ALEXIS Biochemicals: Nigericin . sodium salt

ALX-380-050

Revised 20-Jun-08

Nigericin . sodium salt
SYNONYMS	Antibiotic K 178
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics - Ionophores

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-050-M005		5 mg	50.00 USD
ALX-380-050-M025		25 mg	200.00 USD

Product Specification

FORMULA:	C₄₀H₆₇O₁₁ . Na
MW:	724.0 . 23.0
CAS NUMBER:	28380-24-1
MERCK INDEX:	14: 6541
SOURCE/HOST:	Isolated from Streptomyces hygroscopicus.
PURITY:	≥98%
SOLUBILITY:	Soluble in methylene chloride (10mg/ml), 100% ethanol or ethyl acetate; insoluble in water.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stock solutions are stable for 1 month when stored at -20°C.
HAZARD:	TOXIC.

Product Description

Acts as an H⁺, K⁺, Pb²⁺ ionophore. Is most commonly an antiporter of H⁺ and K⁺. Inhibits the Golgi functions.

Product Specific Literature References

Nigericin, a new crystalline antibiotic from an unidentified streptomyces: R. L. Harned, et al.; Antibiot. Chemother. 1, 594 (1951)
ntracellular processing and transport of influenza-virus envelope proteins in Madin-Darby canine kidney cells. Effects of the carboxylic ionophores monensin and nigericin: P.U. Daniels & J.M. Edwardson; Biochem. J. 252, 693 (1988) Abstract
Nigericin-induced Na+/H+ and K+/H+ exchange in synaptosomes: effect on [3H]GABA release: R. Rodriguez & M. Sitges; Neurochem. Res. 21, 889 (1996) Abstract
Nigericin inhibits accumulation of the steroidogenic acute regulatory protein but not steroidogenesis: S.R. King, et al.; Mol. Cell. Endocrinol. 166, 147 (2000) Abstract
Nigericin inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes: C.Y. Chu, et al.; J. Cell. Biochem. 85, 83 (2002) Abstract
The ionophore nigericin transports Pb2+ with high activity and selectivity: a comparison to monensin and ionomycin: S.A. Hamidinia, et al.; Biochemistry 43, 15956 (2004) Abstract

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