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ALX-350-069 Revised 02-Oct-08
Vincristine . sulfate
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SYNONYMS VCR . sulfate
Leukocristine . sulfate
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Cell Cycle Research
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-069-M001   1 mg 35.00 USD Add To Cart
ALX-350-069-M005   5 mg 95.00 USD Add To Cart
Product Specification
FORMULA: C46H56N4O10 . H2SO4
MW: 825.0 . 98.1
CAS NUMBER: 2068-78-2
MERCK INDEX: 14: 9986
RTECS: OH6340000
SOURCE/HOST: Semisynthetic from catharanthine or vindoline.
PURITY: ≥95%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water (25mg/ml) or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months at -20°C.
HANDLING: Protect from light and moisture.
HAZARD: MAY BE TERATOGENIC.

Product Description
Plant alkaloid that arrests the cell cycle in G2/M phase by blocking mitotic spindle formation. Depolymerizes microtubules and blocks binding of tubulin to microtubule proteins. Induces apoptosis. Triggers Raf-1 activation, phosphorylation of Bcl-2 family proteins and induction of p53 expression.
Product Specific Literature References
Cell death induced by vincristine in the intestinal crypts of mice and in a human Burkitt's lymphoma cell line: B.V. Harmon, et al.; Cell Prolif. 25, 523 (1992) Abstract
Binding selectivity of rhizoxin, phomopsin A, vinblastine, and ansamitocin P-3 to fungal tubulins: differential interactions of these antimitotic agents with brain and fungal tubulins [published erratum appears in BBRC 190, 1180 (1993)]: Y. Li, et al.; BBRC 187, 722 (1992) Abstract
Interaction of vinca alkaloids with tubulin: a comparison of vinblastine, vincristine, and vinorelbine: S. Lobert, et al.; Biochemistry 35, 6806 (1996) Abstract
Raf-1/bcl-2 phosphorylation: a step from microtubule damage to cell death: M.V. Blagosklonny, et al.; Cancer Res. 57, 130 (1997) Abstract
Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle: A. Jordan, et al.; Med. Res. Rev. 18, 259 (1998) Abstract
Bcl-xL is phosphorylated in malignant cells following microtubule disruption: M.S. Poruchynsky, et al.; Cancer Res. 58, 3331 (1998) Abstract
The effect of antimicrotubule agents on signal transduction pathways of apoptosis: a review: L.G. Wang, et al.; Cancer Chemother. Pharmacol. 44, 355 (1999), (Review) Abstract
Vincristine-induced apoptosis in vivo in peripheral blood mononuclear cells of children with acute lymphoblastic leukaemia (ALL): E. Groninger, et al.; Br. J. Haematol. 111, 875 (2000) Abstract
Selective toxicity of vincristine against chronic lymphocytic leukemia cells in vitro: J.A. Vilpo, et al.; Eur. J. Haematol. 65, 370 (2000) Abstract
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Further Categories Containing This Product:
Cell Cycle Blockers & Inhibitors / Related Products • Antitumor Agents (Anti-proliferative) • Natural Products for Cytoskeletal Research • Microtubule Modulators • Alkaloids • Natural Products - Antitumor Reagents • Antitumor Agents (Apoptosis Inducers) • Antitumor Agents (DNA Interaction & Gene Regulation) • Natural Products - Apoptosis Inducers & Inhibitors
 
 
ALX-350-075 Revised 08-Apr-08
Rottlerin
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SYNONYMS Mallotoxin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Protein Kinase Inhibitors
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ALX-350-075-M010   10 mg 40.00 USD Add To Cart
ALX-350-075-M025   25 mg 95.00 USD Add To Cart
Product Specification
FORMULA: C30H28O8
MW: 516.6
CAS NUMBER: 82-08-6
MERCK INDEX: 14: 8272
RTECS: AM6913800
SOURCE/HOST: Isolated from Mallotus philippinensis.
PURITY: ≥98% (HPLC)
APPEARANCE: Orange to brown solid.
SOLUBILITY: Soluble in DMSO, chloroform or 100% ethanol. Insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description

