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Natural Products / Antibiotics
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ALX-350-161 Revised 11-Aug-08 New product
Macrosporin
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SYNONYMS 1,7-Dihydroxy-3-methoxy-6-methyl-9,10-anthracenedione
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products
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ALX-350-161-M001   1 mg 150.00 USD Add To Cart
Product Specification
FORMULA: C16H12O5
MW: 284.3
CAS NUMBER: 22225-67-8
SOURCE/HOST: Isolated from Alternaria sp.
PURITY: ≥97% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Identity determined by 1H-NMR and MS.

Product Description

Anthraquinone.
Product Specific Literature References
Metabolites of Dactylaria lutea. The structures of dactylariol and the antiprotozoal antibiotic dactylarin: A.M. Becker, et al.; J. Antibiot. (Tokyo) 31, 324 (1978) Abstract
High-performance liquid chromatographic determination of macrosporin, altersolanol A, alterporriol A, B and C in fermentation of Alternaria porri (Ellis) Ciferri: R. Suemitsu, et al.; J. Chromatogr. 454, 406 (1988) Abstract
Biologically active polyketide metabolites from an undetermined fungicolous hyphomycete resembling Cladosporium: U. Höller, et al.; J. Nat. Prod. 65, 876 (2002) Abstract
Natural occurrence of fungi and fungal metabolites in moldy tomatoes: B. Andersen & J.C. Frisvad; J. Agric. Food Chem. 52, 7507 (2004) Abstract
New and cytotoxic anthraquinones from Pleospora sp. IFB-E006, an endophytic fungus in Imperata cylindrical: H.M. Ge, et al.; Planta Med. 71, 1063 (2005) Abstract
Secondary metabolite profiling of Alternaria dauci, A. porri, A. solani, and A. tomatophila: B. Andersen, et al.; Mycol. Res. 112, 241 (2007) Abstract
Metabolite production by different Ulocladium species: B. Andersen & M. Hollensted; Int. J. Food Microbiol. 126, 172 (2008) Abstract
Further Categories Containing This Product:
Other Toxins
 
 
ALX-350-162 Revised 11-Aug-08 New product
Altersolanol A
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SYNONYMS As-A 2
NSC 173943
(1R-(1α,2β,3β,4α))-1,2,3,4-Tetrahydro-1,2,3,4,5-pentahydroxy-7-methoxy-2-methyl-9,10-anthracenedione
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products with Antibiotic Activity
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ALX-350-162-M001   1 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C16H16O8
MW: 336.3
CAS NUMBER: 22268-16-2
SOURCE/HOST: Isolated from Alternaria sp.
PURITY: ≥97% (HPLC)
APPEARANCE: Yellow-orange to brown solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Identity determined by 1H-NMR and MS.

Product Description
Tetrahydroanthraquinone with phytotoxic and antibacterial activity.
Product Specific Literature References
Metabolites of Dactylaria lutea. The structures of dactylariol and the antiprotozoal antibiotic dactylarin: A.M. Becker, et al.; J. Antibiot. (Tokyo) 31, 324 (1978) Abstract
High-performance liquid chromatographic determination of macrosporin, altersolanol A, alterporriol A, B and C in fermentation of Alternaria porri (Ellis) Ciferri: R. Suemitsu, et al.; J. Chromatogr. 454, 406 (1988) Abstract
Mode of phytotoxic action of altersolanols : H. Haraguchi, et al.; Phytochemistry 43, 989 (1996)
Biologically active polyketide metabolites from an undetermined fungicolous hyphomycete resembling Cladosporium: U. Höller, et al.; J. Nat. Prod. 54, 876 (2002) Abstract
Secondary metabolite profiling of Alternaria dauci, A. porri, A. solani, and A. tomatophila: B. Andersen, et al.; Mycol. Res. 112, 241 (2008) Abstract
 
 
ALX-350-216 Revised 23-Nov-07
(-)-Eburnamonine
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SYNONYMS (3α,16α)-Eburnamenin-14(15H)-one
Vincamone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Neurological Research
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ALX-350-216-M100   100 mg 30.00 USD Add To Cart
Product Specification
FORMULA: C19H22N2O
MW: 294.4
CAS NUMBER: 4880-88-0
MERCK INDEX: 14: 3487
PURITY: ≥99%
APPEARANCE: White powder.
SOLUBILITY: Soluble in chloroform.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Cerebral metabolic stimulant; shows antihypoxic effects. Vasodilator.
Product Specific Literature References
Experimental approach of activity and mechanism(s) of action of drugs used in cerebral metabolic insufficiency. Application to 1-eburnamonine: P. Linee, et al.; Eur. Neurol. 20, 253 (1981) Abstract
’Cerebroactive’ drugs. Clinical pharmacology and therapeutic role in cerebrovascular disorders: A. Spagnoli & G. Tognoni; Drugs 26, 44 (1983), Review Abstract
Experimental clinical studies on the effect of eburnamonine in cerebrovascular disorders: W. Jansen, et al.; Pharmacopsychiatry 19, 389 (1986) Abstract
Asymmetric synthesis of (-)-eburnamonine and (+)-epi-eburnamonine from (4S)-4-ethyl-4-[2-(hydroxycarbonyl)ethyl]-2-butyrolactone: A.G. Wee & Q. Yu; J. Org. Chem. 66, 8935 (2001) Abstract
Further Categories Containing This Product:
Acetylcholine Receptors (Muscarinic) / Related Products
 
