• Home
  • Sitemap
  • Help
  • Technical Support
  • Contact
Nitric Oxide Pathway
You are here: Product Lines > Nitric Oxide Pathway
 
Toolbar - View Selection
 
 Items 60-80 of 348 Page 4 of 18 Select Page: << 1 2 3 4 5 6 7 8 9 10  >>  
ALX-270-171 Revised 30-Jun-08
Chlorpromazine . hydrochloride
Add to Clipboard
SYNONYMS 2-Chloro-10-(3-dimethylaminopropyl)phenothiazine . HCl
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Calmodulin Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-171-G001   1 g 22.00 USD Add To Cart
ALX-270-171-G005   5 g 66.00 USD Add To Cart
Product Specification
FORMULA: C17H19ClN2S . HCl
MW: 318.9 . 36.5
CAS NUMBER: 69-09-0
MERCK INDEX: 14: 2185
RTECS: SO1750000
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in 100% ethanol, methanol or water (50mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Not stable in aqueous solution. We strongly recommend always to use freshly prepared solutions.
HANDLING: Protect from light.
HAZARD: VERY TOXIC.

Product Description
Inhibits calmodulin stimulation of cyclic nucleotide phosphodiesterase. Dopamine antagonist. D2 antagonist. H1 antagonist. Inhibits TNF-α production. Potent PLA2 inhibitor. Inhibits nitric oxide synthase (NOS) in mouse brain and prevents lipopolysaccharide induction of NOS in mouse lung. Antipsychotic.
Product Specific Literature References
Chlorpromazine as a substitute for ortho-dianisidine and ortho-tolidine in the determination of chlorine, hemoglobin, and peroxidase activity: H.B. Collier; Clin. Biochem. 7, 331 (1974) Abstract
Drug-protein interactions: binding of chlorpromazine to calmodulin, calmodulin fragments, and related calcium binding proteins: D.R. Marshak, et al.; Biochemistry 24, 144 (1985) Abstract
Selective inhibition of group II phospholipase A2 by quercetin: M. Lindahl & C. Tagesson; Inflammation 17, 573 (1993) Abstract
Chlorpromazine inhibits both the constitutive nitric oxide synthase and the induction of nitric oxide synthase after LPS challenge: M. Palacios, et al.; BBRC 196, 280 (1993) Abstract
Protective effect of calmodulin inhibitors against acute cyanide- induced lethality and convulsions in mice: H. Yamamoto; Toxicol. Lett. 66, 73 (1993) Abstract
Pharmacologic inhibitors of tumor necrosis factor production exert differential effects in lethal endotoxemia and in infection with live microorganisms in mice: M.G. Netea, et al.; J. Infect. Dis. 171, 393 (1995) Abstract
Pharmacological regulation of mitochondrial nitric oxide synthase: A. Boveris, et al.; Methods Enzymol. 359, 328 (2002) Abstract
Brain mitochondrial nitric oxide synthase: in vitro and in vivo inhibition by chlorpromazine: S. Lores-Arnaiz, et al.; Arch. Biochem. Biophys. 430, 170 (2004) Abstract
Further Categories Containing This Product:
Dopaminergics & Dopamine Receptors / Related Products • Phosphodiesterases / Related Products • TNF-alpha & TNF Receptors Other Products • PLA2 Inhibitors • Chemopreventive Agents Other Products • NOS Inhibitors (NOS Induction & Enzyme Activity)
 
 
ALX-106-003 Revised 06-Jun-06
L-Citrulline
Add to Clipboard
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY NOS Inhibitors (NOS Induction & Enzyme Activity)
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-106-003-G005   5 g 20.00 USD Add To Cart
Product Specification
FORMULA: C6H13N3O3
MW: 175.2
CAS NUMBER: 372-75-8
MERCK INDEX: 14: 2331
PURITY: ≥99%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Essential intermediate in the biosynthesis of nitric oxide from L-arginine.
Product Specific Literature References
A novel citrulline-forming enzyme implicated in the formation of nitric oxide by vascular endothelial cells: R.M.J. Palmer and S. Moncada; BBRC 158, 348 (1989) Abstract
The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: cultured endothelial cells recycle L-citrulline to L-arginine: M. Hecker, et al.; PNAS 87, 8612 (1990) Abstract
N omega-hydroxy-L-arginine is an intermediate in the biosynthesis of nitric oxide from L-arginine: D.J. Stuehr, et al.; J. Biol. Chem. 266, 6259 (1991) Abstract; Full Text
 
