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ALX-270-171
Revised 30-Jun-08
Chlorpromazine . hydrochloride
SYNONYMS
2-Chloro-10-(3-dimethylaminopropyl)phenothiazine . HCl
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Calmodulin Inhibitors
Ordering Information
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ALX-270-171-G001
1 g
22.00 USD
ALX-270-171-G005
5 g
66.00 USD
Product Specification
FORMULA:
C
17
H
19
ClN
2
S . HCl
MW:
318.9 . 36.5
CAS NUMBER:
69-09-0
MERCK INDEX:
14:
2185
RTECS:
SO1750000
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in 100% ethanol, methanol or water (50mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
USE/STABILITY:
Not stable in aqueous solution. We strongly recommend always to use freshly prepared solutions.
HANDLING:
Protect from light.
HAZARD:
VERY TOXIC.
Product Description
Inhibits calmodulin stimulation of cyclic nucleotide phosphodiesterase. Dopamine antagonist. D
2
antagonist. H
1
antagonist. Inhibits TNF-α production. Potent PLA
2
inhibitor. Inhibits nitric oxide synthase (NOS) in mouse brain and prevents lipopolysaccharide induction of NOS in mouse lung. Antipsychotic.
Product Specific Literature References
Chlorpromazine as a substitute for ortho-dianisidine and ortho-tolidine in the determination of chlorine, hemoglobin, and peroxidase activity:
H.B. Collier; Clin. Biochem.
7
, 331 (1974)
Abstract
Drug-protein interactions: binding of chlorpromazine to calmodulin, calmodulin fragments, and related calcium binding proteins:
D.R. Marshak, et al.; Biochemistry
24
, 144 (1985)
Abstract
Selective inhibition of group II phospholipase A2 by quercetin:
M. Lindahl & C. Tagesson; Inflammation
17
, 573 (1993)
Abstract
Chlorpromazine inhibits both the constitutive nitric oxide synthase and the induction of nitric oxide synthase after LPS challenge:
M. Palacios, et al.; BBRC
196
, 280 (1993)
Abstract
Protective effect of calmodulin inhibitors against acute cyanide- induced lethality and convulsions in mice:
H. Yamamoto; Toxicol. Lett.
66
, 73 (1993)
Abstract
Pharmacologic inhibitors of tumor necrosis factor production exert differential effects in lethal endotoxemia and in infection with live microorganisms in mice:
M.G. Netea, et al.; J. Infect. Dis.
171
, 393 (1995)
Abstract
Pharmacological regulation of mitochondrial nitric oxide synthase:
A. Boveris, et al.; Methods Enzymol.
359
, 328 (2002)
Abstract
Brain mitochondrial nitric oxide synthase: in vitro and in vivo inhibition by chlorpromazine:
S. Lores-Arnaiz, et al.; Arch. Biochem. Biophys.
430
, 170 (2004)
Abstract
Further Categories Containing This Product:
Dopaminergics & Dopamine Receptors / Related Products
•
Phosphodiesterases / Related Products
•
TNF-alpha & TNF Receptors Other Products
•
PLA2 Inhibitors
•
Chemopreventive Agents Other Products
•
NOS Inhibitors (NOS Induction & Enzyme Activity)
ALX-380-052
Revised 16-Oct-07
Fusaric acid
SYNONYMS
5-Butylpicolinic acid
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics Other Products
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ALX-380-052-M050
50 mg
20.00 USD
Product Specification
FORMULA:
C
10
H
13
NO
2
MW:
179.2
CAS NUMBER:
536-69-6
MERCK INDEX:
14:
4314
SOURCE/HOST:
Isolated from
Gibberella fujikuroi
.
PURITY:
≥99%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
TOXIC.
Product Description
Antibiotic. Inhibitor of dopamine β-hydroxylase.
Product Specific Literature References
Biochemistry of the bakanaefungus. I. Fusarinic acid, a new product of the bakanae fungus:
T. Yubata, et al.; J. Agric. Chem. Soc. Jpn.
10
, 1059 (1934)
Pharmacological activities of fusaric acid (5-butylpicolinic acid):
H. Wang & T.B. Ng; Life Sci.
65
, 849 (1999), Review
Abstract
Further Categories Containing This Product:
Dopaminergics & Dopamine Receptors / Related Products
ALX-550-041
Revised 10-Sep-07
(+)-Bromocriptine . methanesulfonate
SYNONYMS
2-Bromo-α-ergocryptine . methanesulfonate
(+)-2-Bromo-12'-hydroxy-2'-(1-methyletyhl)-5'-(2-methylpropyl)-ergotaman-3',6'-18-trionemethanesulfonate
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Dopaminergics & Dopamine Receptors / Related Products
Ordering Information
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Format:
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ALX-550-041-M010
10 mg
25.00 USD
ALX-550-041-M050
50 mg
80.00 USD
Product Specification
FORMULA:
C
32
H
40
BrN
5
O
5
. CH
3
SO
3
H
MW:
654.6 . 96.1
CAS NUMBER:
22260-51-1
MERCK INDEX:
14:
1416
PURITY:
≥98%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in DMSO or 100% ethanol; slightly soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Agonist at D
2
and D
3
dopamine receptors.
