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ALX-201-419 Revised 25-Jun-08 New product
Epstein-Barr Virus-induced Gene 3 (human):Fc (human) (recombinant)
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SYNONYMS EBI3 (human):Fc (human) (recombinant)
EBV-induced Gene 3 Protein (human):Fc (human) (recombinant)
IL-27 Subunit β (human):Fc (human) (recombinant)
Interleukin-27 Subunit β (human):Fc (human) (recombinant)
IL-27B (human):Fc (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukins
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-419-C010   10 µg 280.00 USD Add To Cart
ALX-201-419-C050   50 µg 680.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. Full-length human Epstein-Barr Virus-induced Gene 3 (aa 1-229) is fused at the C-terminus to the Fc portion of human IgG1.
CONCENTRATION:  
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2μm-filtered solution in PBS.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q14213: Epstein-Barr Virus-induced Gene 3 (human) 
MANUFACTURER Manufactured by AdipoGen, Inc.
Related Products
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-155-037 Revised 16-Apr-08 New product
Extracellular Death Factor
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SYNONYMS EDF
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Apoptosis Inducers & Inhibitors Other Products
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ALX-155-037-M001   1 mg 40.00 USD Add To Cart
ALX-155-037-M005   5 mg 120.00 USD Add To Cart
Product Specification
SEQUENCE: H-Asn-Asn-Trp-Asn-Asn-OH
FORMULA: C27H36N10O10
MW: 660.6
SOURCE/HOST: Synthetic.
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white powder.
FORMULATION: Lyophilized.
SOLUBILITY: Soluble in water or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Programmed cell death (PCD) also occurs in bacteria. PCD in E. coli depends on cell-to-cell communication, a process known as quorum sensing. The communicating cells produce and emit the extracellular death factor (EDF). After reaching a sufficent concentration, EDF activates the cell death pathway in a subset of cells.
Product Specific Literature References
A linear pentapeptide is a quorum-sensing factor required for mazEF-mediated cell death in Escherichia coli: I. Kolodkin-Gal, et al.; Science 318, 652 (2007) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-522-141 Revised 05-Aug-08 New product
Fc (human):Dectin-1 (mouse) (recombinant)
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SYNONYMS Fc (human):Dendritic Cell-associated C-type Lectin 1 (mouse) (recombinant)
Fc (human):β-Glucan Receptor (mouse) (recombinant)
Fc (human):C-type Lectin Superfamily Member 12 (mouse) (recombinant)
Fc (human):C-type Lectin Domain Family 7 Member A (mouse) (recombinant)
PRODUCT LINE Other Products
PRODUCT CATEGORY Lectins Other Products
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ALX-522-141-C050   50 µg 390.00 USD Add To Cart
Product Specification
MW: ~58kDa
SOURCE/HOST: Produced in CHO cells. The extracellular domain of mouse dectin-1 (aa 71-244) is fused at the N-terminus to the Fc portion of human IgG1.
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Lonza)
RECONSTITUTION: Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
General Information
Dectin-1 is a type II transmembrane protein and a member of the group V C-type lectin-like receptors [1]. Dectin-1 is present on myeloid cells, including macrophages, DCs and neutrophils, and it is also present on certain lymphocytes. Dectin-1 recognises β-1,3-glucans in a calcium-independent fashion. Through its specificity for β-glucans, Dectin-1 can recognize a number of fungal species and may play an important role in antifungal immunity [2].
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q6QLQ4: Dectin-1 (mouse)
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
[1] Dectin-1: a signalling non-TLR pattern-recognition receptor: G.D. Brown; Nat. Rev. Immunol. 6, 33 (2006) Abstract
[2] Dectin-1 and its role in antifungal immunity: M. Kimberg & G.D. Brown; Med. Mycol. Epub ahead of print, (2008) Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-270-481 Revised 11-Aug-08 New product
Fenofibrate
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SYNONYMS 2-[4-(4-Chlorobenzoyl)phenoxy]-2-methyl-propanoic acid 1-methylethyl ester
Procetofen
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PPAR Agonists
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ALX-270-481-G005   5 g 30.00 USD Add To Cart
Product Specification
FORMULA: C20H21ClO4
MW: 360.8
CAS NUMBER: 49562-28-9
MERCK INDEX: 14: 3978
RTECS: UA2453400
PURITY: ≥98% (UPLC)
APPEARANCE: White to off-white crystalline solid.
SOLUBILITY: Soluble in acetone, ether, DMSO or dimethyl formamide; slightly soluble in 100% ethanol or methanol; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: HARMFUL.

