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Obesity & Adipokines
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ALX-420-029 Revised 22-Feb-08
GW1929
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SYNONYMS N-(2-Benzoylphenyl)-L-tyrosine PPARγ Agonist
(2S)-((2-Benzoylphenyl)amino-3-[4-[2-(methylpyridin-2-ylamino)ethoxy]phenyl)propionic acid
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PPAR Agonists
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-420-029-M001   1 mg 80.00 USD Add To Cart
ALX-420-029-M005   5 mg 360.00 USD Add To Cart
Product Specification
FORMULA: C30H29N3O4
MW: 495.6
PURITY: ≥97%
APPEARANCE: Off-white to yellow crystalline solid.
SOLUBILITY: Soluble in DMSO or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Potent (<10nM) and subtype-selective (>1'000-fold) PPARγ agonist which does not contain a thiazolidinedione moiety. The glucose-lowering effect of GW1929 in rats is 100-fold more potent than that of troglitazone (Prod. No. ALX-270-355).
Product Specific Literature References
N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents: B.R. Henke, et al.; J. Med. Chem. 41, 5020 (1998) Abstract
Superoxide anion-dependent Raf/MEK/ERK activation by peroxisome proliferator activated receptor gamma agonists 15-deoxy-delta(12,14)-prostaglandin J(2), ciglitazone, and GW1929: W.C. Huang, et al.; Exp. Cell Res. 277, 192 (2002) Abstract
15-Deoxy-{delta}12,14-prostaglandin j2 inhibits interleukin-1{beta}-induced nuclear factor-{kappa}b in human amnion and myometrial cells: mechanisms and implications: T.M. Lindström & P.R. Bennett; J. Clin. Endocrinol. Metab. 90, 3534 (2005) Abstract; Full Text
 
 
ALX-270-356 Revised 04-May-06
GW9662
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SYNONYMS 2-Chloro-5-nitrobenzanilide
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PPAR Antagonists
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ALX-270-356-M001   1 mg 10.00 USD Add To Cart
ALX-270-356-M005   5 mg 35.00 USD Add To Cart
ALX-270-356-M025   25 mg 140.00 USD Add To Cart
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Product Specification
FORMULA: C13H9N2O3Cl
MW: 276.7
CAS NUMBER: 22978-25-2
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 100% ethanol, DMSO or dimethyl formamide.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Blocks the PPARγ-induced differentiation of monocytes to osteoclasts by >90% at a dose of 0.1µM. Much more potent antagonist than BADGE (Prod. No. ALX-270-353).
Product Specific Literature References
IL-4 inhibits osteoclast formation through a direct action on osteoclast precursors via peroxisome proliferator-activated receptor gamma 1: A.C. Bendixen, et al.; PNAS 98, 2443 (2001) Abstract; Full Text
Functional consequences of cysteine modification in the ligand binding sites of peroxisome proliferator activated receptors by GW9662: L.M. Leesnitzer, et al.; Biochemistry 41, 6640 (2002) Abstract
Activation of peroxisome proliferator-activated receptor gamma inhibits osteoprotegerin gene expression in human aortic smooth muscle cells: M. Fu, et al.; BBRC 294, 597 (2002) Abstract
15-Deoxy-{delta}12,14-prostaglandin j2 inhibits interleukin-1{beta}-induced nuclear factor-{kappa}b in human amnion and myometrial cells: mechanisms and implications: T.M. Lindström & P.R. Bennett; J. Clin. Endocrinol. Metab. 90, 3534 (2005) Abstract; Full Text
 
