Advanced Search
© 2008 Alexis Corporation
You are here:
Product Lines
> Natural Products / Antibiotics
Antibiotics
Natural Products
Toxins
Toolbar - View Selection
Current View:
Price List
Brief
Detail
Search Results
Current Sort:
Sort by Product Name
Sort by Product ID
Sort by Result Relevance
Sort by Class
Show:
20 Products
50 Products
100 Products
All Products
Show Selected Products Only
Show
Products Only
Items
500-600
of 704
Page 6
of 8
Select Page:
<<
1
2
3
4
5
6
7
8
>>
ALX-630-020
Revised 29-Oct-07
Penitrem A
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Neurotoxins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-630-020-M001
1 mg
30.00 USD
ALX-630-020-M005
5 mg
120.00 USD
Product Specification
FORMULA:
C
37
H
44
NO
6
Cl
MW:
634.2
CAS NUMBER:
12627-35-9
SOURCE/HOST:
Isolated from
Penicillium palitans
.
PURITY:
≥98%
SOLUBILITY:
Must first be dissolved in organic solvents such as methanol, acetone or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
POTENT NEUROTOXIN.
Product Description
Fungal mycotoxin, which increases the spontaneous release of GABA and aspartate from cerebrocortical synaptosomes in rat neuromuscular junction. Specific and potent blocker of smooth muscle high-conductance Ca
2+
-activated K
+
channels.
Product Specific Literature References
Effects of a fungus tremorgenic toxin (penitrem A) on transmission in rat phrenic nerve-diaphragm preparations:
B.J. Wilson, et al.; Brain Res.
40
, 540 (1972)
Abstract
Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels:
H.G. Knaus, et al.; Biochemistry
33
, 5819 (1994)
Abstract
Brain neurotoxicity of Penitrem A: electrophysiological, behavioral and histopathological study:
P. Breton, et al.; Toxicon
36
, 645 (1998)
Abstract
Further Categories Containing This Product:
Mycotoxins
•
K+ Channel Blockers & Inhibitors
•
GABA-ergics & GABA Receptors/Related Products
•
Alkaloids
ALX-270-112
Revised 16-Jun-08
Pentoxifylline
SYNONYMS
Trental
3,7-Dihydro-3,7-dimethyl-1-(5-oxohexyl)-
1H
-purine-2,6-dione
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Other Signal Transduction Pathway Modulators
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-112-G001
1 g
15.00 USD
ALX-270-112-G005
5 g
35.00 USD
Product Specification
FORMULA:
C
13
H
18
N
4
O
3
MW:
278.3
CAS NUMBER:
6493-05-6
MERCK INDEX:
14:
7136
SOURCE/HOST:
Isolated from
Penicillium expansum
.
PURITY:
≥99%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
Product Description
Phosphodiesterase inhibitor. Blocks the synthesis of TNF-α. Improves blood flow by decreasing blood viscosity.
Product Specific Literature References
Pentoxifylline inhibits lipopolysaccharide-induced serum tumor necrosis factor and mortality:
P. Noel, et al.; Life Sci.
47
, 1023 (1990)
Abstract
Pentoxifylline inhibits the expression of tissue factor mRNA in endotoxin-activated human monocytes:
V. Ollivier, et al.; FEBS Lett.
322
, 231 (1993)
Abstract
Pentoxifylline:
C.P. Samlaska & E.A. Winfield; J. Am. Acad. Dermatol.
30
, 603 (1994), Review
Abstract
Suppression of hypercholesterolemic atherosclerosis by pentoxifylline and its mechanism:
K. Prasad & P. Lee; Atherosclerosis
192
, 313 (2007)
Abstract
Further Categories Containing This Product:
Phosphodiesterases/Related Products
•
TNF-alpha & TNF Receptors Other Products
•
Nitric Oxide Pathway Other Products
ALX-385-015
Revised 12-Aug-08
Peonidin chloride
SYNONYMS
3,4',5,7-Tetrahydroxy-3'-methoxyflavylium chloride
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Flavonoids/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-385-015-M005
5 mg
280.00 USD
Product Specification
FORMULA:
C
16
H
13
O
6
Cl
MW:
336.7
CAS NUMBER:
134-01-0
MERCK INDEX:
14:
7143
PURITY:
≥99% (HPLC)
APPEARANCE:
Beige to reddish-brown solid.
SOLUBILITY:
Soluble in 100% ethanol or water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light.
Product Description
Antioxidant flavonoid. Shows anti-inflammatory and chemopreventive properties.
Product Specific Literature References
Structure-antioxidant activity relationships of flavonoids and phenolic acids:
C.A. Rice-Evans, et al.; Free Radical Biol. & Med.
