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Obesity & Adipokines
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ALX-270-113 Revised 08-Apr-08
Phloretin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Protein Kinase Inhibitors
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ALX-270-113-M100   100 mg 37.00 USD Add To Cart
Product Specification
FORMULA: C15H14O5
MW: 274.3
CAS NUMBER: 60-82-2
MERCK INDEX: 14: 7326
PURITY: ≥98%
APPEARANCE: Off-white to beige solid.
SOLUBILITY: Soluble in acetone, DMSO, 100% ethanol or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Flavonoid. Protein kinase C (PKC) inhibitor. PGF2a receptor antagonist. In astrocytes, these receptors are linked to phospholipase C, thus affecting phosphoinositide hydrolysis and intracellular Ca2+ levels. Inhibits myo-inositol uptake and 5’-iodothyronine deiodinase. Prevents TNF-α stimulated upregulation of VCAM-1, ICAM-1 and E-selectin. Enhances adiponectin expression.
Product Specific Literature References
Effects on water diffusion of inhibitors affecting various transport processes in human red blood cells: G. Benga, et al.; Eur. J. Cell Biol. 59, 219 (1992) Abstract
Phloretin as an antagonist of prostaglandin F2 alpha receptor in cultured rat astrocytes: J. Kitanaka, et al.; J. Neurochem. 60, 704 (1993) Abstract
Characterization of the inhibition by stilbene disulphonates and phloretin of lactate and pyruvate transport into rat and guinea-pig cardiac myocytes suggests the presence of two kinetically distinct carriers in heart cells: X. Wang, et al.; Biochem. J. 290, 249 (1993) Abstract
The effect of glucose and galactose toxicity on myo-inositol transport and metabolism in human skin fibroblasts in culture: G.T. Berry, et al.; Pediat. Res. 35, 141 (1994) Abstract
Activating effect of the flavonoid phloretin on Ca(2+)-activated K+ channels in myelinated nerve fibers of Xenopus laevis: D.S. Koh, et al.; Neurosci. Lett. 165, 167 (1994) Abstract
Thyroid hormones in tissues from fetal and adult rats: G. Morreale de Escobar; Endocrinology 134, 2410 (1994) Abstract
Gonadotropin-releasing hormone induced Ca2+ influx in nonsecreting pituitary adenoma cells: role of voltage-dependent Ca2+ channels and protein kinase C: N. Prevarskaya, et al.; Mol. Cell. Neurosci. 5, 699 (1994) Abstract
The flavonoid phloretin suppresses stimulated expression of endothelial adhesion molecules and reduces activation of human platelets: V. Stangl, et al.; J. Nutr. 135, 172 (2005) Abstract
Phloretin enhances adipocyte differentiation and adiponectin expression in 3T3-L1 cells: M. Hassan, et al.; BBRC 361, 208 (2007) Abstract
Further Categories Containing This Product:
Adiponectin [ACRP30] / Related Products • PKC Inhibitors • Adhesion Molecules & Receptors Other Products • Active Substances from Fruit and Vegetables
 
 
ALX-270-204 Revised 24-Jun-08
bpV(phen)
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SYNONYMS Potassium bisperoxo (1,10-phenanthroline) oxovanadate (V)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Oxovanadates
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ALX-270-204-M005   5 mg 53.00 USD Add To Cart
ALX-270-204-M025   25 mg 195.00 USD Add To Cart
Product Specification
FORMULA: K[VO(O2)2C12H8N2] . 3H2O
MW: 350.3 . 54.0
PURITY: ≥98% (51V-NMR)
APPEARANCE: Yellow to orange powder.
SOLUBILITY: Soluble in water (10mM).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
IDENTITY: Identity determined by MS and 51V-NMR (D2O)

Product Description
Potent protein phosphotyrosine phosphatase inhibitor. Also shown to be a potent insulin receptor kinase activator; excellent insulin mimetic in vitro and in vivo.
Product Specific Literature References
Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics: B.I. Posner, et al.; J. Biol. Chem. 269, 4596 (1994) Abstract; Full Text
Selective activation of the rat hepatic endosomal insulin receptor kinase. Role for the endosome in insulin signaling: A.P. Bevan, et al.; J. Biol. Chem. 270, 10784 (1995) Abstract; Full Text
In vivo insulin mimetic effects of pV compounds: role for tissue targeting in determining potency: A.P. Bevan, et al.; Am. J. Physiol. 268, E60 (1995) Abstract
Hypoglycemic effects of peroxovanadium compounds in Sprague-Dawley and diabetic BB rats: J.F. Yale, et al.; Diabetes 44, 1274 (1995) Abstract
A role for tyrosine phosphorylation in both activation and inhibition of the insulin receptor tyrosine kinase in vivo: P.G. Drake, et al.; Endocrinology 137, 4960 (1996) Abstract
Phosphatidylinositol 3'-kinase and p70s6k are required for insulin but not bisperoxovanadium 1,10-phenanthroline (bpV(phen)) inhibition of insulin-like growth factor binding protein gene expression. Evidence for MEK-independent activation of mitogen-activ: C.J. Band & B.I. Posner; J. Biol. Chem. 272, 138 (1997) Abstract; Full Text
Lipopolysaccharide down-regulates the leukotriene C4 synthase gene in the monocyte-like cell line, THP-1: K.J. Serio, et al.; J. Immunol. 170, 2121 (2003) Abstract; Full Text
Further Categories Containing This Product:
Insulin & Insulin Receptor / Related Products
 