 
ALX-430-117 Revised 16-May-08
CMH . hydrochloride
Add to Clipboard
SYNONYMS 1-Hydroxy-3-methoxycarbonyl-2,2,5,5-tetramethylpyrrolidine . HCl
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Spin Traps, Spin Probes & Spin Labels
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-117-M010   10 mg 65.00 USD Add To Cart
ALX-430-117-M050   50 mg 195.00 USD Add To Cart
ALX-430-117-M250   250 mg 450.00 USD Add To Cart
Product Specification
FORMULA: C10H19NO3 . HCl
MW: 201.3 . 36.5
PURITY: ≥99% (EPR)
APPEARANCE: White to off-white crystalline powder.
SOLUBILITY: Soluble in DMSO, 100% ethanol, methanol or water.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C

Product Description
Analog of CPH (Prod. No. ALX-430-078) with higher cell permeability and 3-fold better reactivity with superoxide. Has been used to study intracellular production of superoxide radicals in plasma, endothelial cells and isolated hearts.
Product Specific Literature References
Detection of superoxide with new cyclic hydroxylamine CMH in plasma, cells and isolated heart: B. Fink & S. Dikalov; Free Radical Biol. Med. 33, S366 (2002)
Oscillatory shear stress stimulates endothelial production of O2- from p47phox-dependent NAD(P)H oxidases, leading to monocyte adhesion: J. Hwang, et al.; J. Biol. Chem. 278, 47291 (2003) Abstract; Full Text
Interactions of peroxynitrite with uric acid in the presence of ascorbate and thiols: implications for uncoupling endothelial nitric oxide synthase: N. Kuzkaya, et al.; Biochem. Pharmacol. 70, 343 (2005) Abstract
Atrial fibrillation increases production of superoxide by the left atrium and left atrial appendage: role of the NADPH and xanthine oxidases: S.C. Dudley, Jr., et al.; Circulation 112, 1266 (2005) Abstract
Nox1 overexpression potentiates angiotensin II-induced hypertension and vascular smooth muscle hypertrophy in transgenic mice: A. Dikalova, et al.; Circulation 112, 2668 (2005) Abstract
Measurement of reactive oxygen species in cardiovascular studies: S. Dikalov, et al.; Hypertension 49, 717 (2007) Abstract
Production of extracellular superoxide by human lymphoblast cell lines: comparison of electron spin resonance techniques and cytochrome C reduction assay: S.I. Dikalov, et al.; Biochem. Pharmacol. 73, 972 (2007) Abstract; Full Text
Related Products
 
 
ALX-620-063 Revised 03-Feb-05
Coelenterazine
Add to Clipboard
SYNONYMS 2-[(4-Hydroxyphenyl)methyl]-6-(4-hydroxyphenyl)-8-(phenylmethyl)-imidazo [1,2-a] pyrazin-3-(7H)-one
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Peroxynitrite / Scavengers / Detection
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-620-063-C050   50 µg 110.00 USD Add To Cart
Product Specification
FORMULA: C26H21N3O3
MW: 423.5
CAS NUMBER: 55779-48-1
PURITY: ≥95%
APPEARANCE: Brown solid.
SOLUBILITY: Slightly soluble in methanol or ethanol. Avoid DMSO.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from light. Keep under inert gas. Keep calcium free when stored in solution.

