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Items 8 of 8
ALX-380-262
Revised 09-Apr-08
Amidepsine A
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Other Natural Products
Ordering Information
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ALX-380-262-M001
1 mg
230.00 USD
ALX-380-262-MM25
2.5 mg
470.00 USD
Product Specification
FORMULA:
C
29
H
29
NO
11
MW:
567.6
SOURCE/HOST:
Isolated from fungal strain FO-2943.
PURITY:
≥95% (HPLC)
APPEARANCE:
Pale white to pale yellow powder.
SOLUBILITY:
Soluble in methanol or ethyl acetate; insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Inhibitor of diacylglycerol acyltransferase (DGAT). Shows inhibitory effect in rat liver microsomes (IC
50
=10.2µM) and Raji cells (IC
50
=15.5µM). Excessive accumulation of triacetylglycerol produced by DGAT may cause fatty liver, obesity and hypertriglyceridemia, which may lead to atherosclerosis, diabetes and metabolic disorders.
Product Specific Literature References
Amidepsines, inhibitors of diacylglycerol acyltransferase produced by Humicola sp. FO-2942. I. Production, isolation and biological properties:
H. Tomoda, et al.; J. Antibiot.
48
, 937 (1995)
Abstract
Amidepsines, inhibitors of diacylglycerol acyltransferase produced by Humicola sp. FO-2942. II. Structure elucidation of amidepsines A, B and C:
H. Tomoda, et al.; J. Antibiot.
48
, 942 (1995)
Abstract
General Information
MANUFACTURER
Fungal strain courtesy of the Kitasato Institute, Tokyo.
Related Products
ALX-380-263
Amidepsine D
Further Categories Containing This Product:
Lipid Metabolism Other Products
ALX-380-263
Revised 09-Apr-08
Amidepsine D
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Other Natural Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-380-263-M001
1 mg
230.00 USD
ALX-380-263-MM25
2.5 mg
470.00 USD
Product Specification
FORMULA:
C
26
H
24
O
10
MW:
496.5
SOURCE/HOST:
Isolated from fungal strain FO-2943.
PURITY:
≥95% (HPLC)
APPEARANCE:
White to light pink powder.
SOLUBILITY:
Soluble in methanol (1mg/ml); insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Inhibitor of diacylglycerol acyltransferase (DGAT). Shows inhibitory effect in rat liver microsomes (IC
50
=17.5µM) and Raji cells (IC
50
=2.8µM). Excessive accumulation of triacetylglycerol produced by DGAT may cause fatty liver, obesity and hypertriglyceridemia, which may lead to atherosclerosis, diabetes and metabolic disorders.
Product Specific Literature References
Amidepsines, inhibitors of diacylglycerol acyltransferase produced by Humicola sp. FO-2942. I. Production, isolation and biological properties:
H. Tomoda, et al.; J. Antibiot.
48
, 937 (1995)
Abstract
Amidepsines, inhibitors of diacylglycerol acyltransferase produced by Humicola sp. FO-2942. II. Structure elucidation of amidepsines A, B and C:
H. Tomoda, et al.; J. Antibiot.
48
, 942 (1995)
Abstract
General Information
MANUFACTURER
Fungal strain courtesy of the Kitasato Institute, Tokyo.
Related Products
ALX-380-262
Amidepsine A
Further Categories Containing This Product:
Lipid Metabolism Other Products
ALX-350-149
Revised 23-Oct-07
Cylindrospermopsin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Other Toxins
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ALX-350-149-C025
25 µg
140.00 USD
ALX-350-149-C100
100 µg
210.00 USD
Product Specification
FORMULA:
C
15
H
21
N
5
O
7
S
MW:
415.4
CAS NUMBER:
143545-90-8
RTECS:
UV9104310
SOURCE/HOST:
Isolated from
Cylindrospermopsis raciborskii
.
PURITY:
≥95% (HPLC)
APPEARANCE:
Glassy solid.
SOLUBILITY:
Soluble in water, methanol or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HAZARD:
VERY TOXIC. HIGHLY IRRITANT.
Product Description
Tricyclic alkaloid hepatotoxin. Exhibits a completely different mechanism of toxicity than microcystins. Protein synthesis inhibitor. Might be carcinogenic. Inhibits pyrimidine nucleotide synthesis.