 
ALX-270-112 Revised 16-Jun-08
Pentoxifylline
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SYNONYMS Trental
3,7-Dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purine-2,6-dione
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Other Signal Transduction Pathway Modulators
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ALX-270-112-G001   1 g 15.00 USD Add To Cart
ALX-270-112-G005   5 g 35.00 USD Add To Cart
Product Specification
FORMULA: C13H18N4O3
MW: 278.3
CAS NUMBER: 6493-05-6
MERCK INDEX: 14: 7136
SOURCE/HOST: Isolated from Penicillium expansum.
PURITY: ≥99%
APPEARANCE: White solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Phosphodiesterase inhibitor. Blocks the synthesis of TNF-α. Improves blood flow by decreasing blood viscosity.
Product Specific Literature References
Pentoxifylline inhibits lipopolysaccharide-induced serum tumor necrosis factor and mortality: P. Noel, et al.; Life Sci. 47, 1023 (1990) Abstract
Pentoxifylline inhibits the expression of tissue factor mRNA in endotoxin-activated human monocytes: V. Ollivier, et al.; FEBS Lett. 322, 231 (1993) Abstract
Pentoxifylline: C.P. Samlaska & E.A. Winfield; J. Am. Acad. Dermatol. 30, 603 (1994), Review Abstract
Suppression of hypercholesterolemic atherosclerosis by pentoxifylline and its mechanism: K. Prasad & P. Lee; Atherosclerosis 192, 313 (2007) Abstract
Further Categories Containing This Product:
Phosphodiesterases / Related Products • TNF-alpha & TNF Receptors Other Products • Nitric Oxide Pathway Other Products
 
 
ALX-270-171 Revised 30-Jun-08
Chlorpromazine . hydrochloride
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SYNONYMS 2-Chloro-10-(3-dimethylaminopropyl)phenothiazine . HCl
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Calmodulin Inhibitors
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ALX-270-171-G001   1 g 22.00 USD Add To Cart
ALX-270-171-G005   5 g 66.00 USD Add To Cart
Product Specification
FORMULA: C17H19ClN2S . HCl
MW: 318.9 . 36.5
CAS NUMBER: 69-09-0
MERCK INDEX: 14: 2185
RTECS: SO1750000
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in 100% ethanol, methanol or water (50mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Not stable in aqueous solution. We strongly recommend always to use freshly prepared solutions.
HANDLING: Protect from light.
HAZARD: VERY TOXIC.

Product Description
Inhibits calmodulin stimulation of cyclic nucleotide phosphodiesterase. Dopamine antagonist. D2 antagonist. H1 antagonist. Inhibits TNF-α production. Potent PLA2 inhibitor. Inhibits nitric oxide synthase (NOS) in mouse brain and prevents lipopolysaccharide induction of NOS in mouse lung. Antipsychotic.
Product Specific Literature References
Chlorpromazine as a substitute for ortho-dianisidine and ortho-tolidine in the determination of chlorine, hemoglobin, and peroxidase activity: H.B. Collier; Clin. Biochem. 7, 331 (1974) Abstract
Drug-protein interactions: binding of chlorpromazine to calmodulin, calmodulin fragments, and related calcium binding proteins: D.R. Marshak, et al.; Biochemistry 24, 144 (1985) Abstract
Selective inhibition of group II phospholipase A2 by quercetin: M. Lindahl & C. Tagesson; Inflammation 17, 573 (1993) Abstract
Chlorpromazine inhibits both the constitutive nitric oxide synthase and the induction of nitric oxide synthase after LPS challenge: M. Palacios, et al.; BBRC 196, 280 (1993) Abstract
Protective effect of calmodulin inhibitors against acute cyanide- induced lethality and convulsions in mice: H. Yamamoto; Toxicol. Lett. 66, 73 (1993) Abstract
Pharmacologic inhibitors of tumor necrosis factor production exert differential effects in lethal endotoxemia and in infection with live microorganisms in mice: M.G. Netea, et al.; J. Infect. Dis. 171, 393 (1995) Abstract
Pharmacological regulation of mitochondrial nitric oxide synthase: A. Boveris, et al.; Methods Enzymol. 359, 328 (2002) Abstract
Brain mitochondrial nitric oxide synthase: in vitro and in vivo inhibition by chlorpromazine: S. Lores-Arnaiz, et al.; Arch. Biochem. Biophys. 430, 170 (2004) Abstract
Further Categories Containing This Product:
Dopaminergics & Dopamine Receptors / Related Products • Phosphodiesterases / Related Products • TNF-alpha & TNF Receptors Other Products • PLA2 Inhibitors • Chemopreventive Agents Other Products • NOS Inhibitors (NOS Induction & Enzyme Activity)
 
 
ALX-270-235 Revised 04-Feb-05
JM 42
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SYNONYMS N-(4,6-Dimethylpyridin-2-yl)-5-bromofurane-2-carboxamide
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY TNF-alpha & TNF Receptors Other Products
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ALX-270-235-M005   5 mg 80.00 USD Add To Cart
Product Specification
FORMULA: C12H11BrN2O2
MW: 295.1
PURITY: ≥98%
APPEARANCE: White solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: For biological studies, solubilize as a maleate salt just before use.
HANDLING: Keep under inert gas. Protect from light.

Product Description
Anti-inflammatory pyridinylamide that inhibits TNF-α production, probably by interacting with a protein kinase C (PKC)-dependent pathway. May serve as an alternative to classical cyclooxygenase (COX) inhibitors in TNF-α involved pathogenesis.
Product Specific Literature References
New antiinflammatory compounds that inhibit tumor necrosis factor production: probable interaction with protein kinase C activation: F. Lang, et al.; J. Pharmacol. Exp. Ther. 275, 171 (1995) Abstract
 
 
ALX-270-236 Revised 04-Feb-05
JM 34
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SYNONYMS N-(4,6-Dimethylpyridin-2-yl)furane-2-carboxamide
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY TNF-alpha & TNF Receptors Other Products
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ALX-270-236-M010   10 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C12H12N2O2
MW: 216.2
PURITY: ≥99%
APPEARANCE: White solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: For biological studies, solubilize as a maleate salt just before use.
HANDLING: Keep under inert gas. Protect from light.

Product Description
Anti-inflammatory pyridinylamide that inhibits TNF-α production, probably by interacting with a protein kinase C (PKC)-dependent pathway of ERK2 phosphorylation. No inhibition of PKC activity in vitro. May serve as an alternative to classical cyclooxygenase (COX) inhibitors in TNF-α pathogenesis.
Product Specific Literature References
New antiinflammatory compounds that inhibit tumor necrosis factor production: probable interaction with protein kinase C activation: F. Lang, et al.; J. Pharmacol. Exp. Ther. 275, 171 (1995) Abstract
An anti-inflammatory benzamide derivative inhibits the protein kinase C (PKC)-dependent pathway of ERK2 phosphorylation in murine macrophages: L. Vernhet, et al.; J. Pharmacol. Exp. Ther. 283, 358 (1997) Abstract; Full Text
 
 
ALX-270-443 Revised 05-May-08
AS601245
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SYNONYMS 1,3-Benzothiazol-2-yl-(2-{[2-(3-pyridinyl)ethyl]amino}-4-pyrimidinyl) acetonitrile
JNK Inhibitor V
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY JNK [SAPK1] / Related Products
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ALX-270-443-M001   1 mg 50.00 USD Add To Cart
ALX-270-443-M005   5 mg 150.00 USD Add To Cart
ALX-270-443-M025   25 mg 520.00 USD Add To Cart
Product Specification
FORMULA: C20H16N6S
MW: 372.5
CAS NUMBER: 345987-15-7
PURITY: ≥95% (HPLC)
APPEARANCE: White to yellow solid.
PURITY DETAIL: Sum of two isomers.
SOLUBILITY: Soluble in DMSO (10mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions are stable for up to 3 months when stored at -20°C.
HANDLING: Hygroscopic. Packaged under inert gas. Protect from light.
HAZARD: HARMFUL.
IDENTITY: Identity determined by 1H-NMR.