Product Description
Cell permeable, very sensitive and specific chemiluminescence probe of the superoxide anion and peroxynitrite. When oxidized by oxygen it emits blue light at 446nm when Ca2+ binds to the complex. Powerful antioxidant. See also 2-(4-Dehydroxy)coelenterazine (Prod. No. ALX-620-062).
Product Specific Literature References
Use of calcium-regulated photoproteins as intracellular Ca2+ indicators: J.R. Blinks; Meth. Enzymol. 172, 164 (1989) Abstract
Slow calcium waves accompany cytokinesis in medaka fish eggs: R.A. Fluck, et al.; J. Cell Biol. 115, 1259 (1991) Abstract
Coelenterazine is a superoxide anion-sensitive chemiluminescent probe: its usefulness in the assay of respiratory burst in neutrophils: M. Lucas & F. Solano; Anal. Biochem. 206, 273 (1992) Abstract
Aequorin-expressing mammalian cell lines used to report Ca2+ mobilization: D. Button & M. Brownstein; Cell Calcium 14, 663 (1993) Abstract
Imaging [Ca2+]i with aequorin using a photon imaging detector: A.L. Miller, et al.; Meth. Cell Biol. 40, 305 (1994) Abstract
Intracellular free calcium level and its response to cAMP stimulation in developing Dictyostelium cells transformed with jellyfish apoaequorin cDNA: S. Saran, et al.; FEBS Lett. 337, 43 (1994) Abstract
The origins of marine bioluminescence: turning oxygen defence mechanisms into deep-sea communication tools: J.F. Rees, et al.; J. Exp. Biol. 201, 1211 (1998) Abstract; Full Text
Chemiluminescent detection of oxidants in vascular tissue. Lucigenin but not coelenterazine enhances superoxide formation: M.M. Tarpey, et al.; Circ. Res. 84, 1203 (1999) Abstract
Further Categories Containing This Product:
Dyes / Stains / Fluorescent Probes / Fluorescent Labels • Antioxidants, Flavonoids & Free Radical Scavengers Other Products • Luciferin & Luciferase / Related Products • Calcium Indicators / Probes • Oxidative Stress Markers & Reagents / Related Products
 
 
ALX-550-516 Revised 21-May-08
Compound A
Add to Clipboard
SYNONYMS CpdA
2-((4-Acetophenyl)-2-chloro-N-methyl)ethylammonium chloride
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Anti-inflammatory Agents
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-516-M005   5 mg 40.00 USD Add To Cart
ALX-550-516-M025   25 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C11H14ClNO2 . HCl
MW: 227.7 . 36.5
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO, 100% ethanol or water.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
USE/STABILITY: Stock solutions in ethanol are stable for up to 1 month when stored at -80°C.
HANDLING: Protect from moisture. After reconstitution, prepare aliquots and store at -80°C.

Product Description
Cell permeable, nonsteroidal glucocorticoid receptor modulator with high binding affinity. Exerts anti-inflammatory potential by down-modulating TNF-induced pro-inflammatory gene expression, such as IL-6 and E-selectin. Unlike dexamethasone (Prod. No. ALX-370-002) it does not enhance glucocorticoid response element (GRE)-driven gene expression or induce glucocorticoid receptor (GR) binding to GRE-dependent genes in vivo.
Product Specific Literature References
A fully dissociated compound of plant origin for inflammatory gene repression: K. De Bosscher, et al.; PNAS 102, 15827 (2005) Abstract
A plant-derived ligand favoring monomeric glucocorticoid receptor conformation with impaired transactivation potential attenuates collagen-induced arthritis: P. Dewint, et al.; J. Immunol. 180, 2608 (2008) Abstract
Related Products
Further Categories Containing This Product:
GITR & GITRL Other Products • Glucocorticoids & Glucocorticoid Receptors / Related Products • RANK & RANKL / OPG Other Products • DNA & RNA Methyl & Alkyl Transferases / Related Products • Antitumor Agents (Hormone-related) • NOS Inhibitors (NOS Induction & Enzyme Activity) • Natural Products - Chemopreventive Agents • Natural Products - Nitric Oxide Pathway Modulators • Other Natural Products - DNA Regulation / Transcription • Natural Products for Cell Cycle Research
 
