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Neuropeptides & Receptors
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ALX-550-164 Revised 26-Nov-04
N-Benzylnaltrindole . hydrochloride
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SYNONYMS 1'-Benzyl-17-(cyclopropylmethyl)-6,7-didehydro-[4,5a]-epoxy-3,14-dihydroxyindolo[2',3',6,7]morphinan . HCl
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Opioid Receptors/Related Products
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ALX-550-164-M001   1 mg 40.00 USD Add To Cart
ALX-550-164-M005   5 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C33H32N2O3 . HCl
MW: 504.6 . 36.5
PURITY: ≥95%
APPEARANCE: White solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Potent δ2-selective opioid receptor antagonist with a long duration of action in vivo.
Product Specific Literature References
N-benzylnaltrindoles as long-acting delta-opioid receptor antagonists: V.L. Korlipara, et al.; J. Med. Chem. 37, 1882 (1994) Abstract
 
 
ALX-550-111 Revised 12-May-03
nor-Binaltorphimine . dihydrochloride
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SYNONYMS nor-BNI . 2HCl
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Opioid Receptors/Related Products
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ALX-550-111-M001   1 mg 25.00 USD Add To Cart
Product Specification
FORMULA: C40H43N3O6 . 2HCl
MW: 661.8 . 73.0
CAS NUMBER: 105618-26-6
PURITY: ≥96%
APPEARANCE: Tan solid.
SOLUBILITY: Soluble in ethanol; sonification required.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Aqueous solutions are highly unstable and should be freshly prepared.

Product Description
Highly selective κ-opioid receptor antagonist.
Product Specific Literature References
Binaltorphimine and nor-binaltorphimine, potent and selective kappa- opioid receptor antagonists: P.S. Portoghese, et al.; Life Sci. 40, 1287 (1987) Abstract
Nor-binaltorphimine, a highly selective kappa-opioid antagonist in analgesic and receptor binding assays: A.E. Takemori, et al.; J. Pharmacol. Exp. Ther. 246, 255 (1988) Abstract
Effects of the selective kappa opioid antagonist, nor-binaltorphimine, on electrically-elicited feeding in the rat: K.D. Carr, et al.; Life Sci. 45, 1787 (1989) Abstract
Structure-activity relationship of N17'-substituted norbinaltorphimine congeners. Role of the N17' basic group in the interaction with a putative address subsite on the kappa opioid receptor: P.S. Portoghese, et al.; J. Med. Chem. 37, 1495 (1994) Abstract
Differential agonist regulation of the human kappa-opioid receptor: A.D. Blake, et al.; J. Neurochem. 68, 1846 (1997) Abstract
 
 
ALX-152-018 Revised 20-Aug-02
Bombesin
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Neuropeptides & Receptors Other Products
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ALX-152-018-P001   1 mg* 40.00 USD Add To Cart
ALX-152-018-P005   5 mg* 160.00 USD Add To Cart
Product Specification
SEQUENCE: Pyr-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2
FORMULA: C71H110N24O18S
MW: 1619.9
CAS NUMBER: 31362-50-2
MERCK INDEX: 14: 1329
QUANTITY: *Sold as net peptide weight.
PURITY: ≥97%
APPEARANCE: While lyophilized powder.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Further Categories Containing This Product:
Peptides
 
 
ALX-152-006 Revised 23-Jan-07
Bradykinin
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Bradykinin Receptor/Related Products
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ALX-152-006-M005   5 mg 22.00 USD Add To Cart
ALX-152-006-M025   25 mg 86.00 USD Add To Cart
Product Specification
SEQUENCE: H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH
FORMULA: C50H73N15O11
MW: 1060.3
CAS NUMBER: 5979-11-3
MERCK INDEX: 14: 1359
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 5% acetic acid.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
Product Description
Activator of eNOS (NOS III).
Product Specific Literature References
Different activation of L-arginine pathway by bradykinin, serotonin, and clonidine in coronary arteries: V. Richard, et al.; Am. J. Physiol. 259, H1433 (1990) Abstract
Bradykinin and ATP stimulate L-arginine uptake and nitric oxide release in vascular endothelial cells: R.G. Bogle, et al.; BBRC 180, 926 (1991) Abstract
Activation of a small-conductance Ca(2+)-dependent K+ channel contributes to bradykinin-induced stimulation of nitric oxide synthesis in pig aortic endothelial cells: K. Groschner, et al.; Biochim. Biophys. Acta 1137, 162 (1992) Abstract
G proteins in aortic endothelial cells and bradykinin-induced formation of nitric oxide: J. Gil-Longo, et al.; Eur. J. Pharmacol. 247, 119 (1993) Abstract
Simultaneous measurements of Ca2+ and nitric oxide in bradykinin-stimulated vascular endothelial cells: L.A. Blatter, et al.; Circ. Res. 76, 922 (1995) Abstract; Full Text
Biosynthesis of endothelium-derived nitric oxide by bradykinin as endogenous precursor: A.R. Volpe, et al.; Immunopharmacology 33, 287 (1996) Abstract
Nitric oxide as mediator of bradykinin-induced pancreatic circulatory and metabolic responses: W.W. Pawlik, et al.; J. Physiol. Pharmacol. 48, 751 (1997) Abstract
Bradykinin-regulated interactions of the mitogen-activated protein kinase pathway with the endothelial nitric-oxide synthase: S.G. Bernier, et al.; J. Biol. Chem. 275, 30707 (2000) Abstract; Full Text
Reciprocal phosphorylation and regulation of endothelial nitric-oxide synthase in response to bradykinin stimulation: M.B. Harris, et al.; J. Biol. Chem. 276, 16587 (2001) Abstract; Full Text
Bradykinin down-regulates, whereas arginine analogs up-regulates, endothelial nitric-oxide synthase expression in coronary endothelial cells: N.D. Vaziri, et al.; J. Pharmacol. Exp. Ther. 313, 121 (2005) Abstract; Full Text
Bradykinin mediates phosphorylation of eNOS in odontoblasts: Y. Korkmaz, et al.; J. Dent. Res. 85, 536 (2006) Abstract
Further Categories Containing This Product:
NOS Regulation • Cell Stress, Oxidative Stress & Redox Signalling Other Products • Peptides
 
