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Obesity & Adipokines
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ALX-157-020 Revised 03-Mar-05
Galanin Like Peptide [GALP] (1-60) (pig)
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PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Galanin & Galanin Receptor / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-157-020-MC01   0.1 mg 490.00 USD Add To Cart
Product Specification
SEQUENCE: H-Ala-Pro-Val-His-Arg-Gly-Arg-Gly-Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Val-Leu-His-Pro-Pro-Ser-Arg-Ala-Glu-Gly-Gly-Gly-Lys-Gly-Lys-Thr-Ala-Leu-Gly-Ile-Leu-Asp-Leu-Trp-Lys-Ala-Ile-Asp-Gly-Leu-Pro-Tyr-Pro-Gln-Ser-Gln-Leu-Ala-Ser-OH
FORMULA: C281H443N81O78
MW: 6204.1
CAS NUMBER: 245114-96-9
SOURCE/HOST: Isolated from pig hypothalamus.
PURITY: ≥95%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
GALP is a 60 amino acid peptide that, unlike galanin, has a non-amidated C-terminus. GALP (aa 9-21) is identical to the biologically active N-terminal (aa 1-13) portion of galanin. Receptor binding studies revealed that GALP has a high affinity for the galanin receptor 2 (IC50=0.24nM) and a lower affinity for the galanin receptor 1 (IC50=0.48nM). GALP is therefore an endogenous ligand that preferentially binds to galanin receptor 2, whereas galanin is relatively non-selective.
Product Specific Literature References
Isolation and cDNA cloning of a novel galanin-like peptide (GALP) from porcine hypothalamus: T. Ohtaki, et al.; J. Biol. Chem. 274, 37041 (1999) Abstract; Full Text
Galanin-like peptide (GALP) is a target for regulation by leptin in the hypothalamus of the rat: A. Jureus, et al.; Endocrinology 141, 2703 (2000) Abstract; Full Text
Galanin-like peptide (GALP) mRNA expression is restricted to arcuate nucleus of hypothalamus in adult male rat brain: J.A. Larm & A.L. Gundlach; Neuroendocrinology 72, 67 (2000) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-350-383 Revised 29-Sep-08 New product
Genipin
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SYNONYMS (+)-Genipin
Methyl (1S,2R,6S)-2-hydroxy-9-(hydroxymethyl)-3-oxabicyclo[4.3.0]nona-4,8-diene-5-carboxylate
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Antidiabetic Agents / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-383-M025   25 mg 65.00 USD Add To Cart
ALX-350-383-M100   100 mg 220.00 USD Add To Cart
Product Specification
FORMULA: C11H14O5
MW: 226.2
CAS NUMBER: 6902-77-8
RTECS: GY5828000
SOURCE/HOST: Isolated from Gardenia jasminoides Ellis.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white crystalline solid.
SOLUBILITY: Soluble in DMSO (50mg/ml), dimethyl formamide (25mg/ml), 100% ethanol (5mg/ml), methanol or ethyl acetate; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: HARMFUL.

Product Description
Cell permeable inhibitor of uncoupling protein 2 (UCP2). Increases glucose-stimulated insulin secretion, mitochondrial membrane potential and ATP levels in pancreatic island cells. Induces apoptosis. Protein cross-linking agent. Anti-inflammatory and anti-angiogenic.
Product Specific Literature References
Genipin-induced apoptosis in hepatoma cells is mediated by reactive oxygen species/c-Jun NH2-terminal kinase-dependent activation of mitochondrial pathway: B.C. Kim, et al.; Biochem. Pharmacol. 70, 1398 (2005) Abstract
Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced beta cell dysfunction in isolated pancreatic islets: C.Y Zhang, et al.; Cell Metab. 3, 417 (2006) Abstract
Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity: L.E. Parton, et al.; Nature 449, 228 (2007) Abstract
Further Categories Containing This Product:
Natural Products for Angiogenesis Research • Natural Products - Anti-inflammatory Agents • Natural Products - Apoptosis Inducers & Inhibitors
 
 
ALX-350-006 Revised 05-Apr-08
Genistein (synthetic)
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SYNONYMS 4',5,7-Trihydroxyisoflavone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Protein Kinase Inhibitors
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ALX-350-006-M010   10 mg 25.00 USD Add To Cart
ALX-350-006-M025   25 mg 50.00 USD Add To Cart
ALX-350-006-M050   50 mg 90.00 USD Add To Cart
ALX-350-006-M100   100 mg 150.00 USD Add To Cart
ALX-350-006-G001   1 g 480.00 USD Add To Cart
Product Specification
FORMULA: C15H10O5
MW: 270.2
CAS NUMBER: 446-72-0
MERCK INDEX: 14: 4391
RTECS: NR2392000
SOURCE/HOST: Synthetic.
PURITY: ≥99% (HPLC)
APPEARANCE: White to yellow crystalline powder.
SOLUBILITY: Soluble in DMSO, 100% ethanol or dilute aqueous base; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: MAY BE CARCINOGENIC. HARMFUL.

