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ALX-460-006 Revised 08-Oct-07
Folic acid
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SYNONYMS Pteroylglutamic acid
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Folic Acid & Folate Receptors/Related Products
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ALX-460-006-G010   10 g 28.00 USD Add To Cart
Product Specification
FORMULA: C19H19N7O6
MW: 441.4
CAS NUMBER: 59-30-3
MERCK INDEX: 14: 4221
PURITY: ≥97%
APPEARANCE: Yellow to orange powder.
SOLUBILITY: Soluble in diluted acids or alkaline solutions; slightly soluble in water or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Alkaline solutions are reasonably stable. Other solutions may be light and heat sensitive.

Further Categories Containing This Product:
Natural Products - Chemopreventive Agents • Active Substances from Fruit and Vegetables • Vitamins
 
 
ALX-270-312 Revised 03-Jan-08
Formononetin (high purity)
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SYNONYMS 7-Hydroxy-4’-methoxyisoflavone (high purity)
7-Hydroxy-3-(4’-methoxyphenyl)-4H-benzopyran-4-one (high purity)
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavonoids/Related Products
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ALX-270-312-M005   5 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C16H12O4
MW: 268.3
CAS NUMBER: 485-72-3
MERCK INDEX: 14: 4244
PURITY: ≥97%
APPEARANCE: White to greyish powder.
SOLUBILITY: Soluble in DMSO (200mg/ml) or methanol (2mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Place in a desiccator under vacuum for 48 hours before use.
HANDLING: Protect from light.

Product Description
Interacts with human estrogen receptors with low potency. Enhances IL-4 production in a dose-dependent manner. Inhibits lecithin peroxidation induced by hydroxyl radicals. Selective inhibitor of the γ-isoform of alcohol dehydrogenase. Antioxidant.
Product Specific Literature References
Interaction of naturally occurring nonsteroidal estrogens with expressed recombinant human estrogen receptor: R.J. Miksicek; J. Steroid Biochem. Mol. Biol. 49, 153 (1994) Abstract
Dietary estrogenic isoflavones are potent inhibitors of beta-hydroxysteroid dehydrogenase of P. testosteronii: W.M. Keung; BBRC 215, 1137 (1995) Abstract
Proliferative response of mammary glandular tissue to formononetin: W. Wang, et al.; Nutr. Cancer 23, 131 (1995) Abstract
Antioxidant activity of phytoestrogenic isoflavones: M.B. Ruiz-Larrea, et al.; Free Radic. Res. 26, 63 (1997) Abstract
Inhibitory effects of isoflavones on lipid peroxidation by reactive oxygen species: S. Toda and Y. Shirataki; Phytother. Res. 13, 163 (1999) Abstract
Isoflavonoids and lignans have different potentials to modulate oxidative genetic damage in human colon cells: B.L. Pool-Zobel, et al.; Carcinogenesis 21, 1247 (2000) Abstract
Disposition of flavonoids via enteric recycling: enzyme-transporter coupling affects metabolism of biochanin A and formononetin and excretion of their phase II conjugates: X. Jia, et al.; J. Pharmacol. Exp. Ther. 310, 1103 (2004) Abstract
Formononetin, a phyto-oestrogen, and its metabolites up-regulate interleukin-4 production in activated T cells via increased AP-1 DNA binding activity: J. Park, et al.; Immunology 116, 71 (2005) Abstract
Further Categories Containing This Product:
Other Natural Products for Inflammation Research • Interleukins Other Products • Active Substances from Fruit and Vegetables • Estrogen & Estrogen Receptors/Related Products • Natural Products - Antioxidants
 
 
ALX-350-001 Revised 05-Apr-08
Forskolin
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SYNONYMS Colforsin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Other Signal Transduction Pathway Modulators
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-001-M001   1 mg 20.00 USD Add To Cart
ALX-350-001-M005   5 mg 52.00 USD Add To Cart
ALX-350-001-M010   10 mg 85.00 USD Add To Cart
ALX-350-001-M025   25 mg 185.00 USD Add To Cart
ALX-350-001-M050   50 mg 325.00 USD Add To Cart
Product Specification
FORMULA: C22H34O7
MW: 410.5
CAS NUMBER: 66575-29-9
MERCK INDEX: 14: 2476
SOURCE/HOST: Isolated from Coleus forskohlii.
PURITY: ≥98% (HPLC)
APPEARANCE: Off-white to green crystals.
SOLUBILITY: Soluble in ethyl acetate (10mg/ml), anhydrous DMSO (5mg/ml) or 100% ethanol (6mg/ml). DMSO is the recommended solvent for activation of cAMP.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
USE/STABILITY: Stock solutions in DMSO are stable for up to 4 months when stored at +4°C.

