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ALX-380-035 Revised 08-Apr-08
Neomycin . sulfate
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Other Signal Transduction Pathway Modulators
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-035-G005   5 g 12.00 USD Add To Cart
ALX-380-035-G010   10 g 18.00 USD Add To Cart
ALX-380-035-G025   25 g 30.00 USD Add To Cart
Product Specification
FORMULA: C23H46N6O13 . 3H2SO4
MW: 614.7 . 294.2
CAS NUMBER: 1405-10-3
MERCK INDEX: 14: 6454
RTECS: QP4375000
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light and moisture.
HAZARD: HARMFUL.

Product Description
Aminoglycoside antibiotic that inhibits translation by binding to the small subunit of prokaryotic ribosomes. Inhibitor of phospholipase C (PLC) due to binding to inositol phospholipids. Neomycin inhibits phosphatidylcholine-phospholipase D activity. Blocks voltage sensitive Ca2+ channels without affecting Na+/Ca2+ antiporters in nerve cells.
Product Specific Literature References
Effects of neomycin on calcium and polyphosphoinositide metabolism of guinea pig synaptosomes: H.D. Griffin, et al.; J. Neurochem. 34, 750 (1980) Abstract
Phosphoinositides in mitogenesis: neomycin inhibits thrombin-stimulated phosphoinositide turnover and initiation of cell proliferation: D.H. Carney, et al.; Cell 42, 479 (1985) Abstract
Inositol 1,4,5-trisphosphate: a possible chemical link in excitation- contraction coupling in muscle: J. Vergara, et al.; PNAS 82, 6352 (1985) Abstract
Neomycin is a potent agent for arachidonic acid release in human platelets: S. Nakashima, et al.; BBRC 146, 820 (1987) Abstract
Binding of neomycin to phosphatidylinositol 4,5-bisphosphate (PIP2): E. Gabev, et al.; Biochim. Biophys. Acta 979, 105 (1989) Abstract
Inhibition of neural phospholipase D activity by aminoglycoside antibiotics: M. Liscovitch, et al.; Biochem. J. 279, 319 (1991) Abstract
Gadolinium and neomycin block voltage-sensitive Ca2+ channels without interfering with the Na(+)-Ca2+ antiporter in brain nerve endings: L.M. Canzoniero, et al.; Eur. J. Pharmacol. 245, 97 (1993) Abstract
Neomycin inhibition of hormone-stimulated smooth muscle contractions in myometrial tissue: M. Philippe; BBRC 205, 245 (1994) Abstract
Nerve extracts and substance P activate the phosphatidylinositol signaling pathway and mitogenesis in newt forelimb regenerates: M.J. Smith, et al.; Dev. Biol. 167, 239 (1995) Abstract
Antiproliferative action of neomycin is associated with inhibition of cyclin D1 activation in glioma cells: P. Cuevas, et al.; Neurol. Res. 25, 961 (2003) Abstract
Neomycin inhibits glioma cell migration: P. Cuevas, et al.; Neurol. Res. 26, 273 (2004) Abstract
Further Categories Containing This Product:
Phospholipase C / Related Products • Phospholipase D / Related Products • Ca2+ Channels Other Products
 
 
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