Product Description
Tyrosine protein kinase inhibitor. Inhibits phosphorylation of EGFR kinase. Inhibits tumor cell proliferation and induces tumor cell differentiation. Inhibits topoisomerase II activity in vivo. Produces cell cycle arrest and apoptosis. Direct inhibitor of insulin-induced glucose uptake in adipocytes (IC50=20µM).
Product Specific Literature References
Genistein, a specific inhibitor of tyrosine-specific protein kinases: T. Akiyama, et al.; J. Biol. Chem. 262, 5592 (1987) Abstract; Full Text
Erbstatin blocks platelet activating factor-induced protein-tyrosine phosphorylation, polyphosphoinositide hydrolysis, protein kinase C activation, serotonin secretion and aggregation of rabbit platelets: H. Salari, et al.; FEBS Lett. 263, 104 (1990) Abstract
Mechanisms of cancer chemoprevention by soy isoflavone genistein: F.H. Sarkar & Y. Li; Cancer Metastasis Rev. 21, 265 (2002) Abstract
Soy isoflavone phyto-pharmaceuticals in interleukin-6 affections. Multi-purpose nutraceuticals at the crossroad of hormone replacement, anti-cancer and anti-inflammatory therapy: N. Dijsselbloem, et al.; Biochem. Pharmacol. 68, 1171 (2004), Review Abstract
Genistein affects testosterone secretion by Leydig cells in roosters (Gallus gallus domesticus): M. Opalka, et al.; Reprod. Biol. 4, 185 (2004) Abstract
Genistein directly inhibits GLUT4-mediated glucose uptake in 3T3-L1 adipocytes: M. Bazuine, et al.; BBRC 325, 511 (2005) Abstract
Decreased circulating levels of tumor necrosis factor-alpha in postmenopausal women during consumption of soy-containing isoflavones: Y. Huang, et al.; J. Clin. Endocrinol. Metab. 90, 3956 (2005) Abstract
Phytoestrogens and lipoproteins in women: C.N. Bairey Merz, et al.; J. Clin. Endocrinol. Metab. 91, 2209 (2006) Abstract
Clinical review: a critical evaluation of the role of soy protein and isoflavone supplementation in the control of plasma cholesterol concentrations: A. Dewell, et al.; J. Clin. Endocrinol. Metab. 91, 772 (2006), Review Abstract
The role of genistein and synthetic derivatives of isoflavone in cancer prevention and therapy: F.H. Sarkar, et al.; Mini Rev. Med. Chem. 6, 401 (2006), Review Abstract
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors • TNF-alpha & TNF Receptors Other Products • Antitumor Agents (Enzyme Inhibitors) • Flavonoids / Related Products • EGFR Kinase Inhibitors • Natural Products - Topoisomerase Inhibitors • Cell Cycle Blockers & Inhibitors / Related Products • Natural Products - Antitumor Reagents • Active Substances from Fruit and Vegetables • Natural Products for Angiogenesis Research • Natural Products - Apoptosis Inducers & Inhibitors • Antitumor Agents (Apoptosis Inducers) • Antitumor Agents (Anti-proliferative) • Natural Products for Cell Cycle Research
 