Product Description
Activates adenylate cyclase leading to an increase in the intracellular concentration of cAMP. Widely used tool for the investigation of the role of cAMP as a second messenger with a broad range of potential therapeutic applications. Inotropic agent and vasodilator. Induces platelet aggregation. Inhibits ion channels by a mechanism that does not involve cAMP. Non-competitive inhibitor of nicotinic acetylcholine receptors.
Product Specific Literature References
Forskolin: a unique diterpene activator of cyclic AMP-generating systems: K.B. Seamon & J.W. Daly; J. Cyclic Nucleotide Res. 7, 201 (1981), Review Abstract
Forskolin, an activator of adenylate cyclase, increases CA2+-dependent electrical activity induced by glucose in mouse pancreatic B cells: J.C. Henquin, et al.; Endocrinology 112, 2218 (1983) Abstract
Pharmacology and inotropic potential of forskolin in the human heart: M.R. Bristow, et al.; J. Clin. Invest. 74, 212 (1984) Abstract
Forskolin and antidiuretic hormone stimulate a Ca2+-activated K+ channel in cultured kidney cells: S.E. Guggino, et al.; Am. J. Physiol. 249, F448 (1985) Abstract
Use of forskolin to study the relationship between cyclic AMP formation and bone resorption in vitro: U.H. Lerner, et al.; Biochem J. 240, 529 (1986) Abstract
Forskolin: a specific stimulator of adenylyl cyclase or a diterpene with multiple sites of action?: A. Laurenza, et al.; Trends Pharmacol. Sci. 10, 442 (1989), Review Abstract
Effect of forskolin on cytosolic Ca++ level and contraction in vascular smooth muscle: A. Abe & H. Karaki; J. Pharmacol. Exp. Ther. 249, 895 (1989) Abstract
Forskolin acts as a noncompetitive inhibitor of nicotinic acetylcholine receptors: M.L. Aylwin & M.M. White; Mol. Pharmacol. 41, 908 (1992) Abstract
The effect of forskolin on blood flow, platelet metabolism, aggregation and ATP release: J.T. Christenson, et al.; Vasa 24, 56 (1995) Abstract
Forskolin as a tool for examining adenylyl cyclase expression, regulation, and G protein signaling: P.A. Insel & R.S. Ostrom; Cell Mol. Neurobiol. 23, 305 (2003), Review Abstract
Effect of forskolin on the expression of claudin-5 in human trophoblast BeWo cells: M. Harada, et al.; Pharmazie 62, 291 (2007) Abstract
Further Categories Containing This Product:
Adenylyl Cyclase Activators • Ion Channels & Transporters Other Products • Acetylcholine Receptors (Nicotinic)/Related Products • Natural Products - Nitric Oxide Pathway Modulators • Natural Products for Neurological Research
 
 
ALX-380-065 Revised 21-Feb-08
Fostriecin
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SYNONYMS Phosphotrienin
CI-920
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Topoisomerase Inhibitors
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ALX-380-065-C010   10 µg 150.00 USD Add To Cart
Product Specification
FORMULA: C19H26O9PNa
MW: 452.4
CAS NUMBER: 87860-39-7
RTECS: UQ0600000
SOURCE/HOST: Isolated from Streptomyces pulveraceous subsp. fostreus.
PURITY: ≥98% (HPLC)
APPEARANCE: Colorless solid.
SOLUBILITY: Soluble in water (50 mg/ml), methanol (10 mg/ml) or 100 % ethanol (10 mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year when stored at -20°C. Use fresh solution.
HANDLING: Protect from light. Hygroscopic. Packaged under inert gas.

