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Neurobiology
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 Items 120-140 of 1093 Page 7 of 55 Select Page: << 1 2 3 4 5 6 7 8 9 10  >>  
ALX-550-116 Revised 16-Aug-02
(2S,4S)-(-)-Azetidine-2,4-dicarboxylic acid
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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ALX-550-116-M001   1 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C5H7NO4
MW: 145.1
PURITY: ≥98%
APPEARANCE: White powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Specific Literature References
Synthesis and metabotropic receptor activity of the novel rigidified glutamate analogues (+)- and (-)-trans-azetidine-2,4-dicarboxylic acid and their N-methyl derivatives: A.P. Kozikowski, et al.; J. Med. Chem. 36, 2706 (1993) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
 
 
ALX-270-485 Revised 07-Apr-08
B2
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SYNONYMS CPNQ
5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Sirtuins / Related Products
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ALX-270-485-MC05   0.5 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C20H17ClN4O3
MW: 396.8
CAS NUMBER: 115687-05-3
PURITY: ≥95%
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO (>5mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light and oxygen.
HAZARD: TOXIC.
IDENTITY: Identity determined by 1H-NMR.

Product Description
Cell permeable inhibitor of sirtuin 2 (SIRT2) (IC50=35μM). Promotes inclusion formation in cellular models of both Huntington’s disease and Parkinson’s disease. Prevents huntingtin-mediated proteasome dysfunction and reduces α-synuclein-mediated toxicity.
Product Specific Literature References
Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington’s and Parkinson’s diseases: R.A. Bodner, et al.; PNAS 103, 4246 (2006) Abstract; Full Text
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Further Categories Containing This Product:
Parkinson's Disease Other Products
 
 
ALX-351-006 Revised 07-Jan-08
Baccatin III, 10-Deacetyl-
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
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ALX-351-006-M005   5 mg 190.00 USD Add To Cart
ALX-351-006-M025   25 mg 590.00 USD Add To Cart
Product Specification
FORMULA: C29H36O10
MW: 544.6
CAS NUMBER: 32981-86-5
SOURCE/HOST: Isolated from Taxus baccata.
PURITY: ≥95%
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light and moisture. Avoid strong oxidizing agents, acids and bases.

Product Description
Intermediate for the preparation of taxol analogs.
Product Specific Literature References
Relationships between the structures of taxol and baccatine III derivatives and their in vitro action on the disassembly of mammalian brain and Physarum amoebal microtubules: H. Lataste, et al.; PNAS 81, 4090 (1984) Abstract
Chemical Studies of 10-Deacetyl Baccatin III. Hemisynthesis of Taxol Derivatives: F. Gueritte-Voegelein, et al.; Tetrahedron Letters 42, 4451 (1986)
A highly efficient, practical approach to natural taxol: J.-N. Denis, et al.; JACS 110, 5917 (1988)
Preclinical evaluation of docetaxel (Taxotere): F. Lavelle, et al.; Semin. Oncol. 22, 3 (1995) Abstract
Further Categories Containing This Product:
Taxol / Related Products • Natural Products for Cytoskeletal Research • Microtubule Modulators
 
 
ALX-550-039 Revised 13-Dec-07
(±)-Baclofen
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SYNONYMS Lioresal
(±)-β-(Aminomethyl)-4-chlorobenzenepropanoic acid
4-Amino-3-(4-chlorophenyl)butanoic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY GABA-ergics & GABA Receptors / Related Products
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ALX-550-039-G001   1 g 50.00 USD Add To Cart
ALX-550-039-G005   5 g 160.00 USD Add To Cart
Product Specification
FORMULA: C10H12ClNO2
MW: 213.7
CAS NUMBER: 1134-47-0
MERCK INDEX: 14: 937
PURITY: ≥99%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water (4.3mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: HARMFUL.