 
ALX-157-021 Revised 25-Sep-06
Ghrelin (human)
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PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Ghrelin / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-157-021-MC05   0.5 mg 230.00 USD Add To Cart
ALX-157-021-M001   1 mg 390.00 USD Add To Cart
Product Specification
SEQUENCE: H-Gly-Ser-Ser(octanoyl)-Phe-Leu-Ser-Pro-Glu-His-Gln-Arg-Val-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg-OH
FORMULA: C149H249N47O42
MW: 3370.9
CAS NUMBER: 258279-04-8
PURITY: ≥98%
FORMULATION: Lyophilized.
SOLUBILITY: Soluble in distilled water or 5% acetic acid.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Ghrelin, a 28 aa peptide predominantly produced by the stomach, is an endogenous ligand for the growth hormone secretagogue receptor (GHS-R) that potently stimulates growth hormone release. Recent studies suggest that peripherally or centrally administrated ghrelin, independent of growth hormone, decreases fat oxidation and increases food intake and adiposity. In addition, plasma ghrelin levels are lower in obese human subjects. Ghrelin promotes the production of orexigenic neuropeptides (neuropeptide Y and agouti-related protein) in the hypothalamic arcuate nuclei and activates the neurons which produce these orexigenic neuropeptides, resulting in an increase in feeding and body weight and thereby opposing the effects of leptin. Moreover, ghrelin shows regulatory effects on the cardiovascular and immune system.
Product Specific Literature References
Ghrelin is a growth-hormone-releasing acylated peptide from stomach: M. Kojima, et al.; Nature 402, 656 (1999) Abstract
Ghrelin: a step forward in the understanding of somatotroph cell function and growth regulation: C. Dieguez & F.F. Casanueva; Eur. J. Endocrinol. 142, 413 (2000) Abstract; Full Text
Ghrelin and immunity: a young player in an old field: V.D. Dixit & D.D. Taub; Exp. Gerontol. 40, 900 (2005), (Review) Abstract
Ghrelin: structure and function: M. Kojima & K. Kangawa; Physiol. Rev. 85, 495 (2005), (Review) Abstract
Developments in ghrelin biology and potential clinical relevance: R.G. Smith, et al.; Trends Endocrinol. Metab. 16, 436 (2005), (Review) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-157-022 Revised 25-Sep-06
Ghrelin (rat)
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PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Ghrelin / Related Products
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ALX-157-022-MC05   0.5 mg 230.00 USD Add To Cart
ALX-157-022-M001   1 mg 390.00 USD Add To Cart
Product Specification
SEQUENCE: H-Gly-Ser-Ser(octanoyl)-Phe-Leu-Ser-Pro-Glu-His-Gln-Lys-Ala-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg-OH
FORMULA: C147H244N45O42
MW: 3313.8
CAS NUMBER: 258338-12-4
PURITY: ≥98%
FORMULATION: Lyophilized.
SOLUBILITY: Soluble in 5% acetic acid.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Ghrelin, a 28 aa peptide predominantly produced by the stomach, is an endogenous ligand for the growth hormone secretagogue receptor (GHS-R) that potently stimulates growth hormone release. Recent studies suggest that peripherally or centrally administrated ghrelin, independent of growth hormone, decreases fat oxidation and increases food intake and adiposity. In addition, plasma ghrelin levels are lower in obese human subjects. Ghrelin promotes the production of orexigenic neuropeptides (neuropeptide Y and agouti-related protein) in the hypothalamic arcuate nuclei and activates the neurons which produce these orexigenic neuropeptides, resulting in an increase in feeding and body weight and thereby opposing the effects of leptin. Moreover, ghrelin shows regulatory effects on th cardiovascular and immune system.
Product Specific Literature References
Ghrelin is a growth-hormone-releasing acylated peptide from stomach: M. Kojima, et al.; Nature 402, 656 (1999) Abstract
Ghrelin: a step forward in the understanding of somatotroph cell function and growth regulation: C. Dieguez & F.F. Casanueva; Eur. J. Endocrinol. 142, 413 (2000) Abstract; Full Text
(Ghrelin and immunity: a young player in an old field: V.D. Dixit & D.D. Taub; Exp. Gerontol. 40, 900 (2005), (Review) Abstract
Ghrelin: structure and function: M. Kojima & K. Kangawa; Physiol. Rev. 85, 495 (2005), (Review) Abstract
Developments in ghrelin biology and potential clinical relevance: R.G. Smith, et al.; Trends Endocrinol. Metab. 16, 436 (2005), (Review) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-550-270 Revised 22-May-07
Glibenclamide
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SYNONYMS Glyburide
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY K+ Channel Blockers & Inhibitors
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ALX-550-270-G001   1 g 17.00 USD Add To Cart
Product Specification
FORMULA: C23H28ClN3O5S
MW: 494.0
CAS NUMBER: 10238-21-8
MERCK INDEX: 14: 4478
RTECS: YS4725200
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO (25mg/ml) or 100% ethanol (5mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
USE/STABILITY: Solutions are stable for up to 3 months when stored at -20°C.
HAZARD: HARMFUL.