Product Description
Antitumor antibiotic. Catalytic inhibitor of topoisomerase II. Strong protein phosphatase 2A (PP2A) inhibitor (IC50=3.2nM). Weak inhibitor for PP1 (IC50=131µM). No apparent effect on PP2B. The binding site for fostriecin on PP2A is different from that of okadaic acid (see Prod. No. ALX-350-003).
Product Specific Literature References
Novel antitumor agents CI-920, PD 113,270 and PD 113,271. II. Isolation and characterization: S.S. Stampwala, et al.; J. Antibiot. (Tokyo) 36, 1601 (1983) Abstract
Novel antitumor agents CI-920, PD 113,270 and PD 113,271. I. Taxonomy, fermentation and biological properties: J.B. Tunac, et al.; J. Antibiot. (Tokyo) 36, 1595 (1983) Abstract
Studies on the biochemical mechanism of the novel antitumor agent, CI- 920: D.W. Fry, et al.; Cancer Chemother. Pharmacol. 13, 171 (1984) Abstract
Anticancer activity of the structurally novel antibiotic Cl-920 and its analogues: W.R. Leopold, et al.; Cancer Res. 44, 1928 (1984) Abstract
Inhibition of type II topoisomerase by fostriecin: T.J. Boritzki, et al.; Biochem. Pharmacol. 37, 4063 (1988) Abstract
Comparison of effects of fostriecin, novobiocin, and camptothecin, inhibitors of DNA topoisomerases, on DNA replication and repair in human cells: C.M. Gedik & A.R. Collins; Nucl. Acids Res. 18, 1007 (1990) Abstract
The cell cycle related differences in susceptibility of HL-60 cells to apoptosis induced by various antitumor agents: W. Gorczyca, et al.; Cancer Res. 53, 3186 (1993) Abstract
Induction of DNA strand breaks associated with apoptosis during treatment of leukemias: W. Gorczyca, et al.; Leukemia 7, 659 (1993) Abstract
Antitumor drug fostriecin inhibits the mitotic entry checkpoint and protein phosphatases 1 and 2A: M. Roberge, et al.; Cancer Res. 54, 6115 (1994) Abstract
Fostriecin: a review of the preclinical data: R.S. de Jong, et al.; Anticancer Drugs 8, 413 (1997) Abstract
Fostriecin, an antitumor antibiotic with inhibitory activity against serine/threonine protein phosphatases types 1 (PP1) and 2A (PP2A), is highly selective for PP2A: A.H. Walsh, et al.; FEBS Lett. 416, 230 (1997) Abstract
Fostriecin, an inhibitor of protein phosphatase 2A, limits myocardial infarct size even when administered after onset of ischemia: C. Weinbrenner, et al.; Circulation 98, 899 (1998) Abstract
Phase I and pharmacokinetic study of the topoisomerase II catalytic inhibitor fostriecin: R.S. de Jong, et al.; Br. J. Cancer 79, 882 (1999) Abstract
Fostriecin: chemistry and biology: D.S. Lewy, et al.; Curr. Med. Chem. 9, 2005 (2002) Abstract
Further Categories Containing This Product:
Antitumor Agents (Enzyme Inhibitors) • Antibiotics - Other Signal Transduction Pathway Modulators • PP2A/Related Products • Antitumor Antibiotics
 
 
ALX-350-119 Revised 20-Feb-08
Fumagillin
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SYNONYMS Fumidil B
Fumadil B
TNP-470
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics for Angiogenesis Research
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ALX-350-119-MC05   0.5 mg 65.00 USD Add To Cart
ALX-350-119-M001   1 mg 105.00 USD Add To Cart
Product Specification
FORMULA: C26H34O7
MW: 458.6
CAS NUMBER: 23110-15-8
MERCK INDEX: 14: 4286
SOURCE/HOST: Isolated from Aspergillus fumigatus.
PURITY: ≥95%
APPEARANCE: Light yellow solid
SOLUBILITY: Soluble in chloroform or diluted aqueous bases. Slightly soluble in methanol and other alcoholic solvents. Insoluble in water.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Unstable in aqueous solutions with pH >9.0 or pH <5.0.
HANDLING: Packaged under inert gas. Protect from light.
HAZARD: HARMFUL.