Product Description
Selective GABAB agonist. Skeletal muscle relaxant.
Product Specific Literature References
GABAB receptors and their significance in mammalian pharmacology: N. Bowery; TIPS 10, 401 (1989) Abstract
3-Thienyl- and 3-furylaminobutyric acids. Synthesis and binding GABAB receptor studies: P. Berthelot, et al.; J. Med. Chem. 34, 2557 (1991) Abstract
 
 
ALX-550-074 Revised 30-Sep-08
R-(+)-Baclofen . hydrochloride
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SYNONYMS R-(+)-β-(Aminomethyl)-4-chlorobenzenepropanoic acid . HCl
R-(+)-4-Amino-3-(4-chlorophenyl)butanoic acid . HCl
PRODUCT LINE Neurobiology
PRODUCT CATEGORY GABA-ergics & GABA Receptors / Related Products
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ALX-550-074-M010   10 mg 45.00 USD Add To Cart
ALX-550-074-M050   50 mg 170.00 USD Add To Cart
Product Specification
FORMULA: C10H12ClNO2 . HCl
MW: 213.7 . 36.5
CAS NUMBER: 63701-55-3
MERCK INDEX: 14: 937
RTECS: MW5084350
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water, dilute aqueous base or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Selective GABAB receptor agonist. Skeletal muscle relaxant. The more active enantiomer of (±)-Baclofen (Prod. No. ALX-550-039).
Product Specific Literature References
3-(p-Chlorophenyl)-4-aminobutanoic acid--resolution into enantiomers and pharmacological activity: B. Witczuk, et al.; Pol. J. Pharmacol. Pharm. 32, 187 (1980) Abstract
Comparative stereostructure-activity studies on GABAA and GABAB receptor sites and GABA uptake using rat brain membrane preparations: E. Falch, et al.; J. Neurochem. 47, 898 (1986) Abstract
Effects of phaclofen and the enantiomers of baclofen on cardiovascular responses to intrathecal administration of L- and D-baclofen in the rat: Y.G. Hong & J.L. Henry; Eur. J. Pharmacol. 196, 267 (1991) Abstract
Effects of GABA(B) receptor ligands in animal tests of depression and anxiety: M. Frankowska, et al.; Pharmacol. Rep. 59, 645 (2007) Abstract
A novel cause of intrathecal baclofen overdosage: lessons to be learnt: C. Dalton, et al.; Clin. Rehabil. 22, 188 (2008) Abstract
Skeletal muscle relaxants: S. See & R. Ginzburg; Pharmacotherapy 28, 207 (2008) Abstract
 
 
ALX-620-080 Revised 23-May-06
bADA
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SYNONYMS Dibenzyl-1-[(R)-biotin-6-aminohexanoyl-aziridine]-2,3-(S,S+R,R)-dicarboxylate
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Proteases Other Products
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ALX-620-080-M002   2 mg 540.00 USD Add To Cart
Product Specification
FORMULA: C34H42N4O7S
MW: 650.8
CAS NUMBER: 744207-03-02
PURITY: ≥98% (HPLC)
APPEARANCE: White to yellow solid.
SOLUBILITY: Soluble in DMSO (50mg/ml), 100% ethanol or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Irreversible, cell permeable, biotin-labelled inhibitor of cysteine proteases.
Product Specific Literature References
Synthesis and antiplasmodial activity of a cysteine protease-inhibiting biotinylated aziridine-2,3-dicarboxylate: C. Gelhaus, et al.; Biol. Chem. 385, 435 (2004) Abstract
Blocking effect of a biotinylated protease inhibitor on the egress of Plasmodium falciparum merozoites from infected red blood cells: C. Gelhaus, et al.; Biol. Chem. 386, 499 (2005) Abstract
Further Categories Containing This Product:
Cathepsin Inhibitors
 
