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Items 14 of 14
ALX-201-411 Revised 03-Apr-08
Lipocalin-2 (human) (recombinant)
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SYNONYMS NGAL (human) (recombinant)
Neutrophil Gelatinase-associated Lipocalin (human) (recombinant)
Siderocalin (human) (recombinant)
Oncogene 24p3 (human) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Adipokines Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-411-C010   10 µg 150.00 USD Add To Cart
ALX-201-411-C050   50 µg 320.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. The mature peptide of human lipocalin-2 is fused to a FLAG®-tag at the C-terminus.
CONCENTRATION: 0.3mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
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General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P80188: Lipocalin-2 (human)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
General Literature References
Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron: T.H. Flo, et al.; Nature 432, 917 (2004) Abstract
The adipokine lipocalin 2 is regulated by obesity and promotes insulin resistance: Q.W. Yan, et al.; Diabetes 56, 2533 (2007) Abstract
Lipocalin 2-mediated growth suppression is evident in human erythroid and monocyte/macrophage lineage cells: K. Miharada, et al.; J. Cell Physiol. 215, 526 (2008) Abstract
The novel role of neutrophil gelatinase-B associated lipocalin (NGAL)/Lipocalin-2 as a biomarker for lupus nephritis: T. Rubinstein, et al.; Autoimmun. Rev. 7, 229 (2008) Abstract
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Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • MMPs Other Products • Cholesterol & Lipid Transport / Related Products
 
 
ALX-201-415 Revised 09-Jul-08
Lipocalin-2 (mouse) (recombinant)
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SYNONYMS NGAL (mouse) (recombinant)
Neutrophil Gelatinase-associated Lipocalin (mouse) (recombinant)
Siderocalin (mouse) (recombinant)
Oncogene 24p3 (mouse) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Adipokines Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-415-C010   10 µg 150.00 USD Add To Cart
ALX-201-415-C050   50 µg 320.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. The mature peptide of mouse lipocalin-2 (aa 1-200) is fused to a FLAG®-tag at the C-terminus.
CONCENTRATION: 0.3mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
Please click on thumbnails to enlarge.
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P11672: Lipocalin-2 (mouse)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
Related Products
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • MMPs Other Products • Cholesterol & Lipid Transport / Related Products
 
 
ALX-201-417 Revised 05-Jun-08
Lipocalin-2 (rat) (recombinant)
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SYNONYMS NGAL (rat) (recombinant)
Neutrophil Gelatinase-associated Lipocalin (rat) (recombinant)
Siderocalin (rat) (recombinant)
Oncogene 24p3 (rat) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Adipokines Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-417-C010   10 µg 150.00 USD Add To Cart
ALX-201-417-C050   50 µg 320.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. The mature peptide of rat lipocalin-2 (aa 1-198) is fused to a FLAG®-tag at the C-terminus.
CONCENTRATION: 0.3mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
Please click on thumbnails to enlarge.
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P30152: Lipocalin-2 (rat)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
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Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • MMPs Other Products • Cholesterol & Lipid Transport / Related Products
 
 
ALX-215-060 Revised 31-Jul-08 New product
Polyclonal Antibody to SorLA (IC)
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SYNONYMS anti-LR11 PAb (IC)
anti-SorL1 PAb (IC)
anti-Sorting Protein-related Receptor Containing LDLR Class A Repeats PAb (IC)
anti-Low-density Lipoprotein Receptor Relative with 11 Ligand-binding Repeats PAb (IC)
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Neuropeptides & Receptors Other Products
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ALX-215-060-1   1 Vial 250.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST: From rabbit.
FORMULATION: Lyophilized.
RECONSTITUTION: Reconstitute with 50μl distilled water.
IMMUNOGEN: Synthetic peptide corresponding to the 18 C-terminal aa from the intracellular tail (IC) of mouse SorLA with an added N-terminal cysteine.
SPECIFICITY: Recognizes human, mouse and rat SorLA.
APPLICATION: Immunocytochemistry (1:3’000)
Western Blot (1:3’000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
BLOCKING PEPTIDE: Blocking Peptide for PAb to SorLA Prod. No. ALX-167-028
Product Description
Recognizes transmembrane SorLA, the membrane stub after ectodomain shedding and also the soluble cytoplasmic domain.
Product Specific Literature References
Ectodomain shedding, translocation and synthesis of SorLA are stimulated by its ligand head activator: W. Hampe, et al.; J. Cell Sci. 113, 4475 (2000) Abstract; Full Text
Characterization of the VPS10 domain of SorLA/LR11 as binding site for the neuropeptide HA: J. Lintzel, et al.; Biol. Chem. 383, 1727 (2002) Abstract
SorLA signaling by regulated intramembrane proteolysis: C. Böhm, et al.; J. Biol. Chem. 281, 14547 (2006) Abstract; Full Text
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease: E. Rogaeva, et al.; Nat. Genet. 39, 168 (2007) Abstract
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Further Categories Containing This Product:
Cholesterol & Lipid Transport / Related Products • Polyclonal Antibodies
 
