ALEXIS Biochemicals: Netropsin . dihydrochloride

ALX-380-088

Revised 12-Oct-07

Netropsin . dihydrochloride
SYNONYMS	4-([((Aminoiminomethyl)amino)acetyl)amino)-N-(5-(((3-amino-3-iminopropyl)amino)carbonyl]-1-methyl-1H-pyrrol-3-yl)-1-methyl-1H-pyrrole-3-carboxamide
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antitumor Antibiotics

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-088-M005		5 mg	40.00 USD

Product Specification

FORMULA:	C₁₈H₂₆N₁₀O₃ . 2HCl
MW:	430.5 . 73.0
CAS NUMBER:	63770-20-7 (hydrochloride)
SOURCE/HOST:	Isolated from Streptomyces netropsis.
PURITY:	≥98%
SOLUBILITY:	Soluble in alcohols or water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HAZARD:	TOXIC.

Product Description

Nucleic acid binding ligand. Binds to A-T-rich regions of the minor groove of DNA.

Product Specific Literature References

Netropsin, a New Antibiotic Produced by a Streptomyces: A.C. Finlay et al.; J. Am. Chem. Soc. 73, 341 (1951)
Efficient Total Syntheses of the Oligopeptide Antibiotics Netropsin and Distamycin: J.W. Lown et al.; J. Org. Chem. 50, 3774 (1985)
Sequence and structural selectivity of nucleic acid binding ligands: J. Ren & J.B. Chaires; Biochemistry 38, 16067 (1999) Abstract
Molecular modelling of the interaction of carbocyclic analogues of netropsin and distamycin with d(CGCGAATTCGCG)2: K. Bielawski, et al.; Acta Biochim. Pol. 47, 855 (2000) Abstract
Recent developments in sequence selective minor groove DNA effectors: B.S. Reddy, et al.; Curr. Med. Chem. 8, 475 (2001), (Review) Abstract

Further Categories Containing This Product:

Other Antibiotics - DNA Regulation/Transcription • Antibiotics - Antiviral/Anti-HIV

another CS2 website

Online Product Ordering

Clipboard [0]

Your items will be kept only for the duration of your visit.