ALEXIS Biochemicals: ONO-RS-082

ALX-270-115

Revised 08-Dec-05

ONO-RS-082
SYNONYMS	2-(p-Amylcinnamoyl)amino-4-chlorobenzoic acid
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	PLA2 Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-115-M005		5 mg	40.00 USD
ALX-270-115-M025		25 mg	120.00 USD

Product Specification

FORMULA:	C₂₁H₂₂ClNO₃
MW:	371.9
CAS NUMBER:	99754-06-0
PURITY:	≥98%
APPEARANCE:	Off-white to yellow solid.
SOLUBILITY:	Soluble in DMSO or 100% ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C
USE/STABILITY:	Solutions are stable for 3 months when stored at -20°C.
HANDLING:	Do not freeze. Protect from light.

Product Description

Phospholipase A₂ inhibitor. Inhibits epinephrine-stimulated thromboxane production in human platelets. Also blocks insulin secretion in pancreatic islets in response to glucose.

Product Specific Literature References

Activation of phospholipases A and C in human platelets exposed to epinephrine: role of glycoproteins IIb/IIIa and dual role of epinephrine: H.S. Banga, et al.; PNAS 83, 9197 (1986) Abstract
Inhibition of phospholipase A2 and insulin secretion in pancreatic islets: R.J. Konrad, et al.; Biochim. Biophys. Acta 1135, 215 (1992) Abstract

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