthesis of the antitumor drugs vinblastine and vincristine.  It is less active as an inhibitor of tubulin self-assembly into microtubules than the latter two compounds.

Product Specific Literature References
Photochemical one-pot synthesis of vinblastine and vincristine: S. Pennanen & A. Huhtikangas; Photochem. Photobiol. 51, 515 (1990) Abstract
Mechanism of interaction of vinca alkaloids with tubulin: catharanthine and vindoline: V. Prakash & S.N. Timasheff; Biochemistry 30, 873 (1991) Abstract
Related Products
Further Categories Containing This Product:
Microtubule Modulators • Natural Products - Antitumor Reagents • Alkaloids
 
 
ALX-380-016 Revised 30-Oct-07
Cefaclor
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SYNONYMS 7-(D-2-Amino-2-phenylacetamido)-3-chloro-3-cephem-4-carboxylic acid
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
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ALX-380-016-G001   1 g 150.00 USD Add To Cart
ALX-380-016-G005   5 g 350.00 USD Add To Cart
ALX-380-016-M050   50 mg 20.00 USD Add To Cart
ALX-380-016-M250   250 mg 50.00 USD Add To Cart
Product Specification
FORMULA: C15H14ClN3O4S
MW: 367.8
CAS NUMBER: 53994-73-3
MERCK INDEX: 14: 1912
PURITY: ≥97%
APPEARANCE: Light yellow powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Broad-spectrum antibiotic acting by inhibiting bacterial cell wall synthesis.
Product Specific Literature References
Chemistry of cephalosporin antibiotics. 30. 3-methoxy- and 3-halo-3-cephems: R. R. Chauvette & P. A. Pennington; J. Med. Chem. 18, 403 (1975) Abstract
Cefaclor into the millennium: W. Brumfitt & J. M. Hamilton-Miller; J. Chemother. 11, 163 (1999), (Review) Abstract
Cefaclor revisited: B. R. Meyers; Clin. Ther. 22, 154 (2000), (Review) Abstract
Immunomodulatory properties of cefaclor: in vivo effect on cytokine release and lymphoproliferative response in rats: K. Mangano, et al.; J. Chemother. 18, 641 (2006) Abstract
 
 
ALX-380-044 Revised 16-Oct-07
Cefazolin . sodium salt
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
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ALX-380-044-G001   1 g 150.00 USD Add To Cart
ALX-380-044-M250   250 mg 45.00 USD Add To Cart
Product Specification
FORMULA: C14H13N8O4S3 . Na
MW: 453.5 . 23.0
CAS NUMBER: 27164-46-1
MERCK INDEX: 14: 1917
SOURCE/HOST: Semisynthetic.
PURITY: ≥98%
APPEARANCE: Off-white powder.
SOLUBILITY: Soluble in water; slightly soluble in methanol and 100% ethanol; insoluble in acetone, chloroform and benzene.
ACTIVITY: ≥900units/mg.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: TOXIC.

Product Description
Inhibits synthesis of bacterial cell wall.
Product Specific Literature References
Cefazolin, a new semisynthetic cephalosporin antibiotic. II. In vitro and in vivo antimicrobial activity:: M. Nishida, et al.; J. Antibiot. (Tokyo) 23, 137 (1970) Abstract
The effect of beta-lactamase stability, penetration, and target affinity on the activity of cefazolin, cefamandole, cefoxitin, and cefuroxime: P. B. Harper; Clin Ther 6, 310 (1984), Review Abstract
 
 
ALX-380-271 Revised 08-Apr-08 New product
Cefotaxime . sodium salt
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
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ALX-380-271-G001   1 g 85.00 USD Add To Cart
ALX-380-271-M250   250 mg 30.00 USD Add To Cart
Product Specification
FORMULA: C16H16N5O7S2 . Na
MW: 454.5 . 23.0
CAS NUMBER: 64485-93-4
MERCK INDEX: 14: 1933
RTECS: XI0250000
APPEARANCE: White to light yellow powder.
SOLUBILITY: Soluble in water (>50mg/ml).
ACTIVITY: Potency is 916-964µg/ml (on dry basis).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light. Hygroscopic.
HAZARD: HARMFUL.

