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ALX-850-327 Revised 31-Jul-08 New product
ADMA Direct (mouse/rat) ELISA Kit
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PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY Nitric Oxide & NOS Detection / Related Products
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ALX-850-327-KI01   1 Kit 1'400.00 USD Add To Cart
Product Specification
SENSITIVITY: 0.05μmol/l
QUANTITY: 96 wells (~80 tests).
APPLICATION: For the quantitative detection of asymmetrical dimethylarginine (ADMA) in mouse or rat EDTA-plasma and serum. Does not cross-react with SDMA, NMMA or L-arginine.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HANDLING: Store standard and controls at -20°C. Store rest of the kit at +4°C.
General Information
Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide (NO) synthesis. NO is one of the major endothelium-derived vasoactive mediators and is involved in the modulation of blood flow and blood pressure. Even small changes of ADMA concentration alter vascular NO production, vascular tone, and systemic vascular resistence. Elevated ADMA concentrations are found in patients with diabetes mellitus, hypercholeste-rolemia, hypertension, pulmonary hypertension, peripheral arterial disease, chronic renal failure, preeclampsia or erectile dysfunction. ADMA is therefore a novel cardiovascular risk factor.
MANUFACTURER Manufactured by Immundiagnostik AG.
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Further Categories Containing This Product:
ELISA & EIA Kits
 
 
ALX-350-163 Revised 15-Sep-08 New product
Agistatine D
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products
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ALX-350-163-M001   1 mg 90.00 USD Add To Cart
ALX-350-163-M005   5 mg 360.00 USD Add To Cart
Product Specification
FORMULA: C11H14O4
MW: 210.2
CAS NUMBER: 144096-47-9
SOURCE/HOST: Isolated from fungus FH-A 6239.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO or acetone.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by 1H-NMR.

Product Description
Analog of agistatine A, which has been described as an inhibitor of cholesterol biosynthesis.
Product Specific Literature References
Secondary Metabolites by Chemical Screening, 29: A. Zeeck, et al.; Liebigs Ann. 1996, 627
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Further Categories Containing This Product:
Cholesterol & Lipid Transport / Related Products
 
 
ALX-350-160 Revised 03-Sep-08 New product
Aloeresin A
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products
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ALX-350-160-M001   1 mg 185.00 USD Add To Cart
Product Specification
FORMULA: C28H28O11
MW: 540.5
CAS NUMBER: 74545-79-2
SOURCE/HOST: Isolated from Aloe sp.
PURITY: ≥97% (HPLC)
APPEARANCE: Brown solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Identity determined by 1H-NMR and MS.

Product Description
Metabolite of aloesin (Prod. No. ALX-350-158).  Inhibits α-glucosidases.
Product Specific Literature References
Metabolism of aloesin and related compounds by human intestinal bacteria: a bacterial cleavage of the C-glucosyl bond and the subsequent reduction of the acetonyl side chain: Q.M. Che, et al.; Chem. Pharm. Bull. (Tokyo) 39, 704 (1991) Abstract
Geographical variation in the major compounds of Aloe ferox leaf exudate: B.E. van Wyk, et al.; Planta Med. 61, 250 (1995) Abstract
High-performance liquid chromatographic profiles of aloe constituents and determination of aloin in beverages, with reference to the EEC regulation for flavouring substances: F. Zonta, et al.; J. Chromatogr. A. 718, 99 (1995) Abstract
Determination of aloesin and aloeresin A for the detection of aloe in beverages: M. Dell’Agli, et al.; J. Agric. Food Chem. 55, 3363 (2007) Abstract
A reversed-phase high-performance liquid chromatographic method for the determination of aloesin, aloeresin A and anthraquinone in Aloe ferox: M. Zahn, et al.; Phytochem. Anal. 19, 122 (2008) Abstract
alpha-Glucosidase inhibitor from Chinese aloes: N. Jong-Anurakkun, et al.; Fitoterapia 79, 456 (2008) Abstract
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Further Categories Containing This Product:
Glycosidases / Related Products
 
 
ALX-350-158 Revised 13-May-08 New product
Aloesin
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SYNONYMS Aloeresin B
NSC 631262
8-β-D-Glucopyranosyl-7-hydroxy-5-methyl-2-(2-oxopropyl)-4H-1-benzopyran-4-one
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Anti-inflammatory Agents
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ALX-350-158-M001   1 mg 110.00 USD Add To Cart
Product Specification
FORMULA: C19H22O9
MW: 394.4
CAS NUMBER: 30861-27-9
SOURCE/HOST: Isolated from Aloe sp.
PURITY: ≥98% (HPLC)
APPEARANCE: Pale yellow to brown powder.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Identity determined by 1H-NMR and MS.