Product Specific Literature References
Severe hepatotoxicity caused by the tropical cyanobacterium (blue-green alga) Cylindrospermopsis raciborskii (Woloszynska) Seenaya and Subba Raju isolated from a domestic water supply reservoir:
P.R. Hawkins, et al.; Appl. Environ. Microbiol.
50
, 1292 (1985)
Abstract
;
Full Text
Cylindrospermopsin, a potent hepatotoxin from the blue-green alga Cylindrospermopsis raciborskii:
I. Ohtani, et al.; JACS
114
, 7941 (1992)
Full Text
Isolation and toxicity of Cylindrospermopsis raciborskii from an ornamental lake:
P.R. Hawkins, et al.; Toxicon.
35
, 341 (1997)
Abstract
Cylindrospermopsin, a cyanobacterial alkaloid: evaluation of its toxicologic activity:
G.R. Shaw, et al.; Ther. Drug Monit.
22
, 89 (2000)
Abstract
Preliminary evidence for in vivo tumour initiation by oral administration of extracts of the blue-green alga cylindrospermopsis raciborskii containing the toxin cylindrospermopsin:
I.R. Falconer & A.R. Humpage; Environ. Toxicol.
16
, 192 (2001)
Abstract
The Palm Island mystery disease 20 years on: a review of research on the cyanotoxin cylindrospermopsin:
D.J. Griffiths and M.L. Saker; Environ. Toxicol.
18
, 78 (2003), Review
Abstract
The cyanobacterial toxin cylindrospermopsin inhibits pyrimidine nucleotide synthesis and alters cholesterol distribution in mice:
M. Reisner, et al.; Toxicol. Sci.
82
, 620 (2004)
Abstract
Further Categories Containing This Product:
Lipid Metabolism Other Products
•
Uridine Derivatives Other Products
•
Protein Synthesis Other Products
•
Alkaloids
ALX-201-421
Revised 09-Oct-08
FTO (human) (recombinant) (His)
SYNONYMS
Fat Mass and Obesity-associated Protein (human) (recombinant) (His)
FATSO (human) (recombinant) (His)
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Obesity & Diabetes Other Products
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ALX-201-421-C010
10 µg
230.00 USD
ALX-201-421-C050
50 µg
510.00 USD
Product Specification
SOURCE/HOST:
Expressed in
E. coli.
The mature peptide of human FTO (aa 2-505) is fused at the N-terminus to a His-tag.
CONCENTRATION:
0.5mg/ml
PURITY:
≥90% (SDS-PAGE)
FORMULATION:
Liquid. 0.2μm-filtered solution in 55mM TRIS, pH 8.2, containing 150mM sodium chloride.
ENDOTOXIN CONTENT:
<1EU/µg protein (LAL-test).
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
Please click on thumbnails to enlarge.
General Information
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link Q9C0B1:
FTO (human)
MANUFACTURER
Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Lipid Metabolism Other Products
•
Recombinant Proteins / Fusion Proteins
ALX-350-279
Revised 02-Jun-08
Isoxanthohumol
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Other Natural Products - DNA Regulation / Transcription
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ALX-350-279-M001
1 mg
60.00 USD
Product Specification
FORMULA:
C
21
H
22
O
5
MW:
354.4
SOURCE/HOST:
Synthetic.
PURITY:
≥98%
APPEARANCE:
White powder.
SOLUBILITY:
Soluble in DMSO (50mg/ml) or methanol (50mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
Product Description
Prenylated flavonoid. Phytoestrogen. Induces apoptosis in mature adipocytes.
Product Specific Literature References
Xanthohumol and related prenylflavonoids from hops and beer: to your good health!
:
J.F. Stevens & J.E. Page; Phytochemistry
65
, 1317 (2004), (Review)
Abstract
Inhibition of endothelial cell functions by novel potential cancer chemopreventive agents:
E. Bertl, et al.; BBRC
325
, 287 (2004)
Abstract
Metabolism of xanthohumol and isoxanthohumol, prenylated flavonoids from hops (Humulus lupulus L.), by human liver microsomes:
D. Nikolic, et al.; J. Mass Spectrom.
40
, 289 (2005)
Abstract
The prenylflavonoid isoxanthohumol from hops (Humulus lupulus L.) is activated into the potent phytoestrogen 8-prenylnaringenin in vitro and in the human intestine:
