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Nitric Oxide Pathway
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ALX-400-016 Revised 28-Nov-04
Galvinoxyl, free radical
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SYNONYMS 2,6-di-t-Butyl-α-(3,5-di-t-butyl-4-oxo-2,5-cyclohexadien-1-ylidene)-p-tolyloxy, free radical
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Free Radicals / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-400-016-M010   10 mg 15.00 USD Add To Cart
ALX-400-016-M050   50 mg 45.00 USD Add To Cart
Product Specification
FORMULA: C29H41O2
MW: 421.6
CAS NUMBER: 2370-18-5
PURITY: ≥95%
APPEARANCE: Dark brownish crystalline powder.
SOLUBILITY: Soluble in chloroform.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Free radical compound.
 
 
ALX-400-018 Revised 30-Nov-06
3-Carboxy-2,2,5,5-tetramethyl-1-pyrrolidine-1-oxyl, free radical
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PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Free Radicals / Related Products
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ALX-400-018-M010   10 mg 20.00 USD Add To Cart
ALX-400-018-M050   50 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C9H16NO3
MW: 186.2
CAS NUMBER: 2154-68-9
PURITY: ≥98%
APPEARANCE: Yellow crystalline powder.
SOLUBILITY: Soluble in water or methanol.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: IRRITANT.

Product Description
Free radical compound.
Product Specific Literature References
Probing the intracellular redox status of tumors with magnetic resonance imaging and redox-sensitive contrast agents: F. Hyodo, et al.; Cancer Res. 66, 9921 (2006) Abstract
 
 
ALX-400-019 Revised 27-Oct-06
4-Amino-TEMPO, free radical
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SYNONYMS 4-Amino-2,2,6,6-tetramethylpiperidine-1-oxyl, free radical
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Free Radicals / Related Products
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ALX-400-019-M010   10 mg 15.00 USD Add To Cart
ALX-400-019-M050   50 mg 45.00 USD Add To Cart
Product Specification
FORMULA: C9H19N2O
MW: 171.3
CAS NUMBER: 14691-88-4
PURITY: ≥97%
APPEARANCE: Orange to red solid or liquid.
SOLUBILITY: Soluble in methanol.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from light and moisture. Packaged under inert gas.
HAZARD: IRRITANT.

Product Description
Free radical compound.
 