20
, 933 (1996), (Review)
Abstract
Peonidin inhibits phorbol-ester-induced COX-2 expression and transformation in JB6 P+ cells by blocking phosphorylation of ERK-1 and -2:
J.Y. Kwon, et al.; Ann. N. Y. Acad. Sci.
1095
, 513 (2007)
Abstract
Further Categories Containing This Product:
Natural Products - Anti-inflammatory Agents
•
Natural Products - Chemopreventive Agents
•
Natural Products - Antioxidants
ALX-630-003
Revised 18-Mar-08
Pertussis Toxin
SYNONYMS
Islet-Activating Protein
PTX
Holotoxin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Neurotoxins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-630-003-C050
50 µg
220.00 USD
Product Specification
CAS NUMBER:
70323-44-3
RTECS:
XW5883750
SOURCE/HOST:
Isolated from
Bordetella pertussis
.
CONCENTRATION:
0.1mg/ml after reconsitution. Determined by a modification of the method of Bradford using BSA as the standard.
PURITY:
Migrates as 5 distinct bands (S1 subunit: A Protomer (Prod. No.
ALX-630-080
); S2-S5 subunits: B Protomer (Prod. No.
ALX-630-081
)).
APPEARANCE:
Lyophilized.
PURITY DETAIL:
Described by Tamura et al., when run on SDS-PAGE prepared according to a modification of the method of Laemmli.
RECONSTITUTION:
Reconstitute with 500µl distilled water to get a solution in 0.01M sodium phosphate buffer, pH 7.0, containing 0.05M NaCl.
The resulting suspension should be made uniform by gentle mixing prior to use. Do not sterile filter, as this will result in loss of material.
For long term storage, reconstitute in a buffer of higher ionic strength, i.e. sterile 0.1M sodium phosphate, pH 7.0, containing 0.5M NaCl.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Do not freeze. Aseptically packed, sealed under vacuum.
HAZARD:
TOXIC.
Product Description
Major protein toxin produced by virulent strains of
Bordetella pertussis
. The purified protein consists of five dissimilar subunits: S-1 (MW 28kDa), S-2 (MW 23kDa), S-3 (MW 22kDa), S-4 (MW 11.7kDa) and S-5 (MW 9.3kDa), in a molar ratio of 1:1:1:2:1. S-1 (A protomer) is responsible for the enzymatic activity of the toxin. Together, S-2, S-3, S-4 and S-5 comprise the B oligomer, responsible for binding the toxin to the cell surface.
Product Specific Literature References
Subunit structure of islet-activating protein, pertussis toxin, in conformity with the A-B model
:
M. Tamura, et al.; Biochemistry
21
, 5516 (1982)
Abstract
Induction of a novel morphological response in Chinese hamster ovary cells by pertussis toxin
:
E.L. Hewlett, et al.; Infect. Immun.
40
, 1198 (1983)
Abstract
Structure-activity analysis of the activation of pertussis toxin
:
H.R. Kaslow, et al.; Biochemistry
26
, 123 (1987)
Abstract
Pertussis toxin and target eukaryotic cells: binding, entry, and activation:
H. R. Kaslow & D. L. Burns; FASEB J.
6
, 2684 (1992), (Review)
Abstract
A proposed mechanism of ADP-ribosylation catalyzed by the pertussis toxin S1 subunit:
C. Locht & R. Antoine; Biochimie
77
, 333 (1995)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
CHO Cell Assay
:
When examined in a CHO cell assay as described by Hewlett et al., the lowest concentration of toxin at which a positive response (clustered growth pattern) was obtained was XXng/ml.
Adenylate Cyclase Assay
: The adenylate cyclase activity of this lot is XXpmol/min/µg in the presence of 1µM calmodulin when assayed by the method of Wolff et al.
Please note:
Product is
not
activated. If used with an intact cell system, the cells will activate the toxin. If used in a cell-free system activation may be achieved by the methods, of Kaslow et al.
General Literature References
Cleavage of structural proteins during the assembly of the head of bacteriophage T4
:
U.K. Laemmli; Nature
227
, 680 (1970)
Abstract
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
:
M.M. Bradford; Anal. Biochem.
72
, 248 (1976)
Abstract
Calmodulin activates prokaryotic adenylate cyclase
:
J. Wolff, et al.; PNAS
77
, 3841 (1980)
Abstract
Further Categories Containing This Product:
Adenylyl Cyclase Activators
•
ADP Ribosylation Factor [ARF]/Related Products
ALX-630-080
Revised 01-Nov-07
Pertussis Toxin A Protomer
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Neurotoxins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-630-080-C010
10 µg
250.00 USD
Product Specification
MW:
28kDa
SOURCE/HOST:
Isolated from
Bordetella pertussis
.