Product Description
Hypolipidemic compound. PPARα (peroxisome proliferator-activated receptor α) agonist (EC50=18µM for mouse and EC50=30µM for human PPARα). Also binds to PPARγ, but with at least 10-fold less affinity and is inactive at PPARδ (up to EC50=100µM).
Product Specific Literature References
Inhibition of membrane-bound hepatic 3 hydroxy-3 methyl glutaryl CoA reductase as the consequence of altered membrane fluidity: E. Wulfert, et al.; Artery 9, 120 (1981) Abstract
Fenofibrate protects lipoproteins from lipid peroxidation: synergistic interaction with alpha-tocopherol: E. Chaput, et al.; Lipids 34, 497 (1999) Abstract
Effects of chronic treatment with statins and fenofibrate on rat skeletal muscle: a biochemical, histological and electrophysiological study: S. Pierno, et al.; Br. J. Pharmacol. 149, 909 (2006) Abstract; Full Text
In vitro and in vivo effects of the PPAR-alpha agonists fenofibrate and retinoic acid in endometrial cancer: S.A. Saidi, et al.; Mol. Cancer 5, 13 (2006) Abstract; Full Text
PPARalpha agonist fenofibrate suppresses tumor growth through direct and indirect angiogenesis inhibition: D. Panigrahy, et al.; PNAS 105, 985 (2008) Abstract; Full Text
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ALX-201-418 Revised 02-Jul-08 New product
FGF-23 (human):Fc (human) (recombinant)
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SYNONYMS Fibroblast Growth Factor 23 (human):Fc (human) (recombinant)
Tumor-derived Hypophosphatemia-inducing Factor (human):Fc (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Fibroblast Growth Factors [FGFs] & Receptors / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-418-C010   10 µg 230.00 USD Add To Cart
ALX-201-418-C050   50 µg 560.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. The original signal peptide and the mature peptide of human FGF 23 (aa 1-251) are fused at the C-terminus to the Fc portion of human IgG.
CONCENTRATION: 1mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2μm-filtered solution in PBS.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
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General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q9GZV9: Fibroblast Growth Factor-23 (human)
MANUFACTURER Manufactured by AdipoGen, Inc.
Related Products
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-420 Revised 21-Aug-08 New product
FGF-19 (human) (recombinant) (His)
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SYNONYMS Fibroblast Growth Factor 19 (human) (recombinant) (His)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Fibroblast Growth Factors [FGFs] & Receptors / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-420-C010   10 µg 260.00 USD Add To Cart
ALX-201-420-C050   50 µg 660.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. The original signal peptide and the mature peptide of human FGF-19 (aa 1-216) are fused at the C-terminus to a His-tag.
CONCENTRATION: 0.3mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2μm-filtered solution in PBS.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
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General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link O95750: Fibroblast Growth Factor-19 (human)
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-423 Revised 25-Jun-08 New product
FGF-23 (human) (recombinant) (His)
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SYNONYMS Fibroblast Growth Factor 23 (human) (recombinant) (His)
Tumor-derived Hypophosphatemia Inducing Factor (human) (recombinant) (His)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Fibroblast Growth Factors [FGFs] & Receptors / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-423-C010   10 µg 240.00 USD Add To Cart
ALX-201-423-C050   50 µg 580.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. The original signal peptide and the mature peptide of human FGF-23 (aa 1-251) are fused at the C-terminus to a His-tag.
CONCENTRATION:  
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2μm-filtered solution in PBS.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
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General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q9GZV9: Fibroblast Growth Factor-23 (human)
MANUFACTURER Manufactured by AdipoGen, Inc.
Related Products
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-430-161 Revised 21-Jul-08 New product
Flavopiridol
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SYNONYMS Alvocidib
(-)-2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3R,4S)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY CDK & Cyclin Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-161-M005   5 mg 60.00 USD Add To Cart
ALX-430-161-M025   25 mg 240.00 USD Add To Cart
Product Specification
FORMULA: C21H20ClNO5
MW: 401.8
CAS NUMBER: 146426-40-6
MERCK INDEX: 14: 4094
SOURCE/HOST: Synthetic.
PURITY: ≥97% (HPLC)
APPEARANCE: Yellow powder.
SOLUBILITY: Soluble in chloroform; slightly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: HARMFUL.
IDENTITY: Identity determined by 1H-NMR.

