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ALX-215-061 Revised 31-Jul-08 New product
Polyclonal Antibody to SorLA (F3)
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SYNONYMS anti-LR11 PAb (F3)
anti-SorL1 PAb (F3)
anti-Sorting Protein-related Receptor Containing LDLR Class A Repeats PAb (F3)
anti-Low-density Lipoprotein Receptor Relative with 11 Ligand-binding Repeats PAb (F3)
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Neuropeptides & Receptors Other Products
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ALX-215-061-1   1 Vial 250.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST: From rabbit.
FORMULATION: Lyophilized.
RECONSTITUTION: Reconstitute with 50μl distilled water.
IMMUNOGEN: Recombinant mouse SorLA (aa 1384-1676 representing the first 4.5 extracellular fibronectin type III domain).
SPECIFICITY: Recognizes human, mouse and rat SorLA.
APPLICATION: Immunocytochemistry (1:1’000)
Western Blot (1:3’000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Description
Recognizes transmembrane SorLA and also the shed ectodomain.
Product Specific Literature References
Ectodomain shedding, translocation and synthesis of SorLA are stimulated by its ligand head activator: W. Hampe, et al.; J. Cell Sci. 113, 4475 (2000) Abstract; Full Text
Characterization of the VPS10 domain of SorLA/LR11 as binding site for the neuropeptide HA: J. Lintzel, et al.; Biol. Chem. 383, 1727 (2002) Abstract
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Further Categories Containing This Product:
Polyclonal Antibodies • Cholesterol & Lipid Transport/Related Products
 
 
ALX-215-060 Revised 31-Jul-08 New product
Polyclonal Antibody to SorLA (IC)
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SYNONYMS anti-LR11 PAb (IC)
anti-SorL1 PAb (IC)
anti-Sorting Protein-related Receptor Containing LDLR Class A Repeats PAb (IC)
anti-Low-density Lipoprotein Receptor Relative with 11 Ligand-binding Repeats PAb (IC)
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Neuropeptides & Receptors Other Products
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ALX-215-060-1   1 Vial 250.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST: From rabbit.
FORMULATION: Lyophilized.
RECONSTITUTION: Reconstitute with 50μl distilled water.
IMMUNOGEN: Synthetic peptide corresponding to the 18 C-terminal aa from the intracellular tail (IC) of mouse SorLA with an added N-terminal cysteine.
SPECIFICITY: Recognizes human, mouse and rat SorLA.
APPLICATION: Immunocytochemistry (1:3’000)
Western Blot (1:3’000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
BLOCKING PEPTIDE: Blocking Peptide for PAb to SorLA Prod. No. ALX-167-028
Product Description
Recognizes transmembrane SorLA, the membrane stub after ectodomain shedding and also the soluble cytoplasmic domain.
Product Specific Literature References
Ectodomain shedding, translocation and synthesis of SorLA are stimulated by its ligand head activator: W. Hampe, et al.; J. Cell Sci. 113, 4475 (2000) Abstract; Full Text
Characterization of the VPS10 domain of SorLA/LR11 as binding site for the neuropeptide HA: J. Lintzel, et al.; Biol. Chem. 383, 1727 (2002) Abstract
SorLA signaling by regulated intramembrane proteolysis: C. Böhm, et al.; J. Biol. Chem. 281, 14547 (2006) Abstract; Full Text
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease: E. Rogaeva, et al.; Nat. Genet. 39, 168 (2007) Abstract
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Further Categories Containing This Product:
Polyclonal Antibodies • Cholesterol & Lipid Transport/Related Products
 
 
ALX-210-956 Revised 23-Jul-08 New product
Polyclonal Antibody to Viperin (AT131)
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SYNONYMS anti-Virus Inhibitory Protein, Endoplasmic Reticulum-associated, Interferon-inducible PAb (AT131)
anti-RSAD2 PAb (AT131)
anti-Radical S-adenosyl Methionine Domain-containing Protein 2 PAb (AT131)
anti-Cig5 PAb (AT131)
anti-Cytomegalovirus-induced Gene 5 Protein PAb (AT131)
PRODUCT LINE Viral Signalling
PRODUCT CATEGORY Antiviral Agents Other Products
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ALX-210-956-C100   100 µg 350.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
PURITY: Epitope-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa near the C-terminus of human viperin.
SPECIFICITY: Recognizes human and mouse viperin.
APPLICATION: Immunoprecipitation (1:200)
Western blot (1:1’000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
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General Information