 
ALX-350-219 Revised 28-May-08
Artemisinin
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SYNONYMS Qinghaosu
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antimalarial Agents
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ALX-350-219-M100   100 mg 35.00 USD Add To Cart
ALX-350-219-G001   1 g 220.00 USD Add To Cart
Product Specification
FORMULA: C15H22O5
MW: 282.4
CAS NUMBER: 63968-64-9
MERCK INDEX: 14: 817
SOURCE/HOST: Isolated from the traditional Chinese anti-malarial herb Artemisia annua L.
PURITY: ≥98%
APPEARANCE: White crystalline solid.
SOLUBILITY: Soluble in methanol, 100% ethanol, dimethyl formamide, DMSO, chloroform or acetone; almost insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light and moisture.
HAZARD: TOXIC.

Product Description
Powerful antimalarial agent. Inhibits angiogenesis by down-regulating HIF-1α and VEGF expression in mouse embryonic stem cells. Crosses the blood-brain barrier. Inhibitor of human iNOS (NOS II).
Product Specific Literature References
Qinghaosu (artemisinin): an antimalarial drug from China: D.L. Klayman; Science 228, 1049 (1985) Abstract
The chemistry, pharmacology, and clinical applications of qinghaosu (artemisinin) and its derivatives: X.D. Luo & C.C. Shen; Med. Res. Rev. 7, 29 (1987) Abstract
Inhibition of angiogenesis in embryoid bodies by artemisinin: M. Wartenberg, et al.; Pflugers Arch. Eur. J. Physiol. 445, S85 (1994)
Artemisinin drugs in the treatment of malaria: from medicinal herb to registered medication: M.A. van Agtmael, et al.; Trends Pharmacol. Sci. 20, 199 (1999), Review Abstract
Artemisinin inhibits inducible nitric oxide synthase and nuclear factor NF-kB activation: E. Aldieri, et al.; FEBS Lett. 552, 141 (2003) Abstract
The antimalaria agent artemisinin exerts antiangiogenic effects in mouse embryonic stem cell-derived embryoid bodies: M. Wartenberg, et al.; Lab. Invest. 83, 1647 (2003) Abstract
An over four millennium story behind qinghaosu (artemisinin)--a fantastic antimalarial drug from a traditional chinese herb: Y. Li & Y.L. Wu; Curr. Med. Chem. 10, 2197 (2003), Review Abstract
From artemisinin to new artemisinin antimalarials: biosynthesis, extraction, old and new derivatives, stereochemistry and medicinal chemistry requirements: R.K. Haynes; Curr. Top. Med. Chem. 6, 509 (2006), Review Abstract
Further Categories Containing This Product:
NOS Inhibitors (NOS Induction & Enzyme Activity) • Hypoxia-inducible Factor [HIF] / Related Products • Natural Products - Nitric Oxide Pathway Modulators • Malaria / Related Products • Natural Products for Angiogenesis Research
 
 
ALX-350-220 Revised 05-May-08
Cafestol
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Chemopreventive Agents
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ALX-350-220-M050   50 mg 160.00 USD Add To Cart
Product Specification
FORMULA: C20H28O3
MW: 316.4
CAS NUMBER: 469-83-0
MERCK INDEX: 14: 1634
SOURCE/HOST: Isolated from the unsaponifiable fraction of petroleum ether extract of coffee beans.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO, 100% ethanol or ethyl acetate.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by 1H-NMR.

