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ALX-430-037 Revised 28-Jan-05
N1,N12-Diethylspermine . tetrahydrochloride
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Neurobiology & Neurodiseases Other Products
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ALX-430-037-M005   5 mg 45.00 USD Add To Cart
ALX-430-037-M010   10 mg 95.00 USD Add To Cart
Product Specification
FORMULA: C14H34N4 . 4HCl
MW: 258.5 . 145.8
PURITY: ≥99%
APPEARANCE: White solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Inhibits polyamine biosynthesis and the synthesis of mitochondrial DNA. Potent antineoplastic agent.
Product Specific Literature References
Relative abilities of bis(ethyl) derivatives of putrescine, spermidine, and spermine to regulate polyamine biosynthesis and inhibit L1210 leukemia cell growth: C.W. Porter, et al.; Cancer Res. 47, 2821 (1987) Abstract
Regulation of ornithine decarboxylase activity by spermidine and the spermidine analogue N1N8-bis(ethyl)spermidinex: C.W. Porter, et al.; Biochem. J. 242, 433 (1987) Abstract
Synthetic polyamine analogues as antineoplastics: R.J. Bergeron, et al.; J. Med. Chem. 31, 1183 (1988) Abstract
High specific induction of spermidine/spermine N1-acetyltransferase in a human large cell lung carcinoma: R.A. Casero, et al.; Biochem. J. 270, 615 (1990) Abstract
Combined regulation of ornithine and S-adenosylmethionine decarboxylases by spermine and the spermine analogue N1 N12- bis(ethyl)spermine: C.W. Porter, et al.; Biochem. J. 268, 207 (1990) Abstract
Selective cellular depletion of mitochondrial DNA by the polyamine analog N1,N12-bis(ethyl)spermine and its relationship to polyamine structure and function: P.M. Vertino, et al.; Mol. Pharmacol. 39, 487 (1991) Abstract
Further Categories Containing This Product:
Antitumor Agents (DNA Interaction & Gene Regulation)
 
 
ALX-201-428 Revised 05-Aug-08 New product
DNER (Extracellular Domain) (human):Fc (human) (recombinant)
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SYNONYMS Delta and Notch-like Epidermal Growth Factor-related Receptor (Extracellular Domain) (human):Fc (human) (recombinant)
BET (Extracellular Domain) (human):Fc (human) (recombinant)
UNQ262/PRO299 (Extracellular Domain) (human):Fc (human) (recombinant)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Delta-like [DLL] & Jagged / Related Products
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ALX-201-428-C010   10 µg 280.00 USD Add To Cart
ALX-201-428-C050   50 µg 660.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. The signal peptide and the extracellular domain of human DNER (aa 1-637) is fused at the C-terminus to the Fc portion of human IgG.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q8NFT8: DNER (human)
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • Neurobiology & Neurodiseases Other Products
 
 
ALX-550-408 Revised 26-Feb-08
L-Kynurenine
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SYNONYMS β-Anthraniloyl-L-alanine
L-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Neurobiology & Neurodiseases Other Products
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ALX-550-408-M050   50 mg 20.00 USD Add To Cart
Product Specification
FORMULA: C10H12N2O3
MW: 208.2
CAS NUMBER: 2922-83-0
MERCK INDEX: 14: 5328
PURITY: ≥95% (TLC)
APPEARANCE: Light yellow solid.
SOLUBILITY: Soluble in water or 0.5 M hydrochloric acid (50mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Key intermediate in the breakdown pathway of tryptophan.
 
