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APO-54N-037 Revised 27-May-08 New product
Netrin-4 (human) ELISA Kit
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SYNONYMS β-Netrin (human) ELISA Kit
Hepar-derived Netrin-like Protein (human) ELISA Kit
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Netrins & Receptors/Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
APO-54N-037-KI01   1 Kit 780.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SENSITIVITY: 50pg/ml (range 78 to 5000pg/ml).
QUANTITY: For 96 wells (~80 tests).
APPLICATION: For the direct measurement of human netrin-4 from serum, plasma or cell culture supernatants.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
General Information
The Netrins (whose name means “one who guides” in Sanskrit) constitutes a family of laminin-related secreted protein. In mice, human and rat, Netrin-1, Netrin-3/NTL2, Netrin-4/β and G-Netrins have been cloned [1]. The Netrins are involved in axonal guidance, are required for regeneration and maintenance of the central nervous system and have been implicated in the development of mammary gland, lung, pancreas, and blood vessel [1, 2]. Netrin-4 (also called β-Netrin) is a novel Netrin more closely related to laminin β chain that is broadly expressed in both neural and non-neural tissues [3]. It acts during the development and controls the migration of neurons [4]. The role of Netrin-4 in guiding neurones seems to be mediated by known Netrin-1 receptors : DCC and UNC5H1 [5]. Netrin-4 gene (NTN4) is transcribed in a variety of cells including epithelial cells and vascular endothelial cells [4]. Recent studies suggest a role of Netrin-1 and 4 in the branching morphogenesis in the lung [2]. Netrin-4 promotes angiogenesis by stimulating proliferation and migration of microvascular endothelial cells to the same extent that vascular endothelial growth factor (VEGF) [6]. Kidney also express Netrin-4 whose level is down regulated upon ischemia-reperfusion injury [7]. Netrin-4 has been reported to be a novel prognostic marker in breast cancer [8].
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q9HB63: Netrin-4 (human)
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
[1] Netrins: beyond the brain: V. Cirulli & M. Yebra; Nat. Rev. Mol. Cell Biol. 8, 296 (2007) Abstract
[2] Novel role for Netrins in regulating epithelial behavior during lung branching morphogenesis: Y. Liu, et al.; Curr. Biol. 14, 897 (2004) Abstract
[3] The Netrin family of guidance factors: emphasis on Netrin-1 signalling: M.J. Barallobre, et al.; Brain Res. Brain Res. Rev. 49, 22 (2005) Abstract
[4] A novel member of the netrin family, beta-netrin, shares homology with the beta chain of laminin: identification, expression, and functional characterization: M. Koch, et al.; J. Cell Biol. 151, 221 (2000) Abstract; Full Text
[5] Characterization of the receptors for axon guidance factor netrin-4 and identification of the binding domains: S. Qin, et al.; Mol. Cell. Neurosci. 34, 243 (2007) Abstract
[6] Netrins promote developmental and therapeutic angiogenesis: B.D. Wilson, et al.; Science 313, 640 (2006) Abstract
[7] Part 1: Functional Studies. Netrin-1 protects against ischemia reperfusion injury of the kidney.: W. Wang, et al.; Am. J. Physiol. Renal Physiol. (2008)
[8] Identification of NTN4, TRA1, and STC2 as prognostic markers in breast cancer in a screen for signal sequence encoding proteins: S. Esseghir, et al.; Clin. Cancer Res. 13, 3164 (2007) Abstract
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Further Categories Containing This Product:
ELISA & EIA Kits
 
 
ALX-201-429 Revised 05-Aug-08 New product
NMNAT1 (human) (recombinant) (His)
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SYNONYMS NMN Adenylyltransferase 1 (human) (recombinant) (His)
Nicotinamide Mononucleotide Adenylyltransferase 1 (human) (recombinant) (His)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY NAD+ Metabolism/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-429-C010   10 µg 140.00 USD Add To Cart
ALX-201-429-C050   50 µg 280.00 USD Add To Cart
Product Specification
EC: 2.7.7.1
SOURCE/HOST: Produced in E. coli. The mature peptide of human NMNAT1 (aa 2-279) is fused at the N-terminus to a His-tag.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2μm-filtered solution in 55mM TRIS, pH 8.2, containing 150mM sodium chloride.
ENDOTOXIN CONTENT: <1EU/μg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 3 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles.
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q9HAN9: NMNAT1 (human)
MANUFACTURER Manufactured by AdipoGen, Inc.
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Further Categories Containing This Product:
Enzymes • Recombinant Proteins/Fusion Proteins
 
