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Antibiotics
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ALX-380-055 Revised 13-Jun-08
Chromomycin A3
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SYNONYMS Toyomycin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Antibiotics - DNA Regulation / Transcription
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-055-M005   5 mg 65.00 USD Add To Cart
ALX-380-055-M025   25 mg 260.00 USD Add To Cart
Product Specification
FORMULA: C57H82O26
MW: 1183.3
CAS NUMBER: 7059-24-7
MERCK INDEX: 14: 2238
RTECS: GB7875000
SOURCE/HOST: Isolated from Streptomyces griseus.
PURITY: ≥97% (HPLC)
APPEARANCE: Off white to yellow powder.
SOLUBILITY: Soluble in ethyl acetate.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: VERY TOXIC.

Product Description
Antibiotic. Inhibits RNA synthesis. Cell permeable fluorescent dye that can be used with Bisbenzimide H33258 (Prod. No. ALX-620-051) to distinguish chromosomes by their total DNA concentration and their DNA base composition. Binds to G:C pairs of helical DNA but does not intercalate. Ex(max): 445nm; Em(max): 575nm.
General Literature References
K. Mizuno; J. Antibiot. 16, 22 (1963)
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Further Categories Containing This Product:
Transcription Inhibitors / Related Products
 
 
ALX-380-112 Revised 03-Apr-08
Chrysomycin A
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SYNONYMS Chrysomycin V
Virenomycin V
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Topoisomerase Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-112-C250   250 µg 140.00 USD Add To Cart
ALX-380-112-M001   1 mg 420.00 USD Add To Cart
Product Specification
FORMULA: C28H28O9
MW: 508.5
CAS NUMBER: 82196-88-1
SOURCE/HOST: Isolated from Streptomyces sp.
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow to greenish solid.
SOLUBILITY: Soluble in DMSO or dimethyl formamide; slightly soluble in 100% ethanol or methanol.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions are stable for at least 3 months when stored at -20°C.
HANDLING: Protect from light also when in solution.

Product Description
Antibiotic. Inhibits topoisomerase II in human. Mediates a unique cross-linking reaction between DNA and histidine H3. Antineoplastic and photosensitizing compound. Exhibits antitumor activity against human cell lines.
Product Specific Literature References
Chrysomycin: a new antibiotic substance for bacterial viruses: F. Strelitz, et al.; J. Bacteriol. 69, 280 (1955) Abstract
The chemistry of the antibiotics chrysomycin A and B. Antitumor activity of chrysomycin A: U. Weiss, et al.; J. Antibiot. (Tokyo) 35, 1194 (1982) Abstract
Biochemical characterisation of elsamicin and other coumarin-related antitumour agents as potent inhibitors of human topoisomerase II: A. Lorico and B.H. Long; Eur. J. Cancer 29A, 1985 (1993) Abstract
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Further Categories Containing This Product:
Antitumor Agents (DNA Interaction & Gene Regulation) • Antitumor Antibiotics
 
 
ALX-380-114 Revised 03-Apr-08
Chrysomycin B
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SYNONYMS Chrysomycin M
Virenomycin M
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Topoisomerase Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-114-C250   250 µg 140.00 USD Add To Cart
ALX-380-114-M001   1 mg 420.00 USD Add To Cart
Product Specification
FORMULA: C27H28O9
MW: 496.5
CAS NUMBER: 83852-56-6
SOURCE/HOST: Isolated from Streptomyces sp.
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO or dimethyl formamide; slightly soluble in 100% ethanol or methanol.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions are stable for at least 3 months when stored at -20°C.
HANDLING: Protect from light.

Product Description
Antibiotic. Inhibits topoisomerase II in human. Mediates a unique cross-linking reaction between DNA and histidine H3. Antineoplastic and photosensitizing compound. Exhibits antitumor activity against human cell lines. Less potent than Chrysomycin A (Prod. No. ALX-380-112).
Product Specific Literature References
Chrysomycin: a new antibiotic substance for bacterial viruses: F. Strelitz, et al.; J. Bacteriol. 69, 280 (1955) Abstract
The chemistry of the antibiotics chrysomycin A and B. Antitumor activity of chrysomycin A: U. Weiss, et al.; J. Antibiot. (Tokyo) 35, 1194 (1982) Abstract
Biochemical characterisation of elsamicin and other coumarin-related antitumour agents as potent inhibitors of human topoisomerase II: A. Lorico and B.H. Long; Eur. J. Cancer 29A, 1985 (1993) Abstract
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Further Categories Containing This Product:
Antitumor Agents (DNA Interaction & Gene Regulation) • Antitumor Antibiotics
 
 
ALX-380-287 Revised 15-Apr-08 New product
Ciprofloxacin
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SYNONYMS 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1- piperazinyl)-3-quinolinecarboxylic acid
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ALX-380-287-G005   5 g 20.00 USD Add To Cart
ALX-380-287-G025   25 g 60.00 USD Add To Cart
Product Specification
FORMULA: C17H18FN3O3
MW: 331.3
CAS NUMBER: 85721-33-1
MERCK INDEX: 14: 2314
RTECS: VB1993800
PURITY: ≥98% (Assay)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in dilute hydrochloric acid; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description