Product Description

Potent inhibitor of cyclin-dependent kinases  (CDKs). Induces apoptosis in certain tumor cells. Interacts with multidrug resistance protein 1 (MRP1).
Product Specific Literature References
Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase: W.F. Jr. De Azevedo, et al.; PNAS 93, 2735 (1996) Abstract; Full Text
Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase (CDK) 2 and CDK4 in human breast carcinoma cells: B.A. Carlson, et al.; Cancer Res. 56, 2973 (1996) Abstract; Full Text
Flavopiridol: a cytotoxic flavone that induces cell death in noncycling A549 human lung carcinoma cells: K.C. Bible & S.H. Kaufmann; Cancer Res. 56, 4856 (1996) Abstract; Full Text
Flavopiridol (L86-8275): selective antitumor activity in vitro and activity in vivo for prostate carcinoma cells: M. Drees, et al.; Clin. Cancer Res. 3, 273 (1997) Abstract; Full Text
The novel cyclin-dependent kinase inhibitor flavopiridol downregulates Bcl-2 and induces growth arrest and apoptosis in chronic B-cell leukemia lines: A. König, et al.; Blood 90, 4307 (1997) Abstract; Full Text
Flavopiridol induces apoptosis of normal lymphoid cells, causes immunosuppression, and has potent antitumor activity In vivo against human leukemia and lymphoma xenografts: F. Arguello, et al.; Blood 91, 2482 (1998) Abstract; Full Text
Cell cycle-independent induction of apoptosis by the anti-tumor drug Flavopiridol in endothelial cells: S. Brüsselbach, et al.; Int. J. Cancer 77, 146 (1998) Abstract
Flavopiridol induces apoptosis in chronic lymphocytic leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence on functional p53: J.C. Byrd, et al.; Blood 92, 3804 (1998) Abstract; Full Text
Identification of cytosolic aldehyde dehydrogenase 1 from non-small cell lung carcinomas as a flavopiridol-binding protein: J.B. Schnier, et al.; FEBS Lett. 454, 100 (1999) Abstract
Potent interaction of flavopiridol with MRP1: J.H. Hooijberg, et al.; Br. J. Cancer 81, 269 (1999) Abstract
Flavopiridol: the first cyclin-dependent kinase inhibitor in human clinical trials: A.M. Senderowicz; Invest. New Drugs 17, 313 (1999), (Review) Abstract
Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate antiapoptosis proteins in B-cell chronic lymphocytic leukemia: S. Kitada, et al.; Blood 96, 393 (2000) Abstract; Full Text
Flavopiridol, a cyclin-dependent kinase inhibitor, enhances radiosensitivity of ovarian carcinoma cells: U. Raju, et al.; Cancer Res. 63, 3263 (2003) Abstract; Full Text
Potential use of pharmacological cyclin-dependent kinase inhibitors as anti-HIV therapeutics: A. Pumrery, et al.; Curr. Pharm. Des. 12, 1949 (2006) Abstract
Flavopiridol synergizes TRAIL cytotoxicity by downregulation of FLIPL: T.E. Fandy, et al.; Cancer Chemother. Pharmacol. 60, 313 (2007) Abstract
Successful treatment of animal models of rheumatoid arthritis with small-molecule cyclin-dependent kinase inhibitors: C. Sekine, et al.; J. Immunol. 180, 1954 (2008) Abstract
Further Categories Containing This Product:
Antitumor Agents (Apoptosis Inducers) • MDR Other Products
 
 
ALX-480-100 Revised 27-Mar-08 New product
Fludarabine
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SYNONYMS 2-Fluoroadenine-9-β-D-arabinofuranoside
PRODUCT LINE Cancer
PRODUCT CATEGORY Antitumor Agents (Apoptosis Inducers)
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-480-100-M005   5 mg 45.00 USD Add To Cart
ALX-480-100-M025   25 mg 180.00 USD Add To Cart
Product Specification
FORMULA: C10H12FN5O4
MW: 285.2
CAS NUMBER: 21679-14-1
MERCK INDEX: 14: 4126
RTECS: AU6207000
PURITY: ≥98% (HPLC)
APPEARANCE: White to pale yellow crystalline powder.
SOLUBILITY: Sparingly soluble in water or organic solvents.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
IDENTITY: Determined by IR.

Product Description

Prodrug converted to the free nucleoside 9-β-D-arabinosyl-2-fluoroadenine (F-ara-A). F-ara-A enters cells and accumulates as the 5’-triphosphate. Interferes with DNA synthesis and repair. Induces apoptosis of cancer cells. Inhibits RNA transcription.
Product Specific Literature References
Fludarabine: a new agent with major activity against chronic lymphocytic leukemia: M.J. Keating, et al.; Blood 74, 19 (1989) Abstract; Full Text
Termination of DNA synthesis by 9-beta-D-arabinofuranosyl-2-fluoroadenine. A mechanism for cytotoxicity: P. Huang, et al.; J. Biol. Chem. 265, 16617 (1990) Abstract; Full Text
Action of 9-beta-D-arabinofuranosyl-2-fluoroadenine on RNA metabolism: P. Huang & W. Plunkett; Mol. Pharmacol. 39, 449 (1991)