Product Description
Cephalosporin antibiotic. Inhibits bacterial cell wall synthesis. Effective against Gram-negative and Gram-positive bacteria. Resistant against β-lactamase.
Product Specific Literature References
Synergistic antibacterial interaction of cefotaxime and desacetylcefotaxime: G. Molinari, et al.; J. Chemother. 3, 6 (1991) Abstract
Comparative study of pharmacokinetics and serum bactericidal activity of ceftizoxime and cefotaxime: F. Vallee & M. LeBel; Antimicrob. Agents Chemother. 35, 2057 (1991) Abstract; Full Text
 
 
ALX-350-332 Revised 03-Apr-08
Celastrol
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SYNONYMS Tripterine
3-Hydroxy-24-nor-2-oxo-1(10),3,5,7-friedelatetraen-29-oic acid
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Anti-inflammatory Agents
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ALX-350-332-M005   5 mg 65.00 USD Add To Cart
ALX-350-332-M025   25 mg 260.00 USD Add To Cart
Product Specification
FORMULA: C29H38O4
MW: 450.6
CAS NUMBER: 34157-83-0
SOURCE/HOST: Isolated from the root of Tripterygium sp.
PURITY: ≥98% (HPLC)
APPEARANCE: Red cubic crystals.
SOLUBILITY: Soluble in 100% ethanol, DMSO or dimethyl formamide; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Cell permeable triterpenoid anti-inflammatory and immunosuppressive compound. Antioxidant. Suppresses LPS-induced cytokine release in macrophages and monocytes (IC50=40nM for IL-1β and IL-1α, 80nM for IL-6, 110nM for prostaglandin E2 and 210nM for IL-8 and TNF-α). Suppresses nitric oxide (NO) production (IC50=230nM) and LPS-induced NF-κB activation (IC50=270nM). Inhibits chymotrypsin-like activity of 20S proteasome (IC50=2.5µM). Inhibits lipid peroxidation induced by ADP and Fe2+ in rat liver mitochondria (IC50=7µM). Induces expression of a wider set of heat shock proteins. Inhibits topoisomerse II.
Product Specific Literature References
The triterpene celastrol as a very potent inhibitor of lipid peroxidation in mitochondria: H. Sassa, et al.; BBRC 172, 890 (1990) Abstract
Structural basis of potent antiperoxidation activity of the triterpene celastrol in mitochondria: effect of negative membrane surface charge on lipid peroxidation: H. Sassa, et al.; Free Radic. Biol. Med. 17, 201 (1994) Abstract
Novel cytokine release inhibitors. Part III: Truncated analogs of tripterine: W. He, et al.; Bioorg. Med. Chem. Lett. 8, 3659 (1998) Abstract
Celastrol, a potent antioxidant and anti-inflammatory drug, as a possible treatment for Alzheimer’s disease: A.C. Allison, et al.; Prog. Neuropsychopharmacol. Biol. Psychiatry 25, 1341 (2001) Abstract
Antiinflammatory constituents of Celastrus orbiculatus inhibit the NF-kappaB activation and NO production: H.Z. Jin, et al.; J. Nat. Prod. 65, 89 (2002) Abstract
Apoptosis induction in HL-60 cells and inhibition of topoisomerase II by triterpene celastrol: M. Nagase, et al.; Biosci. Biotechnol. Biochem. 67, 1883 (2003) Abstract; Full Text
Celastrol inhibits pro-inflammatory cytokine secretion in Crohn’s disease biopsies: G.F. Pinna, et al.; BBRC 322, 778 (2004) Abstract
Celastrols as inducers of the heat shock response and cytoprotection: S.D. Westerheide, et al.; J. Biol. Chem. 279, 56053 (2004) Abstract; Full Text
Celastrol protects against MPTP- and 3-nitropropionic acid-induced neurotoxicity: C. Cleren, et al.; J. Neurochem. 94, 995 (2005) Abstract
Celastrol blocks neuronal cell death and extends life in transgenic mouse model of amyotrophic lateral sclerosis: M. Kiaei, et al.; Neurodegener. Dis. 2, 246 (2005) Abstract
Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice: H. Yang, et al.; Cancer Res. 66, 4758 (2006) Abstract; Full Text
Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-kappaB-regulated gene products and TAK1-mediated NF-kappaB activation: G. Sethi, et al.; Blood 109, 2727 (2007) Abstract
Induction of heat shock proteins in differentiated human and rodent neurons by celastrol: A.M. Chow & I.R. Brown; Cell Stress Chaperones 12, 237 (2007) Abstract
Further Categories Containing This Product:
Natural Products - Nitric Oxide Pathway Modulators • Natural Products - Immunomodulators • Stress & Heat Shock Proteins Other Products • Natural Products - Topoisomerase Inhibitors • Natural Products - Antioxidants • NF-kB Pathway Inhibitors • Ubiquitin & Proteasome Other Products
 
