• Home
  • Sitemap
  • Help
  • Technical Support
  • Contact
Nitric Oxide Pathway
You are here: Product Lines > Nitric Oxide Pathway
 
Toolbar - View Selection
 
 Items 100-120 of 347 Page 6 of 18 Select Page: << 1 2 3 4 5 6 7 8 9 10  >>  
ALX-610-021 Revised 04-Nov-05
Dihydrorhodamine 123
Add to Clipboard
SYNONYMS DHR
PRODUCT LINE Other Products
PRODUCT CATEGORY Dyes/Stains/Fluorescent Probes/Fluorescent Labels
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-610-021-M005   5 mg 153.00 USD Add To Cart
ALX-610-021-M010   10 mg 272.00 USD Add To Cart
Product Specification
FORMULA: C21H18N2O3
MW: 346.4
CAS NUMBER: 109244-58-8
PURITY: ≥98%
APPEARANCE: Pink crystalline solid.
SOLUBILITY: Soluble in organic solvents such as ethanol, DMSO or dimethyl formamide.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions are stable for at least 6 months when stored at -20°C.

Product Description
Sensitive indicator of peroxynitrite formation. DHR is oxidized by peroxynitrite to the highly fluorescent product rhodamine. Formation of rhodamine can be monitored by fluorescence spectroscopy (Ex(max): 500nm, Em(max): 536nm), or by absorbance spectroscopy at 500nm (ε=78'800M-1cm-1). Neither nitric oxide, superoxide, nor hydrogen peroxide alone appear to oxidize DHR.
Product Specific Literature References
Peroxynitrite-mediated oxidation of dihydrorhodamine 123: N.W. Kooy, et al.; Free Radic. Biol. Med. 16, 149 (1994) Abstract
Attenuation of oxidation and nitration reactions of peroxynitrite by selenomethionine, selenocystine and ebselen: K. Briviba, et al.; Biochem. J. 319, 13 (1996) Abstract
Dichlorodihydrofluorescein and dihydrorhodamine 123 are sensitive indicators of peroxynitrite in vitro: implications for intracellular measurement of reactive nitrogen and oxygen species: J.P. Crow; Nitric Oxide 1, 145 (1997) Abstract
Glutathione peroxidase protects against peroxynitrite-mediated oxidations. A new function for selenoproteins as peroxynitrite reductase: H. Sies, et al.; J. Biol. Chem. 272, 27812 (1997) Abstract; Full Text
Dihydrofluorescein diacetate is superior for detecting intracellular oxidants: comparison with 2',7'-dichlorodihydrofluorescein diacetate, 5(and 6)-carboxy-2',7'-dichlorodihydrofluorescein diacetate: S.L. Hempel, et al.; Free Radic. Biol. Med. 27, 146 (1999) Abstract
Detection of reactive nitrogen species using 2,7-dichlorodihydrofluorescein and dihydrorhodamine 123: H. Ischiropoulos, et al.; Meth. Enzymol. 301, 367 (1999) Abstract
Further Categories Containing This Product:
Respiratory Chain Other Products • Peroxynitrite/Scavengers/Detection
 
 
ALX-106-006 Revised 15-Oct-07
NG, NG-Dimethyl-L-arginine . dihydrochloride
Add to Clipboard
SYNONYMS H-Arg(di-Me)-OH . 2HCl (asymmetrical)
ADMA . 2HCl
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY NOS Inhibitors (NOS Induction & Enzyme Activity)
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-106-006-M005   5 mg 33.00 USD Add To Cart
ALX-106-006-M025   25 mg 85.00 USD Add To Cart
Product Specification
FORMULA: C8H18N4O2 . 2 HCl . H2O
MW: 202.2 . 73.0 . 18.0
PURITY: ≥97%
APPEARANCE: White to off-white crystalline solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions are stable for up to 4 months when stored at -20°C.
HANDLING: Hygroscopic.

Product Description
Endogenous nitric oxide synthase (NOS) inhibitor.
Product Specific Literature References
Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure: P. Vallance, et al.; Lancet 339, 572 (1992), and references cited therein. Abstract
Further Categories Containing This Product:
PRMTs, Mono- & Dimethylarginine/Related Products
 
 
ALX-106-008 Revised 23-Feb-06
NG, N'G-Dimethyl-L-arginine . dihydrochloride
Add to Clipboard
SYNONYMS SDMA . 2HCl
H-Arg(di-Me)-OH . 2HCl (symmetrical)
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY NOS Inhibitors (NOS Induction & Enzyme Activity)
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-106-008-M005   5 mg 33.00 USD Add To Cart
ALX-106-008-M025   25 mg 85.00 USD Add To Cart
Product Specification
FORMULA: C8H18N4O2 . 2HCl
MW: 202.2 . 73.0
PURITY: ≥98%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Hygroscopic.

Product Description
Has shown not to inhibit nitric oxide synthesis, both in vitro and in vivo.
Product Specific Literature References
Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure: P. Vallance, et al.; Lancet 339, 572 (1992), and references cited therein. Abstract
Further Categories Containing This Product:
PRMTs, Mono- & Dimethylarginine/Related Products
 
 
ALX-106-007 Revised 03-Feb-05
NG, N'G-Dimethyl-L-arginine . di(p-hydroxyazobenzene-p'-sulfonate)
Add to Clipboard
SYNONYMS SDMA . 2HABS
H-Arg(di-Me)-OH . 2HABS (symmetrical)
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY NOS Inhibitors (NOS Induction & Enzyme Activity)
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-106-007-M005   5 mg 23.00 USD Add To Cart
ALX-106-007-M025   25 mg 55.00 USD Add To Cart
Product Specification
FORMULA: C8H18N4O2 . 2C12H10N2O4S
MW: 202.2 . 556.6
CAS NUMBER: 102783-24-4
PURITY: ≥97%
APPEARANCE: Orange powder.
SOLUBILITY: Soluble in methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Has been shown not to inhibit nitric oxide synthesis, both in vitro and in vivo. This salt form is more stable than the dihydrochloride.
Product Specific Literature References
Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure: P. Vallance, et al.; Lancet 339, 572 (1992), and references cited therein.
L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells: J.B. Hibbs Jr., et al.; J. Immunol. 138, 550 (1987) Abstract
Further Categories Containing This Product:
PRMTs, Mono- & Dimethylarginine/Related Products
 
 
ALX-106-005 Revised 24-Feb-05
NG, NG-Dimethyl-L-arginine . di(p-hydroxyazobenzene-p'-sulfonate)
Add to Clipboard
SYNONYMS ADMA . 2HABS
H-Arg(di-Me)-OH . 2HABS (asymmetrical)
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY NOS Inhibitors (NOS Induction & Enzyme Activity)
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-106-005-M005   5 mg 23.00 USD Add To Cart
ALX-106-005-M025   25 mg 55.00 USD Add To Cart
Product Specification
FORMULA: C8H18N4O2 . 2C12H10N2O4S
MW: 202.2 . 556.6
PURITY: ≥97%
APPEARANCE: Orange powder.
SOLUBILITY: Soluble in methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Inhibits nitric oxide synthesis. This salt form is more stable than the dihydrochloride.
Product Specific Literature References
L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells: J.B. Hibbs Jr., et al.; J. Immunol. 138, 550 (1987) Abstract
Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure: P. Vallance, et al.; Lancet 339, 572 (1992), and references cited therein. Abstract
Further Categories Containing This Product:
PRMTs, Mono- & Dimethylarginine/Related Products
 
 
ALX-270-003 Revised 08-Aug-08
Diphenyleneiodonium chloride
Add to Clipboard
SYNONYMS Dibenziodolium chloride
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY NOS Inhibitors (NOS Induction & Enzyme Activity)
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-003-M025   25 mg 85.00 USD Add To Cart
ALX-270-003-M100   100 mg 255.00 USD Add To Cart
Product Specification
FORMULA: C12H8ICl
MW: 314.5
CAS NUMBER: 4673-26-1
PURITY: ≥98% (TLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: 10mg/ml soluble in DMSO (warm).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: HARMFUL.

