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ALX-201-287 Revised 19-May-08 New product
ART2.1 (rat) (recombinant) (His)
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SYNONYMS ecto-ADP-ribosyltransferase 1 (rat) (recombinant) (His)
ART2a (rat) (recombinant) (His)
RT6.1 (rat) (recombinant) (His)
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Mono(ADP-ribosyl)transferases/Related Products
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ALX-201-287-C010   10 µg 270.00 USD Add To Cart
Product Specification
EC: 2.4.2.31
SOURCE/HOST: Produced in E. coli. Rat ART2.1 is fused at the C-terminus to a His-tag.
CONCENTRATION: 0.5mg/ml
PURITY: ≥98%
FORMULATION: Liquid. In PBS containing 50% glycerol.
SHIPPING: SHIPPED ON DRY ICE
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles.
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P17982: ART2a (rat)
General Literature References
Regulatory role of arginine 204 in the catalytic activity of rat alloantigens ART2a and ART2b: L.A. Stevens, et al.; J. Biol. Chem. 278, 19591 (2003) Abstract; Full Text
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Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
 
 
ALX-201-288 Revised 05-Aug-08 New product
ART2.2 (rat) (recombinant) (His)
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SYNONYMS ecto-ADP-ribosyltransferase 2 (rat) (recombinant) (His)
ART2b (rat) (recombinant) (His)
RT6.2 (rat) (recombinant) (His)
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Mono(ADP-ribosyl)transferases/Related Products
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ALX-201-288-C010   10 µg 270.00 USD Add To Cart
Product Specification
EC: 2.4.2.31
SOURCE/HOST: Produced in E. coli. Rat ART2.2 is fused at the C-terminus to a His-tag.
CONCENTRATION: 0.1mg/ml
PURITY: ≥98%
PURITY DETAIL: Affinity purified
FORMULATION: Liquid. In PBS containing 50% glycerol.
APPLICATION: Functional Application (1:10-1:100): Hydrolysation of NAD, auto-ADP ribosylation
SHIPPING: SHIPPED ON DRY ICE
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Substrate binding and catalysis of ecto-ADP-ribosyltransferase 2.2 from rat: H. Ritter, et al.; Biochemistry 42, 10155 (2003) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P20974: ART2b (rat)
General Literature References
Structure of the ecto-ADP-ribosyl transferase ART2.2 from rat: C. Mueller-Dieckmann, et al.; J. Mol. Biol. 322, 687 (2002) Abstract
Expression, purification, crystallization and preliminary X-ray analysis of rat ecto-ADP-ribosyltransferase 2 (ART2.2): C. Mueller-Dieckmann, et al.; Acta Crystallogr. D. Biol. Crystallogr. 58, 1211 (2002) Abstract
Regulatory role of arginine 204 in the catalytic activity of rat alloantigens ART2a and ART2b: L.A. Stevens, et al.; J. Biol. Chem. 278, 19591 (2003) Abstract; Full Text
Functional aspects of protein mono-ADP-ribosylation: D. Corda & M. Di Girolamo; EMBO J. 22, 1953 (2003) Abstract; Full Text
ART2, a T cell surface mono-ADP-ribosyltransferase, generates extracellular poly(ADP-ribose): A.R. Morrison, et al.; J. Biol. Chem. 281, 33363 (2006) Abstract; Full Text
Mammalian ADP-ribosyltransferases and ADP-ribosylhydrolases: F. Koch-Nolte, et al.; Front. Biosc. 13, 6716 (2008) Abstract
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Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
 
 
ALX-380-126 Revised 17-Jul-08 New product
Asperloxine A
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
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ALX-380-126-M001   1 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C21H19N3O5
MW: 393.4
SOURCE/HOST: Isolated from Aspergillus ochraceus.
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO, methanol or acetone.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Identity determined by 1H-NMR.

Product Description

Natural benzodiazepine. Anti-inflammatory.
Product Specific Literature References
Big effects from small changes: possible ways to explore nature’s chemical diversity: H.B. Bode, et al.; Chembiochem. 3, 619 (2002) Abstract
Further Categories Containing This Product:
Benzodiazepines/Related Products • Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
 
 
ALX-270-485 Revised 07-Apr-08 New product
B2
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SYNONYMS CPNQ
5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Sirtuins/Related Products
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ALX-270-485-MC05   0.5 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C20H17ClN4O3
MW: 396.8
CAS NUMBER: 115687-05-3
PURITY: ≥95%
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO (>5mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light and oxygen.
HAZARD: TOXIC.
IDENTITY: Identity determined by 1H-NMR.