 
ALX-380-030 Revised 17-Oct-07
Bafilomycin A1
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - ATPase Inhibitors
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ALX-380-030-C100   100 µg 70.00 USD Add To Cart
ALX-380-030-M001   1 mg 210.00 USD Add To Cart
Product Specification
FORMULA: C35H58O9
MW: 622.8
CAS NUMBER: 88899-55-2
SOURCE/HOST: Isolated from Streptomyces griseus.
PURITY: ≥95%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in 100% ethanol, methanol or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description
Macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H+-ATPase. Valuable tool for distinguishing among different types of ATPases. Inhibitor of endosomal acidification.
Product Specific Literature References
Metabolic products of microorganisms. 224. Bafilomycins, a new group of macrolide antibiotics. Production, isolation, chemical structure and biological activity: G. Werner, et al.; J. Antibiot. 37, 110 (1984) Abstract
Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells: E.J. Bowman, et al.; PNAS 85, 7972 (1988) Abstract
The evolution of H+-ATPases [see comments]: N. Nelson & L. Taiz; TIPS 14, 113 (1989), (Review) Abstract
Kinetic studies of chromaffin granule H+-ATPase and effects of bafilomycin A1: H. Hanada, et al.; BBRC 170, 873 (1990) Abstract
Inhibition of osteoclast proton transport by bafilomycin A1 abolishes bone resorption: K. Sundqui, et al.; BBRC 168, 309 (1990) Abstract
The cytotoxic action of diphtheria toxin and its degradation in intact Vero cells are inhibited by bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase: T. Umata, et al.; J. Biol. Chem. 265, 21940 (1990) Abstract; Full Text
Bafilomycin A1 inhibits the targeting of lysosomal acid hydrolases in cultured hepatocytes: K. Oda, et al.; BBRC 178, 369 (1991) Abstract
Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells: T. Yoshimori, et al.; J. Biol. Chem. 266, 17707 (1991) Abstract; Full Text
Inhibitory effect of modified bafilomycins and concanamycins on P- and V-type adenosinetriphosphatases: S. Drose, et al.; Biochemistry 32, 3902 (1993) Abstract
Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, blocks lysosomal cholesterol trafficking in macrophages: T. Furuchi, et al.; J. Biol. Chem. 268, 27345 (1993) Abstract; Full Text
Bafilomycin inhibits proton flow through the H+ channel of vacuolar proton pumps: B.P. Crider, et al.; J. Biol. Chem. 269, 17379 (1994) Abstract; Full Text
Active vacuolar H+ATPase is required for both endocytic and exocytic processes during viral infection of BHK-21 cells: H. Palokangas, et al.; J. Biol. Chem. 269, 17577 (1994) Abstract; Full Text
Inositol trisphosphate-dependent and -independent Ca2+ mobilization pathways at the vacuolar membrane of Candida albicans: C.M. Calvert & D. Sanders; J. Biol. Chem. 270, 7272 (1995) Abstract; Full Text
The vacuolar H(+)-ATPase inhibitor bafilomycin A1 differentially affects proteolytic processing of mutant and wild-type beta-amyloid precursor protein: C. Haass, et al.; J. Biol. Chem. 270, 6186 (1995) Abstract; Full Text
Cell-type and amyloid precursor protein-type specific inhibition of A beta release by bafilomycin A1, a selective inhibitor of vacuolar ATPases: J. Knops, et al.; J. Biol. Chem. 270, 2419 (1995) Abstract; Full Text
Specific inhibitors of vacuolar type H(+)-ATPases induce apoptotic cell death: T. Nishihara, et al.; BBRC 212, 255 (1995) Abstract
Inhibition of mitogen-induced DNA synthesis by bafilomycin A1 in Swiss 3T3 fibroblasts: A.J. Saurin, et al.; Biochem. J. 313, 65 (1996) Abstract
Autophagy, bafilomycin and cell death: the "a-B-cs" of plecomacrolide-induced neuroprotection: J.J. Shacka, et al.; Autophagy 2, 228 (2006), Review Abstract
Bafilomycin A1-sensitive pathway is required for the maturation of cystic fibrosis transmembrane conductance regulator: T. Okiyoneda, et al.; Biochim. Biophys. Acta 1763, 1017 (2006) Abstract
Further Categories Containing This Product:
H+-ATPase / Related Products • Vesicles & Membrane Trafficking Other Products • Autophagy Other Products • Antibiotics - Apoptosis Inducers & Inhibitors
 