 
ALX-430-081 Revised 22-May-08
TEMPOL
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SYNONYMS 4-OH-TEMPO
4-Hydroxy-TEMPO
4-Hydroxy-2,2,6,6-tetramethylpiperidinyloxy, free radical
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Spin Traps, Spin Probes & Spin Labels
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-081-M250   250 mg 15.00 USD Add To Cart
ALX-430-081-M500   500 mg 25.00 USD Add To Cart
ALX-430-081-G001   1 g 38.00 USD Add To Cart
Product Specification
FORMULA: C9H18NO2
MW: 172.2
CAS NUMBER: 2226-96-2
PURITY: ≥98% (HPLC, EPR)
APPEARANCE: Yellow to orange crystalline solid.
SOLUBILITY: Soluble in water, 100% ethanol, methanol or DMSO.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Free radical scavenger useful for both in vivo and in vitro experiments.
Product Specific Literature References
Measurement of intracellular oxygen concentration using the spin label TEMPOL: P.D. Morse, 2nd & H.M. Swartz; Magn. Reson. Med. 2, 114 (1985) Abstract
Inhibition of oxygen-dependent radiation-induced damage by the nitroxide superoxide dismutase mimic, tempol: J.B. Mitchell, et al.; Arch. Biochem. Biophys. 289, 62 (1991) Abstract
Tempol, a stable free radical, is a novel murine radiation protector: S.M. Hahn, et al.; Cancer Res. 52, 1750 (1992) Abstract
Protective effect of 4-hydroxy-TEMPO, a low molecular weight superoxide dismutase mimic, on free radical toxicity in experimental pancreatitis: Z. Sledzinski, et al.; Int. J. Pancreatol. 18, 153 (1995) Abstract
A novel antioxidant alleviates heat hyperalgesia in rats with an experimental painful peripheral neuropathy: M. Tal; Neuroreport 7, 1382 (1996) Abstract
Stable nitroxide radicals protect lipid acyl chains from radiation damage: A.M. Samuni & Y. Barenholz; Free Radic. Biol. Med. 22, 1165 (1997) Abstract
Tempol inhibits neutrophil and hydrogen peroxide-mediated DNA damage: S.M. Hahn, et al.; Free Radic. Biol. Med. 23, 879 (1997) Abstract
Effects of the superoxide dismutase-mimic compound TEMPOL on oxidant stress-mediated endothelial dysfunction: A.I. Haj-Yehia, et al.; Antioxid. Redox. Signal. 1, 221 (1999) Abstract
The nitroxide tempol induces oxidative stress, p21(WAF1/CIP1), and cell death in HL60 cells: M.B. Gariboldi, et al.; Free Radic. Biol. Med. 29, 633 (2000) Abstract
Nitroxide TEMPOL impairs mitochondrial function and induces apoptosis in HL60 cells: E. Monti, et al.; J. Cell. Biochem. 82, 271 (2001) Abstract
Spin trapping agents (Tempol and POBN) protect HepG2 cells overexpressing CYP2E1 against arachidonic acid toxicity: M.J. Perez & A.I. Cederbaum; Free Radic. Biol. Med. 30, 734 (2001) Abstract
Systemic arterial pressure response to two weeks of Tempol therapy in SHR: involvement of NO, the RAS, and oxidative stress: L. Yanes, et al.; Am. J. Physiol. Regul. Integr.Comp. Physiol. 288, R903 (2005) Abstract
Tempol, one of nitroxides, is a novel ultraviolet-A1 radiation protector for human dermal fibroblasts: S.X. Yan, et al.; J. Dermatol. Sci. 37, 137 (2005) Abstract
Cancer chemoprevention by the antioxidant tempol acts partially via the p53 tumor suppressor: L. Erker, et al.; Hum. Mol. Genet. 14, 1699 (2005) Abstract
Antioxidant enzymes and effects of tempol on the development of hypertension induced by nitric oxide inhibition: J. Sainz, et al.; Am. J. Hypertens. 18, 871 (2005) Abstract
Neuroprotective effects of TEMPOL in central and peripheral nervous system models of Parkinson’s disease: Q. Liang, et al.; Biochem. Pharmacol. 70, 1371 (2005)
The role of oxidant stress in angiotensin II-mediated contraction of human resistance arteries in the state of health and the presence of cardiovascular disease: M.B. Hussain, et al.; Vascul. Pharmacol. 45, 395 (2006) Abstract
Acute effects of the superoxide dismutase mimetic tempol on split kidney function in two-kidney one-clip hypertensive rats: G.S. Guron, et al.; J. Hypertens. 24, 387 (2006) Abstract
The effects of tempol, 3-aminobenzamide and nitric oxide synthase inhibitors on acoustic injury of the mouse cochlea: H. Murashita, et al.; Hear. Res. 214, 1 (2006) Abstract
The nitroxide Tempol modulates anthracycline resistance in breast cancer cells: M.B. Gariboldi, et al.; Free Radic. Biol. Med. 40, 1409 (2006) Abstract
Probing the intracellular redox status of tumors with magnetic resonance imaging and redox-sensitive contrast agents: F. Hyodo, et al.; Cancer Res. 66, 9921 (2006) Abstract
Neuroprotective effects of the stable nitroxide compound Tempol on 1-methyl-4-phenylpyridinium ion-induced neurotoxicity in the Nerve Growth Factor-differentiated model of pheochromocytoma PC12 cells: T. Lipman, et al.; Eur. J. Pharmacol. 549, 50 (2006) Abstract
A mitochondria-targeted nitroxide is reduced to its hydroxylamine by ubiquinol in mitochondria: J. Trnka, et al.; Free Radic. Biol. Med. 44, 1406 (2008) Abstract
Further Categories Containing This Product:
Free Radicals / Related Products
 
 
ALX-430-100 Revised 18-Feb-08
TOAC
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SYNONYMS 2,2,6,6-Tetramethylpiperidine-1-oxyl-4-amino-4-carboxylic acid, free radical
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Spin Traps, Spin Probes & Spin Labels
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ALX-430-100-M100   100 mg 45.00 USD Add To Cart
Product Specification
FORMULA: C10H19N2O3
MW: 215.3
CAS NUMBER: 15871-57-5
PURITY: ≥96%
APPEARANCE: White to light yellow crystalline solid.
SOLUBILITY: Soluble in DMSO, 100% ethanol, acetone or benzene; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Nitroxide spin-labelled C α,α-disubstituted glycine derivative. Effective β-turn and 3(10)/α-helix promoter in peptides. Excellent rigid electron paramagnetic resonance probe and fluorescence quencher.
Product Specific Literature References
Crystallographic characterization of geometry and conformation of TOAC, a nitroxide spin-labelled C alpha,alpha-disubstituted glycine, in simple derivatives and model peptides: J.L. Flippen-Anderson, et al.; Int. J. Pept. Prot. Res. 47, 231 (1996) Abstract
Solution structures of TOAC-labeled Trichogin GA IV peptides from allowed (ga ca. 2) and half-field electron spin resonance: D.J. Anderson, et al.; JACS 121, 6919 (1999)
First interchain peptide interaction detected by ESR in fully synthetic, template-assisted, two-helix bundles: A. Polese, et al.; JACS 121, 11071 (1999)
Correlation between the mobility of spin-labeled peptide chains and resin solvation: an approach to optimize the synthesis of aggregating sequences: E.M. Cilli, et al.; J. Org. Chem. 64, 9118 (1999)
TOAC: a useful C<συπ>α</συπ>-tetrasubstituted α-amino acid for peptide conformational analysis by CD spectroscopy in the visible region. Part I: T.T.T. Bui, et al.; J. Chem. Soc. Perkin Trans. 2 1043 (2000)
Electron spin resonance of TOAC labeled peptides: folding transitions and high frequency spectroscopy: J.C. McNulty, et al.; Biopolymers 55, 479 (2000) Abstract
Solid-phase synthesis of peptides containing the spin-labeled 2,2,6,6-tetramethylpiperidine-1-oxyl-4-amino-4-carboxylic acid (TOAC): L. Martin, et al.; J. Pept. Res. 58, 424 (2001) Abstract
Further Categories Containing This Product:
Free Radicals / Related Products
 