 
ALX-420-032 Revised 06-Aug-07
GW501516
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PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PPAR Agonists
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ALX-420-032-M001   1 mg 83.00 USD Add To Cart
ALX-420-032-M005   5 mg 367.00 USD Add To Cart
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Product Specification
FORMULA: C21H18F3NO3S2
MW: 453.5
CAS NUMBER: 317318-70-0
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in acetonitrile, DMSO, dimethyl formamide, 100% ethanol or methanol; slightly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Specific agonist for PPARδ (EC50=1.1nM) with a 1'000-fold selectivity over the other human subtypes.
Product Specific Literature References
A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport: W.R. Oliver, Jr., et al.; PNAS 98, 5306 (2001) Abstract; Full Text
The peroxisome proliferator-activated receptor beta/delta agonist, GW501516, regulates the expression of genes involved in lipid catabolism and energy uncoupling in skeletal muscle cells: U. Dressel, et al.; Mol. Endocrinol. 17, 2477 (2003) Abstract
Peroxisome proliferator-activated receptor (PPAR) alpha and PPARbeta/delta, but not PPARgamma, modulate the expression of genes involved in cardiac lipid metabolism: A.J. Gilde, et al.; Circ. Res. 92, 518 (2003) Abstract
PPARdelta activation induces COX-2 gene expression and cell proliferation in human hepatocellular carcinoma cells: B. Glinghammar, et al.; BBRC 308, 361 (2003) Abstract
Novel selective small molecule agonists for peroxisome proliferator-activated receptor delta (PPARdelta)-synthesis and biological activity: M.L. Sznaidman, et al.; Bioorg. Med. Chem. Lett. 13, 1517 (2003) Abstract
Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity: Y.X. Wang, et al.; Cell 113, 159 (2003) Abstract
A short and efficient synthesis of the pharmacological research tool GW501516 for the peroxisome proliferator-activated receptor delta: Z.L. Wei & A.P. Kozikowski; J. Org. Chem. 68, 9116 (2003) Abstract
 
 
ALX-350-371 Revised 10-Mar-08 New product
Harmine
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SYNONYMS Leucoharmine
Banisterine
Telepathine
Yageine
7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products - DNA Regulation/Transcription
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ALX-350-371-M250   250 mg 22.00 USD Add To Cart
Product Specification
FORMULA: C13H12N2O
MW: 212.3
CAS NUMBER: 442-51-3
MERCK INDEX: 14: 4616
RTECS: UV0175000
SOURCE/HOST: Originally isolated from Peganum harmala.
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO, dimethyl formamide or 100% ethanol; slightly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: HARMFUL.

Product Description
Alkaloid of the β-carboline family. Regulates PPARγ expression. Inhibits the Wnt signalling pathway in a cell-specific manner. Down-regulates inflammatory gene expression (TNF-α, IL-1β, iNOS). Reversibly inhibits monoamine oxidase inhibitor A (MAO-A), but has no effect on MAO-B.
Product Specific Literature References
The chemotherapy of derivatives of harmine and harmaline. I: C.E. Coulthard, et al.; Biochee. J. 27, 727 (1933) Abstract; Full Text
The chemotherapy of derivatives of harmine and harmaline. II: C.E. Coulthard; Biochem. J. 28, 264 (1934) Abstract; Full Text
Interrelationships between amphetamine and harmala alkaloids: H. Schmitt; Nature 203, 877 (1964) Abstract
Effect of moclobemide on rat brain monoamine oxidase A and B: comparison with harmaline and clorgyline: J. Gerardy; Prog. Neuropsychopharmacol. Biol. Psychiatry 18, 793 (1994) Abstract
Hypothermic effect of harmala alkaloid in rats: involvement of serotonergic mechanism: A.F. Abdel-Fattah, et al.; Pharmacol. Biochem. Behav. 52, 421 (1995) Abstract
The mode of action of thiazolidinediones: H. Hauner; Diabet. Metab. Res. Rev. 18, S10 (2002) Abstract
Antitumor and neurotoxic effects of novel harmine derivatives and structure-activity relationship analysis: Q. Chen, et al.; Int. J. Cancer 114, 675 (2005) Abstract
The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARgamma expression: H. Waki, et al.; Cell Metab. 5, 357 (2007) Abstract
Further Categories Containing This Product:
Natural Products - Other Signal Transduction Pathway Modulators • Antidiabetic Agents/Related Products • Interleukin-1 [IL-1] & Receptors/Related Products • Wnt Signalling Pathway Other Products • TNF-alpha & TNF Receptors Other Products • NOS Regulation • Alkaloids
 
