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ALX-522-109
Revised 14-Apr-08
DCC (Fibronectin Domain 5) (human) (recombinant)
SYNONYMS
Deleted in Colorectal Cancer Protein (Fibronectin Domain 5) (human) (recombinant)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Netrins & Receptors/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-522-109-C050
50 µg
360.00 USD
Product Specification
SOURCE/HOST:
Produced in
E. coli
. The fibronectin domain 5 (FBN5) of human DCC (aa 841-941) is fused to a N-terminal tag.
CONCENTRATION:
1mg/ml after reconstitution.
PURITY:
≥95% (SDS-PAGE)
FORMULATION:
Lyophilized. Contains PBS.
ENDOTOXIN CONTENT:
<0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION:
Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
SPECIFICITY:
Binds to human netrin-1.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 6 months after receipt when stored at -20°C.
HANDLING:
Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Product Specific Literature References
Netrin-1 expression confers a selective advantage for tumor cell survival in metastatic breast cancer:
J. Fitamant, et al.; PNAS
105
, 4850 (2008)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link Q16218:
Deleted in Colorectal Cancer Protein (human)
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin:
B.V. Geisbrecht, et al.; J. Biol. Chem.
278
, 32561 (2003)
Abstract
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
ALX-804-853
Revised 31-Jul-07
Monoclonal Antibody to DCC (human) (Axel-1)
SYNONYMS
anti-Deleted in Colorectal Cancer Protein (human) MAb (Axel-1)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Netrins & Receptors/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-853-C100
100 µg
340.00 USD
ALX-804-853PF-C100
Preservative Free
100 µg
340.00 USD
ALX-804-853TD-T100
ATTO 488
100 tests
380.00 USD
ALX-804-853TS-T100
ATTO 647N
100 tests
380.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
Axel-1
ISOTYPE:
Mouse IgG2aλ
SOURCE/HOST:
Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION:
1mg/ml
PURITY:
≥95% (SDS-PAGE)
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
ALX-804-853
: Liquid. In PBS containing 0.02% sodium azide.
ALX-804-853PF
: Liquid. In PBS.
ALX-804-853TD
: Liquid. In PBS containing 0.02% sodium azide.
ALX-804-853TS
: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant human DCC fibronectin domain 5 (Prod. No.
ALX-522-109
).
SPECIFICITY:
Recognizes human DCC.
APPLICATION:
Flow Cytometry
Functional Application: Blocking
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C.
HANDLING:
For long term storage keep unconjugated antibody at -20°C. Avoid freeze/thaw cycles. Keep conjugated formats at +4°C. Do not freeze. Protect from light.
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-574
Revised 25-Oct-05
Monoclonal Antibody to Nerve Growth Factor Receptor (human) (MGR15)
SYNONYMS
anti-NGFR (human) MAb (MGR15)
anti-TNFRSF 16 (human) MAb (MGR15)
anti-p75
NTR
(human) MAb (MGR15)
anti-p75 Neurotrophin Receptor (human) MAb (MGR15)
anti-CD271 (human) MAb (MGR15)
anti-Low-affinity Nerve Growth Factor Receptor (human) MAb (MGR15)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
Nerve Growth Factors [NGF] & Receptors/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-574-C050
50 µg
210.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
MGR15
ISOTYPE:
Mouse IgM
CONCENTRATION:
0.4mg/ml
FORMULATION:
Liquid. In 20mM TRIS, pH 7.4, containing 1.25M sodium chloride and 0.02% sodium azide.
IMMUNOGEN:
SKNBE neuroblastoma cell line transfected with human NGFR (nerve growth factor receptor; p75
NTR
).
SPECIFICITY:
Recognizes an epitope present in the extracellular domain of human NGFR.
APPLICATION:
Flow Cytometry
Immunohistochemistry (frozen sections)
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
HANDLING:
Do not freeze.
General Literature References
Trk receptors: roles in neuronal signal transduction
:
E.J. Huang, et al.; Annu. Rev. Biochem.
72
, 609 (2003)
Abstract
Neurotrophin signaling through the p75 neurotrophin receptor
:
P.P. Roux, et al.; Prog. Neurobiol.