 
ALX-380-063 Revised 03-Apr-08
Bafilomycin B1
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - ATPase Inhibitors
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ALX-380-063-M001   1 mg 70.00 USD Add To Cart
Product Specification
FORMULA: C44H65NO13
MW: 816.0
CAS NUMBER: 88899-56-3; 80112-34-1
SOURCE/HOST: Isolated from Streptomyces griseus.
PURITY: ≥95%
APPEARANCE: Off-white to yellow powder.
SOLUBILITY: Soluble in methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description
Macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H+-ATPase.
Product Specific Literature References
Metabolic products of microorganisms. 224. Bafilomycins, a new group of macrolide antibiotics. Production, isolation, chemical structure and biological activity: G. Werner, et al.; J. Antibiot. (Tokyo) 37, 110 (1984) Abstract
Bafilomycins and concanamycins as inhibitors of V-ATPases and P-ATPases: S. Drose and K. Altendorf; J. Exp. Biol. 200, 1 (1997) Abstract
Biosynthetic investigations of the V-type ATPase inhibitors bafilomycin A1, B1 and concanamycin A: T. Schuhmann and S. Grond; J. Antibiot. (Tokyo) 57, 655 (2004) Abstract
Autophagy, bafilomycin and cell death: the "a-B-cs" of plecomacrolide-induced neuroprotection: J.J. Shacka, et al.; Autophagy 2, 228 (2006) Abstract
Further Categories Containing This Product:
H+-ATPase / Related Products
 
 
ALX-380-209 Revised 13-Nov-07
Bafilomycin C1
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SYNONYMS L-681,110A1
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - ATPase Inhibitors
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ALX-380-209-M001   1 mg 220.00 USD Add To Cart
Product Specification
FORMULA: C39H60O12
MW: 720.4
CAS NUMBER: 88979-61-7
SOURCE/HOST: Isolated from Streptomyces sp. MST-AS5338.
PURITY: ≥95% (HPLC)
APPEARANCE: White to tan solid.
SOLUBILITY: Soluble in 100% ethanol, methanol, dimethyl formamide oder DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: May undergo transformation to methyl ketal on long term storage in methanol. We recommend to use fresh solutions.
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description

Macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H+-ATPase. Shows antibacterial, antifungal, insecticidal and antihelmintic activity. Potential antiosteoporotic agent in treating bone lytic diseases.
Product Specific Literature References
Metabolic products of microorganisms. 224. Bafilomycins, a new group of macrolide antibiotics. Production, isolation, chemical structure and biological activity: G. Werner, et al.; J. Antibiot. (Tokyo) 37, 110 (1984) Abstract
Purification of vacuolar ATPase with bafilomycin C1 affinity chromatography: T.J. Rautiala, et al.; BBRC 194, 50 (1993) Abstract
Bafilolides, potent inhibitors of the motility and development of the free-living stages of parasitic nematodes: E. Lacey, et al.; Int. J. Parasitol. 25, 349 (1995) Abstract
Structure and function of V-ATPases in osteoclasts: potential therapeutic targets for the treatment of osteolysis: J. Xu, et al.; Histol. Histopathol. 222, 443 (2007) Abstract
Further Categories Containing This Product:
Bone Metabolism Other Products • H+-ATPase / Related Products • Antibiotics - Antifungal
 
 
ALX-550-213 Revised 06-Jun-08
(±)-BAY K 8644
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SYNONYMS 1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)-phenyl]pyridine-3-carboxylic acid methyl ester
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Ca2+ Channels (L-type)
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ALX-550-213-M005   5 mg 80.00 USD Add To Cart
ALX-550-213-M025   25 mg 320.00 USD Add To Cart
Product Specification
FORMULA: C16H15F3N2O4
MW: 356.3
CAS NUMBER: 93468-89-4
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow powder.
SOLUBILITY: Soluble in DMSO, 100% ethanol or methanol; sl