Product Description
Inhibitor of angiogenesis and endothelial cell proliferation. Specific inhibitor of methionine aminopeptidase type II (MetAP-II). Antineoplastic. Anti-infective.
Product Specific Literature References
Fumagillin (H-3), a new antibiotic with amebicidal properties: C.M. Mc, et al.; Science 113, 202 (1951) Abstract
Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth: D. Ingber, et al.; Nature 348, 555 (1990) Abstract
The anti-angiogenic agent fumagillin covalently modifies a conserved active-site histidine in the Escherichia coli methionine aminopeptidase: W.T. Lowther, et al.; PNAS 95, 12153 (1998) Abstract; Full Text
Molecular recognition of angiogenesis inhibitors fumagillin and ovalicin by methionine aminopeptidase 2: E.C. Griffith, et al.; PNAS 95, 15183 (1998) Abstract
Fumagillin treatment of intestinal microsporidiosis: J.M. Molina, et al.; N. Engl. J. Med. 346, 1963 (2002) Abstract
Whirling disease of salmonid fish: life cycle, biology, and disease: M.A. Gilbert & W.O. Granath, Jr.; J. Parasitol. 89, 658 (2003) Abstract
Fumagillin treatment of hepatocellular carcinoma in rats: an in vivo study of antiangiogenesis: I.S. Sheen, et al.; World J. Gastroenterol. 11, 771 (2005) Abstract
Fumagillin: an anti-infective as a parent molecule for novel angiogenesis inhibitors: B. Lefkove, et al.; Expert Rev. Anti Infect. Ther. 5, 573 (2007), Review Abstract
FGFR1/PI3K/AKT signaling pathway is a novel target for antiangiogenic effects of the cancer drug fumagillin (TNP-470): G.J. Chen, et al.; J. Cell Biochem. 101, 1492 (2007) Abstract
Further Categories Containing This Product:
Aminopeptidases/Related Products • Fibroblast Growth Factors [FGFs] & Receptors/Related Products • Antitumor Agents (Anti-proliferative) • Natural Products - Other Anti-infective Agents • Antitumor Antibiotics
 
 
ALX-630-110 Revised 18-Feb-08
Fumigaclavine A
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Mycotoxins
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ALX-630-110-M001   1 mg 90.00 USD Add To Cart
ALX-630-110-M005   5 mg 360.00 USD Add To Cart
Product Specification
FORMULA: C18H22N2O2
MW: 298.4
CAS NUMBER: 6879-59-0
SOURCE/HOST: Isolated from Aspergillus sp.
PURITY: ≥98% (HPLC)
APPEARANCE: Brown solid.
SOLUBILITY: Soluble in methanol, DMSO or acetone.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: TOXIC.

Product Description
Ergot alkaloid. Mycotoxin.
Product Specific Literature References
Nuclear magnetic resonance spectral analysis of the ergot alkaloids: N.J. Bach, et al.; J. Org. Chem. 39, 1272 (1974) Abstract
Mycotoxins produced by Aspergillus fumigatus isolated from silage: R.J. Cole, et al.; Ann. Nutr. Aliment. 31, 685 (1977) Abstract
Production of fumigaclavine A by Aspergillus tamarii Kita: K.K. Janardhanan, et al.; Can. J. Microbiol. 30, 247 (1984) Abstract
Abundant respirable ergot alkaloids from the common airborne fungus Aspergillus fumigatus: D.G. Panaccione & C.M. Coyle; Appl. Environ. Microbiol. 71, 3106 (2005) Abstract; Full Text
Post-genome research on the biosynthesis of ergot alkaloids: S.M. Li & I.A. Unsold; Planta Med. 72, 117 (2006) Abstract
Further Categories Containing This Product:
Alkaloids
 
 
ALX-350-127 Revised 07-May-08
Fumitremorgin C
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SYNONYMS FTC
SM-Q
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Mycotoxins
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ALX-350-127-C250   250 µg 130.00 USD Add To Cart
Product Specification
FORMULA: C22H25N3O3
MW: 379.5
CAS NUMBER: 118974-02-0
SOURCE/HOST: Isolated from Aspergillus fumigatus.
PURITY: ≥96% (HPLC)
APPEARANCE: Off-white to light brown powder.
SOLUBILITY: Soluble in DMSO, methanol or chloroform.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: TOXIC.