67
, 203 (2002)
Abstract
Further Categories Containing This Product:
CD Antibodies
•
Monoclonal Antibodies
ALX-804-833
Revised 21-Dec-06
Monoclonal Antibody to Nerve Growth Factor Receptor (human) (Nagy-1)
SYNONYMS
anti-NGFR (human) MAb (Nagy-1)
anti-TNFRSF 16 (human) MAb (Nagy-1)
anti-p75
NTR
(human) MAb (Nagy-1)
anti-p75 Neurotrophin Receptor (human) MAb (Nagy-1)
anti-CD271 (human) MAb (Nagy-1)
anti-Low-affinity Nerve Growth Factor Receptor (human) MAb (Nagy-1)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
Nerve Growth Factors [NGF] & Receptors/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-833-C100
100 µg
320.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
Nagy-1
ISOTYPE:
Rat IgG2a
SOURCE/HOST:
Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION:
1mg/ml
PURITY:
≥95% (SDS-PAGE)
PURITY DETAIL:
Epitope-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant human NGFR (nerve growth factor receptor; p75
NTR
):Fc (Prod. No.
ALX-522-044
).
SPECIFICITY:
Recognizes human NGFR.
APPLICATION:
Flow Cytometry (1:1'000)
Immunoprecipitation (1:200)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C.
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
An autocrine function of nerve growth factor for cell cycle regulation of vascular endothelial cells:
A. Tanaka, et al.; BBRC
313
, 1009 (2004)
Abstract
p75NTR--live or let die:
A. Nykjaer, et al.; Curr. Opin. Neurobiol.
15
, 49 (2005)
Abstract
Further Categories Containing This Product:
CD Antibodies
•
Monoclonal Antibodies
ALX-804-838
Revised 02-Jul-07
Monoclonal Antibody to Netrin-1 (Nora-1)
SYNONYMS
anti-Netrin-1 MAb (Nora-1)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Netrins & Receptors/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-838-C100
100 µg
360.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE:
Nora-1
ISOTYPE:
Mouse IgG2a
SOURCE/HOST:
Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION:
0.5mg/ml
PURITY:
≥95% (SDS-PAGE)
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant human, mouse and chicken netrin-1 (aa 28-264).
SPECIFICITY:
Recognizes human, mouse and chicken netrin-1.
APPLICATION:
ELISA
Immunohistochemistry
Immunoprecipitation (1:100)
Western Blot (1:1’000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C.
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
POSITIVE CONTROL:
Prod. No.
ALX-522-100
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
Netrin-1 controls colorectal tumorigenesis by regulating apoptosis:
L. Mazelin, et al.; Nature
431
, 80 (2004)
Abstract
Related Products
ALX-522-100
Netrin-1 (human) (recombinant)
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-860
Revised 12-Dec-07
Monoclonal Antibody to Netrin-4 (human) (Netry-1)
SYNONYMS
anti-β-Netrin (human) MAb (Netry-1)
anti-Hepar-derived Netrin-like Protein (human) MAb (Netry-1)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Netrins & Receptors/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-860-C100
100 µg
360.00 USD
ALX-804-860B-C100
Biotin
100 µg
380.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
Netry-1
ISOTYPE:
Mouse IgG1
SOURCE/HOST:
Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION:
1mg/ml
PURITY:
≥95% (SDS-PAGE)
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant human netrin-4 (Prod. No.
ALX-522-113
).
SPECIFICITY:
Recognizes human netrin-4.
APPLICATION:
ELISA
Immunoprecipitation (1:200)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored as recommended.
HANDLING:
For long term storage keep unconjugated antibody at -20°C. Avoid freeze/thaw cycles. Keep conjugated formats at +4°C. Do not freeze. Protect from light.
POSITIVE CONTROL:
Prod. No.
ALX-522-113
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
Related Products
ALX-522-136
Netrin-4 (mouse) (recombinant)
APO-54N-037
Netrin-4 (human) ELISA Kit
APO-54N-033
Netrin-4 (human) Detection Set [For ELISA Application]
ALX-804-862
Monoclonal Antibody to Netrin-4 (Netry-2)
ALX-210-953
Polyclonal Antibody to Netrin-4 (AT128)
ALX-522-113
Netrin-4 (human) (recombinant)
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-862
Revised 28-May-08
Monoclonal Antibody to Netrin-4 (Netry-2)
SYNONYMS
anti-β-Netrin MAb (Netry-2)
anti-Hepar-derived Netrin-like Protein MAb (Netry-2)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Netrins & Receptors/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-862-C100
100 µg
360.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE:
Netry-2
ISOTYPE:
Mouse IgG1
SOURCE/HOST:
Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION:
1mg/ml
PURITY:
≥95% (SDS-PAGE)
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant human netrin-4 (Prod. No.