Mitochondrial uncoupler that depolarizes the mitochondrial membrane potential, reduces cellular ATP levels, activates 5‘-AMP-activated protein kinase (AMPK) and affects mitochondrial production of reactive oxygen species (ROS). Potent activator of multiple Ca2+-sensitive K+ channels. Blocks several kinases and non-kinase proteins in vitro. Has been widely-used as a selective inhibitor of protein kinase Cδ (PKCδ). However, recent studies indicate that rottlerin has no direct effect on PKCδ and that it should not be used to determine the involvement of PKCδ in biological processes.
Product Specific Literature References
The mouse ear edema: a quantitatively evaluable assay for tumor promoting compounds and for inhibitors of tumor promotion: M. Gschwendt, et al.; Cancer Lett. 25, 177 (1984) Abstract
Rottlerin, a novel protein kinase inhibitor: M. Gschwendt, et al.; BBRC 199, 93 (1994) Abstract
Elongation factor-2 kinase: effective inhibition by the novel protein kinase inhibitor rottlerin and relative insensitivity towards staurosporine: M. Gschwendt, et al.; FEBS Lett. 338, 85 (1994) Abstract
Rottlerin: an inappropriate and ineffective inhibitor of PKCdelta: S.P. Soltoff; TIPS 28, 453 (2007) Abstract
Further Categories Containing This Product:
PKA Inhibitors • CAM Kinase Inhibitors • Casein Kinase Inhibitors • PKC Inhibitors
 
 
ALX-350-076 Revised 16-Jun-08
Sanguinarine chloride
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SYNONYMS Pseudochelerythrine
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - ATPase Inhibitors
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ALX-350-076-M005   5 mg 75.00 USD Add To Cart
Product Specification
FORMULA: C20H14NO4Cl
MW: 367.8
CAS NUMBER: 5578-73-4
MERCK INDEX: 14: 8356
RTECS: VP5220000
SOURCE/HOST: Isolated from the leaves and stems of Macleaya cordata and M. microcarpa.
PURITY: ≥98% (HPLC)
APPEARANCE: Orange solid.
SOLUBILITY: Soluble in methanol; slightly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: HARMFUL.

Product Description
Na+/K+-and Mg2+-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. Modulates the Bcl-2 family. Shows antiplaque activity in humans.
Product Specific Literature References
Sanguinarine, inhibitor of Na-K dependent ATP'ase: K.D. Straub & P. Carver; BBRC 62, 913 (1975) Abstract
Isoquinoline alkaloids. Inhibitory actions on cation-dependent ATP-phosphohydrolases: L.R. Meyerson, et al.; Neurochem. Res. 3, 239 (1978) Abstract
Sanguinarine, a new antiplaque agent: retention and plaque specificity: G.L. Southard, et al.; J. Am. Dent. Assoc. 108, 338 (1984) Abstract
Sanguinarine-induced apoptosis is associated with an early and severe cellular glutathione depletion: E. Debiton, et al.; Cancer Chemother. Pharmacol. 51, 474 (2003) Abstract
Activation of prodeath Bcl-2 family proteins and mitochondrial apoptosis pathway by sanguinarine in immortalized human HaCaT keratinocytes: V.M. Adhami, et al.; Clin. Cancer Res. 9, 3176 (2003) Abstract
The effect of chelerythrine on cell growth, apoptosis, and cell cycle in human normal and cancer cells in comparison with sanguinarine: J. Malikova, et al.; Cell Biol. Toxicol. 22, 439 (2006) Abstract
Chelerythrine and sanguinarine dock at distinct sites on BclXL that are not the classic BH3 binding cleft: Y.H. Zhang, et al.; J. Mol. Biol. 364, 538 (2006) Abstract
Induction of apoptosis by sanguinarine in C6 rat glioblastoma cells is associated with the modulation of the Bcl-2 family and activation of caspases through downregulation of extracellular signal-regulated kinase and Akt: M.H. Han, et al.; Anticancer Drugs 18, 913 (2007) Abstract
Metabolism of sanguinarine: the facts and the myths: Z. Dvorak & V. Simanek; Curr. Drug Metab. 8, 173 (2007), Review Abstract
Further Categories Containing This Product:
Na+ / K+-ATPase / Related Products • Bcl-2 Family Modulators • Natural Products - Anti-inflammatory Agents • Natural Products - Antioxidants • Alkaloids • Natural Products - Apoptosis Inducers & Inhibitors
 
 
ALX-350-077 Revised 30-Jun-08
Swainsonine
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SYNONYMS 8α,β-Octahydroindolizidine-1α,2α,8β-triol
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
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ALX-350-077-MC05   0.5 mg 85.00 USD Add To Cart
ALX-350-077-M001   1 mg 148.00 USD Add To Cart
Product Specification
FORMULA: C8H15NO3
MW: 173.2
CAS NUMBER: 72741-87-8
SOURCE/HOST: Synthetic.
PURITY: ≥98% (TLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO, methanol or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by 1H-NMR.

Product Description
Reversibly inhibits the active site of lysosomal α-mannosidase. Also inhibits the growth of tumors and prevents metastasis in murine models. Could inhibit cell proliferation in vitro and the growth of human gastric carcinoma in vivo. Blocks the processing of high mannose oligosaccharides to form complex type oligosaccharides.
Product Specific Literature References
Inhibitors of glycoprotein synthesis: A.D. Elbein; Meth. Enzymol. 98, 135 (1983) Abstract
Purification and characterization of Ca2+/calmodulin-dependent protein kinase V from rat cerebrum: H. Mochizuki, et al.; J. Biol. Chem. 268, 9143 (1993) Abstract; Full Text
Swainsonine protects both murine and human haematopoietic systems from chemotherapeutic toxicity: J.L. Klein, et al.; Br. J. Cancer 80, 87 (1999) Abstract
Swainsonine stimulates bone marrow cell proliferation and differentiation in different strains of inbred mice: O.A. Oredipe, et al.; Pharmacol. Res. 47, 69 (2003) Abstract
Inhibition of the growth of human gastric carcinoma in vivo and in vitro by swainsonine: J.Y. Sun, et al.; Phytomedicine 14, 353 (2007) Abstract
Further Categories Containing This Product:
Alkaloids • Natural Products with Antibiotic Activity • Glycosidases / Related Products
 
 
ALX-350-080 Revised 11-Jan-08
Microcystin-LW
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Microcystins
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ALX-350-080-C025   25 µg 135.00 USD Add To Cart
ALX-350-080-C100   100 µg 390.00 USD Add To Cart
Product Specification
FORMULA: C54H72N8O12
MW: 1025.2
SOURCE/HOST: Isolated from Microcystis aeruginosa.
PURITY: ≥95% (HPLC)
APPEARANCE: Whitish film adhered to inside of the vial.
SOLUBILITY: Soluble in 100% methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: For maximum product recovery after thawing, centrifuge the vial before opening the cap.
HAZARD: MAY BE CARCINOGENIC. HIGHLY IRRITANT. VERY TOXIC.

Product Description
Analog of microcystin-LR (Prod. No. ALX-350-012) with Trp substituted in place of Arg. Hydrophobic and believed to be more cell permeable than other microcystins. May prove useful in biochemical studies in intact cells. Microcystin-LW has a characteristically different absorption spectrum compared to other microcystins, making it a useful reference compound for HPLC analysis. The Trp confers an absorption maximum at 222nm, whereas most microcystins have a characteristic maximum at 239nm.
Product Specific Literature References
Extraction and high-performance liquid chromatographic method for the determination of microcystins in raw and treated waters: L.A. Lawton, et al.; Analyst 119, 1525 (1994) Abstract
Isolation and characterization of microcystins from laboratory cultures and environmental samples of Microcystis aeruginosa and from an associated animal toxicosis: L.A. Lawton, et al.; Nat. Toxins 3, 50 (1995) Abstract
Comparative toxicity of four microcystins of different hydrophobicities to the protozoan, Tetrahymena pyriformis: C.J. Ward & G.A. Codd; J. Appl. Microbiol. 86, 874 (1999) Abstract
Detection and quantification of microcystins (cyanobacterial hepatotoxins) with recombinant antibody fragments isolated from a naive human phage display library: J. McElhiney, et al.; FEMS Microbiol. Lett. 193, 83 (2000) Abstract
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Further Categories Containing This Product:
Other Toxins
 
 
ALX-350-081 Revised 30-Jun-08
Microcystin-LF
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Microcystins
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-081-C025   25 µg 135.00 USD Add To Cart
ALX-350-081-C100   100 µg 390.00 USD Add To Cart
Product Specification
FORMULA: C52H71N7O12
MW: 986.2
SOURCE/HOST: Isolated from Microcystis aeruginosa.
PURITY: ≥95% (HPLC)
APPEARANCE: Whitish film adhered to inside of the vial.
SOLUBILITY: Soluble in methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable in solution for at least 4 weeks when stored at -20 °C.
HANDLING: For maximum product recovery after thawing, centrifuge the vial before opening the cap.
HAZARD: HIGHLY IRRITANT. VERY TOXIC. MAY BE CARCINOGENIC.
IDENTITY: Identity determined by MS.

Product Description
Analog of microcystin-LR (Prod. No. ALX-350-012) with Phe substituted in place of Arg. Hydrophobic and believed to be more cell permeable than other microcystins. More toxic than the more hydrophilic analogs such as microcystin-LR and microcystin-LY.
Product Specific Literature References
Extraction and high-performance liquid chromatographic method for the determination of microcystins in raw and treated waters: L.A. Lawton, et al.; Analyst 119, 1525 (1994) Abstract
First report of microcystins from a Brazilian isolate of the cyanobacterium Microcystis aeruginosa: S.M.F.O. Azevedo, et al.; J. Appl. Phycology 6, 261 (1994)
Isolation and characterization of microcystins from laboratory cultures and environmental samples of Microcystis aeruginosa and from an associated animal toxicosis: L.A. Lawton, et al.; Nat. Toxins 3, 50 (1995) Abstract
Comparative toxicity of four microcystins of different hydrophobicities to the protozoan, Tetrahymena pyriformis: C.J. Ward & G.A. Codd; J. Appl. Microbiol. 86, 874 (1999) Abstract
Detection and quantification of microcystins (cyanobacterial hepatotoxins) with recombinant antibody fragments isolated from a naive human phage display library: J. McElhiney, et al.; FEMS Microbiol. Lett. 193, 83 (2000) Abstract
Pseudodiarrhoea in zebra mussels Dreissena polymorpha (Pallas) exposed to microcystins: G. Juhel, et al.; J. Exp. Biol. 209, 810 (2006) Abstract
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Further Categories Containing This Product:
Other Toxins
 
 
ALX-350-084 Revised 07-Apr-08
Lavendustin C methyl ester
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SYNONYMS Compound 5 methyl ester
5-Amino-N-(2,5-dihydroxybenzyl)methyl salicylate
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Protein Kinase Inhibitors
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ALX-350-084-M001   1 mg 50.00 USD Add To Cart
ALX-350-084-M005   5 mg 200.00 USD Add To Cart
Product Specification
FORMULA: C15H15NO5
MW: 289.3
SOURCE/HOST: Synthetic.
PURITY: ≥97%
APPEARANCE: Off-white solid.
SOLUBILITY: Soluble in DMSO or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description
Inhibitor of EGFR tyrosine kinase with improved bioavailability over lavendustin C (Prod. No. ALX-270-066).
Product Specific Literature References
Synthesis and structure-activity studies of a series of [(hydroxybenzyl)amino]salicylates as inhibitors of EGF receptor- associated tyrosine kinase activity: H. Chen, et al.; J. Med. Chem. 36, 4094 (1993) Abstract
Structure-activity relationships in a series of 5-[(2,5- dihydroxybenzyl)amino]salicylate inhibitors of EGF-receptor-associated tyrosine kinase: importance of additional hydrophobic aromatic interactions: H. Chen, et al.; J. Med. Chem. 37, 845 (1994) Abstract
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Further Categories Containing This Product:
Tyrosine Kinase Inhibitors • EGFR Kinase Inhibitors
 
 
ALX-350-086 Revised 08-Apr-08
Nordihydroguaiaretic acid
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SYNONYMS NDGA
4,4'-(2,3-Dimethyl-1,4-butanediyl)bis[1,2-benzenediol]
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products for Inflammation Research
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ALX-350-086-G001   1 g 62.00 USD Add To Cart
Product Specification
FORMULA: C18H22O4
MW: 302.4
CAS NUMBER: 500-38-9
MERCK INDEX: 14: 6693
SOURCE/HOST: Synthetic.
PURITY: ≥95%
APPEARANCE: Crystalline powder.
SOLUBILITY: Soluble in 100% ethanol, methanol or acetone; slightly soluble in hot water.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C

Product Description
Antioxidant and antineoplastic. Lipoxygenase inhibitor. Stimulates the rapid retrograde movement of both Golgi stacks and the trans-Golgi network to the endoplasmatic reticulum (ER). Displays pleiotropic effects on cells, which include apoptosis, cell proliferation, differentiation and chemotaxis. Anticancer agent.
Product Specific Literature References
Inhibition of tumoral cell respiration and growth by nordihydroguaiaretic acid: M. Pavani, et al.; Biochem. Pharmacol. 48, 1935 (1994) Abstract
Nordihydroguaiaretic acid blocks protein transport in the secretory pathway causing redistribution of Golgi proteins into the endoplasmic reticulum: T. Fujiwara, et al.; J. Biol. Chem. 273, 3068 (1998) Abstract; Full Text
Effect of nordihydroguaiaretic acid on the secretion of lipoprotein lipase: S.M. Kim, et al.; J. Biochem. Mol. Biol. 35, 518 (2002) Abstract; Full Text
Mechanisms underlying the activation of large conductance Ca2+-activated K+ channels by nordihydroguaiaretic acid: H. Yamamura, et al.; Jpn. J. Pharmacol. 89, 53 (2002) Abstract
Direct interaction of the Golgi membrane with the endoplasmic reticulum membrane caused by nordihydroguaiaretic acid: T. Fujiwara, et al.; BBRC 301,