 
ALX-215-061 Revised 31-Jul-08 New product
Polyclonal Antibody to SorLA (F3)
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SYNONYMS anti-LR11 PAb (F3)
anti-SorL1 PAb (F3)
anti-Sorting Protein-related Receptor Containing LDLR Class A Repeats PAb (F3)
anti-Low-density Lipoprotein Receptor Relative with 11 Ligand-binding Repeats PAb (F3)
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Neuropeptides & Receptors Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-215-061-1   1 Vial 250.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST: From rabbit.
FORMULATION: Lyophilized.
RECONSTITUTION: Reconstitute with 50μl distilled water.
IMMUNOGEN: Recombinant mouse SorLA (aa 1384-1676 representing the first 4.5 extracellular fibronectin type III domain).
SPECIFICITY: Recognizes human, mouse and rat SorLA.
APPLICATION: Immunocytochemistry (1:1’000)
Western Blot (1:3’000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Description
Recognizes transmembrane SorLA and also the shed ectodomain.
Product Specific Literature References
Ectodomain shedding, translocation and synthesis of SorLA are stimulated by its ligand head activator: W. Hampe, et al.; J. Cell Sci. 113, 4475 (2000) Abstract; Full Text
Characterization of the VPS10 domain of SorLA/LR11 as binding site for the neuropeptide HA: J. Lintzel, et al.; Biol. Chem. 383, 1727 (2002) Abstract
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Further Categories Containing This Product:
Cholesterol & Lipid Transport / Related Products • Polyclonal Antibodies
 
 
ALX-270-475 Revised 17-Jan-08
Ciprofibrate
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SYNONYMS 2-[4-(2,2-Dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Cholesterol & Lipid Transport / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-475-M025   25 mg 50.00 USD Add To Cart
ALX-270-475-M100   100 mg 150.00 USD Add To Cart
ALX-270-475-M250   250 mg 300.00 USD Add To Cart
Product Specification
FORMULA: C13H14Cl2O3
MW: 289.2
CAS NUMBER: 52214-84-3
MERCK INDEX: 14: 2313
RTECS: UF0880000
PURITY: ≥98% (HPLC)
APPEARANCE: White to light yellow powder.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: TOXIC. MAY BE CARCINOGENIC.

Product Description
Hypolipidemic compound. PPARα (peroxisome proliferator-activated receptor α) agonist.
Product Specific Literature References
Comparison of the effects of various peroxisome proliferators on peroxisomal enzyme activities, DNA synthesis, and apoptosis in rat and human hepatocyte cultures: V. Goll, et al.; Toxicol. Appl. Pharmacol. 160, 21 (1999) Abstract
Phosphorylation of peroxisome proliferator-activated receptor alpha in rat Fao cells and stimulation by ciprofibrate: P. Passilly, et al.; Biochem. Pharmacol. 58, 1001 (1999) Abstract
Differences in cell proliferation in rodent and human hepatic derived cell lines exposed to ciprofibrate: M.C. Clemencet, et al.; Cancer Lett. 222, 217 (2005) Abstract
P450 CYP2C epoxygenase and CYP4A ω-hydroxylase mediate ciprofibrate-induced PPARα-dependent peroxisomal proliferation: A. Gatica, et al.; J. Lipid Res. 48, 924 (2007) Abstract; Full Text
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Further Categories Containing This Product:
PPAR Agonists • Apoptosis Inducers & Inhibitors Other Products
 