Product Description
ATP-dependent K+ channel blocker in the pancreas, which in turn causes intracellular Ca2+ levels to rise and for insulin to be secreted. Antidiabetic. High affinity binding sites have been identified in the cardiovascular system, the CNS, and pancreatic beta cells. Large potency differences are observed between pancreatic tissue and vascular tissue.
Product Specific Literature References
Glipizide: a review of its pharmacological properties and therapeutic use: R.N. Brogden, et al.; Drugs 18, 329 (1979) Abstract
Intracellular ATP directly blocks K+ channels in pancreatic B-cells: D.L. Cook & C.N. Hales; Nature 311, 271 (1984) Abstract
Antidiabetic sulfonylureas control action potential properties in heart cells via high affinity receptors that are linked to ATP-dependent K+ channels: M. Fosset, et al.; J. Biol. Chem. 263, 7933 (1988) Abstract; Full Text
In vitro effects of sulfonylurea on glucose transport and translocation of glucose transporters in adipocytes from streptozocin-induced diabetic rats: D.R. Jacobs, et al.; Diabetes 38, 205 (1989) Abstract
Glyburide blocks the relaxation response to BRL 34915 (cromakalim), minoxidil sulfate and diazoxide in vascular smooth muscle: R.J. Winquist, et al.; J. Pharmacol. Exp. Ther. 248, 149 (1989) Abstract
Potassium channel modulators: scientific applications and therapeutic promise: D.W. Robertson & M.I. Steinberg; J. Med. Chem. 33, 1529 (1990) Abstract
D.R. Gehlert, et al.; J. Pharmacol. Exp. Ther. 257, 901 (1991) Abstract
High affinity [3H]glibenclamide binding sites in rat neuronal and cardiac tissue: localization and developmental characteristics: J.A. Miller, et al.; J. Pharmacol. Exp. Ther. 256, 358 (1991) Abstract
Glyburide and tolbutamide induce desensitization of insulin release in rat pancreatic islets by different mechanisms: A.M. Rabuazzo, et al.; Endocrinology 131, 1815 (1992) Abstract
Further Categories Containing This Product:
Ca2+ Modulators • Antidiabetic Agents / Related Products
 
 
ALX-550-271 Revised 06-Nov-07
Glipizide
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY K+ Channel Blockers & Inhibitors
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ALX-550-271-M100   100 mg 15.00 USD Add To Cart
ALX-550-271-G001   1 g 40.00 USD Add To Cart
ALX-550-271-G005   5 g 160.00 USD Add To Cart
Product Specification
FORMULA: C21H27N5O4S
MW: 445.5
CAS NUMBER: 29094-61-9
MERCK INDEX: 14: 4442
PURITY: ≥99%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO or methanol; insoluble in 100 % ethanol or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
ATP-dependent K+ channel blocker.
Product Specific Literature References
RP 49356 and cromakalim relax airway smooth muscle in vitro by opening a sulphonylurea-sensitive K+ channel: a comparison with nifedipine: D. Raeburn & T.J. Brown; J. Pharmacol. Exp. Ther. 256, 480 (1991) Abstract
Quantitative autoradiography of the binding sites for [125I] iodoglyburide, a novel high-affinity ligand for ATP-sensitive potassium channels in rat brain: D.R. Gehlert, et al.; J. Pharmacol. Exp. Ther. 257, 901 (1991) Abstract
Further Categories Containing This Product:
Antidiabetic Agents / Related Products
 
 
ALX-201-202 Revised 22-Jan-08
Growth Hormone (20kDa) (human) (recombinant)
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SYNONYMS GH (20kDa) (human) (recombinant)
Somatotropin (20kDa) (human) (recombinant)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Growth Hormones / Related Products
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ALX-201-202-C100   100 µg 125.00 USD Add To Cart
Product Specification
MW: ~20kDa.
SOURCE/HOST: Produced in E. coli.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. In 88mM mannitol, pH 7.4, containing 5mM phosphate.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • Obesity & Diabetes Other Products
 
 
ALX-201-201 Revised 20-May-05
Growth Hormone (human) (recombinant)
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SYNONYMS GH (human) (recombinant)
Somatotropin (human) (recombinant)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Growth Hormones / Related Products
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ALX-201-201-C100   100 µg 125.00 USD Add To Cart
Product Specification
MW: ~22.2kDa.
SOURCE/HOST: Produced in E. coli.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. In 88mM mannitol, pH 7.4, containing 5mM phosphate.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • Obesity & Diabetes Other Products
 
 
ALX-420-029 Revised 22-Feb-08
GW1929