Product Description
Cell permeable inhibitor of sirtuin 2 (SIRT2) (IC50=35μM). Promotes inclusion formation in cellular models of both Huntington’s disease and Parkinson’s disease. Prevents huntingtin-mediated proteasome dysfunction and reduces α-synuclein-mediated toxicity.
Product Specific Literature References
Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington’s and Parkinson’s diseases: R.A. Bodner, et al.; PNAS 103, 4246 (2006) Abstract; Full Text
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Further Categories Containing This Product:
Parkinson's Disease Other Products
 
 
ALX-167-028 Revised 28-Jul-08 New product
Blocking Peptide for PAb to SorLA (IC) (Prod. No. ALX-215-060)
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PRODUCT LINE Immunology
PRODUCT CATEGORY Blocking Peptides
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ALX-167-028-C050   50 µg 150.00 USD Add To Cart
Product Specification
SEQUENCE: CE2198DAPMITGFSDDVPMVIA2215
MW: 2010.3
CONCENTRATION: 0.2mg/ml
PURITY: ≥95%
FORMULATION: Liquid. In TBS containing 0.1% BSA and 0.02% sodium azide.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Description
Synthetic peptide corresponding to the 18 C-terminal amino acids of mouse SorLA with an added N-terminal cysteine.
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ALX-270-487 Revised 22-Jul-08 New product
BML-259
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SYNONYMS N-(5-Isopropylthiazol-2-yl)phenylacetamide
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY CDK & Cyclin Inhibitors
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ALX-270-487-M005   5 mg 70.00 USD Add To Cart
Product Specification
FORMULA: C14H16N2OS
MW: 260.4
CAS NUMBER: 267654-00-2
PURITY: ≥98% (TLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: 30mg/ml soluble in DMSO or dimethyl formamide, 0.25mg/ml soluble in 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions are stable for up to 3 months when stored at -20°C.

Product Description
Potent inhibitor of CDK5 (IC50 = 64nM) and CDK2 / cyclin E (IC50 = 98nM).
Product Specific Literature References
Discovery and SAR of 2-aminothiazole inhibitors of cyclin-dependent kinase 5/p25 as a potential treatment for Alzheimer’s disease: C.J. Helal, et al.; Bioorg. Med. Chem. Lett. 14, 5521 (2004) Abstract
 
 
ALX-201-204/1 Revised 06-Jun-08 New product
pro-Bone Morphogenetic Protein 2 (human) (recombinant)
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SYNONYMS proBMP-2 (human) (recombinant)
PRODUCT LINE Bone Metabolism
PRODUCT CATEGORY Bone Morphogenetic Proteins [BMPs] & Receptors/Related Products
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ALX-201-204/1-C010   10 µg 380.00 USD Add To Cart
Product Specification
MW: ~85.5kDa.
SOURCE/HOST: Produced in E. coli and renatured from inclusion body material.
CONCENTRATION: 100μg/ml after reconstitution.
PURITY: ≥98% (SDS-PAGE, UV, MS)
FORMULATION: Lyophilized from 0.1M K-HEPES, pH 7.0, containing 3% mannitol.
ENDOTOXIN CONTENT: <0.02EU/mg protein.
RECONSTITUTION: Reconstitute with 100μl distilled water at +4°C for 30 minutes.
BIOLOGICAL ACTIVITY: Administration leads to ectopic bone formation in rats.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
USE/STABILITY: The reconstituted solution can be diluted into other aqueous buffers and stored at +4°C for up to two weeks. Below 10μg/ml, 0.5% BSA or serum should be added.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80°C.
Product Specific Literature References
Biophysical comparison of BMP-2, ProBMP-2, and the free pro-peptide reveals stabilization of the pro-peptide by the mature growth factor : F. Hillger, et al.; J. Biol. Chem. 280, 14974 (2005) Abstract; Full Text
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
 
 
ALX-201-205/1 Revised 17-Jun-08 New product
Bone Morphogenetic Protein 2 (human) (recombinant)
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SYNONYMS BMP-2 (human) (recombinant)
PRODUCT LINE Bone Metabolism
PRODUCT CATEGORY Bone Morphogenetic Proteins [BMPs] & Receptors/Related Products
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ALX-201-205/1-C010   10 µg 280.00 USD Add To Cart
Product Specification
MW: ~25.9kDa.
SOURCE/HOST: Produced in E. coli and renatured from inclusion body material.
CONCENTRATION: 100-500μg/ml after reconstitution. 
PURITY: ≥98% (SDS-PAGE, UV, MS)
FORMULATION: Lyophilized.
ENDOTOXIN CONTENT: <0.02EU/mg protein.
RECONSTITUTION: Reconstitute with 20-100μl 50mM sodium acetate solution, pH 4.3.
BIOLOGICAL ACTIVITY: Induces alkaline phosphatase expression at an EC50 = 14nM in C2C12 cells.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
USE/STABILITY:

The reconstituted solution can be further diluted in sodium acetate solution and stored at +4°C for up to two weeks. Below 10μg/ml, 0.5% BSA or serum should be added.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80°C.
Product Specific Literature References
Biophysical comparison of BMP-2, ProBMP-2, and the free pro-peptide reveals stabilization of the pro-peptide by the mature growth factor: F. Hillger, et al.; J. Biol. Chem. 280, 14974 (2005) Abstract; Full Text
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
 