 
ALX-340-039 Revised 05-Feb-05
MEDICA 16
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SYNONYMS 3,3,14,14-Tetramethylhexadecanedioic acid
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Cholesterol & Lipid Transport / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-340-039-M005   5 mg 92.00 USD Add To Cart
Product Specification
FORMULA: C20H38O4
MW: 342.5
CAS NUMBER: 87272-20-6
PURITY: ≥98%
APPEARANCE: Crystalline solid.
SOLUBILITY: 100mg/ml soluble in DMSO, dimethyl formamide or 100% ethanol. Slightly soluble in aqueous buffers.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C

Product Description
Hypolipidemic and antidiabetic agent, shown to reduce adiposity. Induces malic enzyme, mitochondrial glycerol-3-phosphate dehydrogenase, and carnitine palmitoyl transferase I. Inhibitor of citrate lyase and acetyl-CoA carboxylase, expected to disinhibit hepatic fatty acid oxidation while up-regulating electron shuttle mechanism, and thus should stimulate reverse electron transport. Exhibits thyromimetic properties with respect to the modulation of rat liver redox and phosphate potentials.
Product Specific Literature References
Inhibition of lipid synthesis by beta beta'-tetramethyl-substituted, C14-C22, alpha, omega-dicarboxylic acids in the rat in vivo: J. Bar-Tana, et al.; J. Biol. Chem. 260, 8404 (1985) Abstract; Full Text
The hypochylomicronemic effect of beta,beta'-methyl-substituted hexadecanedioic acid (MEDICA 16) is mediated by a decrease in apolipoprotein C-III: B. Frenkel, et al.; J. Biol. Chem. 263, 8491 (1988) Abstract; Full Text
Adipose reduction by beta,beta'-tetramethyl-substituted hexadecanedioic acid (MEDICA 16): R. Tzur, et al.; Int. J. Obes. 13, 313 (1989), Review Abstract
Inhibition of rat liver acetyl-CoA carboxylase by beta, beta'-tetramethyl-substituted hexadecanedioic acid (MEDICA 16): G. Rose-Kahn & J. Bar-Tana; Biochim. Biophys. Acta 1042, 259 (1990) Abstract
Hypolipidemic effect of beta, beta'-tetramethyl hexadecanedioic acid (MEDICA 16) in hyperlipidemic JCR:LA-corpulent rats: J.C. Russell, et al.; Arterioscler. Thromb. 11, 602 (1991) Abstract
Tissue selective modulation of redox and phosphate potentials by beta,beta'-methyl-substituted hexadecanedioic acid: B. Kalderon, et al.; Endocrinology 131, 1629 (1992) Abstract
Mode of action of peroxisome proliferators as hypolipidemic drugs. Suppression of apolipoprotein C-III: R. Hertz, et al.; J. Biol. Chem. 270, 13470 (1995) Abstract; Full Text
Sensitization to insulin induced by beta,beta'-methyl-substituted hexadecanedioic acid (MEDICA 16) in obese Zucker rats in vivo: N. Mayorek, et al.; Diabetes 46, 1958 (1997) Abstract
Mitochondria uncoupling by a long chain fatty acyl analogue: O. Hermesh, et al.; J. Biol. Chem. 273, 3937 (1998) Abstract; Full Text
Development of insulin resistance in the JCR:LA-cp rat: role of triacylglycerols and effects of MEDICA 16: J.C. Russell, et al.; Diabetes 47, 770 (1998) Abstract; Full Text
Peroxisome proliferators as adjuvants for the reverse-electron-transport therapy of obesity: an explanation for the large increase in metabolic rate of MEDICA 16-treated rats: M.F. McCarty; Med. Hypotheses 53, 272 (1999) Abstract
Mitochondrial protonophoric activity induced by a thyromimetic fatty acid analogue: O. Hermesh, et al.; Biochim. Biophys. Acta 1457, 166 (2000) Abstract
Fatty acid cycling in the fasting rat: B. Kalderon, et al.; Am. J. Physiol. Endocrinol. Metab. 279, E221 (2000) Abstract; Full Text
MEDICA 16 inhibits hepatic acetyl-CoA carboxylase and reduces plasma triacylglycerol levels in insulin-resistant JCR: LA-cp rats: L.L. Atkinson, et al.; Diabetes 51, 1548 (2002) Abstract
Genotoxicity of streptozotocin: A.D. Bolzan and M.S. Bianchi; Mutat. Res. 512, 121 (2002), (Review) Abstract
Further Categories Containing This Product:
Antidiabetic Agents / Related Products
 
