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Nitric Oxide Pathway
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ALX-101-004 Revised 03-Aug-07
L-Arginine
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SYNONYMS H-L-Arg-OH
PRODUCT LINE Combinatorial Chemistry
PRODUCT CATEGORY L-Amino Acids
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-101-004-G025   25 g 17.00 USD Add To Cart
Product Specification
FORMULA: C6H14N4O2
MW: 174.2
CAS NUMBER: 74-79-3
MERCK INDEX: 14: 780
RTECS: CF1934200
PURITY: ≥98%
APPEARANCE: White powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Specific Literature References
L-arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation: R.M.J. Palmer, et al.; BBRC 153, 1251 (1988) Abstract
Vascular endothelial cells synthesize nitric oxide from L-arginine: R.M.J. Palmer, et al.; Nature 333, 664 (1988) Abstract
Insulin secretion from pancreatic B cells caused by L-arginine-derived nitrogen oxides: H.H.H.W. Schmidt, et al.; Science 255, 721 (1992) Abstract
The importance of L-arginine metabolism in melanoma: an hypothesis for the role of nitric oxide and polyamines in tumor angiogenesis: M. Joshi; Free Radic. Biol. Med. 22, 573 (1997), (Review) Abstract
L-arginine increases UVA cytotoxicity in irradiated human keratinocyte cell line: potential role of nitric oxide: C. Didier, et al.; FASEB J. 13, 1817 (1999) Abstract; Full Text
L-Arginine supplementation enhances diabetic wound healing: involvement of the nitric oxide synthase and arginase pathways: M.B. Witte, et al.; Metabolism 51, 1269 (2002) Abstract
Pharmacokinetics and pharmacodynamics of L-arginine in rats: a model of stimulated neuronal nitric oxide synthesis: E.L. Heinzen & G.M. Pollack; Brain Res. 989, 67 (2003) Abstract
L-arginine regulates neuronal nitric oxide synthase production of superoxide and hydrogen peroxide: P. Tsai, et al.; Biochem. Pharmacol. 69, 971 (2005) Abstract
Protective effects of L-arginine against cisplatin-induced renal oxidative stress and toxicity: role of nitric oxide: S. Saleh & E. El-Demerdash; Basic Clin. Pharmacol. Toxicol. 97, 91 (2005) Abstract
General Information
Physiological precursor for the formation of nitric oxide (NO) by nitric oxide synthase (NOS). Enhances the release of NO.
Further Categories Containing This Product:
Arginine & Arginases / Related ProductsNitric Oxide Donors
 
 
ALX-101-005 Revised 22-Nov-06
D-Arginine
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SYNONYMS H-D-Arg-OH
PRODUCT LINE Combinatorial Chemistry
PRODUCT CATEGORY D-Amino Acids
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-101-005-G005   5 g 62.00 USD Add To Cart
Product Specification
FORMULA: C6H14N4O2
MW: 174.2
CAS NUMBER: 157-06-2
PURITY: ≥99.0%
APPEARANCE: White powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Further Categories Containing This Product:
Arginine & Arginases / Related Products
 
 
ALX-101-018 Revised 30-Jan-06
L-Glutamic acid
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PRODUCT LINE Combinatorial Chemistry
PRODUCT CATEGORY L-Amino Acids
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ALX-101-018-G001   1 g 12.00 USD Add To Cart
Product Specification
FORMULA: C5H9NO4
MW: 147.1
CAS NUMBER: 56-86-0
MERCK INDEX: 14: 4469
RTECS: LZ9700000
PURITY: ≥99%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Further Categories Containing This Product:
Excitatory Amino AcidsNitric Oxide Pathway Other Products
 
 
ALX-101-036 Revised 22-Nov-06
L-Ornithine . hydrochloride
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PRODUCT LINE Combinatorial Chemistry
PRODUCT CATEGORY L-Amino Acids
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ALX-101-036-G005   5 g 12.00 USD Add To Cart
ALX-101-036-G025   25 g 27.00 USD Add To Cart
Product Specification
FORMULA: C5H12N2O2 . HCl
MW: 132.1 . 36.5
CAS NUMBER: 3184-13-2
MERCK INDEX: 14: 6874
RTECS: RM2985000
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Further Categories Containing This Product:
Arginine & Arginases / Related Products
 
