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Lipid Metabolism / Related Products
You are here: Product Lines > Obesity & Adipokines > Lipid Metabolism / Related Products
 
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ALX-350-152 Revised 20-Jun-08
Orlistat
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SYNONYMS Tetrahydrolipstatin
N-Formyl-L-leucine-(1S)-1-(((2S,3S)-3-hexyl-4-oxo-2-oxetanyl)methyl)dodecyl ester
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Fatty Acid Synthase [FAS] / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-152-M050   50 mg 40.00 USD Add To Cart
ALX-350-152-M250   250 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C29H53NO5
MW: 495.7
CAS NUMBER: 96829-58-2
MERCK INDEX: 14: 6869
SOURCE/HOST: Synthetic. Originally isolated from Streptomyces sp.
PURITY: ≥97%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions are stable for up to 6 weeks when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Protect from light and moisture.

Product Description
Cell permeable, irreversible inhibitor of gastric and pancreatic lipases. Shows only minimal activity against amylase, trypsin, chymotrypsin, or phospholipase A2 (PLA2). Partially inhibits the hydrolysis of triglycerides and lowers the absorption of dietary fat and promotes weight loss. Anti-obesity drug. Exhibits antitumor activity by inhibition of the thioesterase domain of fatty acid synthase (FAS) both in vitro and in vivo.
Product Specific Literature References
Interactions of lipoprotein lipase with the active-site inhibitor tetrahydrolipstatin (Orlistat): A. Lookene, et al.; Eur. J. Biochem. 222, 395 (1994) Abstract
Degree of in vivo inhibition of human gastric and pancreatic lipases by Orlistat (Tetrahydrolipstatin, THL) in the stomach and small intestine: B. Sternby, et al.; Clin. Nutr. 21, 395 (2002) Abstract
A fatty acid synthase blockade induces tumor cell-cycle arrest by down-regulating Skp2: L.M. Knowles, et al.; J. Biol. Chem. 279, 30540 (2004) Abstract; Full Text
Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity: S.J. Kridel, et al.; Cancer Res. 64, 2070 (2004) Abstract
Antitumoral actions of the anti-obesity drug orlistat (XenicalTM) in breast cancer cells: blockade of cell cycle progression, promotion of apoptotic cell death and PEA3-mediated transcriptional repression of Her2/neu (erbB-2) oncogene: J.A. Menendez, et al.; Ann. Oncol. 16, 1253 (2005) Abstract
Differential uptake of subfractions of triglyceride-rich lipoproteins by THP-1 macrophages: A.M. Palmer, et al.; Atherosclerosis 180, 233 (2005) Abstract
Orlistat and sibutramine beyond weight loss: E. Mannucci, et al.; Nutr. Metab. Cardiovasc. Dis. 70, 1228 (2008) Abstract
Further Categories Containing This Product:
Natural Products - Antitumor Reagents • Obesity & Diabetes Other Products
 
 
ALX-300-134 Revised 06-Feb-05
4-Oxatetradecanoic acid
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PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Fatty Acids
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ALX-300-134-M010   10 mg 110.00 USD Add To Cart
Product Specification
FORMULA: C13H26O3
MW: 230.3
CAS NUMBER: 4720-16-8
PURITY: ≥98%
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Analog of myristate with same chain length but a polar oxygen atom incorporated in place of a methylene group, resulting in reduced hydrophobicity. Inhibits HIV replication. Acts as fungicide against Cryptococcus neoformans. May exert its effects by inhibiting the activity of N-myristoyltransferase or by altering the physiology of proteins which have incorporated this analog in place of myristic acid.
Product Specific Literature References
4-oxatetradecanoic acid is fungicidal for Cryptococcus neoformans and inhibits replication of human immunodeficiency virus I: C.A. Langner, et al.; J. Biol. Chem. 267, 17159 (1992) Abstract; Full Text
 
 
ALX-210-442 Revised 15-May-06
Polyclonal Antibody to FABP4 (human)
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SYNONYMS anti-Fatty Acid Binding Protein 4 (human) PAb
anti-Adipocyte Fatty Acid Binding Protein (human) PAb
anti-ALBP (human) PAb
anti-Adipocyte Lipid Binding Protein (human) PAb
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Fatty Acid Binding Proteins [FABPs] / Related Products
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ALX-210-442-C100   100 µg 310.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml.
PURITY DETAIL: Purified IgG.
FORMULATION: Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN: Recombinant human FABP4 (fatty acid binding protein 4).
SPECIFICITY: Recognizes human FABP4. Detects a band of ~15kDa by Western blot.
APPLICATION: ELISA (direct and indirect: 1:5’000-1:10’000)
Western Blot (1:5’000-1:10’000 using ECL. Suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature).
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
POSITIVE CONTROL: Prod. No. ALX-201-340
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General Information
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-441 Revised 15-May-06
Polyclonal Antibody to FABP3 (human)
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SYNONYMS anti-Fatty Acid Binding Protein 3 (human) PAb
anti-Heart-type Fatty Acid Binding Protein (human) PAb
anti-Muscle-type Fatty Acid Binding Protein (human) PAb
anti-MDGI (human) PAb
anti-Mammary-derived Growth Inhibitor (human) PAb
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Fatty Acid Binding Proteins [FABPs] / Related Products
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ALX-210-441-C100   100 µg 310.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml.
PURITY DETAIL: Purified IgG.
FORMULATION: Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN: Recombinant human FABP3 (fatty acid binding protein 3).
SPECIFICITY: Recognizes human FABP3. Detects a band of ~15kDa by Western blot.
APPLICATION: ELISA (direct and indirect: 1:5’000-1:10’000)
Western Blot (1:5’000-1:10’000 using ECL. Suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature).
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
POSITIVE CONTROL: Prod. No. ALX-201-341
Product Images
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General Information
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-431 Revised 14-Mar-06
Polyclonal Antibody to SCD1 (mouse)
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SYNONYMS anti-Stearoyl-CoA Desaturase 1 (mouse) PAb
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Adipokines Other Products
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ALX-210-431-C100   100 µg 310.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
PURITY DETAIL: Purified IgG.
FORMULATION: Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN: Synthetic peptide corresponding to aa 21-33 (A21PPSGNEREKVKT33) of mouse SCD1 (stearoyl-CoA desaturase 1).
SPECIFICITY: Recognizes mouse SCD1. Detects a band of ~41kDa by Western Blot.
APPLICATION: ELISA (direct and indirect: 1:2’000-1:5’000)
Western Blot (1:2’000-1:5’000 using ECL; suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk; suggested incubation time is 1 hour at room temperature)
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
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General Information
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Lipid Metabolism Other Products • Polyclonal Antibodies
 
 
ALX-385-001 Revised 08-Apr-08
Quercetin . dihydrate
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SYNONYMS 3,3',4',5,7-Pentahydroxyflavone . 2H2O
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavonols
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ALX-385-001-G005   5 g 15.00 USD Add To Cart
ALX-385-001-G025   25 g 45.00 USD Add To Cart
Product Specification
FORMULA: C15H10O7 . 2H2O
MW: 302.2 . 36.0
CAS NUMBER: 6151-25-3
MERCK INDEX: 14: 8034
RTECS: LK8950000
SOURCE/HOST: Isolated from Sophora japonica L.
PURITY: ≥95% (HPLC)
APPEARANCE: Yellow powder with a green or brown cast.
SOLUBILITY: Soluble in 100% ethanol or 1M sodium hydroxide; almost insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: MAY BE MUTAGENIC. TOXIC.

Product Description
Antioxidant flavonoid. Inhibitor of mitochondrial ATPase, cAMP- and cGMP-phosphodiesterases. Inhibitor of protein tyrosine kinases and protein kinase C (PKC). Induces apoptosis. Blocks cells at the G0/G1 interface. Activator of human deacetylase SIRT1. Reversible inhibitor of fatty acid synthase (FAS). Inhibits the production of the inflammatory mediators nitric oxide (NO), TNF-α and IL-12 in activated macrophages.
Product Specific Literature References
Effects of quercetin and F1 inhibitor on mitochondrial ATPase and energy-linked reactions in submitochondrial particles: D.R. Lang & E. Racker; Biochim. Biophys. Acta 333, 180 (1974)
Flavonoid compounds are potent inhibitors of cyclic AMP phosphodiesterase: A. Beretz, et al.; Experientia 34, 1054 (1978) Abstract
Flavonoids are selective cyclic GMP phosphodiesterase inhibitors: M. Ruckstuhl, et al.; Biochem. Pharmacol. 28, 535 (1979) Abstract
The effect of quercetin on the phosphorylation activity of the Rous sarcoma virus transforming gene product in vitro and in vivo: Y. Graziani, et al.; Eur. J. Biochem. 135, 583 (1983) Abstract
Inhibition of the calcium- and phospholipid-dependent protein kinase activity from mouse brain cytosol by quercetin: M. Gschwendt, et al.; BBRC 117, 444 (1983) Abstract
Tyrosine protein kinase activity in the DMBA-induced rat mammary tumor: inhibition by quercetin: J. Levy, et al.; BBRC 123, 1227 (1984) Abstract
The phospholipid- and calcium-dependent protein kinase as a target in tumor chemotherapy: H. Grunicke, et al.; Adv. Enzyme Regul. 28, 201 (1989) Abstract
Induction of apoptosis by quercetin: involvement of heat shock protein: Y.Q. Wei, et al.; Cancer Res. 54, 4952 (1994) Abstract
Multiple effects of tyrosine kinase inhibitors on vascular smooth muscle contraction: C.M. Filipeanu, et al.; Eur. J. Pharmacol. 281, 29 (1995) Abstract
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Molecular mechanisms in the antiproliferative action of quercetin: B. Csokay, et al.; Life Sci. 60, 2157 (1997) Abstract
Modulation of the heat-induced activation of mitogen-activated protein (MAP) kinase by quercetin: Y. Nagasaka & K. Nakamura; Biochem. Pharmacol. 56, 1151 (1998) Abstract
Quercetin-induced apoptosis in colorectal tumor cells: possible role of EGF receptor signaling: M. Richter, et al.; Nutr. Cancer 34, 88 (1999) Abstract
Quercetin and anti-CD95(Fas/Apo1) enhance apoptosis in HPB-ALL cell line: M. Russo, et al.; FEBS Lett. 462, 322 (1999) Abstract
The effect of quercetin on induction of apoptosis: J. Rzymowska, et al.; Folia Histochem. Cytobiol. 37, 125 (1999) Abstract
Quercetin, coenzyme Q10, and L-canavanine as protective agents against lipid peroxidation and nitric oxide generation in endotoxin-induced shock in rat brain: H.M. Abd El-Gawad & A.E. Khalifa; Pharmacol. Res. 43, 257 (2001) Abstract
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan: K.T. Howitz, et al.; Nature 425, 191 (2003)
Presence of fatty acid synthase inhibitors in the rhizome of Alpinia officinarum hance: B.H. Li and W.X. Tian; J. Enzyme Inhib. Med. Chem. 18, 349 (2003) Abstract
Inhibitory effects of the flavonoids isolated from Waltheria indica on the production of NO, TNF-alpha and IL-12 in activated macrophages: Y.K. Rao, et al.; Biol. Pharm. Bull. 28, 912 (2005) Abstract
Pharmacological inhibitors of Fatty Acid Synthase (FASN)--catalyzed endogenous fatty acid biogenesis: a new family of anti-cancer agents?: R. Lupu & J. A. Menendez; Curr. Pharm. Biotechnol. 7, 483 (2006), (Review) Abstract
Onions: a source of unique dietary flavonoids: R. Slimestad, et al.; J. Agric. Food Chem. 55, 10067 (2007) Abstract
Further Categories Containing This Product:
PKC Inhibitors • Active Substances from Fruit and Vegetables • Natural Products - ATPase Inhibitors • Sirtuins / Related Products • Tyrosine Kinase Inhibitors • Fatty Acid Synthase [FAS] / Related Products • Phosphodiesterases / Related Products • Natural Products - Apoptosis Inducers & Inhibitors • Cell Cycle Blockers & Inhibitors / Related Products • Natural Products - Anti-inflammatory Agents • Natural Products - Anti-inflammatory Agents • Natural Products - Nitric Oxide Pathway Modulators • Natural Products - Antioxidants
 