Product Description
Mycotoxin. Tremorgenic. Potent and specific inhibitor of the breast cancer resistance protein (BCRP; ABCG2). Reverses multidrug resistance mediated by BCRP and increases cytotoxicity of several anticancer agents in vitro.
Product Specific Literature References
Mycotoxins produced by Aspergillus fumigatus species isolated from molded silage: R.J. Cole, et al.; J. Agric. Food Chem. 25, 826 (1977) Abstract
Novel mammalian cell cycle inhibitors, tryprostatins A, B and other diketopiperazines produced by Aspergillus fumigatus. I. Taxonomy, fermentation, isolation and biological properties: C.B. Cui, et al.; J. Antibiot. 49, 527 (1996) Abstract
Reversal of a novel multidrug resistance mechanism in human colon carcinoma cells by fumitremorgin: S.K. Rabindran, et al.; Cancer Res. 58, 5850 (1998) Abstract
Fumitremorgin C reverses multidrug resistance in cells transfected with the breast cancer resistance protein.: S.K. Rabindran, et al.; Cancer Res. 60, 47 (2000) Abstract
Characterization of drug transport, ATP hydrolysis, and nucleotide trapping by the human ABCG2 multidrug transporter. Modulation of substrate specificity by a point mutation.: Ozvegy, et al.; J. Biol. Chem. 277, 47980 (2002) Abstract
The role of breast cancer resistance protein in acute lymphoblastic leukemia.: S.L. Plasschaert, et al.; Clin. Cancer Res. 9, 5171 (2003) Abstract
Plasma pharmacokinetics and tissue distribution of the breast cancer resistance protein (BCRP/ABCG2) inhibitor fumitremorgin C in SCID mice bearing T8 tumors: T.S. Garimella, et al.; Cancer Chemother. Pharmacol. 55, 101 (2005) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Optical Rotation: [α]D= +19° ±1° (c=1.0 in methanol).
Further Categories Containing This Product:
Other Natural Products for Cancer Research • Breast Cancer Resistance Protein [BCRP/MXR]/Related Products • MDR Inhibitors
 
 
ALX-350-017 Revised 22-Apr-08
Fumonisin B1
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Other Tumor Promoters
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ALX-350-017-M001   1 mg 60.00 USD Add To Cart
ALX-350-017-M005   5 mg 245.00 USD Add To Cart
Product Specification
FORMULA: C34H59NO15
MW: 721.8
CAS NUMBER: 116355-83-0
MERCK INDEX: 14: 4289
RTECS: TZ8350000
SOURCE/HOST: Isolated from Fusarium moniliforme.
PURITY: ~98% (TLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water, methanol, DMSO or acetonitrile.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: MAY BE CARCINOGENIC. MAY BE MUTAGENIC. MAY BE TERATOGENIC. HARMFUL.

Product Description
Mycotoxin. Induces DNA damage in the liver and cancer. Inhibitor of sphingosine biosynthesis. Induces apoptosis. Activates Akt (protein kinase B; PKB), which leads to increased survival, inhibition of GSK-3β activity and post-translational stabilization of cyclin D1.
Product Specific Literature References
Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme: E. Wang, et al.; J. Biol. Chem. 266, 14486 (1991) Abstract; Full Text
Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ: A.H. Merrill Jr., et al.; J. Biol. Chem. 268, 27299 (1993) Abstract; Full Text
Biological activities of fumonisins, mycotoxins from Fusarium moniliforme, in jimsonweed (Datura stramonium L.) and mammalian cell cultures: H.K. Abbas, et al.; Toxicon 31, 345 (1993) Abstract
Fumonisins and Alternaria alternata lycopersici toxins: sphinganine analog mycotoxins induce apoptosis in monkey kidney cells: H. Wang, et al.; PNAS 93, 3461 (1996) Abstract
A potential mechanism for fumonisin B(1)-mediated hepatocarcinogenesis: cyclin D1 stabilization associated with activation of Akt and inhibition of GSK-3beta activity: D. Ramljak, et al.; Carcinogenesis 21, 1537 (2000) Abstract
Implications of apoptosis for toxicity, carcinogenicity, and risk assessment: fumonisin B(1) as an example: Y.P. Dragan, et al.; Toxicol. Sci. 61, 6 (2001), Review Abstract
Fumonisin B(1): oxidative status and DNA damage in rats: A.M. Domijan, et al.; Toxicology 232, 163 (2007) Abstract
Further Categories Containing This Product:
Akt [PKB]/Related Products • Carcinogens & Tumor Promoters Other Products • Sphingolipids & Glycosphingolipids Other Products • Mycotoxins • DNA Damage & Repair Other Products • Natural Products - Apoptosis Inducers & Inhibitors