Product Specific Literature References
Bromocriptine produces decreases in cocaine self-administration in the rat:
C.B. Hubner & G.F. Koob; Neuropsychopharmacology
3
, 101 (1990)
Abstract
ALX-550-048
Revised 11-Jan-07
7-Hydroxy-DPAT . hydrobromide
SYNONYMS
(±)-7-Hydroxy-2-dipropylaminotetralin . HBr
7-OH-DPAT . HBr
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Dopaminergics & Dopamine Receptors / Related Products
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ALX-550-048-M010
10 mg
50.00 USD
Product Specification
FORMULA:
C
16
H
25
NO . HBr
MW:
247.4 . 80.9
CAS NUMBER:
74938-11-7
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light.
Product Description
Selective D
3
dopamine receptor agonist.
Product Specific Literature References
Identification, characterization, and localization of the dopamine D3 receptor in rat brain using 7-[3H]hydroxy-N,N-di-n-propyl-2- aminotetralin:
D. Levesque, et al.; PNAS
89
, 8155 (1992)
Abstract
Behavioural effects of the putative D-3 dopamine receptor agonist 7-OH- DPAT in relation to other "D-2-like" agonists:
S.A. Daly & J.L. Waddington; Neuropharmacology
32
, 509 (1993)
Abstract
Expression and pharmacological characterization of the human D3 dopamine receptor:
S.B. Freedman, et al.; J. Pharmacol. Exp. Ther.
268
, 417 (1994)
Abstract
ALX-550-088
Revised 28-Jan-05
Clozapine
SYNONYMS
8-Chloro-11-(4-methyl-1-piperazinyl)-5
H
-dibenzo[b,e]-[1,4]diazepine
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Dopaminergics & Dopamine Receptors / Related Products
Ordering Information
Product Numbers:
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ALX-550-088-M005
5 mg
15.00 USD
ALX-550-088-M025
25 mg
35.00 USD
ALX-550-088-M100
100 mg
95.00 USD
Product Specification
FORMULA:
C
18
H
19
ClN
4
MW:
326.8
CAS NUMBER:
5786-21-0
MERCK INDEX:
14:
2423
PURITY:
≥98%
APPEARANCE:
Pale yellow powder.
SOLUBILITY:
Soluble in DMSO or dilute aqueous acid.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
Product Description
Selective antagonist for D
4
-dopamine receptor. Antagonist at 5HT
2A
, 5HT
2C
, 5HT
3
, 5HT
6
and 5HT
7
receptors.
Product Specific Literature References
Binding of typical and atypical antipsychotics to 5-HT1C and 5-HT2 sites: clozapine potently interacts with 5-HT1C sites:
H. Canton, et al.; Eur. J. Pharmacol.
191
, 93 (1990)
Abstract
The involvement of dopamine D1 and D2 receptors in the effects of the classical neuroleptic haloperidol and the atypical neuroleptic clozapine:
B.A. Ellenbroek, et al.; Eur. J. Pharmacol.
196
, 103 (1991)
Abstract
Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine:
H.H. Van Tol, et al.; Nature
350
, 610 (1991)
Abstract
Clozapine and N-desmethylclozapine are potent 5-HT1C receptor antagonists:
M. Kuoppamaki, et al.; Eur. J. Pharmacol.
245
, 179 (1993)
Abstract
5-HT1C receptor-mediated phosphoinositide hydrolysis in the rat choroid plexus after chronic treatment with clozapine:
M. Kuoppamaki, et al.; Eur. J. Pharmacol.
255
, 91 (1994)
Abstract
Clozapine is a potent and selective muscarinic M4 receptor agonist:
S.H. Zorn, et al.; Eur. J. Pharmacol.
269
, R1 (1994)
Abstract
Interaction of clozapine with the histamine H3 receptor in rat brain:
A.A. Rodrigues, et al.; Br. J. Pharmacol.
114
, 1523 (1995)
Abstract
Further Categories Containing This Product:
Serotonergics & Serotonin Receptors / Related Products
ALX-550-129
Revised 13-Dec-04
L-α-Methyl-DOPA
SYNONYMS
MK-351
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Dopaminergics & Dopamine Receptors / Related Products
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ALX-550-129-G001
1 g
20.00 USD
Product Specification
FORMULA:
C
10
H
13
NO
4
MW:
211.2
CAS NUMBER:
555-30-6
MERCK INDEX:
14:
6055
PURITY:
≥99%
APPEARANCE:
White photosensitive solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Antihypertensive. L-Aromatic amino acid decarboxylase inhibitor.
ALX-550-143
Revised 19-Aug-02
Benztropine . mesylate
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Acetylcholine Receptors (Muscarinic) / Related Products
Ordering Information
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ALX-550-143-G001
1 g
20.00 USD
Product Specification
FORMULA:
C
21
H
25
NO . CH
3
SO
3
H
MW:
307.4 . 96.1
CAS NUMBER:
132-17-2
MERCK INDEX:
14:
1121
PURITY:
≥99%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HAZARD:
TOXIC.