 
ALX-340-037 Revised 08-Jul-08
8(S)-HETE
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SYNONYMS 8-Hydroxy-[S-(E,Z,Z,Z)]-5,9,11,14-eicosatetraenoic acid
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Hydroxy, Hydroperoxy & Oxo Fatty Acids/Related Products
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ALX-340-037-C025   25 µg 165.00 USD Add To Cart
Product Specification
FORMULA: C20H32O3
MW: 320.5
CAS NUMBER: 98462-03-4
PURITY: ≥98%
FORMULATION: Liquid. Solution in ethanol.
SOLUBILITY: Soluble in DMSO or dimethyl formamide; slightly soluble in PBS, pH 7.2 (0.8mg/ml) or 0.1M Na2CO3 (2mg/ml)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C. Stable for at least 6 months in other organic solvents when stored at -20°C. Keep aqueous solutions on ice and use within 12 hours.
HANDLING: Protect from light and oxygen.

Product Description
Activator of PPARα. Activates mouse skin protein kinase C (PKC).
Product Specific Literature References
Investigation of the mechanism of biosynthesis of 8-hydroxyeicosatetraenoic acid in mouse skin: M.A. Hughes & A.R. Brash; Biochim. Biophys. Acta 1081, 347 (1991) Abstract
In vitro activation of mouse skin protein kinase C by fatty acids and their hydroxylated metabolites: H.H. Lo, et al.; Lipids 29, 547 (1994) Abstract
Differential activation of peroxisome proliferator-activated receptors by eicosanoids: K. Yu, et al.; J. Biol. Chem. 270, 23975 (1995) Abstract; Full Text
Expression of peroxisome proliferator-activated receptors in urinary tract of rabbits and humans: Y. Guan, et al.; Am. J. Physiol. 273, F1013 (1997) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION To change the solvent, evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.
Further Categories Containing This Product:
PPAR Agonists • PKC Activators
 
 
ALX-300-131 Revised 04-Feb-05
2-Hydroxymyristic acid
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SYNONYMS 2-Hydroxy-tetradecanoic acid
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Fatty Acids
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ALX-300-131-M025   25 mg 35.00 USD Add To Cart
Product Specification
FORMULA: C14H28O3
MW: 244.4
CAS NUMBER: 2507-55-3
PURITY: ≥97%
APPEARANCE: White solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Selective inhibitor of protein myristoylation in cells, able to distinguish myristoylation from palmitoylation. Metabolic activation appears to be required. Myristoylation takes place on glycine residues at the N-terminus of proteins and provides a strong membrane anchor for the modified proteins, many of which require myristoylation for full activity.
Product Specific Literature References
Activation of p56lck through mutation of a regulatory carboxy-terminal tyrosine residue requires intact sites of autophosphorylation and myristylation: N. Abraham & A. Veillette; Mol. Cell. Biol. 10, 5197 (1990) Abstract
Metabolic activation of 2-substituted derivatives of myristic acid to form potent inhibitors of myristoyl CoA:protein N-myristoyltransferase: L.A. Paige, et al.; Biochemistry 29, 10566 (1990) Abstract
The G protein connection: molecular basis of membrane association [published erratum appears in TIBS 17, 177 (1992)]: A.M. Spiegel, et al.; TIBS 16, 338 (1991), (Review) Abstract
Treatment of T cells with 2-hydroxymyristic acid inhibits the myristoylation and alters the stability of p56lck: M.J.S. Nadler, et al.; Biochemistry 32, 9250 (1993) Abstract
Reversible palmitoylation of the protein-tyrosine kinase p56lck: L.A. Paige, et al.; J. Biol. Chem. 268, 8669 (1993) Abstract; Full Text
Inhibition of varicella-zoster virus replication by an inhibitor of protein myristoylation: D.R. Harper, et al.; J. Gen. Virol. 74, 1181 (1993) Abstract
 
