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ALX-350-061 Revised 08-Oct-08
Nodularin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Microcystins
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-061-C050   50 µg 37.00 USD Add To Cart
ALX-350-061-C100   100 µg 70.00 USD Add To Cart
ALX-350-061-C250   250 µg 155.00 USD Add To Cart
ALX-350-061-M001   1 mg 530.00 USD Add To Cart
Product Specification
FORMULA: C41H60N8O10
MW: 825.0
CAS NUMBER: 118399-22-7
RTECS: GU2294250
SOURCE/HOST: Isolated from Nodularia spumigena.
PURITY: ≥95% (HPLC)
APPEARANCE: Dry residue containing traces of monobasic potassium phosphate.
SOLUBILITY: Soluble in methanol:water (1:1).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: TOXIC.

Product Description
Inhibitor of protein phosphatase 1 (PP1) (IC50=1.8nM), protein phosphatase 2A (PP2A) (IC50=0.026nM) and to a lesser extent protein phosphatase 2B (PP2B) (IC50=8.7µm). Similar to microcystin-LR (Prod. No. ALX-350-012) but with increased water solubility. Genotoxic. Hepatoxic. Induces oxidative DNA damage by oxidation of purines. Induces apoptosis in HepG2 cells.
Product Specific Literature References
Nodularin, microcystin and the configuration of Adda: K.L. Rinehart, et al.; JACS 110, 8557 (1988)
Toxicity and partial structure of a hepatotoxic peptide produced by the cyanobacterium Nodularia spumigena Mertens emend. L575 from New Zealand: W.W. Carmichael, et al.; Appl. Environ. Microbiol. 54, 2257 (1988) Abstract
Inhibition of protein phosphatases by microcystins and nodularin associated with hepatotoxicity: S. Yoshizawa, et al.; J. Cancer Res. Clin. Oncol. 116, 609 (1990) Abstract
Rapid purification of the peptide toxins microcystin-LR and nodularin: C. Martin, et al.; FEMS Microbiol. Lett. 56, 1 (1990) Abstract
In vitro and in vivo effects of protein phosphatase inhibitors, microcystins and nodularin, on mouse skin and fibroblasts: R. Matsushima, et al.; BBRC 171, 867 (1990) Abstract
Internal surface reversed-phase high-performance liquid chromatographic separation of the cyanobacterial peptide toxins microcystin-LA, -LR, -YR, -RR and nodularin: J.A. Meriluoto, et al.; J. Chromatogr. 509, 390 (1990) Abstract
Cyanobacterial nodularin is a potent inhibitor of type 1 and type 2A protein phosphatases: R.E. Honkanen, et al.; Mol. Pharmacol. 40, 577 (1991) Abstract
Degradation of the cyanobacterial hepatotoxin, nodularin, under light and dark conditions: H. Twist & G.A. Codd; FEMS Microbiol. Lett. 151, 83 (1997) Abstract
Isolation and detection of microcystins and nodularins, cyanobacterial peptide hepatotoxins: J. Meriluoto, et al.; Methods Mol. Biol. 145, 65 (2000) Abstract
Influence of microcystin-YR and nodularin on the activity of some proteolytic enzymes in mouse liver: A. Lankoff & A. Kolataj; Toxicon 39, 419 (2001) Abstract
Nodularin-Har: a new nodularin from Nodularia: K. Saito, et al; J. Nat. Prod. 64, 139 (2001) Abstract
Detection of nodularin in flounders and cod from the Baltic Sea: V. Sipia, et al.; Environ. Toxicol. 16, 121 (2001) Abstract
The microcystins and nodularins: cyclic polypeptide inhibitors of PP1 and PP2A: B.M. Gulledgea, et al.; Curr. Med. Chem. 9, 1991 (2002) Abstract
Study on the distribution of nodularin in tissues and cell level in mice: Z. Zhang, et al.; Zhonghua Yu Fang Yi Xue Za Zhi 36, 100 (2002) Abstract
Genotoxic potential of Microcystin-LR and nodularin in vitro in primary cultured rat hepatocytes and in vivo in rat liver: N. Bouaicha, et al.; Environ. Toxicol. 20, 341 (2005) Abstract
Bacterial degradation of microcystins and nodularin: S. Imanishi, et al.; Chem. Res. Toxicol. 18, 591 (2005) Abstract
Nodularin-induced genotoxicity following oxidative DNA damage and aneuploidy in HepG2 cells: A. Lankoff, et al.; Toxicol. Lett. 164, 239 (2006) Abstract
Further Categories Containing This Product:
Other Toxins
 
 

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