 
ALX-430-102 Revised 04-Jun-08
RSSR
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SYNONYMS bis-(2,2,5,5-Tetramethyl-3-imidazoline-1-oxyl-4-yl)disulfide, biradical
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Spin Traps, Spin Probes & Spin Labels
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ALX-430-102-M010   10 mg 70.00 USD Add To Cart
ALX-430-102-M025   25 mg 140.00 USD Add To Cart
ALX-430-102-M050   50 mg 240.00 USD Add To Cart
Product Specification
FORMULA: C14H24N4O2S2
MW: 344.5
PURITY: ≥97% (HPLC)
APPEARANCE: Off-white to yellow powder.
SOLUBILITY: Soluble in DMSO, water, 100% ethanol or methanol; DMSO is recommended for stock solution.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description

Cell permeable supersensitive spin label (detection limit varies from 10nM to 100nM) for quick detection of reduced thiols using ESR. Allows following the reactions of sulfhydryl groups with RSSR to form thiol spin label adducts, for the monitoring of intracellular redox states of glutathione and other thiols.
Product Specific Literature References
Quantitative determination of SH groups in low- and high-molecular-weight compounds by an electron spin resonance method: V.V. Khramtsov, et al.; Anal. Biochem. 182, 58 (1989) Abstract
Quantitative determination of thiol groups in low and high molecular weight compounds by electron paramagnetic resonance: L.M. Weiner; Meth. Enzymol. 251, 87 (1995) Abstract
Quantitative determination and reversible modification of thiols using imidazolidine biradical disulfide label: V.V. Khramtsov, et al.; J. Biochem. Biophys. Methods 35, 115 (1997) Abstract
Use of imidazoline nitroxides in studies of chemical reactions. ESR measurements of the concentration and reactivity of protons, thiols and nitric oxide.: V.V. Khramtsov & L. B. Volodarsky; Spin labeling. The next Millennium. 145, 109 (1998)
Unique in vivo applications of spin traps: L.J. Berliner, et al.; Free Radic. Biol. Med. 30, 489 (2001) Abstract
In vitro and in vivo measurement of pH and thiols by EPR-based techniques: V.V. Khramtsov, et al.; Antioxid. Redox. Signal. 6, 667 (2004) Abstract
Further Categories Containing This Product:
Free Radicals / Related Products
 
 
ALX-430-145 Revised 25-Apr-07
PTMIO, free radical
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SYNONYMS 4-Phenyl-2,2,5,5-tetramethyl-3-imidazoline-1-oxyl nitroxide
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Free Radicals / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-145-M050   50 mg 45.00 USD Add To Cart
ALX-430-145-M250   250 mg 180.00 USD Add To Cart
ALX-430-145-G001   1 g 510.00 USD Add To Cart
Product Specification
FORMULA: C13H17N2O
MW: 217.3
CAS NUMBER: 39753-69-0
PURITY: ≥99% (1H-NMR, EPR)
APPEARANCE: Orange solid.
PURITY DETAIL: No paramagnectic impurities detected by EPR.
SOLUBILITY: Soluble in 100% ethanol, DMSO, acetone, chloroform or hexane. Insoluble in water.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C

Product Description

Free radical similar to 4-Amino-TEMPO (Prod. No. ALX-400-019) and 3-Carboxy-2,2,5,5-tetramethyl-1-
pyrrolidine-1-oxyl (Prod. No. ALX-400-018), but more lipophilic than the former compounds. May be useful for membrane dynamic studies.
Product Specific Literature References
Probing the intracellular redox status of tumors with magnetic resonance imaging and redox-sensitive contrast agents: F. Hyodo, et al.; Cancer Res. 66, 9921 (2006) Abstract
General Literature References
Neuroprotective effects of the stable nitroxide compound Tempol on 1-methyl-4-phenylpyridinium ion-induced neurotoxicity in the Nerve Growth Factor-differentiated model of pheochromocytoma PC12 cells: T. Lipman, et al.; Eur. J. Pharmacol. 549, 50 (2006) Abstract
Determining the topology of integral membrane peptides using EPR spectroscopy: J.J. Inbaraj, et al.; J. Am. Chem. Soc. 128, 9549 (2006) Abstract
Further Categories Containing This Product:
Spin Traps, Spin Probes & Spin Labels
 