 
ALX-380-053 Revised 19-Jun-08
Cerulenin
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SYNONYMS 2,3-Epoxy-4-oxo-7,10-dodecadienamide
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Apoptosis Inducers & Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-053-M005   5 mg 60.00 USD Add To Cart
ALX-380-053-M010   10 mg 110.00 USD Add To Cart
ALX-380-053-M050   50 mg 420.00 USD Add To Cart
Product Specification
FORMULA: C12H17NO3
MW: 223.3
CAS NUMBER: 17397-89-6
MERCK INDEX: 14: 2004
RTECS: JR1670000
SOURCE/HOST: Isolated from Cephalosporium caerulens.
PURITY: ≥98%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO, dimethyl formamide, dichloromethane, methanol, 100% ethanol or acetone; slighly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: HARMFUL.

Product Description
Antibiotic. Fatty acid synthase (FAS) inhibitor reported to bind in equimolar ratio to β-keto-acyl-ACP synthase, thus inhibiting protein acylation. Produces metabolic effects similar to effects of leptin, but through mechanisms that are independent of, or down-stream from, both leptin and melanocortin receptors. Apoptosis inducer. Inhibitor of bacterial fatty acid synthesis (inhibits FabH, FabB and FabF condensation enzymes).
Product Specific Literature References
Studies on cerulenin, 3. Isolation and physico-chemical properties of cerulenin: Y. Sato, et al.; J. Antibiot. (Tokyo) 200, 344 (1967) Abstract
Effect of cerulenin on the synthesis of very-long-chain fatty acids in microsomes from leek seedlings: F. Schneider, et al.; Biochim. Biophys. Acta 1152, 243 (1993) Abstract
Cerulenin-resistant mutants of Saccharomyces cerevisiae with an altered fatty acid synthase gene: J. Inokashi, et al.; Mol. Gen. Genet. 244, 90 (1994) Abstract
Cerulenin mimics effects of leptin on metabolic rate, food intake, and body weight independent of the melanocortin system, but unlike leptin, cerulenin fails to block neuroendocrine effects of fasting: H. Makimura, et al.; Diabetes 50, 733 (2001) Abstract; Full Text
Key role of mitochondria in cerulenin-mediated apoptosis: S.J. Heiligtag, et al.; Cell Death Differ. 9, 1017 (2002) Abstract
Fatty acid synthase inhibitors cerulenin and C75 retard growth and induce caspase-dependent apoptosis in human melanoma A-375 cells: T.S. Ho, et al.; Biomed. Pharmacother. 61, 578 (2007) Abstract
Further Categories Containing This Product:
Fatty Acid Synthase [FAS]/Related Products
 
 
ALX-380-242 Revised 03-Apr-08 New product
Chaetocin (high purity)
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
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ALX-380-242-M001   1 mg 330.00 USD Add To Cart
Product Specification
FORMULA: C30H28N6O6S4
MW: 696.9
CAS NUMBER: 28097-03-2
RTECS: FM3032000
SOURCE/HOST: Isolated from Chaetomium sp. MST-FP2085.
PURITY: ≥99% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO, dimethyl formamide, methanol or 100% ethanol; poorly soluble in water.
SHIPPING: