ALEXIS Biochemicals: Nerve Growth Factor Receptor (human):Fc (human) (recombinant)

ALX-522-044

Revised 25-Oct-05

Nerve Growth Factor Receptor (human):Fc (human) (recombinant)
SYNONYMS	NGFR (human):Fc (human) (recombinant) TNFRSF 16 (human):Fc (human) (recombinant) p75^NTR (human):Fc (human) (recombinant) p75 Neurotrophin Receptor (human):Fc (human) (recombinant) CD271 (human):Fc (human) (recombinant) Low-affinity Nerve Growth Factor Receptor (human):Fc (human) (recombinant)
PRODUCT LINE	Chemokines & Cytokines
PRODUCT CATEGORY	Nerve Growth Factors [NGF] & Receptors / Related Products

Ordering Information

Product Specification

SPECIES CROSSREACTIVITY:	Human Mouse Rat
MW:	~80kDa (under reducing conditions).
SOURCE/HOST:	Produced in HEK 293 cells. The cysteine-rich domain of human NGFR (nerve growth factor receptor; p75^NTR) (aa 1-264) is fused to the Fc portion of human IgG1.
CONCENTRATION:	1mg/ml after reconstitution.
PURITY:	≥90% (SDS-PAGE)
FORMULATION:	Lyophilized. Contains PBS.
ENDOTOXIN CONTENT:	<0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION:	Reconstitute in 50µl sterile water. Further dilutions can be made with medium containing 5% fetal calf serum.
SPECIFICITY:	Binds human, mouse and rat NGF (nerve growth factor).
BIOLOGICAL ACTIVITY:	Inhibits rat NGF-mediated activation of rat PC12 cells.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 6 months after receipt when stored at -20°C. After reconstitution, it is recommended to make appropriate aliquots and to store them at -20°C.
HANDLING:	Avoid freeze/thaw cycles.

Product Images

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General Information

BACKGROUND/TECHNICAL INFORMATION	Swiss-Prot link P08138: NGFR (human) (precursor) AfCS Signalling Gateway link A001650: NGFR (mouse)
MANUFACTURER	Manufactured by Apotech Corporation.

General Literature References

Neurotrophins in cell survival/death decisions: P. Casaccia-Bonnefil, et al.; Adv. Exp. Med. Biol. 468, 275 (1999) Abstract