Product Description
Binds strongly to flavoproteins and is thus a powerful and specific inhibitor of several important enzymes, including nitric oxide synthase (NOS), NADPH-ubiquinone oxidoreductase, NADPH oxidases and NADPH cytochrome P450 oxidoreductase. Nitric oxide synthase, which shows significant homology with cytochrome P450 reductase, has shown to be irreversibly inhibited by this compound.
Product Specific Literature References
Specific labelling of a constituent polypeptide of bovine heart mitochondrial reduced nicotinamide-adenine dinucleotide-ubiquinone reductase by the inhibitor diphenyleneiodonium: C.I. Ragan & D.P. Bloxham; Biochem. J. 163, 605 (1977) Abstract
The inhibition by diphenyleneiodonium and its analogues of superoxide generation by macrophages: J.T. Hancock & O.T.G. Jones; Biochem. J. 242, 103 (1987) Abstract
Indications to an NADPH oxidase as a possible pO2 sensor in the rat carotid body: H. Acker, et al.; FEBS Lett. 256, 75 (1989) Abstract
Purification and some properties of the 45 kDa diphenylene iodonium- binding flavoprotein of neutrophil NADPH oxidase: C.M. Yea, et al.; Biochem. J. 265, 95 (1990) Abstract
Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs: D.J. Stuehr, et al.; FASEB J. 5, 98 (1991) Abstract
Inhibition of cytochrome P450 reductase by the diphenyliodonium cation. Kinetic analysis and covalent modifications: D.G. Tew; Biochemistry 32, 10209 (1993) Abstract
Diphenyleneiodonium sulfate, an NADPH oxidase inhibitor, prevents early alcohol-induced liver injury in the rat: H. Kono, et al.; Am. J. Physiol. Gastrointest. Liver Physiol. 280, G1005 (2001) Abstract
Diphenyleneiodonium inhibits NF-kappaB activation and iNOS expression induced by IL-1beta: involvement of reactive oxygen species: A.F. Mendes, et al.; Mediators Inflamm. 10, 209 (2001) Abstract
Preferential inhibition of the plasma membrane NADH oxidase (NOX) activity by diphenyleneiodonium chloride with NADPH as donor: D.J. Morre; Antioxid. Redox Signal 4, 207 (2002) Abstract
G2 cell cycle arrest, down-regulation of cyclin B, and induction of mitotic catastrophe by the flavoprotein inhibitor diphenyleneiodonium: R.M. Scaife; Mol. Cancer Ther. 3, 1229 (2004) Abstract
Induction of apoptosis and modulation of production of reactive oxygen species in human endothelial cells by diphenyleneiodonium: A. Balcerczyk, et al.; Biochem. Pharmacol. 69, 1263 (2005) Abstract
Selective and irreversible cell cycle inhibition by diphenyleneiodonium: R.M. Scaife; Mol. Cancer Ther. 4, 876 (2005) Abstract
Further Categories Containing This Product:
Oxygenases Other Products • Respiratory Chain Other Products • Cytochrome P450 [CYP450]/Related Products
 
 
ALX-430-119 Revised 31-Jul-07
DIPPMPO
Add to Clipboard
SYNONYMS 5-(Diisopropoxyphosphoryl)-5-methyl-1-pyrroline-N-oxide
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Spin Traps, Spin Probes & Spin Labels
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-119-M050   50 mg 160.00 USD Add To Cart
ALX-430-119-M500   500 mg 1'120.00 USD Add To Cart
Product Specification
FORMULA: C11H22NO4P
MW: 263.3
PURITY: ≥98% (1H-NMR)
APPEARANCE: Colorless crystals.
SOLUBILITY: Soluble in water, 100% ethanol or methylene chloride.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -80°C
HANDLING: Protect from light. Hygroscopic.