 
ALX-805-085 Revised 12-Jul-07
Monoclonal Antibody to Thy-1 (human) (BC9-G2)
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SYNONYMS anti-CD90 (human) MAb (BC9-G2)
PRODUCT LINE Immunology
PRODUCT CATEGORY CD Antibodies
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ALX-805-085-L002   2 ml 330.00 USD Add To Cart
Product Specification
CLONE: BC9-G2
ISOTYPE: Mouse IgG3.
FORMULATION: Liquid. Culture supernatant.
IMMUNOGEN: Human Thy-1 (CD90) transfected CHO cells.
SPECIFICITY: Recognizes human Thy-1. Detects a band of ~25-35kDa by Western blot.
APPLICATION: Flow Cytometry
Immunoprecipitation
Western Blot
Functional Application (Blocks Thy-1 mediated cell-cell adhesion)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
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Product Specific Literature References
[1] Interaction of human Thy-1 (CD 90) with the integrin alphavbeta3 (CD51/CD61): an important mechanism mediating melanoma cell adhesion to activated endothelium: A. Saalbach, et al.; Oncogene 24, 4710 (2005) Abstract
[2] Increased neutrophil adherence in psoriasis: role of the human endothelial cell receptor Thy-1 (CD90): A. Wetzel, et al.; J. Invest. Dermatol. 126, 441 (2006) Abstract
[3] Dermal fibroblasts induce maturation of dendritic cells: A. Saalbach, et al.; J. Immunol. 178, 4966 (2007) Abstract
General Information
Human Thy-1 is a glycosyl phosphatidylinositol (GPI)-anchored glycoprotein of the immunoglobulin superfamily expressed in various cell types, particularly in cells of the neuronal system, activited microvascular endothelial cells, fibroblasts and blood stem cells. Thy-1 is involved in cell adhesion. Human Thy-1 interacts with the integrin αvβ3 (CD51/CD61) and Mac-1 (CD11b/CD18). In astrocytes, binding of Thy-1 to beta3-integrin promotes focal adhesion formation.
General Literature References
Human Thy-1 (CD90) on activated endothelial cells is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18): A. Wetzel, et al.; J. Immunol. 172, 3850 (2004) Abstract; Full Text
Further Categories Containing This Product:
Adhesion Molecules & Receptors • Neurobiology & Neurodiseases Other Products • Monoclonal Antibodies
 
 
ALX-522-096 Revised 27-Mar-08
Thy-1 (mouse):Fc (human) (recombinant)
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SYNONYMS CD90 (mouse):Fc (human) (recombinant)
PRODUCT LINE Immunology
PRODUCT CATEGORY CD Proteins
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ALX-522-096-C050   50 µg 365.00 USD Add To Cart
Product Specification
MW: ~48kDa (SDS-PAGE)
SOURCE/HOST: Produced in HEK 293 cells. The extracellular domain of mouse Thy-1 (aa 20-131) is fused to the Fc portion of human IgG1.
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 50µl sterile distilled water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
General Information
Thy-1 is a glycosyl phosphatidylinositol (GPI)-anchored glycoprotein of the immunoglobulin superfamily expressed in various cell types, particularly in cells of the neuronal system, activited microvascular endothelial cells, fibroblasts and blood stem cells. Thy-1 is involved in cell adhesion. Thy-1 interacts with the integrin avB3 (CD51/CD61) and Mac-1 (CD11b/CD18). In astrocytes, binding of Thy-1 to β3-integrin promotes focal adhesion formation.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P01831: Thy-1 (mouse)
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Thy-1 binds to integrin beta(3) on astrocytes and triggers formation of focal contact sites: L. Leyton, et al.; Curr. Biol. 11, 1028 (2001) Abstract
Human Thy-1 (CD90) on activated endothelial cells is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18): A. Wetzel, et al.; J. Immunol. 172, 3850 (2004) Abstract; Full Text
Interaction of human Thy-1 (CD 90) with the integrin alphavbeta3 (CD51/CD61): an important mechanism mediating melanoma cell adhesion to activated endothelium: A. Saalbach, et al.; Oncogene 24, 4710 (2005) Abstract
Related Products
Further Categories Containing This Product:
Neurobiology & Neurodiseases Other Products • Recombinant Proteins / Fusion Proteins • Adhesion Molecules & Receptors
 
