ALEXIS Biochemicals: Nutlin-3

ALX-430-128

Revised 21-Feb-08

Nutlin-3
SYNONYMS	(±)-4-[4,5-bis-(4-Chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydroimidazole-1-carbonyl]-piperazin-2-one
PRODUCT LINE	Cell Cycle
PRODUCT CATEGORY	p53 Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-430-128-M001		1 mg	35.00 USD
ALX-430-128-M005		5 mg	160.00 USD
ALX-430-128-M025		25 mg	560.00 USD

Product Specification

FORMULA:	C₃₀H₃₀Cl₂N₄O₄
MW:	581.5
CAS NUMBER:	548472-68-0
PURITY:	≥98% (HPLC)
APPEARANCE:	White to off-white crystalline solid.
SOLUBILITY:	Soluble in methanol, 100% ethanol, DMSO, dimethyl formamide or acetonitrile; sparingly soluble in a 1:10 solution of ethanol:PBS, pH 7.2.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least one year after receipt when stored at -20°C. We do not recommend storing the aqueous solution for more than one day.
HAZARD:	IRRITANT.

Product Description

Inhibitor of p53/MDM2 interaction (IC₅₀=0.09µM).

Product Specific Literature References

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2: L.T. Vassilev, et al.; Science 303, 844 (2004) Abstract
Reactivation of the p53 pathway as a treatment modality for KSHV-induced lymphomas: G. Sarek, et al.; J. Clin. Invest. 117, 1019 (2007) Abstract; Full Text

General Literature References

Drug discovery and p53: D.P. Lane, et al.; Drug Discov. Today 8, 347 (2003) Abstract

Further Categories Containing This Product:

Ubiquitin Ligases [E3]

another CS2 website

Online Product Ordering

Clipboard [0]

Your items will be kept only for the duration of your visit.