ALX-522-113
).
SPECIFICITY:
Recognizes human and mouse netrin-4.
APPLICATION:
ELISA
Immunoprecipitation (1:200)
Western Blot (1:1´000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C.
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
POSITIVE CONTROL:
Prod. No.
ALX-522-113
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
Related Products
APO-54N-037
Netrin-4 (human) ELISA Kit
ALX-522-136
Netrin-4 (mouse) (recombinant)
APO-54N-033
Netrin-4 (human) Detection Set [For ELISA Application]
ALX-210-953
Polyclonal Antibody to Netrin-4 (AT128)
ALX-522-113
Netrin-4 (human) (recombinant)
ALX-804-860
Monoclonal Antibody to Netrin-4 (human) (Netry-1)
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-851
Revised 03-May-07
Monoclonal Antibody to RGMC (human) (Fery-1)
SYNONYMS
anti-Repulsive Guidance Molecule C (human) MAb (Fery-1)
anti-Hemojuvelin (human) MAb (Fery-1)
anti-Hemochromatosis Type 2 Protein (human) MAb (Fery-1)
anti-HFE2 (human) MAb (Fery-1)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Dependence Receptors Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-851-C100
100 µg
320.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
Fery-1
ISOTYPE:
Mouse IgG2b
SOURCE/HOST:
Purified from concentrated hybridoma tissue cell culture supernatant.
CONCENTRATION:
1mg/ml
PURITY:
≥95% (SDS-PAGE)
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant human RGMC (aa 36-398) (Prod. No.
ALX-522-104
).
SPECIFICITY:
Recognizes human RGMC.
APPLICATION:
Flow Cytometry
Immunoprecipitation
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C.
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
Related Products
ALX-522-104
RGMC, Soluble (human) (recombinant)
Further Categories Containing This Product:
Bone Morphogenetic Proteins [BMPs] & Receptors/Related Products
•
Polyclonal Antibodies
•
Growth, Survival and Development of Neurons Other Products
ALX-804-575
Revised 25-Oct-05
Monoclonal Antibody to TRK Receptor (human) (MGR12)
SYNONYMS
anti-TrkA (human) MAb (MGR12)
anti-Tyrosine Kinase Receptor A (human) MAb (MGR12)
anti-Tropomyosin-related Receptor (human) MAb (MGR12)
anti-High-affinity Nerve Growth Factor Receptor (human) MAb (MGR12)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Dependence Receptors Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-575-C100
100 µg
320.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
MGR12
ISOTYPE:
Mouse IgG1
CONCENTRATION:
1mg/ml
FORMULATION:
Liquid. In 150mM sodium chloride, pH 7.4, containing 0.02% sodium azide.
IMMUNOGEN:
SKNBE neuroblastoma cell line transfected with TrkA (TRK receptor).
SPECIFICITY:
Recognizes an epitope present in the extracellular domain of human TrkA. Detects a band of ~140kDa by IP.
APPLICATION:
Flow Cytometry
Immunohistochemistry (frozen sections)
Immunoprecipitation
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
HANDLING:
Do not freeze.
Product Specific Literature References
Production of a monoclonal antibody directed against the high-affinity nerve growth factor receptor
:
E. Tagliabue, et al.; Int. J. Biol. Markers
14
, 68 (1999)
Abstract
Further Categories Containing This Product:
Nerve Growth Factors [NGF] & Receptors/Related Products
•
Receptor Tyrosine Kinases Other Products
•
Monoclonal Antibodies
ALX-804-846
Revised 04-Jan-07
Monoclonal Antibody to UNC5B (Guido-1)
SYNONYMS
anti-UNC-5 Homolog B MAb (Guido-1)
anti-UNC5H2 MAb (Guido-1)
anti-UNC-5 Homolog 2 MAb (Guido-1)
anti-p53-regulated Receptor For Death And Life Protein 1 MAb (Guido-1)
anti-P53RDL1 MAb (Guido-1)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Netrins & Receptors/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-846-C100
100 µg
370.00 USD