 
ALX-380-034 Revised 30-Jul-08
Concanamycin A
Add to Clipboard
SYNONYMS Folimycin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - ATPase Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-034-C025   25 µg 55.00 USD Add To Cart
ALX-380-034-C100   100 µg 180.00 USD Add To Cart
ALX-380-034-M001   1 mg 750.00 USD Add To Cart
Product Specification
FORMULA: C46H75NO14
MW: 866.1
CAS NUMBER: 80890-47-7
RTECS: CB9732000
SOURCE/HOST: Isolated from Streptomyces sp.
PURITY: ≥96% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in methanol, DMSO or acetonitrile; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: VERY TOXIC.
IDENTITY: Identity determined by 1H-NMR.

Product Description
Antibiotic. More potent and specific H+-ATPase inhibitor than bafilomycin A1 (Prod. No. ALX-380-030). Inhibits acidification of organelles such as lysosomes and the Golgi apparatus. Blocks cell surface expression of viral glycoproteins without affecting their synthesis. Exhibits cytotoxic effects in a number of cell lines in a cell viability assay. Induces nitric oxide (NO) production.
Product Specific Literature References
Isolation and characterization of concanamycins A, B and C: H. Kinashi, et al.; J. Antibiot. (Tokyo) 37, 1333 (1984) Abstract
Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells: E.J. Bowman, et al.; PNAS 85, 7972 (1988) Abstract
Structure and function of vacuolar class of ATP-driven proton pumps: M. Forgac; Physiol. Rev. 69, 765 (1989) Abstract
Intravesicular acidification correlates with binding of ADP- ribosylation factor to microsomal membranes: S. Zeuzem, et al.; PNAS 89, 6619 (1992) Abstract
Inhibitory effect of modified bafilomycins and concanamycins on P- and V-type adenosinetriphosphatases: S. Drose, et al.; Biochemistry 32, 3902 (1993) Abstract
Folimycin (concanamycin A), a specific inhibitor of V-ATPase, blocks intracellular translocation of the glycoprotein of vesicular stomatitis virus before arrival to the Golgi apparatus: M. Muroi, et al.; Cell Struct. Funct. 18, 139 (1993) Abstract
Folimycin (concanamycin A), an inhibitor of V-type H(+)-ATPase, blocks cell-surface expression of virus-envelope glycoproteins: M. Muroi, et al.; BBRC 193, 999 (1993) Abstract
Purification of vacuolar ATPase with bafilomycin C1 affinity chromatography: T.J. Rautiala, et al.; BBRC 194, 50 (1993) Abstract
Involvement of the vacuolar H(+)-ATPases in the secretory pathway of HepG2 cells: M. Yilla, et al.; J. Biol. Chem. 268, 19092 (1993) Abstract; Full Text
Specific inhibitors of vacuolar type H(+)-ATPases induce apoptotic cell death: T. Nishihara, et al.; BBRC 212, 255 (1995) Abstract
Characterization of the ATPase activity of P-glycoprotein from multidrug-resistant Chinese hamster ovary cells: F.J. Sharom, et al.; Biochem. J. 308 (Pt2), 381 (1995) Abstract
Concanamycin A, the specific inhibitor of V-ATPases, binds to the V(o) subunit c: M. Huss, et al.; J. Biol. Chem. 277, 40544 (2002) Abstract
Organization of the biosynthetic gene cluster for the macrolide concanamycin A in Streptomyces neyagawaensis ATCC 27449: S.F. Haydock, et al.; Microbiology 151, 3161 (2005) Abstract; Full Text
Nitric oxide production by the vacuolar-type (H+)-ATPase inhibitors bafilomycin A1 and concanamycin A and its possible role in apoptosis in RAW 264.7 cells: J. Hong, et al.; J. Pharmacol. Exp. Ther. 319, 672 (2006) Abstract
Related Products
Further Categories Containing This Product:
Antibiotics - Nitric Oxide Pathway Modulators • H+-ATPase / Related Products • Antitumor Antibiotics
 