 
ALX-550-189 Revised 17-Dec-04
BRL 52537 . hydrochloride
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SYNONYMS (±)-1-(3,4-Dichlorophenyl)acetyl-2-(1-pyrrolidinyl)methylpiperidine . HCl
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Opioid Receptors/Related Products
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ALX-550-189-M005   5 mg 60.00 USD Add To Cart
ALX-550-189-M025   25 mg 240.00 USD Add To Cart
Product Specification
FORMULA: C18H24Cl2N2O . HCl
MW: 355.3 . 36.5
CAS NUMBER: 130497-35-5
PURITY: ≥98%
APPEARANCE: White solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Potent and highly κ/μ selective κ-opioid receptor agonist (25 times more potent than morphine).
Product Specific Literature References
(2S)-1-(arylacetyl)-2-(aminomethyl)piperidine derivatives: novel, highly selective kappa opioid analgesics: V. Vecchietti, et al.; J. Med. Chem. 34, 397 (1991) Abstract
 
 
ALX-152-031 Revised 24-Nov-06
(Des-Arg1)-Bradykinin
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SYNONYMS Bradykinin (2-9)
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Bradykinin Receptor/Related Products
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ALX-152-031-M001   1 mg 15.00 USD Add To Cart
ALX-152-031-M005   5 mg 50.00 USD Add To Cart
Product Specification
SEQUENCE: H-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH
FORMULA: C44H61N11O10
MW: 904.0
CAS NUMBER: 16875-11-9
APPEARANCE: Lyophilized.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Further Categories Containing This Product:
NOS Regulation • Cell Stress, Oxidative Stress & Redox Signalling Other Products • Peptides
 
 
ALX-152-032 Revised 08-Dec-06
(Des-Arg9)-Bradykinin
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Bradykinin Receptor/Related Products
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ALX-152-032-M005   5 mg 75.00 USD Add To Cart
ALX-152-032-M025   25 mg 300.00 USD Add To Cart
Product Specification
SEQUENCE: H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-OH
FORMULA: C44H61N11O10
MW: 904.0
CAS NUMBER: 15958-92-6
PURITY: ≥99%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water (1mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Further Categories Containing This Product:
Cell Stress, Oxidative Stress & Redox Signalling Other Products • NOS Regulation • Peptides
 
 
ALX-550-175 Revised 16-Dec-04
DIPPA . hydrochloride
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SYNONYMS 2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl]acetamide . HCl
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Opioid Receptors/Related Products
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ALX-550-175-M001   1 mg 20.00 USD Add To Cart
ALX-550-175-M005   5 mg 80.00 USD Add To Cart
Product Specification
FORMULA: C22H23Cl2N3OS . HCl
MW: 448.4 . 36.5
PURITY: ≥95%
APPEARANCE: Off-white powder.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Irreversible and selecitve κ-opioid receptor antagonist.
Product Specific Literature References
2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1- pyrrolidinyl)ethyl]acetamide: an opioid receptor affinity label that produces selective and long-lasting kappa antagonism in mice: A.C. Chang, et al.; J. Med. Chem. 37, 1547 (1994) Abstract
kappa Opioid receptor selective affinity labels: electrophilic benzeneacetamides as kappa-selective opioid antagonists: A.C. Chang, et al.; J. Med. Chem. 37, 4490 (1994) Abstract
 
 
ALX-380-264 Revised 04-Jun-08
EM574
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SYNONYMS Motilide
Idremcinal
8,9-Didehydro-N-demethyl-9-deoxo-6-deoxy-6,9-epoxy-N-(1-methylethyl)-erythromycin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Other Signal Transduction Pathway Modulators
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ALX-380-264-M001   1 mg 280.00 USD Add To Cart
Product Specification
FORMULA: C39H69NO12
MW: 744.0
CAS NUMBER: 110480-13-2
SOURCE/HOST: Semisynthetic from erythromycin A.
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white powder.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