Product Description
C-glycosylated chromone compound. Competitive inhibitor of tyrosinase. Shows weak free radical scavenging activity. Anti-inflammatory. Modulates melanogenesis (pigmentation-altering agent). Used in the cosmetic industry.
Product Specific Literature References
The distribution of aloesin in some South African Aloe species: T.J. McCarthy & L.J. Haynes; Planta Med. 15, 342 (1967) Abstract
Chromones in aloe species. I. Aloesin--a C-glucosyl-7-hydroxychromone: D.K. Holdsworth; Planta Med. 19, 322 (1971) Abstract
Aloesin up-regulates cyclin E/CDK2 kinase activity via inducing the protein levels of cyclin E, CDK2, and CDC25A in SK-HEP-1 cells: K.Y. Lee, et al.; Biochem. Mol. Biol. Int. 41, 285 (1997) Abstract
Modulation of melanogenesis by aloesin: a competitive inhibitor of tyrosinase: K. Jones, et al.; Pigment Cell Res. 15, 335 (2002) Abstract
Antioxidant, free radical scavenging and anti-inflammatory effects of aloesin derivatives in Aloe vera: A. Yagi, et al.; Planta Med. 68, 957 (2002) Abstract
Mushroom tyrosinase inhibition activity of some chromones: L.Z. Piao, et al.; Chem. Pharm. Bull. (Tokyo) 50, 309 (2002) Abstract
Aloesin inhibits hyperpigmentation induced by UV radiation: S. Choi, et al.; Clin. Exp. Dermatol. 27, 513 (2002) Abstract
Determination of aloesin and aloeresin A for the detection of aloe in beverages: M. Dell Agli, et al.; J. Agric. Food Chem. 55, 3363 (2007) Abstract
Aloeresin I, an anti-inflammatory 5-methylchromone from cape aloe: G. Speranza, et al.; Planta Med. 71, 79 (2005) Abstract
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ALX-350-162 Revised 11-Aug-08 New product
Altersolanol A
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SYNONYMS As-A 2
NSC 173943
(1R-(1α,2β,3β,4α))-1,2,3,4-Tetrahydro-1,2,3,4,5-pentahydroxy-7-methoxy-2-methyl-9,10-anthracenedione
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products with Antibiotic Activity
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ALX-350-162-M001   1 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C16H16O8
MW: 336.3
CAS NUMBER: 22268-16-2
SOURCE/HOST: Isolated from Alternaria sp.
PURITY: ≥97% (HPLC)
APPEARANCE: Yellow-orange to brown solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Identity determined by 1H-NMR and MS.

Product Description
Tetrahydroanthraquinone with phytotoxic and antibacterial activity.
Product Specific Literature References
Metabolites of Dactylaria lutea. The structures of dactylariol and the antiprotozoal antibiotic dactylarin: A.M. Becker, et al.; J. Antibiot. (Tokyo) 31, 324 (1978) Abstract
High-performance liquid chromatographic determination of macrosporin, altersolanol A, alterporriol A, B and C in fermentation of Alternaria porri (Ellis) Ciferri: R. Suemitsu, et al.; J. Chromatogr. 454, 406 (1988) Abstract
Mode of phytotoxic action of altersolanols : H. Haraguchi, et al.; Phytochemistry 43, 989 (1996)
Biologically active polyketide metabolites from an undetermined fungicolous hyphomycete resembling Cladosporium: U. Höller, et al.; J. Nat. Prod. 54, 876 (2002) Abstract
Secondary metabolite profiling of Alternaria dauci, A. porri, A. solani, and A. tomatophila: B. Andersen, et al.; Mycol. Res. 112, 241 (2008) Abstract
 