S. Possemiers, et al.; J. Nutr.
136
, 1862 (2006)
Abstract
Identification of human hepatic cytochrome P450 enzymes involved in the metabolism of 8-prenylnaringenin and isoxanthohumol from hops (Humulus lupulus L.):
J. Guo, et al.; Drug Metab. Dispos.
34
, 1152 (2006)
Effect of xanthohumol and isoxanthohumol on 3T3-L1 cell apoptosis and adipogenesis:
J.Y. Yang, et al.; Apoptosis
12
, 1953 (2007)
Abstract
Further Categories Containing This Product:
Flavanones
•
Estrogen & Estrogen Receptors / Related Products
•
Lipid Metabolism Other Products
•
Natural Products - Apoptosis Inducers & Inhibitors
•
Active Substances from Fruit and Vegetables
•
Natural Products - Other Signal Transduction Pathway Modulators
ALX-210-431
Revised 14-Mar-06
Polyclonal Antibody to SCD1 (mouse)
SYNONYMS
anti-Stearoyl-CoA Desaturase 1 (mouse) PAb
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Adipokines Other Products
Ordering Information
Product Numbers:
Format:
Size:
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ALX-210-431-C100
100 µg
310.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Purified IgG.
FORMULATION:
Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN:
Synthetic peptide corresponding to aa 21-33 (A
21
PPSGNEREKVKT
33
) of mouse SCD1 (stearoyl-CoA desaturase 1).
SPECIFICITY:
Recognizes mouse SCD1. Detects a band of ~41kDa by Western Blot.
APPLICATION:
ELISA
(direct and indirect: 1:2’000-1:5’000)
Western Blot
(1:2’000-1:5’000 using ECL; suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk; suggested incubation time is 1 hour at room temperature)
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
Please click on thumbnails to enlarge.
General Information
MANUFACTURER
Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Lipid Metabolism Other Products
•
Polyclonal Antibodies
ALX-380-285
Revised 16-Sep-08
Triacsin C
SYNONYMS
2,4,7-Undecatrienal nitrosohydrazone
WS1228A
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Apoptosis Inducers & Inhibitors
Ordering Information
Product Numbers:
Format:
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Unit Price:
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ALX-380-285-MC05
0.5 mg
190.00 USD
ALX-380-285-M001
1 mg
350.00 USD
Product Specification
FORMULA:
C
11
H
17
N
3
O
MW:
207.3
CAS NUMBER:
76896-80-5
SOURCE/HOST:
Isolated from
Streptomyces aureofaciens.
PURITY:
≥94% (HPLC)
APPEARANCE:
White to light brown powder.
SOLUBILITY:
Soluble in DMSO (10mg/ml) or methanol (5mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Keep under inert gas. Protect from light.
MELTINGPOINT:
102-103°C
Product Description
Analog of polyunsaturated fatty acid. Potent inhibitor of long-chain fatty acyl CoA synthetase. Selectively inhibits arachidonoyl-CoA synthetase in intact cells. Blocks β-cell apoptosis induced by fatty acids (lipoapoptosis) and synthesis of triglycerides, diglycerides and cholesterol esters. Potent vasodilator. Used in a rat model of obesity.
Product Specific Literature References
Triacsin C: a differential inhibitor of arachidonoyl-CoA synthetase and nonspecific long chain acyl-CoA synthetase:
E.J. Hartman, et al.; Prostaglandins
37
, 655 (1989)
Abstract
Evidence for an essential role of long chain acyl-CoA synthetase in animal cell proliferation. Inhibition of long chain acyl-CoA synthetase by triacsins caused inhibition of Raji cell proliferation:
H. Tomoda, et al.; J. Biol. Chem.
266
, 4214 (1991)
Abstract
;
Full Text
The acyl-CoA synthetase inhibitor triacsin C enhanced eicosanoid release in leukocytes:
S. Oh-ishi, et al.; Jpn. J. Pharmacol.
59
, 417 (1992)
Abstract
;
Full Text
Triacsin C blocks de novo synthesis of glycerolipids and cholesterol esters but not recycling of fatty acid into phospholipid: evidence for functionally separate pools of acyl-CoA:
R.A. Igal, et al.; Biochem. J.