 
ALX-380-295 Revised 15-Apr-08 New product
Norfloxacin
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SYNONYMS 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-295-G001   1 g 20.00 USD Add To Cart
ALX-380-295-G005   5 g 50.00 USD Add To Cart
Product Specification
FORMULA: C16H18FN3O3
MW: 319.3
CAS NUMBER: 70458-96-7
MERCK INDEX: 14: 6700
RTECS: VB2005000
PURITY: ≥98% (Assay)
APPEARANCE: White to yellow crystalline solid.
SOLUBILITY: Slightly soluble in water, 100% ethanol or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Fluoroquinolone antibacterial agent. Inhibits bacterial DNA replication. Blocks DNA replication by interfering with an ATP-induced structural transition of DNA complexed with DNA gyrase (topoisomerase). Effective against Gram-negative bacteria; less effective against Gram-positive bacteria. Potentially anxiogenic.
Product Specific Literature References
Structure-activity relationships of antibacterial 6,7- and 7,8-disubstituted 1-alkyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acids: H. Koga, et al.; J. Med. Chem. 23, 1358 (1980) Abstract
Comparative activities of AM-715 and pipemidic and nalidixic acids against experimentally induced systemic and urinary tract infections: K. Hirai, et al.; Antimicrob. Agents Chemother. 19, 188 (1981) Abstract; Full Text
In vitro activity of MK-0366 against clinical urinary pathogens including gentamicin-resistant Pseudomonas aeruginosa: J. Downs, et al.; Antimicrob. Agents Chemother. 21, 670 (1982) Abstract
Comparison of the antibacterial activity of norfloxacin (MK 0366, AM 715), a new organic acid, with that of other orally absorbed chemotherapeutic agents: H.H. Gadebusch, et al.; Infection 10, 41 (1982) Abstract
Treatment of penicillin-resistant Neisseria gonorrhoeae with oral norfloxacin: S.R. Crider, et al.; N. Engl. J. Med. 311, 137 (1984) Abstract
Norfloxacin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use: B. Holmes, et al.; Drugs 30, 482 (1985) Abstract
Norfloxacin: clinical pharmacology and clinical use: R.C. Rowen, et al.; Pharmacotherapy 7, 92 (1987) Abstract
Pharmacokinetic-pharmacodynamic modeling of the electroencephalogram effect of norfloxacin in rats: M. Chenel, et al.; Antimicrob. Agents Chemother. 47, 1952 (2003) Abstract; Full Text
Norfloxacin-induced DNA gyrase cleavage complexes block Escherichia coli replication forks, causing double-stranded breaks in vivo: J.R. Pohlhaus & K.N. Kreuzer; Mol. Microbiol. 56, 1416 (2005) Abstract; Full Text
Anxiogenic potential of ciprofloxacin and norfloxacin in rats: S. Sen, et al.; Singapore Med. J. 48, 1028 (2007) Abstract; Full Text
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Further Categories Containing This Product:
Antibiotics - Topoisomerase Inhibitors • Antibiotics - DNA Replication Inhibitors
 