Fluoroquinolone antibacterial agent. Inhibits bacterial DNA gyrase (topoisomerase). Inhibits cell division and causes double-strand breaks in the bacterial chromosome. Broad-spectrum antibiotic effective against Gram-positive, Gram-negative and anaerobic bacteria. Effective against Mycobacterium tuberculosis. Potentially anxiogenic.
Product Specific Literature References
Is ciprofloxacin active against clinically important anaerobes?: B. Watt & F.V. Brown; J. Antimicrob. Chemother. 17, 605 (1986) Abstract
Ciprofloxacin and norfloxacin, two fluoroquinolone antimicrobials: D.E. Nix & J.M DeVito; Clin. Pharm. 6, 105 (1987) Abstract
Mechanisms of action of and resistance to ciprofloxacin: D.C. Hooper, et al.; Am. J. Med. 82, 12 (1987) Abstract
Moxifloxacin, ofloxacin, sparfloxacin, and ciprofloxacin against Mycobacterium tuberculosis: evaluation of in vitro and pharmacodynamic indices that best predict in vivo efficacy: R.K. Shandil, et al.; Antimicrob. Agents Chemother. 51, 576 (2007) Abstract; Full Text
Anxiogenic potential of ciprofloxacin and norfloxacin in rats: S. Sen, et al.; Singapore Med. J. 48, 1028 (2007) Abstract; Full Text
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Further Categories Containing This Product:
Antibiotics - DNA Replication Inhibitors • Antibiotics - Topoisomerase Inhibitors
 
 
ALX-380-288 Revised 08-Aug-08 New product
Ciprofloxacin . hydrochloride
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SYNONYMS 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid . hydrochloride
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ALX-380-288-G005   5 g 20.00 USD Add To Cart
ALX-380-288-G025   25 g 55.00 USD Add To Cart
Product Specification
FORMULA: C17H18FN3O3 . HCl . H2O
MW: 331.3 . 36.5 . 18.0
CAS NUMBER: 86393-32-0
MERCK INDEX: 14: 2314
PURITY: ≥88.5% (Assay)
APPEARANCE: White to light yellow powder.
SOLUBILITY: Soluble in water (35mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Fluoroquinolone antibacterial agent. Inhibits bacterial DNA gyrase (topoisomerase). Inhibits cell division and causes double-strand breaks in the bacterial chromosome. Broad-spectrum antibiotic effective against Gram-positive, Gram-negative and anaerobic bacteria. Effective against Mycobacterium tuberculosis. Potentially anxiogenic.
Product Specific Literature References
Is ciprofloxacin active against clinically important anaerobes?: B. Watt & F.V. Brown; J. Antimicrob. Chemother. 17, 605 (1986) Abstract
Ciprofloxacin and norfloxacin, two fluoroquinolone antimicrobials: D.E. Nix & J.M. DeVito; Clin. Pharm. 6, 105 (1987) Abstract
Mechanisms of action of and resistance to ciprofloxacin: D.C. Hooper, et al.; Am. J. Med. 82, 12 (1987) Abstract
Moxifloxacin, ofloxacin, sparfloxacin, and ciprofloxacin against Mycobacterium tuberculosis: evaluation of in vitro and pharmacodynamic indices that best predict in vivo efficacy: R.K. Shandil, et al.; Antimicrob. Agents Chemother. 51, 576 (2007) Abstract; Full Text
Anxiogenic potential of ciprofloxacin and norfloxacin in rats: S. Sen, et al.; Singapore Med. J. 48, 1028 (2007) Abstract; Full Text
Related Products
Further Categories Containing This Product:
Antibiotics - DNA Replication Inhibitors • Antibiotics - Topoisomerase Inhibitors
 
 
ALX-380-058 Revised 03-Apr-08
Citrinin
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SYNONYMS Antimycin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-058-M001   1 mg 15.00 USD Add To Cart
ALX-380-058-M005   5 mg 60.00 USD Add To Cart
ALX-380-058-M010   10 mg 105.00 USD Add To Cart
ALX-380-058-M025   25 mg 210.00 USD Add To Cart
Product Specification
FORMULA: C13H14O5
MW: 250.3
CAS NUMBER: 518-75-2
MERCK INDEX: 14: 2327
SOURCE/HOST: Isolated from Penicillium citrinum.
PURITY: ≥98%
APPEARANCE: Yellow crystals.
SOLUBILITY: Soluble in 100% ethanol or dioxane. Insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Solutions change color with changes in pH from yellow (pH 4.6) to red (pH 9.9).
HAZARD: TOXIC.