 
ALX-522-091 Revised 27-Mar-08
Thy-1 (human):Fc (human) (recombinant)
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SYNONYMS CD90 (human):Fc (human) (recombinant)
PRODUCT LINE Immunology
PRODUCT CATEGORY CD Proteins
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ALX-522-091-C050   50 µg 360.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. The extracellular domain of human Thy-1 (aa 20-130) is fused to the Fc portion of human IgG1.
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 50µl sterile distilled water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
APPLICATION: Binds to human αvβ3 integrin.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
General Information
Human Thy-1 is a glycosyl phosphatidylinositol (GPI)- anchored glycoprotein of the immunoglobulin superfamily expressed in various cell types, particularly in cells of the neuronal system, activited microvascular endothelial cells, fibroblasts and blood stem cells. Thy-1 is involved in cell adhesion. Human Thy-1 interacts with the integrin αvβ3 (CD51/CD61) and Mac-1 (CD11b/CD18). In astrocytes, binding of Thy-1 to beta3-integrin promotes focal adhesion formation.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P04216: Thy-1 (human)
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Thy-1 binds to integrin beta(3) on astrocytes and triggers formation of focal contact sites: L. Leyton, et al.; Curr. Biol. 11, 1028 (2001) Abstract
Human Thy-1 (CD90) on activated endothelial cells is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18): A. Wetzel, et al.; J. Immunol. 172, 3850 (2004) Abstract
Interaction of human Thy-1 (CD 90) with the integrin alphavbeta3 (CD51/CD61): an important mechanism mediating melanoma cell adhesion to activated endothelium: A. Saalbach, et al.; Oncogene 24, 4710 (2005) Abstract
Further Categories Containing This Product:
Neurobiology & Neurodiseases Other Products • Recombinant Proteins / Fusion Proteins • Adhesion Molecules & Receptors
 
 
ALX-522-097 Revised 27-Mar-08
Thy-1 (RLE) (mouse):Fc (human) (recombinant)
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SYNONYMS CD90 (RLE) (mouse):Fc (human) (recombinant)
PRODUCT LINE Immunology
PRODUCT CATEGORY CD Proteins
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ALX-522-097-C050   50 µg 365.00 USD Add To Cart
Product Specification
MW: ~48kDa (SDS-PAGE)
SOURCE/HOST: Produced in HEK 293 cells. The extracellular domain of mouse Thy-1 (aa 20-131) is fused to the Fc portion of human IgG1. The integrin binding sequence RLD of mouse Thy-1 has been changed to RLE abolishing the binding of integrins.
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 50µl sterile distilled water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
General Information
Thy-1 is a glycosyl phosphatidylinositol (GPI)-anchored glycoprotein of the immunoglobulin superfamily expressed in various cell types, particularly in cells of the neuronal system, activited microvascular endothelial cells, fibroblasts and blood stem cells. Thy-1 is involved in cell adhesion. Thy-1 interacts with the integrin avB3 (CD51/CD61) and Mac-1 (CD11b/CD18). In astrocytes, binding of Thy-1 to β3-integrin promotes focal adhesion formation.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P01831: Thy-1 (mouse)
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Thy-1 binds to integrin beta(3) on astrocytes and triggers formation of focal contact sites: L. Leyton, et al.; Curr. Biol. 11, 1028 (2001) Abstract
Human Thy-1 (CD90) on activated endothelial cells is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18): A. Wetzel, et al.; J. Immunol. 172, 3850 (2004) Abstract; Full Text
Interaction of human Thy-1 (CD 90) with the integrin alphavbeta3 (CD51/CD61): an important mechanism mediating melanoma cell adhesion to activated endothelium: A. Saalbach, et al.; Oncogene 24, 4710 (2005) Abstract
Related Products
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • Adhesion Molecules & Receptors • Neurobiology & Neurodiseases Other Products
 
 
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