ALEXIS Biochemicals: OCH

ALX-306-029

Revised 05-May-08

OCH
SYNONYMS	(2S,3S,4R)-1-O-(α-D-Galactopyranosyl)-2-tetracosanoyl- aminononan-3,4-diol
PRODUCT LINE	Immunology
PRODUCT CATEGORY	Natural Killer T [NKT] Cells / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-306-029-C250		250 µg	120.00 USD
ALX-306-029-M001		1 mg	250.00 USD

Product Specification

FORMULA:	C₃₉H₇₈NO₉
MW:	704.1
PURITY:	≥95% (¹H-NMR)
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in DMSO, 100% ethanol (warm) or methanol (warm).
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
HANDLING:	After reconstitution, aliquot into glass vials.

Product Description

Truncated analog of α-Gal-Cer. Selectively induces IL-4, as opposed to IFN-γ. Offers protection in mouse against experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. Also offers protection against diabetes in NOD mice and against collagen induced arthritis. Stimulation of NKT cells with α-Gal-Cer results in release of a mixture of Th1 and Th2 cytokines, stimulation with OCH results in release of primarily Th2 cytokine.

Product Specific Literature References

Synthesis and evaluation of sphinganine analogues of KRN7000 and OCH: R.M. Ndonye, et al.; J. Org. Chem. 70, 10260 (2005) Abstract
Total synthesis of an immunosuppressive glycolipid, (2S,3S,4R)-1-O- (alpha-d-galactosyl)-2- tetracosanoylamino-1,3,4-nonanetriol: K. Murata, et al.; J. Org. Chem. 70, 2398 (2005) Abstract
Glycolipids for natural killer T cells: P.B. Savage, et al.; Chem. Soc. Rev. 351, 771 (2006) Abstract

Further Categories Containing This Product:

Ceramides / Cerebrosides / Sphingolipids / Related Products

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