Product Description

Beside DEPMPO (Prod. No. ALX-430-093), most efficient spin trap for the in vitro and in vivo detection of O-, N-, S-, and C-centered free radicals. Has a longer life-time than DMPO (Prod. No. ALX-430-129). More lipophilic (Kp=2.1) than DEPMPO.
Product Specific Literature References
5-(Diisopropoxyphosphoryl)-5-methyl-1-pyrroline-N-oxide, DIPPMPO, a crystalline analog of the nitrone DEPMPO: synthesis and spin trapping properties: F. Chalier & P. Tordo; J. C. S. Perkin Trans. II 2002, 2110 Abstract
The line asymmetry of electron spin resonance spectra as a tool to determine the cis:trans ratio for spin-trapping adducts of chiral pyrrolines N-oxides: the mechanism of formation of hydroxyl radical adducts of EMPO, DEPMPO, and DIPPMPO : M. Culcasi, et al.; Free Radic. Biol. Med. 40, 1524 (2006) Abstract
 
 
ALX-430-088 Revised 13-Aug-08
DMPIO
Add to Clipboard
SYNONYMS 2,2-Dimethyl-4-phenyl-2H-imidazole-1-oxide
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Spin Traps, Spin Probes & Spin Labels
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-088-M010   10 mg 20.00 USD Add To Cart
ALX-430-088-M050   50 mg 70.00 USD Add To Cart
Product Specification
FORMULA: C11H12N2O
MW: 188.2
PURITY: ≥98% (GLC)
APPEARANCE: White to off-white crystalline solid.
SOLUBILITY: Soluble in 100% ethanol, DMSO; only weakly soluble in water.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
MELTINGPOINT: 108-109°C

Product Description
Widely used, cell permeable and highly sensitive spin trap. Alternative to PBN (Prod. No. ALX-430-082). More lipophilic than TMIO (Prod. No. ALX-430-073). Does not trap the superoxide radical.
Product Specific Literature References
Spin trapping of O-, C-, and S-centered radicals and peroxynitrite by 2H-imidazole-1-oxides: S.I. Dikalov, et al.; BBRC 218, 616 (1996) Abstract
Oxygen-centered spin adducts of 5,5-dimethyl-1-pyrroline N-oxide (DMPO) and 2H-imidazole-1-oxides: A.G. Krainev, et al.; J. Magnet. Reson. Series B. 111, 272 (1996) Abstract
 
 
ALX-430-090 Revised 28-Aug-07
DMPO (high purity)
Add to Clipboard
SYNONYMS 5,5-Dimethyl-1-pyrroline-N-oxide (high purity)
2,2-Dimethyl-3,4-dihydro-2H-pyrrole 1-oxide (high purity)
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Spin Traps, Spin Probes & Spin Labels
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-090-M500   500 mg 115.00 USD Add To Cart
ALX-430-090-G001   1 g 190.00 USD Add To Cart
Product Specification
FORMULA: C6H11NO
MW: 113.2
PURITY: ≥99% (GLC)
APPEARANCE: White crystalline to colorless liquid.
SOLUBILITY: Soluble in water, 100% ethanol, methanol or DMSO.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from light and moisture. Hygroscopic.