 
ALX-350-094 Revised 24-Jul-08
Berberine . hemisulfate
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SYNONYMS Natural Yellow 18
5,6-Dihydro-9,10-dimethoxybenzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products with Antibiotic Activity
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ALX-350-094-G001   1 g 15.00 USD Add To Cart
Product Specification
FORMULA: C20H18NO4 . 0.5SO4
MW: 336.4 . 48.0
CAS NUMBER: 633-66-9
MERCK INDEX: 14: 1154
RTECS: DR9867000
PURITY: ≥98% (TLC)
APPEARANCE: Off-white to yellow powder.
SOLUBILITY: 50mg/ml soluble in methanol:water 2:1.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: TOXIC.
IDENTITY: Determined by IR: Identical to standard reference.

Product Description
Alkaloid which exhibits relatively weak antibiotic properties, because of its efflux by multidrug resistance pumps. The antimicrobial action of berberine is potentiated by 5’-methoxyhydnocarpin, a multidrug pump inhibitor. Lowers cholesterol levels through a mechanism different from that of statins. Upregulates the expression of liver low-density lipoprotein receptor (LDLR) resulting in improved clearance of plasma LDL cholesterol through receptor mediated endocytosis. Possesses anti-inflammatory, anti-diabetic and anti-angiogenic effects. Induces apoptosis.
Product Specific Literature References
Berberine sulfate: antimicrobial activity, bioassay, and mode of action: A.H. Amin, et al.; Can. J. Microbiol. 15, 1067 (1969) Abstract
Bacteria lacking a multidrug pump: a sensitive tool for drug discovery: P.C. Hsieh, et al.; PNAS 95, 6602 (1998) Abstract; Full Text
Synergy in a medicinal plant: antimicrobial action of berberine potentiated by 5’-methoxyhydnocarpin, a multidrug pump inhibitor: F.R. Stermitz, et al.; PNAS 97, 1433 (2000) Abstract; Full Text
Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins: W. Kong, et al.; Nat. Med. 10, 1344 (2004) Abstract
The anti-inflammatory potential of berberine in vitro and in vivo: C.L. Kuo, et al.; Cancer Lett. 203, 127 (2004) Abstract
Therapeutic effects of berberine in impaired glucose tolerance rats and its influence on insulin secretion: S.H. Leng, et al.; Acta Pharmacol. Sin. 25, 496 (2004) Abstract
Berberine inhibits HIF-1alpha expression via enhanced proteolysis: S. Lin, et al.; Mol. Pharmacol. 66, 612 (2004) Abstract
Apoptosis of human leukemia HL-60 cells and murine leukemia WEHI-3 cells induced by berberine through the activation of caspase-3: C.C. Lin, et al.; Anticancer Res. 26, 227 (2006) Abstract
Berberine acutely inhibits insulin secretion from beta cells through cAMP signaling pathway: L. Zhou, et al.; Endocrinology (2008) Abstract
Berberine modifies cysteine 179 of IkappaBalpha kinase, suppresses nuclear factor-kappaB-regulated antiapoptotic gene products, and potentiates apoptosis.: M.K. Pandey, et al.; Cancer Res. 68, 5370 (2008) Abstract
Further Categories Containing This Product:
Antidiabetic Agents / Related Products • Natural Products - Chemopreventive Agents • Cholesterol & Lipid Transport / Related Products • Alkaloids • Natural Products - Anti-inflammatory Agents
 
 
ALX-350-134 Revised 28-May-08
Pyripyropene A
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SYNONYMS (+)-Pyripyropene A
PPPA
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products
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ALX-350-134-C500   500 µg 190.00 USD Add To Cart
Product Specification
FORMULA: C31H37NO10
MW: 583.6