Product Description
Antibiotic. Induces mitochondrial permeability pore opening and inhibits respiration by interfering with complex I of the respiratory chain. Mycotoxin. Acts as nephrotoxin in all species in which it has been tested. Has been implicated as a cause of Balkan nephropathy and yellow rice fever in humans. Induces apoptosis.
Product Specific Literature References
Mechanism of citrinin-induced dysfunction of mitochondria. III. Effects on renal cortical and liver mitochondrial swelling: G.M. Chagas, et al.; J. Appl. Toxicol. 15, 91 (1995) Abstract
Mycotoxins: J.W. Bennett & M. Klich; Clin. Microbiol. Rev. 16, 497 (2003) Abstract
Citrinin induces apoptosis in HL-60 cells via activation of the mitochondrial pathway: F.Y. Yu, et al.; Toxicol. Lett. 161, 143 (2006) Abstract
Citrinin induces apoptosis via a mitochondria-dependent pathway and inhibition of survival signals in embryonic stem cells, and causes developmental injury in blastocysts: W.H. Chan; Biochem. J. 404, 317 (2007) Abstract
Further Categories Containing This Product:
Respiratory Chain Other Products • Antibiotics - Apoptosis Inducers & Inhibitors • Mycotoxins
 
 
ALX-380-289 Revised 05-Aug-08 New product
Clinafloxacin
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SYNONYMS 7-(3-Amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
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ALX-380-289-M250   250 mg 55.00 USD Add To Cart
ALX-380-289-G001   1 g 160.00 USD Add To Cart
Product Specification
FORMULA: C17H17ClFN3O3
MW: 365.8
CAS NUMBER: 105956-97-6
MERCK INDEX: 14: 2355
PURITY: ≥95% (Assay)
APPEARANCE: White to light yellow crystalline powder.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by NMR.

Product Description
Fluoroquinolone with broad-spectrum activity against Gram-negative and Gram-positive bacteria, aerobes and anaerobes. Inhibits bacterial DNA topoisomerase IV and DNA gyrase.
Product Specific Literature References
DNA gyrase and topoisomerase IV are dual targets of clinafloxacin action in Streptococcus pneumoniae: X.S. Pan & L.M. Fisher; Antimicrob. Agents Chemother. 42, 2810 (1998) Abstract; Full Text
Streptococcus pneumoniae DNA gyrase and topoisomerase IV: overexpression, purification, and differential inhibition by fluoroquinolones: X.S. Pan and L.M. Fisher; Antimicrob. Agents Chemother. 43, 1129 (1999) Abstract; Full Text
Fluoroquinolones inhibit preferentially Streptococcus pneumoniae DNA topoisomerase IV than DNA gyrase native proteins: E. Fernandez-Moreira, et al.; Microb. Drug Resist. 6, 259 (2000) Abstract
Activities of clinafloxacin, gatifloxacin, gemifloxacin, and trovafloxacin against recent clinical isolates of levofloxacin-resistant Streptococcus pneumoniae: J.H. Jorgensen, et al.; Antimicrob. Agents Chemother. 44, 2962 (2000) Abstract; Full Text
Further Categories Containing This Product:
Antibiotics - DNA Replication Inhibitors • Antibiotics - Topoisomerase Inhibitors
 
 
ALX-350-316 Revised 16-Jun-08
Cochliodinol
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
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ALX-350-316-MC05   0.5 mg 150.00 USD Add To Cart
Product Specification
FORMULA: C32H30N2O4
MW: 506.6
CAS NUMBER: 11051-88-0
RTECS: DK3529000
SOURCE/HOST: Isolated from Chaetomium globosum.
PURITY: ≥97% (HPLC)
APPEARANCE: White to brown solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Identity determined by 1H-NMR, 13C-NMR and MS.

Product Description
Antibiotic. Displays antibacterial and antitumor activity.
Product Specific Literature References
The toxicity of cochliodinol, an antibiotic metabolite of Chaetomium spp: D. Brewer, et al.; Can. J. Microbiol. 16, 433 (1970) Abstract
The Chemistry of Cochliodinol, a Metabolite of Chaetomium spp.: W.A. Jerram, et al.; Can. J. Chem. 53, 727 (1975)
The antibacterial activity of some naturally occurring 2,5-dihydroxy-1,4-benzoquinones: D. Brewer, et al.; Can. J. Microbiol. 30, 1068 (1984) Abstract
 
 
ALX-380-033 Revised 17-Oct-07
Colchicine
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Cytoskeletal Research
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ALX-380-033-G001   1 g 58.00 USD Add To Cart
Product Specification
FORMULA: C22H25NO6
MW: 399.4
CAS NUMBER: 64-86-8
MERCK INDEX: 14: 2471
RTECS: GH0700000
SOURCE/HOST: Isolated from Colchicum autumnale.
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 100% ethanol or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light and moisture.
HAZARD: VERY TOXIC.

Product Description
Inhibitor of microtubules by specific binding to tubulin. Induces apoptosis.