 
ALX-370-007 Revised 09-Sep-08
Corticosterone
Add to Clipboard
SYNONYMS (11β)-11,21-Dihydroxypregn-4-ene-3,20-dione
Reichstein's Substance H
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Glucocorticoids & Glucocorticoid Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-370-007-M050   50 mg 18.00 USD Add To Cart
Product Specification
FORMULA: C21H30O4
MW: 346.5
CAS NUMBER: 50-22-6
MERCK INDEX: 14: 2538
RTECS: GM7650000
PURITY: ≥98% (HPLC)
APPEARANCE: White to light yellow solid.
SOLUBILITY: Soluble in 100% ethanol (50mg/ml) or dioxane (20mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: MAY BE TERATOGENIC. IRRITANT.

Further Categories Containing This Product:
Apoptosis Inducers & Inhibitors Other Products • Nitric Oxide Pathway Other Products
 
 
ALX-430-078 Revised 10-Nov-06
CPH . hydrochloride
Add to Clipboard
SYNONYMS 1-Hydroxy-3-carboxy-2,2,5,5-tetramethylpyrrolidine . HCl
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Spin Traps, Spin Probes & Spin Labels
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-078-M010   10 mg 65.00 USD Add To Cart
ALX-430-078-M050   50 mg 195.00 USD Add To Cart
ALX-430-078-M250   250 mg 450.00 USD Add To Cart
Product Specification
FORMULA: C9H17NO3 . HCl
MW: 187.2 . 36.5
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO, 100% ethanol, methanol or water.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C

Product Description
Effective, cell permeable and non-toxic spin trap for the detection of superoxide radical and peroxynitrite, both in vitro and in vivo. Resistant to reduction by vitamin C and thiols.
Product Specific Literature References
Spin trapping of superoxide radicals and peroxynitrite by 1-hydroxy-3- carboxy-pyrrolidine and 1-hydroxy-2,2,6, 6-tetramethyl-4-oxo-piperidine and the stability of corresponding nitroxyl radicals towards biological reductants: S. Dikalov, et al.; BBRC 231, 701 (1997) Abstract
Quantification of superoxide radicals and peroxynitrite in vascular cells using oxidation of sterically hindered hydroxylamines and electron spin resonance: S. Dikalov, et al.; Nitric Oxide 1, 423 (1997) Abstract
Comparison of glyceryl trinitrate-induced with pentaerythrityl tetranitrate-induced in vivo formation of superoxide radicals: effect of vitamin C: S. Dikalov, et al.; Free Radic. Biol. Med. 27, 170 (1999) Abstract
A new approach for extracellular spin trapping of nitroglycerin-induced superoxide radicals both in vitro and in vivo: B. Fink, et al.; Free Radic. Biol. Med. 28, 121 (2000) Abstract
Noninvasive diagnostic tool for inflammation-induced oxidative stress using electron spin resonance spectroscopy and an extracellular cyclic hydroxylamine: S.I. Dikalov, et al.; Arch. Biochem. Biophys. 402, 218 (2002) Abstract
Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase: N. Kuzkaya, et al.; J. Biol. Chem. 278, 22546 (2003) Abstract; Full Text
Interactions of peroxynitrite with uric acid in the presence of ascorbate and thiols: implications for uncoupling endothelial nitric oxide synthase: N. Kuzkaya, et al.; Biochem. Pharmacol. 70, 343 (2005) Abstract
Indoxyl sulfate induces complex redox alterations in mesangial cells: A.K. Gelasco & J.R. Raymond; Am. J. Physiol. Renal Physiol. 290, F1551 (2006) Abstract
 
 
ALX-350-028 Revised 12-Sep-08
Curcumin (high purity)
Add to Clipboard
SYNONYMS 1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione
Diferuloylmethane
PRODUCT LINE