 
ALX-350-250 Revised 22-Jul-08 New product
Butyrolactone I
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PRODUCT LINE Cell Cycle
PRODUCT CATEGORY CDK & Cyclin Inhibitors
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ALX-350-250-C200   200 µg 135.00 USD Add To Cart
Product Specification
FORMULA: C24H24O7
MW: 424.5
CAS NUMBER: 87414-49-1
PURITY: ≥99% (TLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: 25mg/ml soluble in 100% ethanol or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Cell permeable and selective inhibitor of the cyclin-dependent kinases CDK1/cyclin B, CDK2 and CDK5. Inhibits cell cycle progression at the G1/S and G2/M transitions. Blocks Fas-induced apoptosis. Displays antitumor activity.
Product Specific Literature References
Butyrolactone I, a selective inhibitor of cdk2 and cdc2 kinase: M. Kitagawa, et al.; Oncogene 8, 2425 (1993) Abstract
Inhibition of cell cycle oscillation of DNA replication by a selective inhibitor of the cdc2 kinase family, butyrolactone I, in Xenopus egg extracts: A. Someya, et al.; BBRC 198, 536 (1994) Abstract
A cyclin-dependent kinase inhibitor, butyrolactone I, inhibits phosphorylation of RB protein and cell cycle progression: M. Kitagawa, et al.; Oncogene 9, 2549 (1994) Abstract
Evidence for cdk5 as a major activity phosphorylating tau protein in porcine brain extract: T. Hosoi, et al.; J. Biochem. 117, 741 (1995) Abstract
Transcriptional activation of the cdc2 gene is associated with Fas- induced apoptosis of human hematopoietic cells: Y. Furukawa, et al.; J. Biol. Chem. 271, 28469 (1996) Abstract; Full Text
Antitumor effects of butyrolactone I, a selective cdc2 kinase inhibitor, on human lung cancer cell lines: K. Nishio, et al.; Anticancer Res. 16, 3387 (1996) Abstract
An exogenous cdk inhibitor, butyrolactone-I, induces apoptosis with increased Bax/Bcl-2 ratio in p53-mutated pancreatic cancer cells: M. Wada, et al.; Anticancer Res. 18, 2559 (1998) Abstract
Effects of cyclin-dependent kinase inhibitors on transcription and ocular circadian rhythm of Aplysia: N. Sankrithi and A. Eskin; J. Neurochem. 72, 605 (1999) Abstract
Butyrolactone I induces cyclin B1 and causes G2/M arrest and skipping of mitosis in human prostate cell lines: M. Suzuki, et al.; Cancer Lett. 138, 121 (1999) Abstract
Butyrolactone I reversibly inhibits meiotic maturation of bovine oocytes, without influencing chromosome condensation activity: M. Kubelka, et al.; Biol. Reprod. 62, 292 (2000) Abstract; Full Text
Involvement of Cdk5/p25 in digoxin-triggered prostate cancer cell apoptosis: H. Lin, et al.; J. Biol. Chem. 279, 29302 (2004) Abstract; Full Text
Regulation of mitotic function of Chk1 through phosphorylation at novel sites by cyclin-dependent kinase 1 (Cdk1): T. Shiromizu, et al.; Genes Cells 11, 477 (2006) Abstract
 
 
ALX-270-480 Revised 10-Mar-08 New product
Caffeic acid ethyl ester
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SYNONYMS CAEE
Ethyl caffeate
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Anti-inflammatory Agents
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ALX-270-480-M050   50 mg 20.00 USD Add To Cart
ALX-270-480-M250   250 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C11H12O4
MW: 208.2
CAS NUMBER: 66648-50-8
SOURCE/HOST: Synthetic.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least one year after receipt when stored at -20°C.
HANDLING: Protect from light and moisture.

Product Description
Shows anti-carcinogenic, anti-inflammatory and immunomodulatory properties. Suppresses lipopolysaccharide (LPS)-induced nitric oxide (NO) production (IC50=5.5µg/ml). Potent and specific inhibitor of NF-κB and its downstream inflammatory mediators inducible nitric oxide synthase (iNOS; NOS II), prostaglandin E2 (PGE2) and cyclooxygenase-2 (COX-2). Prevents DNA single-strand breaks caused by H2O2.
Product Specific Literature References
Inhibitory effects of caffeic acid ethyl ester on H2O2-induced cytotoxicity and DNA single-strand breaks in Chinese hamster V79 cells: T. Nakayama, et al.; Biosci. Biotechnol. Biochem. 60, 316 (1996) Abstract
Ethyl caffeate suppresses NF-kappaB activation and its downstream inflammatory mediators, iNOS, COX-2, and PGE2 in vitro or in mouse skin: Y.M. Chiang, et al.; Br. J. Pharmacol. 146, 352 (2005)