 
ALX-201-431 Revised 06-Aug-08 New product
ANGPTL4 (Intact Form) (human) (recombinant) (His)
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SYNONYMS Angiopoietin-like Protein 4 (Intact Form) (human) (recombinant) (His)
FIAF (Intact Form) (human) (recombinant) (His)
Fasting-induced Adipose Factor (Intact Form) (human) (recombinant) (His)
HFARP (Intact Form) (human) (recombinant) (His)
Hepatic Fibrinogen/Angiopoietin-related Protein (Intact Form) (human) (recombinant) (His)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Angiopoietin-like Proteins [ANGPTLs] / Related Products
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ALX-201-431-C010   10 µg 320.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in CHO cells. The signal peptide and the mature peptide of human ANGPTL4 (aa 1-406) are fused at the C-terminus to a His-tag.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2μm-filtered solution in PBS.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q9BY76: ANGPTL4 (human)
MANUFACTURER Manufactured by AdipoGen, Inc.
General Literature References
Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation: J.C. Yoon, et al.; Mol. Cell Biol. 20, 5342 (2000) Abstract; Full Text
Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene: S. Kersten, et al.; J. Biol. Chem. 275, 28488 (2000) Abstract; Full Text
Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice: A. Xu, et al.; PNAS 102, 6086 (2005) Abstract; Full Text
Genes that mediate breast cancer metastasis to lung: A.J. Minn, et al.; Nature 436, 518 (2005) Abstract; Full Text
Angiopoietin-like-4 is a potential angiogenic mediator in arthritis: L.M. Hermann, et al.; Clin. Immunol. 115, 93 (2005) Abstract
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Recombinant Proteins / Fusion Proteins
 
 
ALX-201-432 Revised 12-Aug-08 New product
ANGPTL4 (Intact Form) (rat) (recombinant) (His)
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SYNONYMS Angiopoietin-like Protein 4 (Intact Form) (rat) (recombinant) (His)
FIAF (Intact Form) (rat) (recombinant) (His)
Fasting-induced Adipose Factor (Intact Form) (rat) (recombinant) (His)
HFARP (Intact Form) (rat) (recombinant) (His)
Hepatic Fibrinogen/Angiopoietin-related Protein (Intact Form) (rat) (recombinant) (His)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Angiopoietin-like Proteins [ANGPTLs] / Related Products
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ALX-201-432-C010   10 µg 300.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in CHO cells. The signal peptide and the mature peptide of rat ANGPTL4 (aa 1-405) are fused at the C-terminus to a His-tag.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2μm-filtered solution in PBS.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
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General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q6TMA8: ANGPTL4 (rat)
MANUFACTURER Manufactured by AdipoGen, Inc.
General Literature References
Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation: J.C. Yoon, et al.; Mol. Cell Biol. 20, 5342 (2000) Abstract; Full Text
Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene: S. Kersten, et al.; J. Biol. Chem. 275, 28488 (2000) Abstract; Full Text
Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice: A. Xu, et al.; PNAS 102, 6086 (2005) Abstract; Full Text
Genes that mediate breast cancer metastasis to lung: A.J. Minn, et al.; Nature 436, 518 (2005) Abstract; Full Text
Angiopoietin-like-4 is a potential angiogenic mediator in arthritis: L.M. Hermann, et al.; Clin. Immunol. 115, 93 (2005) Abstract
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Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-424 Revised 09-Jun-08 New product
ANGPTL4 (Fibrinogen-like Domain) (mouse) (recombinant)
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SYNONYMS Angiopoietin-like Protein 4 (Fibrinogen-like Domain) (mouse) (recombinant)
FIAF (Fibrinogen-like Domain) (mouse) (recombinant)
Fasting-induced Adipose Factor (Fibrinogen-like Domain) (mouse) (recombinant)
HFARP (Fibrinogen-like Domain) (mouse) (recombinant)
Hepatic Fibrinogen/Angiopoietin-related Protein (Fibrinogen-like Domain) (mouse) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Angiopoietin-like Proteins [ANGPTLs] / Related Products
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ALX-201-424-C010   10 µg 250.00 USD Add To Cart
ALX-201-424-C050   50 µg 660.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. Fibrinogen-like domain of mouse ANGPTL4 (angiopoietin-like protein 4) (aa 167-410) is fused at the N-terminus to a FLAG®-tag.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
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General Information
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link Q9Z1P8: Angiopoietin-related protein 4 (mouse) [Precursor]

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
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