Product Description
Cell permeable hydrophilic spin trap for both in vivo and in vitro studies of superoxide, O-, C-, S- and N- centered free radicals.
Product Specific Literature References
The spin trapping of superoxide and hydroxyl free radicals with DMPO (5,5-dimethylpyrroline-N-oxide): more about iron: G.R. Buettner; Free Radic. Res. Comm. 19 Suppl 1, S79 (1993) Abstract
Nitric oxide, superoxide and peroxynitrite: putative mediators of NMDA-induced cell death in cerebellar granule cells: M. Lafon-Cazal, et al.; Neuropharmacology 32, 1259 (1993) Abstract
Nitrone spin traps and a nitroxide antioxidant inhibit a common pathway of thymocyte apoptosis: A.F. Slater, et al.; Biochem. J. 306, 771 (1995) Abstract
Oxygen-centered spin adducts of 5,5-dimethyl-1-pyrroline N-oxide (DMPO) and 2H-imidazole 1-oxides: A.G. Krainev, et al.; J. Magn. Reson. B. 111, 272 (1996) Abstract
Formation of reactive oxygen species by pentaerithrityltetranitrate and glyceryl trinitrate in vitro and development of nitrate tolerance: S. Dikalov, et al.; J. Pharmacol. Exp. Ther. 286, 938 (1998) Abstract; Full Text
Formation of spin trap adducts during the decomposition of peroxynitrite: R.M. Gatti, et al.; Arch. Biochem. Biophys. 349, 36 (1998) Abstract
MDL 101,002, a free radical spin trap, is efficacious in permanent and transient focal ischemia models: M.P. Johnson, et al.; Life Sci. 63, 241 (1998) Abstract
Generation of nitric oxide from spin-trapping agents under oxidative conditions: K. Saito, et al.; Biosci. Biotech. Biochem. 62, 275 (1998)
Electron spin resonance detection of extracellular superoxide anion released by cultured endothelial cells: J.P. Souchard, et al.; Free Radic. Res. 29, 441 (1998) Abstract
Superoxide generation from endothelial nitric-oxide synthase. A Ca2+/calmodulin-dependent and tetrahydrobiopterin regulatory process: Y. Xia, et al.; J. Biol. Chem. 273, 25804 (1998) Abstract; Full Text
ESR measurement of rapid penetration of DMPO and DEPMPO spin traps through lipid bilayer membranes: K. Anzai, et al.; Arch. Biochem. Biophys. 415, 251 (2003) Abstract
Hydroxyl radical generation caused by the reaction of singlet oxygen with a spin trap, DMPO, increases significantly in the presence of biological reductants: C. Nishizawa, et al.; Free Radic. Res. 38, 385 (2004) Abstract
A new kinetic approach to the evaluation of rate constants for the spin trapping of superoxide/hydroperoxyl radical by nitrones in aqueous media: R. Lauricella, et al.; Org. Biomol. Chem. 2, 1304 (2004) Abstract
Superoxide radical anion adduct of 5,5-dimethyl-1-pyrroline n-oxide (DMPO). 1. The thermodynamics of formation and its acidity: F.A. Villamena, et al.; J. Phys. Chem. A. Mol. Spectrosc. Kinet. Environ. Gen. Theory 109, 6083 (2005) Abstract
Superoxide radical anion adduct of 5,5-dimethyl-1-pyrroline N-oxide (DMPO). 2. The thermodynamics of decay and EPR spectral properties: F.A. Villamena, et al.; J. Phys. Chem. A. Mol. Spectrosc. Kinet. Environ. Gen. Theory 109, 6089 (2005) Abstract
Characterization of the high-resolution ESR spectra of superoxide radical adducts of 5-(diethoxyphosphoryl)-5-methyl-1-pyrroline N-oxide (DEPMPO) and 5,5-dimethyl-1-pyrroline N-oxide (DMPO). Analysis of conformational exchange: S. Dikalov, et al.; Free Radic. Res. 39, 825 (2005) Abstract
Assignment of the EPR spectrum of 5,5-dimethyl-1-pyrroline N-oxide (DMPO) superoxide spin adduct: J.L. Clement, et al.; J. Org. Chem. 70, 1198 (2005) Abstract
Evaluation of spin trapping agents and trapping conditions for detection of cell-generated reactive oxygen species: H. Shi, et al.; Arch. Biochem. Biophys. 437, 59 (2005) Abstract
Nitric oxide decreases the stability of DMPO spin adducts: K.J. Reszka, et al.; Nitric Oxide 15, 133 (2006) Abstract
Immunolocalization of hypochlorite-induced, catalase-bound free radical formation in mouse hepatocytes: M.G. Bonini et al.; Free Rad. Biol. Med. 42, 530 (2007)