Product Description
Inducer of glutathione S-transferases. Has chemoprotective activity, reducing the genotoxicity of several carcinogens.
Product Specific Literature References
R.O. Bengis and R.J. Anderson; J. Biol. Chem. 47, 99 (1932)
K.H. Slotta and K. Neisser; Ber. 71, 1991 (1938)
Isolation and identification of kahweol palmitate and cafestol palmitate as active constituents of green coffee beans that enhance glutathione S-transferase activity in the mouse: L.K.T. Lam, et al.; Cancer Res. 42, 1193 (1982)
The coffee-specific diterpenes cafestol and kahweol protect against aflatoxin B1-induced genotoxicity through a dual mechanism: C. Cavin, et al.; Carcinogenesis 19, 1369 (1998) Abstract
Cafestol and kahweol, two coffee specific diterpenes with anticarcinogenic activity: C. Cavin, et al.; Food Chem. Toxicol. 40, 1155 (2002) Abstract
Further Categories Containing This Product:
Cytochrome P450 [CYP450] / Related Products • Glutathione S-Transferase • Active Substances from Fruit and Vegetables
 
 
ALX-350-222 Revised 28-Mar-08
Dihydromyristicin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Chemopreventive Agents
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ALX-350-222-M100   100 mg 70.00 USD Add To Cart
Product Specification
FORMULA: C11H14O3
MW: 194.2
CAS NUMBER: 52811-28-6
PURITY: ≥98% (TLC)
APPEARANCE: Colorless liquid.
SOLUBILITY: Soluble in 100% ethanol or ethyl acetate; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Hydrogenated product of myristicin (Prod. No. ALX-350-227), a natural constituent of parsley. Inducer of glutathione S-transferases.
Product Specific Literature References
Myristicin: a potential cancer chemopreventive agent from parsley leaf oil: G.-Q. Zheng, et al.; J. Agri. Food Chem. 40, 107 (1992)
Inhibition of benzo[a]pyrene-induced tumorigenesis by myristicin, a volatile aroma constituent of parsley leaf oil: G.Q. Zheng, et al.; Carcinogenesis 13, 1921 (1992) Abstract
Further Categories Containing This Product:
Antitumor Agents (Enzyme Activators & Inducers) • Glutathione S-Transferase • Active Substances from Fruit and Vegetables
 
 
ALX-350-223 Revised 07-Apr-08
Kahweol
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Chemopreventive Agents
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ALX-350-223-M010   10 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C20H26O3
MW: 314.2
CAS NUMBER: 6894-43-5
SOURCE/HOST: Natural product isolated from the unsaponifiable fraction of petroleum ether extract of coffee beans.
PURITY: ≥98% (HPLC)
APPEARANCE: Off-white to yellow solid.
SOLUBILITY: Soluble in ethyl acetate, acetone or DMSO; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Induces glutathione S-transferase. Has anti-cancer, chemoprotective, anti-inflammatory and anti-atherosclerotic properties.
Product Specific Literature References
R.O. Bengis & R.J. Anderson; J. Biol. Chem. 47, 99 (1932)
Isolation and identification of kahweol palmitate and cafestol palmitate as active constituents of green coffee beans that enhance glutathione S-transferase activity in the mouse: L.K. Lam, et al.; Cancer Res. 42, 1193 (1982) Abstract
Effects of derivatives of kahweol and cafestol on the activity of glutathione S-transferase in mice: L.K. Lam, et al.; J. Med. Chem. 30, 1399 (1987) Abstract
Placental glutathione S-transferase (GST-P) induction as a potential mechanism for the anti-carcinogenic effect of the coffee-specific components cafestol and kahweol: B. Schilter, et al.; Carcinogenesis 17, 2377 (1996) Abstract
Chemoprotection against the formation of colon DNA adducts from the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the rat: W.W. Huber, et al.; Mutat. Res. 376, 115 (1997) Abstract
The coffee-specific diterpenes cafestol and kahweol protect against aflatoxin B1-induced genotoxicity through a dual mechanism: C. Cavin, et al.; Carcinogenesis 19, 1369 (1998) Abstract
Cafestol and kahweol, two coffee specific diterpenes with anticarcinogenic activity: C. Cavin, et al.; Food Chem. Toxicol. 40, 1155 (2002) Abstract
The coffee diterpene kahweol inhibits tumor necrosis factor-alpha-induced expression of cell adhesion molecules in human endothelial cells: H.G. Kim, et al.; Toxicol. Appl. Pharmacol. 217, 332 (2006) Abstract
Further Categories Containing This Product:
Glutathione S-Transferase • Antitumor Agents (Enzyme Activators & Inducers) • TNF-alpha & TNF Receptors Other Products • CD11a, CD18 [LFA-1] & CD54 [ICAM-1], CD102 [ICAM-2], CD50 [ICAM-3] / Related Products • Natural Products - Anti-inflammatory Agents • Active Substances from Fruit and Vegetables
 
