ALEXIS Biochemicals: Nimodipine

ALX-550-277

Revised 03-Mar-05

Nimodipine
SYNONYMS	1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl-1-methylethyl ester
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Ca2+ Channels (L-type)

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-550-277-M010		10 mg	12.00 USD
ALX-550-277-M050		50 mg	30.00 USD
ALX-550-277-M250		250 mg	80.00 USD
ALX-550-277-G001		1 g	190.00 USD

Product Specification

FORMULA:	C₂₁H₂₆N₂O₇
MW:	418.5
CAS NUMBER:	66085-59-4
MERCK INDEX:	14: 6551
PURITY:	≥99%
APPEARANCE:	Yellowish solid.
SOLUBILITY:	Soluble in DMSO or methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C
HANDLING:	Protect from light.
HAZARD:	TOXIC.

Product Description

Ca²⁺ channel antagonist. Highly potent at L-type channels. Enhances memory in old or brain-damaged animals. Ameliorates experimental diabetic neuropathy in streptozotocin-induced diabetic rats. Vasodilator.

Product Specific Literature References

Anticonvulsant profile of the dihydropyridine calcium channel antagonists, nitrendipine and nimodipine: S.J. Dolin, et al.; Eur. J. Pharmacol. 152, 19 (1988) Abstract
1,4-Dihydropyridine activators and antagonists: structural and functional distinctions: D.J. Triggle & D. Rampe; TIPS 10, 507 (1989) Abstract
Nimodipine and the recovery of memory: I. Izquierdo; TIPS 11, 309 (1990) Abstract
Multiple types of high-threshold calcium channels in rabbit sensory neurons: high-affinity block of neuronal L-type by nimodipine: R.T. McCarthy and P.E. TanPiengco; J. Neurosci. 12, 2225 (1992) Abstract
Amelioration by the Ca2+ antagonist, nimodipine of an existing neuropathy in the streptozotocin-induced, diabetic rat: A.C. Kappelle, et al.; Br. J. Pharmacol. 108, 780 (1993) Abstract
Calmodulin controls neuronal nitric-oxide synthase by a dual mechanism. Activation of intra- and interdomain electron transfer: A.C. Kappelle, et al.; Br. J. Pharmacol. 111, 887 (1994) Abstract

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