• Home
  • Sitemap
  • Help
  • Technical Support
  • Contact
Toolbar - View Selection
 
Items 1 of 1
ALX-350-061 Revised 30-Jun-08
Nodularin
Add to Clipboard
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Microcystins
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-061-C050   50 µg 37.00 USD Add To Cart
ALX-350-061-C100   100 µg 70.00 USD Add To Cart
ALX-350-061-C250   250 µg 155.00 USD Add To Cart
ALX-350-061-M001   1 mg 530.00 USD Add To Cart
Product Specification
FORMULA: C41H60N8O10
MW: 825.0
CAS NUMBER: 118399-22-7
SOURCE/HOST: Isolated from Nodularia spumigena.
PURITY: ≥95% (HPLC)
APPEARANCE: Dry residue containing traces of monobasic potassium phosphate.
SOLUBILITY: Soluble in methanol:water (1:1).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: TUMOR PROMOTER. HIGHLY IRRITANT.

Product Description
Inhibitor of protein phosphatase 1 (PP1) (IC50=1.8nM), protein phosphatase 2A (PP2A) (IC50=0.026nM) and to a lesser extent protein phosphatase 2B (PP2B) (IC50=8.7µm). Similar to microcystin-LR (Prod. No. ALX-350-012) but with increased water solubility. Genotoxic. Induces oxidative DNA damage by oxidation of purines. Induces apoptosis in HepG2 cells.
Product Specific Literature References
Nodularin, microcystin and the configuration of Adda: K.L. Rinehart, et al.; JACS 110, 8557 (1988)
Toxicity and partial structure of a hepatotoxic peptide produced by the cyanobacterium Nodularia spumigena Mertens emend. L575 from New Zealand: W.W. Carmichael, et al.; Appl. Environ. Microbiol. 54, 2257 (1988) Abstract
Inhibition of protein phosphatases by microcystins and nodularin associated with hepatotoxicity: S. Yoshizawa, et al.; J. Cancer Res. Clin. Oncol. 116, 609 (1990) Abstract
Rapid purification of the peptide toxins microcystin-LR and nodularin: C. Martin, et al.; FEMS Microbiol. Lett. 56, 1 (1990) Abstract
In vitro and in vivo effects of protein phosphatase inhibitors, microcystins and nodularin, on mouse skin and fibroblasts: R. Matsushima, et al.; BBRC 171, 867 (1990) Abstract
Internal surface reversed-phase high-performance liquid chromatographic separation of the cyanobacterial peptide toxins microcystin-LA, -LR, -YR, -RR and nodularin: J.A. Meriluoto, et al.; J. Chromatogr. 509, 390 (1990) Abstract
Cyanobacterial nodularin is a potent inhibitor of type 1 and type 2A protein phosphatases: R.E. Honkanen, et al.; Mol. Pharmacol. 40, 577 (1991) Abstract
Degradation of the cyanobacterial hepatotoxin, nodularin, under light and dark conditions: H. Twist & G.A. Codd; FEMS Microbiol. Lett. 151, 83 (1997) Abstract
Isolation and detection of microcystins and nodularins, cyanobacterial peptide hepatotoxins: J. Meriluoto, et al.; Methods Mol. Biol. 145, 65 (2000) Abstract
Influence of microcystin-YR and nodularin on the activity of some proteolytic enzymes in mouse liver: A. Lankoff & A. Kolataj; Toxicon 39, 419 (2001) Abstract
Nodularin-Har: a new nodularin from Nodularia: K. Saito, et al; J. Nat. Prod. 64, 139 (2001) Abstract
Detection of nodularin in flounders and cod from the Baltic Sea: V. Sipia, et al.; Environ. Toxicol. 16, 121 (2001) Abstract
The microcystins and nodularins: cyclic polypeptide inhibitors of PP1 and PP2A: B.M. Gulledgea, et al.; Curr. Med. Chem. 9, 1991 (2002) Abstract
Study on the distribution of nodularin in tissues and cell level in mice: Z. Zhang, et al.; Zhonghua Yu Fang Yi Xue Za Zhi 36, 100 (2002) Abstract
Genotoxic potential of Microcystin-LR and nodularin in vitro in primary cultured rat hepatocytes and in vivo in rat liver: N. Bouaicha, et al.; Environ. Toxicol. 20, 341 (2005) Abstract
Bacterial degradation of microcystins and nodularin: S. Imanishi, et al.; Chem. Res. Toxicol. 18, 591 (2005) Abstract
Nodularin-induced genotoxicity following oxidative DNA damage and aneuploidy in HepG2 cells: A. Lankoff, et al.; Toxicol. Lett. 164, 239 (2006) Abstract
Further Categories Containing This Product:
Other Toxins
 
 

Your items will be kept only for the duration of your visit.