 
ALX-380-296 Revised 15-Apr-08 New product
Norfloxacin nicotinate
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SYNONYMS 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid nicotinate
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-296-G001   1 g 20.00 USD Add To Cart
ALX-380-296-G005   5 g 50.00 USD Add To Cart
Product Specification
FORMULA: C16H18FN3O3 . C6H5NO2
MW: 319.3 . 123.1
CAS NUMBER: 11803-81-9
PURITY: ≥98% (Assay)
APPEARANCE: White to yellow crystalline solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Fluoroquinolone antibacterial agent. Derivative of norfloxacin (Prod. No. ALX-380-296) with dramatically improved water solubility. Instantly dissociates into norfloxacin and nicotinic acid in the body therefore acting as norfloxacin. Inhibits bacterial DNA replication by interfering with an ATP-induced structural transition of DNA complexed with DNA gyrase (topoisomerase). Effective against Gram-negative bacteria; less effective against Gram-positive bacteria.
Product Specific Literature References
Efficacy of norfloxacin nicotinate treatment of broiler breeders against Haemophilus paragallinarum: A. Lublin, et al.; Avian Dis. 37, 673 (1993) Abstract
Norfloxacin nicotinate in the treatment of Pseudomonas aeruginosa infection in the genital tract of a bull: S. Marcus, et al.; Vet. Res. Commun. 18, 331 (1994) Abstract
Tissue distribution and binding to plasma proteins of norfloxacin nicotinate after intramuscular administration in pigs: M. Shem-Tov, et al.; Zentralbl. Veterinarmed. B. 41, 257 (1994) Abstract
Clinical pharmacokinetic characterization of norfloxacin nicotinate in swine following systemic administration: M. Shem-Tov & G. Ziv; Zentralbl. Veterinarmed. B. 41, 60 (1994) Abstract
Effect of lactation on single-dose pharmacokinetics of norfloxacin nicotinate in ewes: S. Soback, et al.; Antimicrob. Agents Chemother. 38, 2336 (1994) Abstract; Full Text
Intravenous disposition kinetics, oral and intramuscular bioavailability and urinary excretion of norfloxacin nicotinate in donkeys: E. Lavy, et al.; J. Vet. Pharmacol. Ther. 18, 101 (1995) Abstract
Norfloxacin nicotinate pharmacokinetics in unweaned and weaned calves: M. Gips & S. Soback; J. Vet. Pharmacol. Ther. 19, 130 (1996) Abstract
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Further Categories Containing This Product:
Antibiotics - Topoisomerase Inhibitors • Antibiotics - DNA Replication Inhibitors
 
 
ALX-270-467 Revised 25-Jun-08 New product
nor-NOHA . diacetate
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SYNONYMS Nω-Hydroxy-nor-L-arginine . diacetate
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY Arginine & Arginases/Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-467-M001   1 mg 35.00 USD Add To Cart
ALX-270-467-M005   5 mg 90.00 USD Add To Cart
ALX-270-467-M025   25 mg 360.00 USD Add To Cart
Product Specification
FORMULA: C5H12N4O3 . 2CH3COOH
MW: 176.2 . 120.1
CAS NUMBER: 189302-40-7
PURITY: ≥97% (TLC)
APPEARANCE: White to slightly yellowish powder.
SOLUBILITY: Soluble in water (50mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Very hygroscopic.