 
ALX-350-225 Revised 20-Feb-08
Limonin
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SYNONYMS Limonoic acid di-δ-lactone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Chemopreventive Agents
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ALX-350-225-M050   50 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C26H30O8
MW: 470.5
CAS NUMBER: 1180-71-8
MERCK INDEX: 14: 5494
SOURCE/HOST: Isolated from grapefruit seed.
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 100% ethanol or glacial acetic acid; slightly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Bitter principle of citrus fruits. Inhibits chemically induced carcinogenesis. Inhibits HIV-1 replication. Shows antinociceptive effect. Does not possess any inherent antioxidant activity.
Product Specific Literature References
V.P. Maier, et al.; ACS Symposium Series 143, 63 (1980)
J.A. Klocke & I. Kubo; Ent. Exp. & Appl. 32, 299 (1982)
R.L. Rouseff; J. Agric. Food Chem. 30, 504 (1982)
M.A. Altieri, et al.; Protect. Ecol. 6, 91 (1984)
The effect of citrus limonoids on hamster buccal pouch carcinogenesis: E.G. Miller, et al.; Carcinogenesis 10, 1535 (1989) Abstract
L.K.T. Lam, et al.; ACS Symposium Series 546, 209 (1994)
Antinociceptive and anti-inflammatory activities of limonin isolated from the fruits of Evodia rutaecarpa var. bodinieri: H. Matsuda, et al.; Planta Med. 64, 339 (1998) Abstract
Citrus limonoids obacunone and limonin inhibit azoxymethane-induced colon carcinogenesis in rats: T. Tanaka, et al.; Biofactors 13, 213 (2000) Abstract
Effect of limonin and nomilin on HIV-1 replication on infected human mononuclear cells: L. Battinelli, et al.; Planta Med. 69, 910 (2003) Abstract
Evaluation of the antioxidant capacity of limonin, nomilin, and limonin glucoside: A.P. Breksa, 3rd & G.D. Manners; J. Agric. Food Chem. 54, 3827 (2006) Abstract
Further Categories Containing This Product:
Analgesic / Anti-nociceptive Agents / Related Products • Natural Products - Antiviral / anti-HIV Agents • Natural Products for Neurological Research • Active Substances from Fruit and Vegetables
 
 
ALX-350-226 Revised 07-Apr-08
Caffeic acid methyl ester
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SYNONYMS Methyl caffeate
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Protein Kinase Inhibitors
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ALX-350-226-M050   50 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C10H10O4
MW: 194.2
CAS NUMBER: 3843-74-1
SOURCE/HOST: Synthetic.
PURITY: ≥98%
APPEARANCE: Slightly yellowish solid.
SOLUBILITY: Soluble in DMSO, methanol or acetone.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by 1H-NMR.

Product Description
Inhibitor of ornithine decarboxylase and protein tyrosine kinases. Has a strong inhibitory effect on human platelet aggregation. Shows antioxidant, antiproliferative and cytotoxic properties.
Product Specific Literature References
Effect of caffeic acid esters on carcinogen-induced mutagenicity and human colon adenocarcinoma cell growth: C.V. Rao, et al.; Chem. Biol. Interactions 84, 277 (1992) Abstract
Inhibition of platelet activation and endothelial cell injury by polyphenolic compounds isolated from Lonicera japonica Thunb: W.C. Chang & F.L. Hsu; Prostaglandins Leukot. Essent. Fatty Acids 45, 307 (1992) Abstract
Phenolic compounds from Duchesnea chrysantha and their cytotoxic activities in human cancer cell: I.R. Lee & M.Y. Yang; Arch. Pharm. Res. 17, 476 (1994) Abstract
Anti-platelet effect of the constituents isolated from the barks and fruits of Magnolia obovata: M.K. Pyo, et al.; Arch. Pharm. Res. 25, 325 (2002) Abstract
Black cohosh (Cimicifuga racemosa L.) protects against menadione-induced DNA damage through scavenging of reactive oxygen species: bioassay-directed isolation and characterization of active principles: J.E. Burdette, et al.; J. Agric. Food Chem. 50, 7022 (2002) Abstract
Phenolic acid derivatives with potential anticancer properties--a structure-activity relationship study. Part 1: methyl, propyl and octyl esters of caffeic and gallic acids: S.M. Fiuza, et al.; Bioorg. Med. Chem. 12, 3581 (2004) Abstract
Further Categories Containing This Product:
Other Natural Products for Cancer Research • Tyrosine Kinase Inhibitors • Antithrombotic Agents / Related Products • Antitumor Agents (Anti-proliferative) • Natural Products - Antioxidants
 
 
ALX-350-227 Revised 28-Apr-08
Myristicin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Chemopreventive Agents
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ALX-350-227-M100   100 mg 110.00 USD Add To Cart
Product Specification
FORMULA: C11H12O3
MW: 192.2
CAS NUMBER: 607-91-0
MERCK INDEX: