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Acetylcholine Receptors (Nicotinic) / Related Products
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ALX-350-112 Revised 29-Nov-07
Anabasine . hydrochloride
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SYNONYMS 3-(2-Piperidinyl)pyridine
2-(3-Pyridyl)piperidine
Neonicotine
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Neurological Research
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ALX-350-112-M025   25 mg 20.00 USD Add To Cart
ALX-350-112-M100   100 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C10H14N2 . HCl
MW: 162.2 . 36.5
CAS NUMBER: 15251-47-5
MERCK INDEX: 14: 619
SOURCE/HOST: Isolated from Anabasis aphylla.
PURITY: ≥97%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in alcohol or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description
Tobacco alkaloid. Potent nicotinic acetylcholine receptor agonist. Insecticide.
Product Specific Literature References
Nicotine, cotinine, and anabasine inhibit aromatase in human trophoblast in vitro: R.L. Barbieri, et al.; J. Clin. Invest. 77, 1727 (1986) Abstract
Anabasine and anatabine as biomarkers for tobacco use during nicotine replacement therapy: P. Jacob, 3rd, et al.; Cancer Epidemiol. Biomarkers Prev. 11, 1668 (2002) Abstract
Anabasine, a selective nicotinic acetylcholine receptor agonist, antagonizes MK-801-elicited mouse popping behavior, an animal model of schizophrenia: J. Mastropaolo, et al.; Behav. Brain Res. 153, 419 (2004) Abstract
Simultaneous and sensitive measurement of anabasine, nicotine, and nicotine metabolites in human urine by liquid chromatography-tandem mass spectrometry: X. Xu, et al.; Clin. Chem. 50, 2323 (2004) Abstract
Anabasine toxicity from a topical folk remedy: N.G. Murphy, et al.; Clin. Pediatr. (Phila) 45, 669 (2006) Abstract
Further Categories Containing This Product:
Acetylcholine Receptors (Nicotinic) / Related Products • Alkaloids • Pesticides / Related Products
 
 
ALX-630-075 Revised 31-Oct-07
α-Bungarotoxin
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SYNONYMS α-BuTx
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Neurotoxins
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ALX-630-075-M001   1 mg 65.00 USD Add To Cart
Product Specification
SEQUENCE: H-Ile-Val-Cys-His-Thr-Thr-Ala-Thr-Ser-Pro-Ile-Ser-Ala-Val-Thr-Cys-Pro-Pro-Gly-Glu-Asn-Leu-Cys-Tyr-Arg-Lys-Met-Trp-Cys-Asp-Ala-Phe-Cys-Ser-Ser-Arg-Gly-Lys-Val-Val-Glu-Leu-Gly-Cys-Ala-Ala-Thr-Cys-Pro-Ser-Lys-Lys-Pro-Tyr-Glu-Glu-Val-Thr-Cys-Cys-Ser-Thr-Asp-Lys-Cys-Asn-Pro-His-Pro-Lys-Gln-Arg-Pro-Gly-OH
(Disulfide bonds between Cys3-Cys23, Cys16-Cys44, Cys29-Cys33, Cys48-Cys59 and Cys60-Cys65)
MW: 7984.2
CAS NUMBER: 11032-79-4
MERCK INDEX: 14: 1488
SOURCE/HOST: Isolated from Bungarus multicinctus.
PURITY: ≥98%
APPEARANCE: Lyophilized powder.
SOLUBILITY: Soluble in water or aqueous buffers.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: POTENT NEUROTOXIN.
Product Description
Post-synaptic neurotoxin that binds irreversibly to acetylcholine receptor sites, producing neuromuscular blockade and skeletal muscle paralysis. Prevents opening of nicotinic receptor-associated ion channels.
Product Specific Literature References
Use of a snake venom toxin to characterize the cholinergic receptor protein: J.P. Changeux, et al.; PNAS 67, 1241 (1970) Abstract
Amino acid sequence of alpha-bungarotoxin from the venom of Bungarus multicinctus: D. Mebs, et al.; BBRC 44, 711 (1971) Abstract
Elapid neurotoxins. Purification, characterization, and immunochemical studies of alpha-bungarotoxin: D.G. Clark, et al.; Biochemistry 11, 1663 (1972) Abstract
Purification, properties and amino acid sequence of alpha-bungarotoxin from the venom of Bungarus multicinctus: D. Mebs, et al.; Hoppe Seylers Z. Physiol. Chem. 353, 243 (1972) Abstract
alpha-Bungarotoxin binding sites in the CNS: B.J. Morley, et al.; Life Sci. 24, 859 (1979) Abstract
Alpha-bungarotoxin binding and central nervous system nicotinic acetylcholine receptors: R.E. Oswald & J.A. Freeman; Neuroscience 6, 1 (1981) Abstract
Determination of the primary amino acid sequence specifying the alpha-bungarotoxin binding site on the alpha subunit of the acetylcholine receptor from Torpedo californica: P.T. Wilson, et al.; PNAS 82, 8790 (1985) Abstract
The crystal structure of alpha-bungarotoxin at 2.5 A resolution: relation to solution structure and binding to acetylcholine receptor: R.A. Love & R.M. Stroud; Protein Eng. 1, 37 (1986) Abstract
Neuronal nicotinic alpha-bungarotoxin sites: M. Quik & S. Geertsen; Can. J. Physiol. Pharmacol. 66, 971 (1988) Abstract
The fall and rise of neuronal alpha-bungarotoxin binding proteins: P.B. Clarke; TIPS 13, 407 (1992), (Review) Abstract
Three subtypes of alpha-bungarotoxin-sensitive nicotinic acetylcholine receptors are expressed in chick retina: K.T. Keyser, et al.; J. Neurosci. 13, 442 (1993) Abstract
Neuronal acetylcholine receptors that bind alpha-bungarotoxin mediate neurite retraction in a calcium-dependent manner: P.C. Pugh and D.K. Berg; J. Neurosci. 14, 889 (1994) Abstract
The alpha-bungarotoxin binding site on the nicotinic acetylcholine receptor: analysis using a phage-epitope library: M. Balass, et al.; PNAS 94, 6054 (1997) Abstract
Nicotine blocks TNF-alpha-mediated neuroprotection to NMDA by an alpha-bungarotoxin-sensitive pathway: N.G. Carlson, et al.; J. Neurobiol. 35, 29 (1998) Abstract
Alpha-Bungarotoxin binding to human muscle acetylcholine receptor measurement of affinity, delineation of AChR subunit residues crucial to binding, and protection of AChR function by synthetic peptide: A. Vincent, et al.; Neurochem. Int. 32, 427 (1998) Abstract
Alpha-bungarotoxin binding to acetylcholine receptor membranes studied by low angle X-ray diffraction: H.S. Young, et al.; Biophys. J. 83, 943 (2003) Abstract
Imaging of receptor trafficking by using alpha-bungarotoxin-binding-site-tagged receptors: Y. Sekine-Aizawa & R. L. Huganir; PNAS 101, 17114 (2004) Abstract
The cholinergic antagonist alpha-bungarotoxin also binds and blocks a subset of GABA receptors: C.M. McCann, et al.; PNAS 103, 5149 (2006) Abstract
MD and NMR studies of alpha-bungarotoxin surface accessibility: V. Venditti, et al.; Biochem. Biophys. Res. Commun . 356, 114 (2007) Abstract
Further Categories Containing This Product:
Acetylcholine Receptors (Nicotinic) / Related Products
 
 
ALX-350-373 Revised 10-Jul-08 New product
Cytisine
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Acetylcholine Receptors (Nicotinic) / Related Products
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ALX-350-373-M005   5 mg 35.00 USD Add To Cart
ALX-350-373-M025   25 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C11H14N2O
MW: 190.2
CAS NUMBER: 485-35-8
MERCK INDEX: 14:2789
RTECS: HA4025000
SOURCE/HOST: Isolated from seeds of Laburnum anagyroides
PURITY: ≥95% (HPLC)
APPEARANCE: Light to dark yellow powder.
SOLUBILITY: Soluble in benzene, acetone, ethyl acetate or 100% ethanol; sparingly soluble in water or methanol.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HAZARD: TOXIC.
IDENTITY: Identity determined by 1H-NMR.

Product Description
Pyridine-like alkaloid. Nicotine agonist. Potent ligand for many nAChR subtypes. Potent agonist at α3β4 and α7 nicotinic acetylcholine receptors and partial agonist at α4β2 nicotinic acetylcholine receptors. Shows analgesic, antihypertensive and inotropic activities.
Product Specific Literature References
Some studies on cytisine and its methylated derivatives: R.B. Barlow & L.J. McLeod; Br. J. Pharmacol. 35, 161 (1969) Abstract; Full Text
Release of [3H]-noradrenaline from rat hippocampal synaptosomes by nicotine: mediation by different nicotinic receptor subtypes from striatal [3H]-dopamine release: P.B. Clarke & M. Reuben; Br. J. Pharmacol. 117, 595 (1996) Abstract; Full Text
Evaluation of anti-nociceptive effects of neuronal nicotinic acetylcholine receptor (NAChR) ligands in the rat tail-flick assay: T.S. Rao, et al.; Neuropharmacology 35, 393 (1996) Abstract
Somatic and prejunctional nicotinic receptors in cultured rat sympathetic neurones show different agonist profiles: D. Kristufek, et al.; J. Physiol. 516, 739 (1999) Abstract; Full Text
Inherited, selective hypoanalgesic response to cytisine in the tail-flick test in CF-1 mice: T.W. Seale, et al.; Neuroreport 9, 201 (1998) Abstract
Effects of cytisine on hydroxyl radicals in vitro and MPTP-induced dopamine depletion in vivo: B. Ferger, et al.; Eur. J. Pharmacol. 360, 155 (1998) Abstract
Cytisine derivatives as ligands for neuronal nicotine receptors and with various pharmacological activities: C.C. Boido, et al.; Farmaco 58, 265 (2003) Abstract
Pharmacological characterization of recombinant bovine alpha3beta4 neuronal nicotinic receptors stably expressed in HEK 293 cells: R.B. Free, et al.; Neurosci. Lett. 343, 180 (2003) Abstract
Nitrogen substitution modifies the activity of cytisine on neuronal nicotinic receptor subtypes: E. Carbonnelle, et al.; Eur. J. Pharmacol. 471, 85 (2003) Abstract
Cytisine binds with similar affinity to nicotinic alpha4beta2 receptors on the cell surface and in homogenates: J. Zhang & J.H. Steinbach; Brain Res. 959, 98 (2003) Abstract
Pharmacological characterization of recombinant bovine alpha3beta4 neuronal nicotinic receptors stably expressed in HEK 293 cells: R.B. Free, et al.; Neurosci. Lett. 343, 180 (2003) Abstract
Cytisine, a partial agonist of high-affinity nicotinic acetylcholine receptors, has antidepressant-like properties in male C57BL/6J mice: Y.S. Mineur, et al.; Neuropharmacology 52, 1256 (2007) Abstract; Full Text
Ligands selective for alpha4beta2 but not alpha3beta4 or alpha7 nicotinic receptors generalise to the nicotine discriminative stimulus in the rat: J.W. Smith, et al.; Psychopharmacology (Berl) 190, 157 (2007) Abstract
 
 
ALX-350-001 Revised 05-Apr-08
Forskolin
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SYNONYMS Colforsin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Other Signal Transduction Pathway Modulators
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ALX-350-001-M001   1 mg 20.00 USD Add To Cart
ALX-350-001-M005   5 mg 52.00 USD Add To Cart
ALX-350-001-M010   10 mg 85.00 USD Add To Cart
ALX-350-001-M025   25 mg 185.00 USD Add To Cart
ALX-350-001-M050   50 mg 325.00 USD Add To Cart
Product Specification
FORMULA: C22H34O7
MW: 410.5
CAS NUMBER: 66575-29-9
MERCK INDEX: 14: 2476
SOURCE/HOST: Isolated from Coleus forskohlii.
PURITY: ≥98% (HPLC)
APPEARANCE: Off-white to green crystals.
SOLUBILITY: Soluble in ethyl acetate (10mg/ml), anhydrous DMSO (5mg/ml) or 100% ethanol (6mg/ml). DMSO is the recommended solvent for activation of cAMP.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
USE/STABILITY: Stock solutions in DMSO are stable for up to 4 months when stored at +4°C.

Product Description
Activates adenylate cyclase leading to an increase in the intracellular concentration of cAMP. Widely used tool for the investigation of the role of cAMP as a second messenger with a broad range of potential therapeutic applications. Inotropic agent and vasodilator. Induces platelet aggregation. Inhibits ion channels by a mechanism that does not involve cAMP. Non-competitive inhibitor of nicotinic acetylcholine receptors.
Product Specific Literature References
Forskolin: a unique diterpene activator of cyclic AMP-generating systems: K.B. Seamon & J.W. Daly; J. Cyclic Nucleotide Res. 7, 201 (1981), Review Abstract
Forskolin, an activator of adenylate cyclase, increases CA2+-dependent electrical activity induced by glucose in mouse pancreatic B cells: J.C. Henquin, et al.; Endocrinology 112, 2218 (1983) Abstract
Pharmacology and inotropic potential of forskolin in the human heart: M.R. Bristow, et al.; J. Clin. Invest. 74, 212 (1984) Abstract
Forskolin and antidiuretic hormone stimulate a Ca2+-activated K+ channel in cultured kidney cells: S.E. Guggino, et al.; Am. J. Physiol. 249, F448 (1985) Abstract
Use of forskolin to study the relationship between cyclic AMP formation and bone resorption in vitro: U.H. Lerner, et al.; Biochem J. 240, 529 (1986) Abstract
Forskolin: a specific stimulator of adenylyl cyclase or a diterpene with multiple sites of action?: A. Laurenza, et al.; Trends Pharmacol. Sci. 10, 442 (1989), Review Abstract
Effect of forskolin on cytosolic Ca++ level and contraction in vascular smooth muscle: A. Abe & H. Karaki; J. Pharmacol. Exp. Ther. 249, 895 (1989) Abstract
Forskolin acts as a noncompetitive inhibitor of nicotinic acetylcholine receptors: M.L. Aylwin & M.M. White; Mol. Pharmacol. 41, 908 (1992) Abstract
The effect of forskolin on blood flow, platelet metabolism, aggregation and ATP release: J.T. Christenson, et al.; Vasa 24, 56 (1995) Abstract
Forskolin as a tool for examining adenylyl cyclase expression, regulation, and G protein signaling: P.A. Insel & R.S. Ostrom; Cell Mol. Neurobiol. 23, 305 (2003), Review Abstract
Effect of forskolin on the expression of claudin-5 in human trophoblast BeWo cells: M. Harada, et al.; Pharmazie 62, 291 (2007) Abstract
Further Categories Containing This Product:
Adenylyl Cyclase Activators • Ion Channels & Transporters Other Products • Acetylcholine Receptors (Nicotinic) / Related Products • Natural Products - Nitric Oxide Pathway Modulators • Natural Products for Neurological Research
 
 
ALX-420-023 Revised 07-Mar-07
Lobeline . hydrochloride
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SYNONYMS L-Lobeline . HCl
2-[6-(2-Hydroxy-2-phenethyl)-1-methyl-2-piperidyl]acetophenone . HCl
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Neurological Research
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-420-023-M050   50 mg 17.00 USD Add To Cart
ALX-420-023-M250   250 mg 50.00 USD Add To Cart
ALX-420-023-G001   1 g 155.00 USD Add To Cart
Product Specification
FORMULA: C22H27NO2 . HCl
MW: 337.5 . 36.5
CAS NUMBER: 134-63-4
MERCK INDEX: 14: 5551
RTECS: OJ8490100
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: TOXIC.

Product Description
Neuronal nicotinic acetylcholine receptor agonist. Respiratory stimulant.
Further Categories Containing This Product:
Acetylcholine Receptors (Nicotinic) / Related Products • Alkaloids
 
 
ALX-802-002 Revised 05-Mar-07
Monoclonal Antibody to Nicotinic Acetylcholine Receptor (88B)
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SYNONYMS anti-nAChR MAb (88B)
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Acetylcholine Receptors (Nicotinic) / Related Products
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ALX-802-002-R100   100 µl 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
Others
CLONE: 88B
ISOTYPE: Mouse IgG1
FORMULATION: Liquid. Ascites diluted in PBS containing 0.05% sodium azide.
IMMUNOGEN: Purified Torpedo californica AChR (acetylcholine receptor).
SPECIFICITY: Recognizes the intracellular domain of skeletal muscle nAChR γ and δ subunits in Torpedo californica and the δ subunit in mouse, rat, chicken, frog and fish. Detects bands of ~60kDa (γ subunit ) and ~65kDa (δ subunit ) by Western blot. Under non-reducing conditions detects a band of ~130kDa (dimer of δ subunit). Does not cross-react with the α1 and β1 subunits in muscle or the neuronal nAChRs.
APPLICATION: Immunohistochemistry (frozen sections (1:1'000))
Immunoprecipitation
Western Blot (1:5'000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Monoclonal antibodies to cytoplasmic domains of the acetylcholine receptor: S.C. Froehner, et al.; J. Biol. Chem. 258, 7112 (1983) Abstract; Full Text
Structure of nicotinic acetylcholine receptors: A. Karlin; Curr. Opinion Neurobiol. 3, 299 (1993) Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-550-526 Revised 02-Oct-08
PNU-120596
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SYNONYMS NSC 216666
N-(5-Chloro-2,4-dimethoxyphenyl)-N’-(5-methyl-3-isoxazolyl)urea
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Acetylcholine Receptors (Nicotinic) / Related Products
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ALX-550-526-M001   1 mg 40.00 USD Add To Cart
ALX-550-526-M005   5 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C13H14ClN3O4
MW: 311.7
CAS NUMBER: 501925-31-1
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO (50mg/ml); slightly soluble in methanol (1mg/ml) or acetonitrile (0.5mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by MS,NMR.

Product Description
Type II positive allosteric modulator (PAM) of α7 neuronal nicotinic acetylcholine receptor (nAChR) (EC50=216nM). Shows no detectable effect on α4β2, α3β4 and α9α10 receptors.
Product Specific Literature References
A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization: R.S. Hurst, et al.; J. Neurosci. 25, 4396 (2005) Abstract; Full Text
Distinct profiles of alpha7 nAChR positive allosteric modulation revealed by structurally diverse chemotypes: J.H. Gronlien, et al.; Mol. Pharmacol. 72, 715 (2007) Abstract
Allosteric Modulators of the alpha7 Nicotinic Acetylcholine Receptor: R. Faghih, et al.; J. Med. Chem. 51, 701 (2008) Abstract
 
 
ALX-550-300 Revised 07-Feb-05
TMB-8 . hydrochloride
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SYNONYMS 8-(Diethylamino)octyl-3,4,5-trimethoxybenzoate . HCl
PRODUCT LINE Inflammation
PRODUCT CATEGORY Platelet Activating Factors [PAF] & Receptors / Related Products
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ALX-550-300-M025   25 mg 50.00 USD Add To Cart
Product Specification
FORMULA: C22H37NO5 . HCl
MW: 395.5 . 36.5
CAS NUMBER: 53464-72-5
PURITY: ≥98%
APPEARANCE: White solid.
SOLUBILITY: Soluble in water or ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light and moisture.

Product Description
Intracellular Ca2+ antagonist of serum-stimulated Na+ influx in human fibroblasts. Inhibits platelet-activating factor (PAF) and PMA-stimulated prostaglandin production in Kupffer cells.
Product Specific Literature References
Inhibition of protein kinase C activation by 8-(N,N-diethylamino)-octyl- 3, 4, 5-trimethoxybenzoate (TMB-8), an intracellular Ca2+ antagonist: M. Sawamura; J. Med. Sci. 31, 221 (1985) Abstract
Platelet-activating factor-mediated synthesis of prostaglandins in rat Kupffer cells: C.R. Gandhi, et al.; Biochim. Biophys. Acta 1136, 68 (1992) Abstract
Calcium-independent effects of TMB-8. Modification of phospholipid metabolism in neuroblastoma cells by inhibition of choline uptake: F.B. Palmer, et al.; Biochem. J. 286, 505 (1992) Abstract
Further Categories Containing This Product:
Ca2+ Modulators • Acetylcholine Receptors (Muscarinic) / Related Products • Acetylcholine Receptors (Nicotinic) / Related Products • Prostaglandins Other Products • Acetylcholine Receptors Other Products
 
 
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