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Product Description
Agonist of the motilin receptor. Shows antimicrobial and gastrointestinal motor stimulating activity in vitro and in vivo. Stimulates contractions of muscle strips in a concentration-dependent manner (10-7-10-5M) and this contractile effect is unaffected by pretreatment with atropine or tetrodotoxin (Prod. No. ALX-630-002). Binds to smooth muscle homogenates wit a Kd value of 7.8 x 10-9. Has orexigenic activity with affinity for the growth-hormone secretagogue receptor (GHS-R, Ghrelin Receptor).
Product Specific Literature References
Gastrointestinal motor-stimulating activity of macrolide antibiotics and the structure-activity relationship: S. Omura, et al.; J. Antibiot. 38, 1631 (1985) Abstract
Macrolides with gastrointestinal motor stimulating activity: S. Omura, et al.; J. Med. Chem. 30, 1941 (1987) Abstract
Motilides, macrolides with gastrointestinal motor stimulating activity. I. O-substituted and tertiary N-substituted derivatives of 8,9-anhydroerythromycin A 6,9-hemiacetal: K. Tsuzuki, et al.; Chem. Pharm. Bull. 37, 2687 (1989) Abstract
EM574, an erythromycin derivative, is a potent motilin receptor agonist in human gastric antrum: M. Satoh, et al.; J. Pharmacol. Exp. Ther. 271, 574 (1994) Abstract
Bioactive metabolites of EM574 and EM523, erythromycin derivatives having strong gastrointestinal motor stimulating activity: Y. Funabashi, et al.; J. Antibiot. 49, 794 (1996) Abstract
Vagus-dependent and vagus-independent mechanisms of action of the erythromycin derivative EM574 and motilin in dogs: N. Inatomi, et al.; Jpn. J. Pharmacol. 71, 29 (1996) Abstract
EM574, an erythromycin derivative, is a motilin receptor agonist in the rabbit: F. Sato, et al.; Eur. J. Pharmacol. 322, 63 (1997) Abstract
Effects of EM574 and cisapride on gastric contractile and emptying activity in normal and drug-induced gastroparesis in dogs: T. Tanaka, et al.; J. Pharmacol. Exp. Ther. 287, 712 (1998) Abstract
EM574, an erythromycin derivative, improves delayed gastric emptying of semi-solid meals in conscious dogs: F. Sato, et al.; Eur. J. Pharmacol. 395, 165 (2000) Abstract
General Information
MANUFACTURER Manufactured by the Kitasato Institute, Tokyo.
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Further Categories Containing This Product:
Neuropeptides & Receptors Other Products • G-Protein Coupled Receptors & Ligands Other Products
 
 
ALX-157-003 Revised 03-Mar-05
Galanin (human)
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PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Galanin & Galanin Receptor/Related Products
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ALX-157-003-PC05   0.5 mg* 190.00 USD Add To Cart
ALX-157-003-P001   1 mg* 280.00 USD Add To Cart
Product Specification
SEQUENCE: H-Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-His-Ala-Val-Gly-Asn-His-Arg-Ser-Phe-Ser-Asp-Lys-Asn-Gly-Leu-Thr-Ser-OH
FORMULA: C139H210N42O43
MW: 3157.4
CAS NUMBER: 119418-04-1
QUANTITY: *Sold as net peptide weight.
PURITY: ≥98%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Specific Literature References
Galanin: profile of a new neuropeptide: L.W. Haynes; TIPS 7, 214 (1986), (Review)
Galanin - a newly isolated biologically active neuropeptide: A. Rökaeus; Trends Neurosci. 10, 158 (1987)
Galanin and the endocrine pancreas: B. Ahren, et al.; FEBS Lett. 229, 233 (1988) Abstract
Galanin. A selective inhibitor of insulin secretion?: J. Dupré; Pancreas 3, 119 (1988) Abstract
Co-existence of galanin and acetylcholine: is galanin involved in memory processed and dementia?: J.N. Crawley & G.L. Wenk; TINS 12, 278 (1989) Abstract
Inhibitory action of galanin on gastric acid secretion in pentobarbital-anesthetized rats: W.J. Rossowski & D.H. Coy; Life Sci. 44, 1807 (1989) Abstract
Galanin in the porcine pancreas: T. Messell, et al.; Regul. Pept. 28, 161 (1990) Abstract
Human galanin: primary structure and identification of two molecular forms: M. Bersani, et al.; FEBS Lett. 283, 189 (1991) Abstract
Isolation and primary structure of pituitary human galanin, a 30- residue nonamidated neuropeptide: W.E. Schmidt, et al.; PNAS 88, 11435 (1991) Abstract
Human galanin: molecular cloning reveals a unique structure: H.F. Evans & J. Shine; Endocrinology 129, 1682 (1991) Abstract
Further Categories Containing This Product:
Neuropeptides & Receptors Other Products • Ca2+ Modulators • Peptides
 
 
ALX-165-001 Revised 04-Feb-05
GP Antagonist-2
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SYNONYMS G-Protein Antagonist-2
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Substance P and Analogs
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ALX-165-001-M001   1 mg 90.00 USD Add To Cart
ALX-165-001-M005   5 mg 360.00 USD Add To Cart