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PPAR Antagonists
You are here: Product Lines > Obesity & Adipokines > Peroxisome Proliferator Activated-Receptors [PPARs] / Related Products > PPAR Antagonists
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ALX-270-353 Revised 16-Feb-07
BADGE
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SYNONYMS Bisphenol A diglycidyl ether
2,2'-[(1-Methylethylidene)bis(4,1-phenyleneoxymethylene)]bis-oxirane
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PPAR Antagonists
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-353-G025   25 g 19.00 USD Add To Cart
Product Specification
FORMULA: C21H24O4
MW: 340.4
CAS NUMBER: 1675-54-3
PURITY: ≥85%
FORMULATION: Neat oil.
SOLUBILITY: Miscible in organic solvents as 100% ethanol, DMSO or dimethyl formamide. Insoluble in PBS, pH 7.2.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions in 100% ethanol, DMSO or dimethyl formamide are stable for at least 1 year if stored at -20°C.

Product Description
Antagonist of PPARγ. Binds to PPARγ with an apparent Kd of 100µM.
Product Specific Literature References
A synthetic antagonist for the peroxisome proliferator-activated receptor gamma inhibits adipocyte differentiation: H.M. Wright, et al.; J. Biol. Chem. 275, 1873 (2000) Abstract; Full Text
Bisphenol A diglycidyl ether induces apoptosis in tumour cells independently of peroxisome proliferator-activated receptor-gamma, in caspase-dependent and -independent manners: S. Fehlberg, et al.; Biochem. J. 362, 573 (2002) Abstract; Full Text
Bisphenol a diglycidyl ether (BADGE) suppresses tumor necrosis factor-alpha production as a PPARgamma agonist in the murine macrophage-like cell line, RAW 264.7: M. Nakamuta, et al.; Cell Biol. Int. 26, 235 (2002) Abstract
Induction of apoptosis in human and rat glioma by agonists of the nuclear receptor PPARgamma: T. Zander, et al.; J. Neurochem. 81, 1052 (2002) Abstract
General Information
Interferes with the ability of 3T3-L1 and 3T3-F442A cells to undergo hormone-mediated cell differentiation.
 
 
ALX-270-356 Revised 04-May-06
GW9662
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SYNONYMS 2-Chloro-5-nitrobenzanilide
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PPAR Antagonists
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ALX-270-356-M001   1 mg 10.00 USD Add To Cart
ALX-270-356-M005   5 mg 35.00 USD Add To Cart
ALX-270-356-M025   25 mg 140.00 USD Add To Cart
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Product Specification
FORMULA: C13H9N2O3Cl
MW: 276.7
CAS NUMBER: 22978-25-2
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 100% ethanol, DMSO or dimethyl formamide.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Blocks the PPARγ-induced differentiation of monocytes to osteoclasts by >90% at a dose of 0.1µM. Much more potent antagonist than BADGE (Prod. No. ALX-270-353).
Product Specific Literature References
IL-4 inhibits osteoclast formation through a direct action on osteoclast precursors via peroxisome proliferator-activated receptor gamma 1: A.C. Bendixen, et al.; PNAS 98, 2443 (2001) Abstract; Full Text
Functional consequences of cysteine modification in the ligand binding sites of peroxisome proliferator activated receptors by GW9662: L.M. Leesnitzer, et al.; Biochemistry 41, 6640 (2002) Abstract
Activation of peroxisome proliferator-activated receptor gamma inhibits osteoprotegerin gene expression in human aortic smooth muscle cells: M. Fu, et al.; BBRC 294, 597 (2002) Abstract
15-Deoxy-{delta}12,14-prostaglandin j2 inhibits interleukin-1{beta}-induced nuclear factor-{kappa}b in human amnion and myometrial cells: mechanisms and implications: T.M. Lindström & P.R. Bennett; J. Clin. Endocrinol. Metab. 90, 3534 (2005) Abstract; Full Text
 
 
ALX-340-026 Revised 16-Jun-06
LY-171,883
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SYNONYMS 1-[2-Hydroxy-3-propyl-4-[4-(1H-tetrazol-5-yl)butoxy]phenyl]ethanone
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PPAR Antagonists
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ALX-340-026-M010   10 mg 68.00 USD Add To Cart
Product Specification
FORMULA: C16H22N4O3
MW: 318.4
CAS NUMBER: 88107-10-2
PURITY: ≥98%
APPEARANCE: White to off-white crystalline solid.
SOLUBILITY: Soluble in 100% ethanol, DMSO or dimethyl formamide. Also soluble in 0.5M aqueous sodium bicarbonate.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Organic stock solutions are stable for at least six months when stored at –20°C.

Product Description
Competitive leukotriene D4 (LTD4) antagonist. Has also been shown to bind to the γ-isofom of the peroxisome proliferator activated receptor (PPARγ).
Product Specific Literature References
LY171883, 1-less than 2-hydroxy-3-propyl-4-less than 4-(1H-tetrazol-5- yl) butoxy greater than phenyl greater than ethanone, an orally active leukotriene D4 antagonist: J.H. Fleisch, et al.; J. Pharmacol. Exp. Ther. 233, 148 (1985) Abstract
Formation of sulphidopeptide-leukotrienes by cell-cell interaction causes coronary vasoconstriction in isolated, cell-perfused heart of rabbit: A. Sala, et al.; Br. J. Pharmacol. 110, 1206 (1993) Abstract
Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid- activated transcription factor: P. Tontonoz, et al.; Cell 79, 1147 (1994) Abstract
15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma: B.M. Forman, et al.; Cell 83, 803 (1995) Abstract
Further Categories Containing This Product:
Leukotrienes Other Products
 
 
ALX-270-368 Revised 08-Dec-04
MK-886
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SYNONYMS L-663,536
3-[1-(p-Chlorobenzyl)-5-(isopropyl)-3-t-butylthioindol-2-yl]-2,2-dimethylpropanoic acid, Na
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PPAR Antagonists
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-368-M005   5 mg 60.00 USD Add To Cart
ALX-270-368-M025   25 mg 225.00 USD Add To Cart
Product Specification
FORMULA: C27H33ClNO2S . Na
MW: 471.1 . 23.0
CAS NUMBER: 118414-82-7
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 100% ethanol (25 mg/ml) or DMSO (25 mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
USE/STABILITY: We do not recommend storing solutions for more than one day.

Product Description
Inhibitor of PPARα activation. Inhibits 5-lipoxygenase activating protein (FLAP) and leukotriene biosynthesis (IC50=102nM). Induces apoptosis through the mitochondrial pathway.
Product Specific Literature References
L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2 - dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor: J. Gillard, et al.; Can. J. Physiol. Pharmacol. 67, 456 (1989) Abstract
Inhibition of peroxisome-proliferator-activated receptor (PPAR)alpha by MK886: J.P. Kehrer, et al.; Biochem. J. 356, 899 (2001) Abstract; Full Text
Mitochondria are direct targets of the lipoxygenase inhibitor MK886. A strategy for cell killing by combined treatment with MK886 and cyclooxygenase inhibitors: A. Gugliucci, et al.; J. Biol. Chem. 277, 31789 (2002) Abstract; Full Text
Further Categories Containing This Product:
Apoptosis Inducers & Inhibitors Other Products
 
 
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