 
ALX-270-402 Revised 08-Mar-05
TOFA
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SYNONYMS 5-(Tetradecyloxy)-2-furoic acid
RMI-14514
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Acetyl-Coenzyme A [Ac-CoA] Carboxylase / Related Products
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ALX-270-402-M010   10 mg 58.00 USD Add To Cart
ALX-270-402-M050   50 mg 230.00 USD Add To Cart
Product Specification
FORMULA: C19H32O4
MW: 324.5
CAS NUMBER: 54857-86-2
PURITY: ≥98% (1H-NMR)
APPEARANCE: White to off-white powder
SOLUBILITY: Soluble in dimethyl formamide, DMSO, 100% ethanol or methanol. Sparingly soluble in aqueous buffers.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C

Product Description
Potent, reversible and competitive inhibitor of acetyl-coenzyme A carboxylase (Ac-CoA carboxylase; ACC), a key enzyme involved in fatty acid biosynthesis. Rescues cancer cells from fatty acid synthase inhibitor C75 (Prod. No. ALX-270-286) cytotoxicity.
Product Specific Literature References
5-(Tetradecyloxy)-2-furancarboxylic acid and related hypolipidemic fatty acid-like alkyloxyarylcarboxylic acids: R.A. Parker, et al.; J. Med. Chem. 20, 781 (1977) Abstract
Interactions between fatty acid synthesis, oxidation, and esterification in the production of triglyceride-rich lipoproteins by the liver: N. Fukuda and J.A. Ontko; J. Lipid Res. 25, 831 (1984) Abstract
Inhibition of fatty acid synthesis decreases very low density lipoprotein secretion in the hamster: C.M. Arbeeny, et al.; J. Lipid Res. 33, 843 (1992) Abstract
Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors: T.M. Loftus, et al.; Science 288, 2379 (2000) Abstract
Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts: E.S. Pizer, et al.; Cancer Res. 60, 213 (2000) Abstract
Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells: W. Zhou, et al.; Cancer Res. 63, 7330 (2003) Abstract
C75, a fatty acid synthase inhibitor, modulates AMP-activated protein kinase to alter neuronal energy metabolism: L.E. Landree, et al.; J. Biol. Chem. 279, 3817 (2004) Abstract
General Literature References
Mechanistic diversity and regulation of Type II fatty acid synthesis: H. Marrakchi, et al; Biochem. Soc. Trans. 30, 1050 (2002) Abstract
Hypothalamic malonyl-CoA as a mediator of feeding behavior: Z. Hu, et al.; PNAS 100, 12624 (2003) Abstract
Fatty acid recycling in adipocytes: a role for glyceroneogenesis and phosphoenolpyruvate carboxykinase: C. Forest, et al.; Biochem. Soc. 31, 1125 (2003) Abstract
 
