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PRMTs, Mono- & Dimethylarginine/Related Products
You are here: Product Lines > Nitric Oxide Pathway > PRMTs, Mono- & Dimethylarginine/Related Products
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ALX-106-006 Revised 15-Oct-07
NG, NG-Dimethyl-L-arginine . dihydrochloride
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SYNONYMS H-Arg(di-Me)-OH . 2HCl (asymmetrical)
ADMA . 2HCl
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY NOS Inhibitors (NOS Induction & Enzyme Activity)
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-106-006-M005   5 mg 33.00 USD Add To Cart
ALX-106-006-M025   25 mg 85.00 USD Add To Cart
Product Specification
FORMULA: C8H18N4O2 . 2 HCl . H2O
MW: 202.2 . 73.0 . 18.0
PURITY: ≥97%
APPEARANCE: White to off-white crystalline solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions are stable for up to 4 months when stored at -20°C.
HANDLING: Hygroscopic.

Product Description
Endogenous nitric oxide synthase (NOS) inhibitor.
Product Specific Literature References
Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure: P. Vallance, et al.; Lancet 339, 572 (1992), and references cited therein. Abstract
Further Categories Containing This Product:
PRMTs, Mono- & Dimethylarginine/Related Products
 
 
ALX-106-008 Revised 23-Feb-06
NG, N'G-Dimethyl-L-arginine . dihydrochloride
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SYNONYMS SDMA . 2HCl
H-Arg(di-Me)-OH . 2HCl (symmetrical)
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY NOS Inhibitors (NOS Induction & Enzyme Activity)
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-106-008-M005   5 mg 33.00 USD Add To Cart
ALX-106-008-M025   25 mg 85.00 USD Add To Cart
Product Specification
FORMULA: C8H18N4O2 . 2HCl
MW: 202.2 . 73.0
PURITY: ≥98%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Hygroscopic.

Product Description
Has shown not to inhibit nitric oxide synthesis, both in vitro and in vivo.
Product Specific Literature References
Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure: P. Vallance, et al.; Lancet 339, 572 (1992), and references cited therein. Abstract
Further Categories Containing This Product:
PRMTs, Mono- & Dimethylarginine/Related Products
 
 
ALX-106-007 Revised 03-Feb-05
NG, N'G-Dimethyl-L-arginine . di(p-hydroxyazobenzene-p'-sulfonate)
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SYNONYMS SDMA . 2HABS
H-Arg(di-Me)-OH . 2HABS (symmetrical)
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY NOS Inhibitors (NOS Induction & Enzyme Activity)
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-106-007-M005   5 mg 23.00 USD Add To Cart
ALX-106-007-M025   25 mg 55.00 USD Add To Cart
Product Specification
FORMULA: C8H18N4O2 . 2C12H10N2O4S
MW: 202.2 . 556.6
CAS NUMBER: 102783-24-4
PURITY: ≥97%
APPEARANCE: Orange powder.
SOLUBILITY: Soluble in methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Has been shown not to inhibit nitric oxide synthesis, both in vitro and in vivo. This salt form is more stable than the dihydrochloride.
Product Specific Literature References
Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure: P. Vallance, et al.; Lancet 339, 572 (1992), and references cited therein.
L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells: J.B. Hibbs Jr., et al.; J. Immunol. 138, 550 (1987) Abstract
Further Categories Containing This Product:
PRMTs, Mono- & Dimethylarginine/Related Products
 