Product Description
Potent and reversible arginase inhibitor. Specifically interacts with the manganese-cluster of the arginase active site. Does not act as a substrate or as an inhibitor of NOS.
Product Specific Literature References
The new alpha-amino acid Nomega-hydroxy-nor-L-arginine: a high-affinity inhibitor of arginase well adapted to bind to its manganese cluster: J. Custot, et al.; JACS 119, 4086 (1997)
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ALX-380-297 Revised 07-Aug-08 New product
Ofloxacin
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SYNONYMS 9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazin-6-carboxylic acid
DL 8280
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ALX-380-297-G005   5 g 45.00 USD Add To Cart
Product Specification
FORMULA: C18H20FN3O4
MW: 361.4
CAS NUMBER: 82419-36-1
MERCK INDEX: 14: 6771
RTECS: UU8815500
PURITY: ≥98% (Assay)
APPEARANCE: White to yellow crystalline solid.
SOLUBILITY: Slightly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Fluoroquinolone with broad-spectrum antibacterial activity against most Gram-negative and Gram-positive bacteria. Effective against Mycobacterium tuberculosis.
Product Specific Literature References
In vitro and in vivo activity of DL-8280, a new oxazine derivative: K. Sato, et al.; Antimicrob. Agents Chemother. 22, 548 (1982) Abstract; Full Text
Comparison of the antibacterial in vitro and in vivo activity of ofloxacin (HOE 280 DL 8280) and nalidixic acid analogues: G. Seibert, et al.; Eur. J. Clin. Microbiol. 2, 548 (1983) Abstract
A new synthesis of 7H-pyrido[1,2,3-de][1,4]benzoxazine derivatives including an antibacterial agent, ofloxacin: H. Egawa, et al.; Chem. Pharm. Bull. 34, 4098 (1986) Abstract
Synthesis and antibacterial activities of optically active ofloxacin and its fluoromethyl derivative: S. Atarashi, et al.; Chem. Pharm. Bull. 35, 1896 (1987) Abstract
Ofloxacin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use: J.P. Monk & D.M. Campoli-Richards; Drugs 33, 346 (1987) Abstract
Mechanism of differential activities of ofloxacin enantiomers: I. Morrissey, et al.; Antimicrob. Agents Chemother. 40, 1775 (1996) Abstract; Full Text
Mechanism of fluoroquinolone action: K. Drlica; Curr. Opin. Microbiol. 2, 504 (1999) Abstract
Ofloxacin-like antibiotics inhibit pneumococcal cell wall-degrading virulence factors: C. Fernandez-Tornero, et al.; J. Biol. Chem. 280, 19948 (2005) Abstract; Full Text
Emergence of ofloxacin resistance in Mycobacterium tuberculosis clinical isolates from China as determined by gyrA mutation analysis using denaturing high-pressure liquid chromatography and DNA sequencing: R. Shi, et al.; J. Clin. Microbiol. 44, 4566 (2006) Abstract; Full Text
Moxifloxacin, ofloxacin, sparfloxacin, and ciprofloxacin against Mycobacterium tuberculosis: evaluation of in vitro and pharmacodynamic indices that best predict in vivo efficacy: R.K. Shandil, et al.; Antimicrob. Agents Chemother. 51, 576 (2007) Abstract; Full Text
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Further Categories Containing This Product:
Antibiotics - Topoisomerase Inhibitors • Antibiotics - DNA Replication Inhibitors
 
 
APO-54N-034 Revised 16-Jul-08 New product
Omentin 1 (human) ELISA Kit
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SYNONYMS Intelectin-1 (human) ELISA Kit
Intestinal Lactoferrin Receptor (human) ELISA Kit
Galactofuranose-binding Lectin (human) ELISA Kit
Endothelial Lectin HL-1 (human) ELISA Kit
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Omentin/Related Products
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APO-54N-034-KI01   1 Kit 780.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SENSITIVITY: 0.4ng/ml (range 0.5 to 32ng/ml).
QUANTITY: For 96 wells (~80 tests).
APPLICATION: For the quantitative determination of human omentin 1 (intelectin-1) from biological fluids (serum, plasma and cell culture supernatant).
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Omentin-1, a novel adipokine, is decreased in overweight insulin-resistant women with polycystic ovary syndrome: ex vivo and in vivo regulation of omentin-1 by insulin and glucose: B.K. Tan, et al.; Diabetes 57, 801 (2008) Abstract
General Information

Obesity is strongly associated to the insulin resistance syndrome, which includes type 2 diabetes mellitus, and to an increased risk of atherosclerotic cardiovascular disease [1]. Several studies have reported that visceral obesity (fat located within omental and mesenteric fat depots) is more closely associated with insulin resitance, type 2 diabetes and cardiovascular disease than is peripheral obesity (subcutaneous) [2]. However, the underlying mechanism is still unclear. Recently, a new protein Omentin 1 (also named Omentin, Intelectin-1, Endothelial Lectin HL-1 and Intestinal Lactoferrin Receptor) has been identified as a major visceral (omental) fat secretory adipokine [3]. Omentin 1 is a secreted protein of ~38kDa containing a fibrinogen-related domain that is highly expressed in the omental fat, and much less in intestine, lung and heart. Addition of recombinant Omentin 1 in vitro does not affect basal, but enhances insulin-stimulated glucose uptake in subcutaneous as well as in omental human adipocytes. Omentin 1 triggers AKT signalling in the absence of insulin [3]. Omentin 1 plasma levels measured by western blotting are decreased in obesity [4]. Omentin 1 is decreased in patients with polycystic ovary syndrome (PCOS), a disease associated with insulin resistance and obesity [5]. Glucose and Insulin negatively regulate Omentin-1 levels ex vivo and in vivo [5].

BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q8WWA0: Intelectin-1 (human) [Precursor]
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
[1] Obesity wars: molecular progress confronts an expanding epidemic: J.S. Flier; Cell 116, 337 (2004) Abstract
[2] Abdominal obesity and metabolic syndrome: J.P. Després & I. Lemieux; Nature 444, 881 (2006) Abstract
[3] Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action: R.Z. Yang, et al.; Am. J. Physiol. Endocrinol. Metab. 290, E1253 (2006) Abstract
[4] Omentin plasma levels and gene expression are decreased in obesity: C.M. de Souza Batista, et al.; Diabetes 56, 1655 (2007) Abstract
[5] Omentin-1, a novel adipokine, is decreased in overweight insulin-resistant women with polycystic ovary syndrome: ex vivo and in vivo regulation of omentin-1 by insulin and glucose: B.K. Tan, et al.; Diabetes 57, 801 (2008) Abstract
Omentin-1, a novel adipokine, is decreased in overweight insulin resistant women with the polycystic ovary syndrome: ex vivo and in vivo regulation of omentin-1 by insulin and glucose: B.K. Tan, et al.; Diabetes 57, 801 (2008) Abstract
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PI(3)K-Akt-mTOR Pathway Other Products • ELISA & EIA Kits
 
 
ALX-380-298 Revised 15-Apr-08 New product
Pefloxacin . mesylate . dihydrate
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SYNONYMS 1-Ethyl-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid . monomethanesulfonate . dihydrate
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-298-G005   5 g 30.00 USD Add To Cart
Product Specification
FORMULA: C17H20FN3O3 . CH4O3S . 2H2O
MW: 333.4 . 96.1 . 36.0
CAS NUMBER: 149676-40-4
MERCK INDEX: 14: 7066
RTECS: VB2002200
PURITY: ≥98%
APPEARANCE: White to yellow crystalline solid.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: HARMFUL.

Product Description
Fluoroquinolone antibacterial agent. Analog of norfloxacin (Prod. No. ALX-380-295). Prevents bacterial DNA replication by inhibiting DNA gyrase (topoisomerse). Highly effective against Staphylococcus aureus, E. coli, other enterobacteria and Pseudomonas aeruginosa. Excellent effcectivity against Gram-negative bacteria, also effective against Gram-positive bacteria.
Product Specific Literature References
Absorption, distribution, metabolic fate, and elimination of pefloxacin mesylate in mice, rats, dogs, monkeys, and humans: G. Montay, et al.; Antimicrob. Agents Chemother. 25, 463 (1984) Abstract; Full Text
Activity of pefloxacin and thirteen other antimicrobial agents in vitro against isolates from hospital and genitourinary infections: B.M. Jones, et al.; J. Antimicrob. Chemother. 17, 739 (1986) Abstract
In vitro activity of pefloxacin against gram-negative and gram-positive bacteria in comparison with other antibiotics: E. Debbia, et al.; Chemioterapia 6, 319 (1987) Abstract
Studies on prodrugs. 7. Synthesis and antimicrobial activity of 3-formylquinolone derivatives: H. Kondo, et al.; J. Med. Chem. 31, 221 (1988) Abstract
In vitro effects of ciprofloxacin and pefloxacin on growth of normal human hematopoietic progenitor cells and on leukemic cell lines: E. Somekh, et al.; J. Pharmacol. Exp. Ther. 248, 415 (1989) Abstract
Binding interactions of pefloxacin mesylate with bovine lactoferrin and human serum albumin: J.C. Fan, et al.; J. Zhejiang Univ. Sci. B. 7, 452 (2006) Abstract; Full Text
Spectrophotometric determination of pefloxacin mesylate in pharmaceuticals: K. Basavaiah, et al.; Acta Pharm. 57, 221 (2007) Abstract
Further Categories Containing This Product:
Antibiotics - Topoisomerase Inhibitors • Antibiotics - DNA Replication Inhibitors