PURITY DETAIL:
One major band by SDS-PAGE; <1% holotoxin by CHO cell assay.
FORMULATION:
Lyophilized.
RECONSTITUTION:
Reconstitute with 500µl distilled water to 10µg of protein in 10mM TRIS, pH 8.0, containing 0.1mM Na
2
ETDA and 0.03% CHAPS.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HAZARD:
TOXIC.
Product Description
The A protomer (S-1) of pertussis toxin possesses both NAD
+
glycohydrolase and ADP-ribosyltransferase activities, but is unable to penetrate cells in the absence of B oligomer. It is, however, as effective as native pertussis toxin in catalyzing ADP-ribosylation in broken cell preparations.
Product Specific Literature References
Subunit structure of islet-activating protein, pertussis toxin, in conformity with the A-B model:
M. Tamura, et al.; Biochemistry
21
, 5516 (1982)
Abstract
Activation by thiol of the latent NAD glycohydrolase and ADP- ribosyltransferase activities of Bordetella pertussis toxin (islet- activating protein):
J. Moss et al.; J. Biol. Chem.
258
, 11879 (1983)
Abstract
;
Full Text
ADP-ribosylation of G proteins with pertussis toxin:
G.S. Kopf & M.J. Woolkalis; Meth. Enzymol.
195
, 257 (1991)
Abstract
Pertussis toxin and target eukaryotic cells: binding, entry, and activation:
H. R. Kaslow & D. L. Burns; FASEB J.
6
, 2684 (1992), (Review)
Abstract
A proposed mechanism of ADP-ribosylation catalyzed by the pertussis toxin S1 subunit:
C. Locht and R. Antoine; Biochimie
77
, 333 (1995), (Review)
Abstract
Further Categories Containing This Product:
Adenylyl Cyclase Activators
•
ADP Ribosylation Factor [ARF]/Related Products
ALX-630-081
Revised 14-Apr-08
Pertussis Toxin B Oligomer
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Neurotoxins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-630-081-C040
40 µg
340.00 USD
Product Specification
SOURCE/HOST:
Isolated from
Bordetella pertussis
.
PURITY:
Four distinct bands on 12% SDS-PAGE/urea gel. <1% holotoxin by CHO cell assay
APPEARANCE:
Lyophilized.
RECONSTITUTION:
Reconstitute with sterile distilled water.
BIOLOGICAL ACTIVITY:
195ng/ml (lowest concentration) of this preparation cause hemagglutination of fresh goose red blood cells when assayed in HA Assay
according to a modification of the method of Sato et al. [2].
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Do not freeze. Do not sterile filter, as this will result in loss of material. Mix suspension gently prior to use.
HAZARD:
TOXIC.
Product Description
Increases cytosolic Ca
2+
levels and stimulates platelet aggregation. Activates phospholipase C (PLC). The B oligomer is a subunit of pertussis toxin responsible for binding of the holotoxin to eukaryotic cell surfaces, facilitating entry of the A promoter into receptive cells. Lacks intrinsic ADP-ribosyltransferase activity but still induces several responses in sensitive cells, e.g. human T cell mitogenesis, human platelet aggregation and insulin-like action in rat adipocytes.
Product Specific Literature References
[1]
Subunit structure of islet-activating protein, pertussis toxin, in conformity with the A-B model:
M. Tamura, et al.; Biochemistry
21
, 5516 (1982)
Abstract
[2]
Separation and purification of the hemagglutinins from Bordetella pertussis:
Y. Sato, et al.; Infect. Immun.
41
, 313 (1983)
Abstract
;
Full Text
[3]
A role of the B-oligomer moiety of islet-activating protein, pertussis toxin, in development of the biological effects on intact cells:
M. Tamura, et al.; J. Biol. Chem.
258
, 6756 (1983)
Abstract
;
Full Text
[4]
Pertussis toxin can activate human platelets. Comparative effects of holotoxin and its ADP-ribosylating S1 subunit:
H.S. Banga, et al.; J. Biol. Chem.
262
, 14871 (1987)
Abstract
;
Full Text
[5]
Human T lymphocyte mitogenesis in response to the B oligomer of pertussis toxin is associated with an early elevation in cytosolic calcium concentrations:
C.F. Strnad & R.A. Carchman; FEBS Lett.