Product Description
Muscarinic acetylcholine receptor antagonist. Inhibits the dopamine transporter.
Further Categories Containing This Product:
Dopaminergics & Dopamine Receptors / Related Products
ALX-550-144
Revised 09-Dec-04
Buspirone . hydrochloride
SYNONYMS
8-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4,5]decane-7,9-dione . HCl
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Serotonergics & Serotonin Receptors / Related Products
Ordering Information
Product Numbers:
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ALX-550-144-G001
1 g
48.00 USD
Product Specification
FORMULA:
C
21
H
31
N
5
O
2
. HCl
MW:
385.5 . 36.5
CAS NUMBER:
33386-08-2
MERCK INDEX:
14:
1504
PURITY:
≥96%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HAZARD:
TOXIC.
Product Description
5-HT
1A
serotonin receptor agonist.
Product Specific Literature References
The discovery and development of buspirone: a new approach to the treatment of anxiety
:
J.S. New; Med. Res. Rev.
10
, 283 (1990), (Review)
Abstract
Further Categories Containing This Product:
Benzodiazepines / Related Products
•
Dopaminergics & Dopamine Receptors / Related Products
•
Adrenergics & Adrenergic Receptors / Related Products
ALX-550-165
Revised 09-Sep-02
2-Chloro-11-(4-methylpiperazino)dibenz[b,f]oxepin . maleate
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Dopaminergics & Dopamine Receptors / Related Products
Ordering Information
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ALX-550-165-M005
5 mg
70.00 USD
Product Specification
FORMULA:
C
19
H
19
N
2
OCl . C
4
H
4
O
4
MW:
326.8 . 116.1
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in ethanol or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
Product Description
High affinity dopamine D
4
receptor ligand. Almost 40 times more potent than clozapine (Prod. No.
ALX-550-088
).
Product Specific Literature References
Binding of 5H-dibenzo[b,e][1,4]diazepine and chiral 5H- dibenzo[a,d]cycloheptene analogues of clozapine to dopamine and serotonin receptors:
S.T. Phillips, et al.; J. Med. Chem.
37
, 2686 (1994)
Abstract
Binding of 5H-dibenzo[a,d]cycloheptene and dibenz[b,f]oxepin analogues of clozapine to dopamine and serotonin receptors:
S.T. Phillips, et al.; J. Med. Chem.
38
, 708 (1995)
Abstract
ALX-550-203
Revised 28-Jan-05
(1S,2R)-cis-5-Methoxy-1-methyl-2-(n-propylamino)tetralin . hydrochloride
SYNONYMS
(+)-AJ76 . HCI
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Dopaminergics & Dopamine Receptors / Related Products
Ordering Information
Product Numbers:
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ALX-550-203-M005
5 mg
75.00 USD
Product Specification
FORMULA:
C
15
H
23
NO . HCl
MW:
233.4 . 36.5
CAS NUMBER:
85379-09-5
PURITY:
≥98%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in water or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
Product Description
Selective dopamine autoreceptor antagonist. Antagonizes the pharmacological effects of cocaine.
Product Specific Literature References
Novel dopamine receptor agonists and antagonists with preferential action on autoreceptors:
A.M. Johansson, et al.; J. Med. Chem.
28
, 1049 (1985)
Abstract
(1S,2R)-5-methoxy-1-methyl-2-(n-propylamino)tetralin ([+]-AJ-76) elevates transmitter synthesis in dopaminergic neurons surviving a partial nigrostriatal lesion:
F. Hefti; Neuropharmacology
26
, 1239 (1987)
Abstract
Resolved cis- and trans-2-amino-5-methoxy-1-methyltetralins: central dopamine receptor agonists and antagonists:
A.M. Johansson, et al.; J. Med. Chem.
30
, 602 (1987)
Abstract
Effects of repeated administration of the preferential dopamine autoreceptor antagonist, (+)-AJ76, on locomotor activity and brain DA metabolism in the rat:
H. Kullingsjo, et al.; Eur. J. Pharmacol.
205
, 241 (1991)
Abstract
Antagonism of cocaine's pharmacological effects by the stimulant dopaminergic antagonists, (+)-AJ76 and (+)-UH232:
M.F. Piercey, et al.; Brain Res.
588
, 217 (1992)
Abstract
Intracerebral infusion of (+)-AJ76 and (+)-UH232: effects on dopamine release and metabolism in vivo:
N. Waters, et al.; Eur. J. Pharmacol.
251
, 181 (1994)
Abstract
ALX-550-204
Revised 13-Dec-04
N-[1-(2-Benzo[b]thien-2-yl)cyclohexyl)]piperidine . maleate
SYNONYMS
BTCP . maleate
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Dopaminergics & Dopamine Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
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ALX-550-204-M005
5 mg
75.00 USD
ALX-550-204-M025
25 mg
300.00 USD
Product Specification
FORMULA:
C
19
H
25
NS . C
4
H
4
O
4
MW:
299.5 . 116.1
CAS NUMBER:
112726-66-6
PURITY:
≥98%
APPEARANCE:
Off-white solid.