 
ALX-380-285 Revised 16-Sep-08
Triacsin C
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SYNONYMS 2,4,7-Undecatrienal nitrosohydrazone
WS1228A
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Apoptosis Inducers & Inhibitors
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ALX-380-285-MC05   0.5 mg 190.00 USD Add To Cart
ALX-380-285-M001   1 mg 350.00 USD Add To Cart
Product Specification
FORMULA: C11H17N3O
MW: 207.3
CAS NUMBER: 76896-80-5
SOURCE/HOST: Isolated from Streptomyces aureofaciens.
PURITY: ≥94% (HPLC)
APPEARANCE: White to light brown powder.
SOLUBILITY: Soluble in DMSO (10mg/ml) or methanol (5mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Keep under inert gas. Protect from light.
MELTINGPOINT: 102-103°C

Product Description
Analog of polyunsaturated fatty acid. Potent inhibitor of long-chain fatty acyl CoA synthetase. Selectively inhibits arachidonoyl-CoA synthetase in intact cells. Blocks β-cell apoptosis induced by fatty acids (lipoapoptosis) and synthesis of triglycerides, diglycerides and cholesterol esters. Potent vasodilator. Used in a rat model of obesity.
Product Specific Literature References
Triacsin C: a differential inhibitor of arachidonoyl-CoA synthetase and nonspecific long chain acyl-CoA synthetase: E.J. Hartman, et al.; Prostaglandins 37, 655 (1989) Abstract
Evidence for an essential role of long chain acyl-CoA synthetase in animal cell proliferation. Inhibition of long chain acyl-CoA synthetase by triacsins caused inhibition of Raji cell proliferation: H. Tomoda, et al.; J. Biol. Chem. 266, 4214 (1991) Abstract; Full Text
The acyl-CoA synthetase inhibitor triacsin C enhanced eicosanoid release in leukocytes: S. Oh-ishi, et al.; Jpn. J. Pharmacol. 59, 417 (1992) Abstract; Full Text
Triacsin C blocks de novo synthesis of glycerolipids and cholesterol esters but not recycling of fatty acid into phospholipid: evidence for functionally separate pools of acyl-CoA: R.A. Igal, et al.; Biochem. J. 324, 529 (1997) Abstract; Full Text
Protection against lipoapoptosis of beta cells through leptin-dependent maintenance of Bcl-2 expression: M. Shimabukuro, et al.; PNAS 95, 9558 (1998) Abstract; Full Text
Complete inhibition of mouse macrophage-derived foam cell formation by triacsin C: I. Namatame, et al.; J. Biochem. 125, 319 (1999) Abstract
Triacsin C inhibits the formation of 1H NMR-visible mobile lipids and lipid bodies in HuT 78 apoptotic cells: E. Iorio, et al.; Biochim. Biophys. Acta 1634, 1 (2003) Abstract
ADRP/adipophilin is degraded through the proteasome-dependent pathway during regression of lipid-storing cells: Y. Masuda, et al.; J. Lipid Res. 47, 87 (2006) Abstract; Full Text
Further Categories Containing This Product:
Lipid Metabolism Other Products
 
 
ALX-350-280 Revised 07-Oct-08
Xanthohumol
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products - DNA Regulation / Transcription
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ALX-350-280-M005   5 mg 135.00 USD Add To Cart
Product Specification
FORMULA: C21H22O5
MW: 354.4
CAS NUMBER: 569-83-5, 6754-58-1
SOURCE/HOST: Isolated from hops (Humulus lupulus).
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow to orange powder.
SOLUBILITY: Soluble in DMSO (25mg/ml), methanol (10mg/ml) or 100% ethanol; soluble in aqueous buffers up to 20μM.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Stable as powder for at least 6 months when stored at +4°C in the dark. Stock solution made in DMSO should not be stored for longer than one month. Working solution is stable for 24 hours at 37°C and up to one week when stored at +4°C. Unstable in acidic (pH < 4.5) and alkaline (pH > 7.5) systems.
IDENTITY: Identity determined by NMR.