Viperin has been identified as a human cytomegalovirus and IFN-γ inducible protein. Its expression is activated by both TLR3-dependent and RIG-I-dependent pathways. Viperin inhibits influenza A virus release of infected cells by altering plasma membrane fluidity and the formation of lipid rafts. It acts on the lipid rafts by decreasing the activity of the enzyme farnesyl diphosphate synthase (FPPS) which is essential for isoprenoid biosynthesis.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q8WXG1: Viperin (human)
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Viperin (cig5), an IFN-inducible antiviral protein directly induced by human cytomegalovirus: K.C. Chin & P. Cresswell; PNAS 99, 2460 (2002) Abstract; Full Text
TLR3 ligation activates an antiviral response in human fetal astrocytes: a role for viperin/cig5: M.A. Rivieccio, et al.; J. Immunol. 177, 4735 (2006) Abstract; Full Text
Further Categories Containing This Product:
Interferons Other Products • Influenza Viruses/Related Products • Polyclonal Antibodies
 
 
ALX-210-959 Revised 28-Apr-08 New product
Polyclonal Antibody to ZBP1 (human) (AT133)
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SYNONYMS anti-Z-DNA-binding Protein 1 (human) PAb (AT133)
anti-Tumor Stroma And Activated Macrophage Protein DLM-1 (human) PAb (AT133)
anti-DAI (human) PAb (AT133)
anti-DNA-dependent Activator of IFN-regulatory Factors (human) PAb (AT133)
PRODUCT LINE Immunology
PRODUCT CATEGORY Innate Immunity Other Products
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ALX-210-959-C100   100 µg 350.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
PURITY DETAIL: Protein A-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human ZBP1 (aa1-429)
SPECIFICITY: Recognizes human ZBP1.
APPLICATION: Immunoprecipitation (1:200)
Western blot (1:1’000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
General Information

ZBP1  is a cytoplasmic recognition receptor that senses and is activated by DNA from several sources. Upon activation, ZBP1 triggers a type I IFN response through the activation of IRF3 and, probably, IRF7.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response: A. Takaoka, et al.; Nature 448, 501 (2007) Abstract
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Further Categories Containing This Product:
Interferons & Interferon Receptors Other Products • Polyclonal Antibodies • DNA Regulation/Transcription Other Products
 
 
ALX-210-961 Revised 05-Aug-08 New product
Polyclonal Antibody to AROS (human) (AT135)
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SYNONYMS anti-Active Regulator of SIRT1 (human) PAb (AT135)
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Sirtuins/Related Products
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ALX-210-961-C100   100 µg 350.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
PURITY DETAIL: Protein A-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human AROS (aa 2-136)
SPECIFICITY: Recognizes human AROS.
APPLICATION: Western blot (1:1’000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
General Information
SIRT1 is a member of the silent information regulator 2 (Sir2) family. It is an NAD+-dependent deacetylase protein that functions in cell death / survival, senescence, and endocrine signaling. It is also involved in the increase of life span following caloric restriction [1]. Recently, the first direct activator of SIRT1 has been described: AROS (active regulator of SIRT1) [2]. This nuclear protein of 142 amino acids interacts with SIRT1 and enhances SIRT1-mediated deacetylation of p53.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
[1] Sirtuins: Sir2-related NAD-dependent protein deacetylases: B.J. North & E. Verdin; Genome Biol. 5, 224 (2004) Abstract; Full Text
[2] Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity: E.J. Kim, et al.; Mol. Cell 28, 277 (2007) Abstract
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Further Categories Containing This Product:
NAD+ Metabolism/Related Products • Polyclonal Antibodies • p53 Other Products
 
 
ALX-210-960 Revised 05-Aug-08 New product
Polyclonal Antibody to CDNF (mouse) (AT134)
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SYNONYMS anti-Conserved Dopamine Neurotrophic Factor (mouse) PAb (AT134)
anti-ARMEL (mouse) PAb (AT134)
anti-ARMET-like Protein 1 Precursor (mouse) PAb (AT134)
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Dopaminergics & Dopamine Receptors/Related Products
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ALX-210-960-C100   100 µg 370.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
PURITY DETAIL: Protein A-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant mouse CDNF (aa 27-187)
SPECIFICITY: Recognizes mouse CDNF.
APPLICATION: Western blot (1:1’000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
General Information
MANUFACTURER Manufactured by Apotech Corporation.
Related Products
Further Categories Containing This Product:
Polyclonal Antibodies • Parkinson's Disease Other Products
 
 
ALX-210-957 Revised 23-Apr-08 New product
Polyclonal Antibody to ZBP1 (mouse) (AT132)
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SYNONYMS anti-Z-DNA-binding Protein 1 (mouse) PAb (AT132)
anti-Tumor Stroma And Activated Macrophage Protein DLM-1 (mouse) PAb (AT132)
anti-DAI (mouse) PAb (AT132)
anti-DNA-dependent Activator of IFN-regulatory Factors (mouse) PAb (AT132)
PRODUCT LINE Immunology
PRODUCT CATEGORY Innate Immunity Other Products
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ALX-210-957-C100   100 µg 350.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
PURITY: Protein A-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant mouse ZBP1 (aa 1-411) fused to a N-terminal tag.
SPECIFICITY: Recognizes mouse ZBP1.
APPLICATION: Immunoprecipitation (1:200)
Western blot (1:1’000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
General Information