 
ALX-101-037 Revised 10-Feb-03
D-Ornithine . hydrochloride
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PRODUCT LINE Combinatorial Chemistry
PRODUCT CATEGORY D-Amino Acids
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ALX-101-037-G001   1 g 17.00 USD Add To Cart
ALX-101-037-G005   5 g 62.00 USD Add To Cart
Product Specification
FORMULA: C5H12N2O2 . HCl
MW: 132.1 . 36.5
CAS NUMBER: 16682-12-5
PURITY: ≥99%
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Further Categories Containing This Product:
Arginine & Arginases / Related Products
 
 
ALX-105-001 Revised 06-Jun-06
NG-Nitro-L-arginine
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SYNONYMS L-NOARG
L-Nitroarginine
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY NOS Inhibitors (NOS Induction & Enzyme Activity)
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ALX-105-001-G005   5 g 22.00 USD Add To Cart
ALX-105-001-G025   25 g 63.00 USD Add To Cart
Product Specification
FORMULA: C6H13N5O4
MW: 219.2
CAS NUMBER: 2149-70-4
PURITY: ≥99%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 0.1N HCl. Moderately soluble in water; insoluble in methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Inhibitor of nitric oxide synthase (NOS).
Product Specific Literature References
L-NG-monomethyl arginine and L-NG-nitro arginine inhibit non-adrenergic, non-cholinergic relaxation of the mouse anococcygeus muscle: A. Gibson, et al.; Br. J. Pharmacol. 99, 602 (1990) Abstract
N omega-nitro-L-arginine: a potent inhibitor of endothelium-derived relaxing factor formation: K. Ishii, et al.; Eur. J. Pharmacol. 176, 219 (1990) Abstract
L-NG-nitro arginine (L-NOARG), a novel, L-arginine-reversible inhibitor of endothelium-dependent vasodilatation in vitro: P.K. Moore, et al.; Br. J. Pharmacol. 99, 408 (1990) Abstract
Inhibitory effects of L-NG-nitro-arginine on the synthesis of EDRF and the cerebroarterial response to vasodilator nerve stimulation: N. Toda, et al.; Life. Sci. 47, 345 (1990) Abstract
The influence of L-NG-nitro-arginine on field stimulation induced contractions and acetylcholine release in guinea pig isolated tracheal smooth muscle: S.R. Brave, et al.; BBRC 179, 1017 (1991) Abstract
Nitric oxide synthase: irreversible inhibition by L-NG-nitroarginine in brain in vitro and in vivo: M.A. Dwyer, et al.; BBRC 176, 1136 (1991) Abstract
On the substrate specificity of nitric oxide synthase: M. Hecker, et al.; FEBS Lett. 294, 221 (1991) Abstract
Enhanced photorelaxation in aorta, pulmonary artery and corpus cavernosum produced by BAY K 8644 or N-nitro-L-arginine: X. Chen and C.N. Gillis; BBRC 186, 1522 (1992) Abstract
Possible involvement of nitric oxide in chlordiazepoxide-induced anxiolysis in mice: R.M. Quock and E. Nguyen; Life Sci. 51, PL255 (1992) Abstract
The role of nitric oxide in mediating non-adrenergic non-cholinergic relaxation in longitudinal muscle of human taenia coli: F.S.-F. Tam & K. Hillier; Life Sci 51, 1277 (1992) Abstract
NO- and NO2-carrying molecules potentiate photorelaxation in rat trachea and aorta: K.C. Chang, et al.; BBRC 191, 509 (1993) Abstract
Selective inhibition of constitutive nitric oxide synthase by L-NG- nitroarginine: E.S. Furfine, et al.; Biochemistry 32, 8512 (1993) Abstract
Blockade of tolerance to morphine but not to kappa opioids by a nitric oxide synthase inhibitor: Y.A. Kolesnikov, et al.; PNAS 90, 5162 (1993) Abstract
Reversible inactivation of endothelial nitric oxide synthase by NG- nitro-L-arginine: B. Mayer, et al.; FEBS Lett. 333, 203 (1993) Abstract
 
 
ALX-105-002 Revised 12-Nov-07
NG-Nitro-D-arginine
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SYNONYMS D-NOARG
D-Nitroarginine
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY NOS Inhibitors (NOS Induction & Enzyme Activity)
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ALX-105-002-M250   250 mg 22.00 USD Add To Cart
ALX-105-002-G001   1 g 53.00 USD Add To Cart
Product Specification
FORMULA: C6H13N5O4
MW: 219.2
CAS NUMBER: 66036-77-9
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 0.1M HCl. Moderately soluble in water; insoluble in methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

 
 
ALX-105-003 Revised 02-Dec-05
L-NAME . hydrochloride
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SYNONYMS NG-Nitro-L-arginine-methyl ester . HCl
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY NOS Inhibitors (NOS Induction & Enzyme Activity)
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ALX-105-003-G005   5 g 32.00 USD Add To Cart
ALX-105-003-G025   25 g 133.00 USD Add To Cart
Product Specification
FORMULA: C7H15N5O4 . HCl
MW: 233.2 . 36.5
CAS NUMBER: 51298-62-5
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Inhibitor of nitric oxide synthase (NOS). More soluble than NG-Nitro-L-arginine (Prod. No. ALX-105-001). Suppresses the release of nitric oxide (NO) from endothelial cells. Has a different effect on the superoxide generation by NOS than L-NMMA (Prod. No. ALX-106-001).
Product Specific Literature References
L-NG-nitro arginine (L-NOARG), a novel, L-arginine-reversible inhibitor of endothelium-dependent vasodilatation in vitro: P.K. Moore, et al.; Br. J. Pharmacol. 99, 408 (1990) Abstract
Generation of superoxide by purified brain nitric oxide synthase: S. Pou, et al.; J. Biol. Chem. 267, 24173 (1992) Abstract; Full Text
 
 
ALX-105-004 Revised 02-Dec-05
D-NAME . hydrochloride
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SYNONYMS NG-Nitro-D-arginine-methyl ester . HCI
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY NOS Inhibitors (NOS Induction & Enzyme Activity)
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-105-004-M250   250 mg 32.00 USD Add To Cart
Product Specification
FORMULA: C7H15N5O4 . HCl
MW: 233.2 . 36.5
CAS NUMBER: 50912-92-0
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in methanol or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Inactive isomer of L-NAME (Prod. No. ALX-105-003).
 
 
ALX-105-009 Revised 06-Jun-06
N-Methyl-D-aspartic acid
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SYNONYMS NMDA
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY NOS Inhibitors (NOS Induction & Enzyme Activity)
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ALX-105-009-M010   10 mg 23.00 USD Add To Cart
ALX-105-009-M050   50 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C5H9NO4
MW: 147.1
CAS NUMBER: 6384-92-5
MERCK INDEX: 14: 6662
RTECS: CI9457000
PURITY: ≥98%
APPEARANCE: White crystalline powder.
SOLUBILITY: Soluble in dilute aqueous base; slightly soluble in water or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HANDLING: Protect from light.

Product Description
Selective ionotropic NMDA receptor agonist.
Product Specific Literature References
Excitatory amino acid transmitters: J.C. Watkins & R.H. Evans; Ann. Rev. Pharmacol. Toxicol. 21, 165 (1981), (Review) Abstract
NMDA receptors and ligands in the vertebrate CNS: T.W. Stone & N.R. Burton; Progr. Neurobiol. 30, 333 (1988), (Review) Abstract
Further Categories Containing This Product:
NMDA Receptors / Related ProductsSpecial Amino Acids
 
 
ALX-105-010 Revised 04-Dec-04
N-Methyl-L-aspartic acid
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SYNONYMS NMLA
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY NOS Inhibitors (NOS Induction & Enzyme Activity)
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ALX-105-010-M010   10 mg 20.00 USD Add To Cart
ALX-105-010-M050   50 mg 50.00 USD Add To Cart
Product Specification
FORMULA: C5H9NO4
MW: 147.1
CAS NUMBER: 4226-18-0
PURITY: ≥98%
APPEARANCE: White crystalline powder.
SOLUBILITY: Soluble in dilute aqueous base.
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