225
, 16 (1987)
Abstract
[6]
Pertussis toxin and target eukaryotic cells: binding, entry, and activation:
H. R. Kaslow & D. L. Burns; FASEB J.
6
, 2684 (1992), (Review)
Abstract
[7]
A proposed mechanism of ADP-ribosylation catalyzed by the pertussis toxin S1 subunit:
C. Locht & R. Antoine; Biochimie
77
, 333 (1995), (Review)
Abstract
Further Categories Containing This Product:
ADP Ribosylation Factor [ARF]/Related Products
•
Adenylyl Cyclase Activators
ALX-350-269
Revised 16-Aug-07
Phallacidin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products for Cytoskeletal Research
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-269-M001
1 mg
130.00 USD
Product Specification
FORMULA:
C
37
H
50
N
8
O
13
S
MW:
846.9
CAS NUMBER:
26645-35-2
SOURCE/HOST:
Isolated from
Amanita phalloides
mushrooms.
PURITY:
≥90%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO, dimethyl formamide, methanol or water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HAZARD:
VERY TOXIC.
Product Description
Biological activity like phalloidin (Prod. No.
ALX-350-265
), but contains a carboxy group for coupling reactions.
Product Specific Literature References
Fluorescence staining of the actin cytoskeleton in living cells with 7-nitrobenz-2-oxa-1,3-diazole-phallacidin:
L.S. Barak, et al.; PNAS
77
, 980 (1980)
Abstract
Phallacidin prevents thrombin-induced increases in endothelial permeability to albumin:
P.G. Phillips, et al.; Am. J. Physiol.
257
, C562 (1989)
Abstract
Further Categories Containing This Product:
Amanitins & Phalloidins/Related Products
•
Actin/Related Products
ALX-350-265
Revised 17-Dec-07
Phalloidin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products for Cytoskeletal Research
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-265-M001
1 mg
135.00 USD
Product Specification
FORMULA:
C
35
H
48
N
8
O
11
S
MW:
788.9
CAS NUMBER:
17466-45-4
MERCK INDEX:
14:
7196
SOURCE/HOST:
Isolated from
Amanita phalloides
mushrooms.
PURITY:
≥95%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO, dimethyl formamide, methanol, 100% ethanol or water (warm).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HAZARD:
VERY TOXIC.
Product Description
Binds to polymeric actin with high affinity. Stabilizes filaments and decreases concentration of monomeric actin.
Product Specific Literature References
Interaction of phalloidin with actin:
A.M. Lengsfeld, et al.; PNAS
71
, 2803 (1974)
Abstract
Interaction of actin with phalloidin: polymerization and stabilization of F-actin:
P. Dancker, et al.; Biochim. Biophys. Acta
400
, 407 (1975)
Abstract
Phalloidin-induced actin polymerization in the cytoplasm of cultured cells interferes with cell locomotion and growth:
J. Wehland, et al.; PNAS
74
, 5613 (1977)
Abstract
What we have learned from phalloidin:
M. Frimmer; Toxicol Lett.
35
, 169 (1987)
Abstract
Effects of cytochalasin and phalloidin on actin:
J.A. Cooper; J. Cell. Biol.
105
, 1473 (1987), (Review)
Abstract
Position and orientation of phalloidin in F-actin determined by X-ray fiber diffraction analysis:
T. Oda, et al.; Biophys. J.
88
, 2727 (2005)
Abstract
Further Categories Containing This Product:
Amanitins & Phalloidins/Related Products
•
Actin/Related Products
ALX-350-267
Revised 08-Apr-08
Phalloidin (Biotin)
SYNONYMS
Biotinyl-hexamethylenamidosuccinyl-aminomethyldithiolano-phalloidin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products for Cytoskeletal Research
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-267-MC01
0.1 mg
175.00 USD
Product Specification
FORMULA:
C
57
H
83
N
13
O
13
S
4
MW:
1286.6
SOURCE/HOST:
Semisynthetic from aminomethyldithiolano-phalloidin.
PURITY:
≥90%
APPEARANCE:
Amorphous solid.
SOLUBILITY:
Soluble in DMSO, dimethyl formamide, methanol or water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Prepare fresh solutions for each application.
HANDLING:
Protect from light and moisture.
HAZARD:
VERY TOXIC.
Product Description
Binds actin filaments and streptavidin simultaneously, due to the long spacer between the two active components.
Product Specific Literature References
Preparation of tetramethylrhodaminyl-phalloidin and uptake of the toxin into short-term cultured hepatocytes by endocytosis:
H. Faulstich, et al.; Exp. Cell Res.
144
, 73 (1983)
Abstract
Biotinylphallotoxins: preparation and use as actin probes:
H. Faulstich, et al.; J. Histochem. Cytochem.
37
, 1035 (1989)
Abstract
Further Categories Containing This Product:
Amanitins & Phalloidins/Related Products
•
Biotinylated Reagents Other Products
•
Actin/Related Products
ALX-350-268
Revised 01-Jun-06
Phalloidin (FITC)
SYNONYMS
Fluoresceinyl-aminomethyldithiolano-phalloidin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products for Cytoskeletal Research
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-268-MC01
0.1 mg
150.00 USD