 
ALX-106-005 Revised 24-Feb-05
NG, NG-Dimethyl-L-arginine . di(p-hydroxyazobenzene-p'-sulfonate)
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SYNONYMS ADMA . 2HABS
H-Arg(di-Me)-OH . 2HABS (asymmetrical)
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY NOS Inhibitors (NOS Induction & Enzyme Activity)
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-106-005-M005   5 mg 23.00 USD Add To Cart
ALX-106-005-M025   25 mg 55.00 USD Add To Cart
Product Specification
FORMULA: C8H18N4O2 . 2C12H10N2O4S
MW: 202.2 . 556.6
PURITY: ≥97%
APPEARANCE: Orange powder.
SOLUBILITY: Soluble in methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Inhibits nitric oxide synthesis. This salt form is more stable than the dihydrochloride.
Product Specific Literature References
L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells: J.B. Hibbs Jr., et al.; J. Immunol. 138, 550 (1987) Abstract
Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure: P. Vallance, et al.; Lancet 339, 572 (1992), and references cited therein. Abstract
Further Categories Containing This Product:
PRMTs, Mono- & Dimethylarginine/Related Products
 
 
ALX-350-240 Revised 05-Dec-07
Ilimaquinone
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SYNONYMS 3-[(Decahydro-1β,2β,4αβ-trimethyl-5-methylene-1-naphthyl)methyl]-2-hydroxy-5-methoxybenzoquinone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Other Signal Transduction Pathway Modulators
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ALX-350-240-C100   100 µg 140.00 USD Add To Cart
Product Specification
FORMULA: C22H30O4
MW: 358.5
CAS NUMBER: 71678-03-0
PURITY: ≥98%
APPEARANCE: Yellow powder.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Displays antimicrobial, anti-HIV and anti-inflammatory properties. Induces reversible breakdown of Golgi membranes. Inhibits the association of β-COP and ADP-ribosylation factor to Golgi membranes. Interacts with methylation enzymes. Shows anticancer activity.
Product Specific Literature References
R.T. Luibrand, et al.; Tetrahedron 35, 609 (1979)
Complete vesiculation of Golgi membranes and inhibition of protein transport by a novel sea sponge metabolite, ilimaquinone: P.A. Takizawa, et al.; Cell 73, 1079 (1993) Abstract
Interactions of (-)-ilimaquinone with methylation enzymes: implications for vesicular-mediated secretion: H.S. Radeke, et al.; Chem. Biol. 6, 639 (1999) Abstract
Ilimaquinone inhibits gap-junctional communication prior to Golgi fragmentation and block in protein transport: V. Cruciani, et al.; Exp. Cell Res. 287, 130 (2003) Abstract
Natural products with anti-HIV activity from marine organisms: L.A. Tziveleka, et al.; Curr. Top. Med. Chem. 3, 1512 (2003), Review Abstract
Interaction of the smooth endoplasmic reticulum and mitochondria: J.G. Goetz & I.R. Nabi; Biochem. Soc. Trans. 34, 370 (2006), Review Abstract
Ilimaquinone, a marine sponge metabolite, displays anticancer activity via GADD153-mediated pathway: P.H. Lu, et al.; Eur. J. Pharmacol. 556, 45 (2007) Abstract
Further Categories Containing This Product:
Golgi Apparatus • ADP Ribosylation Factor [ARF]/Related Products • PRMTs, Mono- & Dimethylarginine/Related Products • Natural Products - Anti-inflammatory Agents • Natural Products - Chemopreventive Agents • Natural Products - Antiviral/anti-HIV Agents
 
 
ALX-201-282 Revised 18-Mar-08
PRMT1 (human) (recombinant) (His)
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SYNONYMS Protein Arginine N-Methyltransferase 1 (human) (recombinant) (His)
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY PRMTs, Mono- & Dimethylarginine/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-282-C002   2 µg 280.00 USD Add To Cart
Product Specification
EC: EC 2.1.1.-
SOURCE/HOST: Produced in SF21 cells. Fused to a His-tag.
CONCENTRATION: 0.5mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride, 0.2% NP-40, 50mM imidazole and 10% glycerol.
SPECIFIC ACTIVITY: ~50-100ng are required for standard HAT assay.
SHIPPING: SHIPPED ON DRY ICE
SHORT TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store in liquid nitrogen.
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q99873: PRMT-1 (human)
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
 
 
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