 
ALX-582-001 Revised 02-Jul-08
Isopropyl-β-D-thiogalactoside (analytical grade, free of dioxane)
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SYNONYMS IPTG (analytical grade, free of dioxane)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Carbohydrates
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ALX-582-001-G001   1 g 33.00 USD Add To Cart
ALX-582-001-G005   5 g 85.00 USD Add To Cart
ALX-582-001-G025   25 g 290.00 USD Add To Cart
Product Specification
FORMULA: C9H18O5S
MW: 238.3
CAS NUMBER: 367-93-1
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water (5%).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

 
 
ALX-350-279 Revised 02-Jun-08
Isoxanthohumol
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products - DNA Regulation/Transcription
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ALX-350-279-M001   1 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C21H22O5
MW: 354.4
SOURCE/HOST: Synthetic.
PURITY: ≥98%
APPEARANCE: White powder.
SOLUBILITY: Soluble in DMSO (50mg/ml) or methanol (50mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Prenylated flavonoid. Phytoestrogen. Induces apoptosis in mature adipocytes.
Product Specific Literature References
Xanthohumol and related prenylflavonoids from hops and beer: to your good health!: J.F. Stevens & J.E. Page; Phytochemistry 65, 1317 (2004), (Review) Abstract
Inhibition of endothelial cell functions by novel potential cancer chemopreventive agents: E. Bertl, et al.; BBRC 325, 287 (2004) Abstract
Metabolism of xanthohumol and isoxanthohumol, prenylated flavonoids from hops (Humulus lupulus L.), by human liver microsomes: D. Nikolic, et al.; J. Mass Spectrom. 40, 289 (2005) Abstract
The prenylflavonoid isoxanthohumol from hops (Humulus lupulus L.) is activated into the potent phytoestrogen 8-prenylnaringenin in vitro and in the human intestine: S. Possemiers, et al.; J. Nutr. 136, 1862 (2006) Abstract
Identification of human hepatic cytochrome P450 enzymes involved in the metabolism of 8-prenylnaringenin and isoxanthohumol from hops (Humulus lupulus L.): J. Guo, et al.; Drug Metab. Dispos. 34, 1152 (2006)
Effect of xanthohumol and isoxanthohumol on 3T3-L1 cell apoptosis and adipogenesis: J.Y. Yang, et al.; Apoptosis 12, 1953 (2007) Abstract
Further Categories Containing This Product:
Natural Products - Other Signal Transduction Pathway Modulators • Estrogen & Estrogen Receptors/Related Products • Natural Products - Apoptosis Inducers & Inhibitors • Active Substances from Fruit and Vegetables • Lipid Metabolism Other Products • Flavonoids/Related Products
 
 
ALX-270-236 Revised 04-Feb-05
JM 34
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SYNONYMS N-(4,6-Dimethylpyridin-2-yl)furane-2-carboxamide
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY TNF-alpha & TNF Receptors Other Products
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ALX-270-236-M010   10 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C12H12N2O2
MW: 216.2
PURITY: ≥99%
APPEARANCE: White solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: For biological studies, solubilize as a maleate salt just before use.
HANDLING: Keep under inert gas. Protect from light.

Product Description
Anti-inflammatory pyridinylamide that inhibits TNF-α production, probably by interacting with a protein kinase C (PKC)-dependent pathway of ERK2 phosphorylation. No inhibition of PKC activity in vitro. May serve as an alternative to classical cyclooxygenase (COX) inhibitors in TNF-α pathogenesis.
Product Specific Literature References
New antiinflammatory compounds that inhibit tumor necrosis factor production: probable interaction with protein kinase C activation: F. Lang, et al.; J. Pharmacol. Exp. Ther. 275, 171 (1995) Abstract
An anti-inflammatory benzamide derivative inhibits the protein kinase C (PKC)-dependent pathway of ERK2 phosphorylation in murine macrophages: L. Vernhet, et al.; J. Pharmacol. Exp. Ther. 283, 358 (1997) Abstract; Full Text
 
 
ALX-270-235 Revised 04-Feb-05
JM 42
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SYNONYMS N-(4,6-Dimethylpyridin-2-yl)-5-bromofurane-2-carboxamide
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY TNF-alpha & TNF Receptors Other Products
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