Product Description
Potent and cell permeable ATP competitive JNK inhibitor (hJNK1: IC50=150nM, hJNK2: IC50=220nM and hJNK3: IC50=70 nM). Displays anti-inflammatory properties and has been shown to reduce TNF-α plasma levels induced by LPS in mice.
Product Specific Literature References
AS601245 (1,3-benzothiazol-2-yl (2-[[2-(3-pyridinyl) ethyl] amino]-4 pyrimidinyl) acetonitrile): a c-Jun NH2-terminal protein kinase inhibitor with neuroprotective properties: S. Carboni, et al.; J. Pharmacol. Exp. Ther. 310, 25 (2004) Abstract; Full Text
Design and synthesis of the first generation of novel potent, selective, and in vivo active (benzothiazol-2-yl)acetonitrile inhibitors of the c-Jun N-terminal kinase: P. Gaillard, et al.; J. Med. Chem. 48, 4596 (2005) Abstract
Further Categories Containing This Product:
TNF-alpha & TNF Receptors Other Products • Anti-inflammatory Agents Other Products
 
 
ALX-350-006 Revised 05-Apr-08
Genistein (synthetic)
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SYNONYMS 4',5,7-Trihydroxyisoflavone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Protein Kinase Inhibitors
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ALX-350-006-M010   10 mg 25.00 USD Add To Cart
ALX-350-006-M025   25 mg 50.00 USD Add To Cart
ALX-350-006-M050   50 mg 90.00 USD Add To Cart
ALX-350-006-M100   100 mg 150.00 USD Add To Cart
ALX-350-006-G001   1 g 480.00 USD Add To Cart
Product Specification
FORMULA: C15H10O5
MW: 270.2
CAS NUMBER: 446-72-0
MERCK INDEX: 14: 4391
RTECS: NR2392000
SOURCE/HOST: Synthetic.
PURITY: ≥99% (HPLC)
APPEARANCE: White to yellow crystalline powder.
SOLUBILITY: Soluble in DMSO, 100% ethanol or dilute aqueous base; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: MAY BE CARCINOGENIC. HARMFUL.

Product Description
Tyrosine protein kinase inhibitor. Inhibits phosphorylation of EGFR kinase. Inhibits tumor cell proliferation and induces tumor cell differentiation. Inhibits topoisomerase II activity in vivo. Produces cell cycle arrest and apoptosis. Direct inhibitor of insulin-induced glucose uptake in adipocytes (IC50=20µM).
Product Specific Literature References
Genistein, a specific inhibitor of tyrosine-specific protein kinases: T. Akiyama, et al.; J. Biol. Chem. 262, 5592 (1987) Abstract; Full Text
Erbstatin blocks platelet activating factor-induced protein-tyrosine phosphorylation, polyphosphoinositide hydrolysis, protein kinase C activation, serotonin secretion and aggregation of rabbit platelets: H. Salari, et al.; FEBS Lett. 263, 104 (1990) Abstract
Mechanisms of cancer chemoprevention by soy isoflavone genistein: F.H. Sarkar & Y. Li; Cancer Metastasis Rev. 21, 265 (2002) Abstract
Soy isoflavone phyto-pharmaceuticals in interleukin-6 affections. Multi-purpose nutraceuticals at the crossroad of hormone replacement, anti-cancer and anti-inflammatory therapy: N. Dijsselbloem, et al.; Biochem. Pharmacol. 68, 1171 (2004), Review Abstract
Genistein affects testosterone secretion by Leydig cells in roosters (Gallus gallus domesticus): M. Opalka, et al.; Reprod. Biol. 4, 185 (2004) Abstract
Genistein directly inhibits GLUT4-mediated glucose uptake in 3T3-L1 adipocytes: M. Bazuine, et al.; BBRC 325, 511 (2005) Abstract
Decreased circulating levels of tumor necrosis factor-alpha in postmenopausal women during consumption of soy-containing isoflavones: Y. Huang, et al.; J. Clin. Endocrinol. Metab. 90, 3956 (2005) Abstract
Phytoestrogens and lipoproteins in women: C.N. Bairey Merz, et al.; J. Clin. Endocrinol. Metab. 91, 2209 (2006) Abstract
Clinical review: a critical evaluation of the role of soy protein and isoflavone supplementation in the control of plasma cholesterol concentrations: A. Dewell, et al.; J. Clin. Endocrinol. Metab. 91, 772 (2006), Review Abstract
The role of genistein and synthetic derivatives of isoflavone in cancer prevention and therapy: F.H. Sarkar, et al.; Mini Rev. Med. Chem. 6, 401 (2006), Review Abstract
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors • TNF-alpha & TNF Receptors Other Products • Antitumor Agents (Enzyme Inhibitors) • Flavonoids / Related Products • EGFR Kinase Inhibitors • Natural Products - Topoisomerase Inhibitors • Cell Cycle Blockers & Inhibitors / Related Products • Natural Products - Antitumor Reagents • Active Substances from Fruit and Vegetables • Natural Products for Angiogenesis Research • Natural Products - Apoptosis Inducers & Inhibitors • Antitumor Agents (Apoptosis Inducers) • Antitumor Agents (Anti-proliferative) • Natural Products for Cell Cycle Research
 
 
ALX-350-121 Revised 14-Mar-08
Rocaglamide
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SYNONYMS Rocaglamide A
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - NF-kB Pathway Inhibitors
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ALX-350-121-C100   100 µg 220.00 USD Add To Cart
Product Specification