ZBP1  is a cytoplasmic recognition receptor that senses and is activated by DNA from several sources. Upon activation, ZBP1 triggers a type I IFN response through the activation of IRF3 and, probably, IRF7.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response: A. Takaoka, et al.; Nature 448, 501 (2007) Abstract
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Further Categories Containing This Product:
Interferons & Interferon Receptors Other Products • Polyclonal Antibodies • DNA Regulation/Transcription Other Products
 
 
ALX-380-127 Revised 30-Jun-08 New product
Polyketomycin
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SYNONYMS Antibiotic K99-5147
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
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ALX-380-127-M001   1 mg 100.00 USD Add To Cart
Product Specification
FORMULA: C44H48O18
MW: 864.9
CAS NUMBER: 200625-47-4
SOURCE/HOST: Isolated from Streptomyces sp.
PURITY: ≥98% (HPLC)
APPEARANCE: Orange to dark brown solid.
SOLUBILITY: Soluble in DMSO, methanol or acetone.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by 1H-NMR.

Product Description

Tetracyclic quinone glycoside. Displays antibacterial, antimalarial and antitumor activity.
Product Specific Literature References
Polyketomycin, a new antibiotic from Streptomyces sp. MK277-AF1. I. Taxonomy, production, isolation, physico-chemical properties and biological activities: I. Momose, et al.; J. Antibiot. 51, 21 (1998) Abstract
Polyketomycin, a new antibiotic from Streptomyces sp. MK277-AF1. II. Structure determination: I. Momose, et al.; J. Antibiot. 51, 26 (1998) Abstract
Biosynthesis of polyketomycin produced by Streptomyces diastatochromogenes Tü 6028: T. Paululat, et al.; J. Antibiot. 52, 96 (1999) Abstract
In vitro antimalarial activities of the microbial metabolites: K. Otoguro, et al.; J. Antibiot. 56, 322 (2003) Abstract
Synthesis of the polyketomycin disaccharide: D.S. Micalizzi, et al.; Tetrahedron: Asymmetry 14, 3183 (2003)
Further Categories Containing This Product:
Antibiotics - Antimalarial • Antitumor Antibiotics
 
 
ALX-380-299 Revised 29-Jul-08 New product
Prulifloxacin
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SYNONYMS 6-Fluoro-1-methyl-7-[4-[(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl]-1-piperazinyl]-4-oxo-1H,4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid
NM441
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ALX-380-299-M250   250 mg 90.00 USD Add To Cart
ALX-380-299-G001   1 g 270.00 USD Add To Cart
Product Specification
FORMULA: C21H20FN3O6S
MW: 461.5
CAS NUMBER: 123447-62-1
MERCK INDEX: 14: 7908
PURITY: ≥98% (Assay)
APPEARANCE: White to yellow crystalline solid.
SOLUBILITY: Slightly soluble in dimethyl formamide, 0.1M NaOH or glacial acetic acid; insoluble in water or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Fluoroquinolone with broad spectrum antibacterial activity against Gram-positive and Gram-negative bacteria.
Product Specific Literature References
In vivo evaluation of NM441, a new thiazeto-quinoline derivative: M. Ozaki, et al.; Antimicrob. Agents Chemother. 35, 2496 (1991) Abstract; Full Text
Studies on pyridonecarboxylic acids. 1. Synthesis and antibacterial evaluation of 7-substituted-6-halo-4-oxo-4H-[1,3]thiazeto[3,2-a]quinoline-3- carboxylic acids: J. Segawa, et al.; J. Med. Chem. 35, 4727 (1992) Abstract
Pharmacokinetics and safety of NM441, a new quinolone, in healthy male volunteers: M. Nakashima, et al.; J. Clin. Pharmacol. 34, 930 (1994) Abstract
Randomized, double-blind study of prulifloxacin versus ciprofloxacin in patients with acute exacerbations of chronic bronchitis: C. Grassi, et al.; Respiration 69, 217 (2002) Abstract; Full Text
Pharmacologic characteristics of prulifloxacin: M.G. Matera; Pulm. Pharmacol. Ther. 19, 20 (2006) Abstract
Prulifloxacin: a new fluoroquinolone for the treatment of acute exacerbation of chronic bronchitis: M. Cazzola, et al.; Pulm. Pharmacol. Ther. 19, 30 (2006) Abstract
Prulifloxacin: a new antibacterial fluoroquinolone: G. Prats, et al.; Expert. Rev. Anti. Infect. Ther. 4, 27 (2006), (Review) Abstract
Further Categories Containing This Product:
Antibiotics - Topoisomerase Inhibitors • Antibiotics - DNA Replication Inhibitors
 
 
ALX-430-158 Revised 03-Apr-08 New product
PTC124