 
ALX-270-097 Revised 07-Sep-06
Ebselen
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SYNONYMS 2-Phenyl-1,2-benzisoselenazol-3-(2H)-one
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Peroxynitrite / Scavengers / Detection
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ALX-270-097-M001   1 mg 12.00 USD Add To Cart
ALX-270-097-M005   5 mg 20.00 USD Add To Cart
ALX-270-097-M025   25 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C13H9NOSe
MW: 274.2
CAS NUMBER: 60940-34-3
PURITY: ≥98% (NMR)
APPEARANCE: White to off-white crystalline solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Selenium-based inhibitor of protein kinase C, NADPH, 5-lipoxygenase, cyclooxygenase (COX) and NADPH oxidase. Anti-inflammatory antioxidant. Mimics glutathione peroxidase. Inhibits oxidative modifications of low density lipoproteins (LDL).
Product Specific Literature References
A novel biologically active seleno-organic compound--III. Effects of PZ 51 (Ebselen) on glutathione peroxidase and secretory activities of mouse macrophages: M.J. Parnham & S. Kindt; Biochem. Pharmacol. 33, 3247 (1984) Abstract
Seleno-organic compounds and the therapy of hydroperoxide-linked pathological conditions: M.J. Parnham & E. Graf; Biochem. Pharmacol. 36, 3095 (1987) Abstract
Kinetic mechanism and substrate specificity of glutathione peroxidase activity of ebselen (PZ51): M. Maiorino, et al.; Biochem. Pharmacol. 37, 2267 (1988) Abstract
Studies on the anti-inflammatory activity of ebselen. Ebselen interferes with granulocyte oxidative burst by dual inhibition of NADPH oxidase and protein kinase C?: I.A. Cotgreave, et al.; Biochem. Pharmacol. 38, 649 (1989) Abstract
T. Nikawa, et al.; Biochem. Pharmacol. 47, 1007 (1994) Abstract
Effects of ebselen and probucol on oxidative modifications of lipid and protein of low density lipoprotein induced by free radicals: N. Noguchi, et al.; Biochim. Biophys. Acta 1213, 176 (1994) Abstract
Strong inhibition of mammalian lipoxygenases by the antiinflammatory seleno-organic compound ebselen in the absence of glutathione: C. Schewe, et al.; Biochem. Pharmacol. 48, 65 (1994) Abstract
Ebselen: a glutathione peroxidase mimic: H. Sies; Meth. Enzymol. 234, 476 (1994) Abstract
Molecular actions of ebselen-an antiinflammatory antioxidant: T. Schewe; Gen. Pharmacol. 26, 1153 (1995) Abstract
Ebselen: H. Sies; Meth. Enzymol. 252, 341 (1995) Abstract
Ebselen as a glutathione peroxidase mimic and as a scavenger of peroxynitrite: H. Sies & H. Masumoto; Adv. Pharmacol. 38, 229 (1997) Abstract
Free radical generation by selenium compounds and their prooxidant toxicity: J.E. Spallholz; Biomed. Environ. Sci. 10, 260 (1997) Abstract
Protection against peroxynitrite by selenoproteins: H. Sies, et al.; Z. Naturforsch. [C] 53, 228 (1998) Abstract
Ebselen protects mice against T cell-dependent, TNF-mediated apoptotic liver injury: G. Tiegs, et al.; J. Pharmacol. Exp. Ther. 287, 1098 (1998) Abstract; Full Text
Further Categories Containing This Product:
PKC Inhibitors • Malaria / Related Products • Lipoxygenases / Related Products • Antioxidants, Flavonoids & Free Radical Scavengers Other Products • COX Inhibitors • Anti-inflammatory Agents Other Products
 
 
ALX-270-252 Revised 03-Mar-05
MEG . sodium succinate
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SYNONYMS Mercaptoethylguanidine . sodium succinate
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY NOS Inhibitors (NOS Induction & Enzyme Activity)
Ordering Information
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ALX-270-252-M010   10 mg 95.00 USD Add To Cart
Product Specification
FORMULA: C3H10N3S . C4H4O4Na
MW: 120.2 . 139.1
PURITY: ≥90%
APPEARANCE: White solid.
SOLUBILITY: Soluble in water.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Keep under inert gas. Keep cool and dry. Protect from moisture.