324
, 529 (1997)
Abstract
;
Full Text
Protection against lipoapoptosis of beta cells through leptin-dependent maintenance of Bcl-2 expression:
M. Shimabukuro, et al.; PNAS
95
, 9558 (1998)
Abstract
;
Full Text
Complete inhibition of mouse macrophage-derived foam cell formation by triacsin C:
I. Namatame, et al.; J. Biochem.
125
, 319 (1999)
Abstract
Triacsin C inhibits the formation of 1H NMR-visible mobile lipids and lipid bodies in HuT 78 apoptotic cells:
E. Iorio, et al.; Biochim. Biophys. Acta
1634
, 1 (2003)
Abstract
ADRP/adipophilin is degraded through the proteasome-dependent pathway during regression of lipid-storing cells:
Y. Masuda, et al.; J. Lipid Res.
47
, 87 (2006)
Abstract
;
Full Text
Further Categories Containing This Product:
Lipid Metabolism Other Products
ALX-350-280
Revised 07-Oct-08
Xanthohumol
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Other Natural Products - DNA Regulation / Transcription
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-350-280-M005
5 mg
135.00 USD
Product Specification
FORMULA:
C
21
H
22
O
5
MW:
354.4
CAS NUMBER:
569-83-5, 6754-58-1
SOURCE/HOST:
Isolated from hops (
Humulus lupulus
).
PURITY:
≥98% (HPLC)
APPEARANCE:
Yellow to orange powder.
SOLUBILITY:
Soluble in DMSO (25mg/ml), methanol (10mg/ml) or 100% ethanol; soluble in aqueous buffers up to 20μM.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
USE/STABILITY:
Stable as powder for at least 6 months when stored at +4°C in the dark. Stock solution made in DMSO should not be stored for longer than one month. Working solution is stable for 24 hours at 37°C and up to one week when stored at +4°C. Unstable in acidic (pH < 4.5) and alkaline (pH > 7.5) systems.
IDENTITY:
Identity determined by NMR.
Product Description
Prenylated chalcone found in beer. Potent inhibitor of diacylglycerol acetyltransferase (DGAT). Inhibits DNA polymerase and induces cell differentiation. Has antiproliferative and cytotoxic effects in human cancer cell lines. Inhibits human P450 enzymes. Induces quinone reductase. Inhibits the expression of HIF-1α and VEGF under hypoxic conditions. Induces apoptosis in mature adipocytes.
Product Specific Literature References
Xanthohumols, diacylglycerol acyltransferase inhibitors, from
Humulus lupulus
:
N. Tabata, et al.; Phytochemistry
46
, 683 (1997)
Abstract
Antiproliferative and cytotoxic effects of prenylated flavonoids from hops (
Humulus lupulus
) in human cancer cell lines:
C.L. Miranda, et al.; Food Chem. Toxicol.
37
, 271 (1999)
Abstract
In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops,
Humulus lupulus
:
M.C. Henderson, et al.; Xenobiotica
30
, 235 (2000)
Abstract
Prenylated chalcones and flavanones as inducers of quinone reductase in mouse Hepa 1c1c7 cells:
C.L. Miranda, et al.; Cancer Lett.
149
, 21 (2000)
Abstract
Cancer chemopreventive activity of Xanthohumol, a natural product derived from hop
:
C. Gerhauser, et al.; Mol. Cancer Ther.
1
, 959 (2002)
Abstract
Xanthohumol and related prenylflavonoids from hops and beer: to your good health!
:
J.F. Stevens & J.E. Page; Phytochemistry
65
, 1317 (2004), (Review)
Abstract
Effect of xanthohumol and isoxanthohumol on 3T3-L1 cell apoptosis and adipogenesis:
J.Y. Yang, et al.; Apoptosis
12
, 1953 (2007)
Abstract
Further Categories Containing This Product:
Active Substances from Fruit and Vegetables
•
Antitumor Agents (Anti-proliferative)
•
Estrogen & Estrogen Receptors / Related Products
•
Hypoxia-inducible Factor [HIF] / Related Products
•
Chalcones
•
Lipid Metabolism Other Products
•
Natural Products - Apoptosis Inducers & Inhibitors
•
Respiratory Chain Other Products
•
Natural Products - Antitumor Reagents
•
Obesity & Diabetes Other Products
•
VEGFs
•
Cell Differentiation
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