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Obesity & Adipokines
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ALX-850-317 Revised 16-Mar-07
Leptin (mouse/rat) ELISA Kit
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PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Leptin/Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-850-317-KI01   1 Kit 461.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
SENSITIVITY: 30pg/ml for mouse leptin and 50pg/ml for rat leptin.
QUANTITY: 96 wells (~80 tests).
APPLICATION: For the quantitative determination of mouse and rat leptin in plasma, serum and tissue culture medium.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
General Information
MANUFACTURER Manufactured by BioVendor.
Further Categories Containing This Product:
ELISA & EIA Kits
 
 
ALX-850-296 Revised 20-Dec-07
Leptin Receptor (human) ELISA Kit
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SYNONYMS OB-R (human) ELISA Kit
CD295 (human) ELISA Kit
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Leptin/Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-850-296-KI01   1 Kit 696.00 USD Add To Cart
Product Specification
SENSITIVITY: 0.4U/ml
QUANTITY: 96 wells (~80 tests).
SPECIFICITY: Human leptin receptor.
APPLICATION: For the quantitative determination of human leptin receptor in serum, plasma and tissue culture medium.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
USE/STABILITY: Stable for at least 6 months when stored at +4°C.
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Product Specific Literature References
Regulation of circulating soluble leptin receptor levels by gender, adiposity, sex steroids, and leptin: observational and interventional studies in humans: J.L. Chan, et al.; Diabetes 51, 2105 (2002) Abstract
Mutations in the human leptin and leptin receptor genes as models of serum leptin receptor regulation: N. Lahlou, et al.; Diabetes 51, 1980 (2002) Abstract
Weight loss increases soluble leptin receptor levels and the soluble receptor bound fraction of leptin: M. Laimer, et al.; Obes. Res. 10, 597 (2002) Abstract
Soluble leptin receptor and insulin resistance as determinant of sleep apnea: D. Manzella, et al.; Int. J. Obes. Relat. Metab. Disord. 26, 370 (2002) Abstract
Opposite modifications in circulating leptin and soluble leptin receptor across the eating disorder spectrum: P. Monteleone, et al.; Mol. Psychiatry 7, 641 (2002) Abstract
Obesity is associated with decreasing levels of the circulating soluble leptin receptor in humans: V. Ogier, et al.; Int. J. Obes. Relat. Metab. Disord. 26, 496 (2002) Abstract
Soluble leptin receptors and serum leptin in end-stage renal disease: relationship with inflammation and body composition: R. Pecoits-Filho, et al.; Eur. J. Clin. Invest. 32, 811 (2002) Abstract
Circulating concentrations of soluble leptin receptor: influence of menstrual cycle and diet therapy: H. Shimizu, et al.; Nutrition 18, 309 (2002) Abstract
Leptin and soluble leptin receptor levels in obese and weight-losing individuals: F.M. van Dielen, et al.; J. Clin. Endocrinol. Metab. 87, 1708 (2002) Abstract
Leptin, soluble leptin receptor, and transforming growth factor-beta1 levels in minimal change nephrotic syndrom: N. Buyan, et al.; Pediatr. Nephrol. 18, 1009 (2003) Abstract
Diurnal and ultradian dynamics of serum adiponectin in healthy men: comparison with leptin, circulating soluble leptin receptor, and cortisol patterns: A. Gavrila, et al.; J. Clin. Endocrinol. Metab. 88, 2838 (2002) Abstract; Full Text
Relationships between the serum levels of soluble leptin receptor and free and bound leptin in non-pregnant women of reproductive age and women undergoing controlled ovarian hyperstimulation: N. Kado, et al.; Hum. Reprod. 18, 715 (2003) Abstract; Full Text
Changes in circulating leptin, leptin receptor, and gonadal hormones from infancy until advanced age in humans: D.R. Mann, et al.; J. Clin. Endocrinol. Metab. 88, 3339 (2003) Abstract; Full Text
Serum ghrelin levels in obese patients: the relationship to serum leptin levels and soluble leptin receptors levels: M. Rosicka, et al.; Physiol. Res. 52, 61 (2003) Abstract; Full Text
Soluble leptin receptor and soluble receptor-bound fraction of leptin in the metabolic syndrome: A. Sandhofer, et al.; Obes. Res. 11, 760 (2003) Abstract; Full Text
Body fat mass and macronutrient intake in relation to circulating soluble leptin receptor, free leptin index, adiponectin, and resistin concentrations in healthy humans: M. Yannakoulia, et al.; J. Clin. Endocrinol. Metab. 88, 1730 (2003) Abstract; Full Text
Leptin and its soluble receptor in plasma of patients suffering from remitting-relapsing multiple sclerosis (MS) In vitro effects of leptin on type-1 and type-2 cytokine secretion by peripheral blood mononuclear cells, T-cells and monocytes of MS patients: K. Chatzantoni, et al.; J. Autoimm. 23, 169 (2004) Abstract
Hormonal and body composition predictors of soluble leptin receptor, leptin, and free leptin index in adolescent girls with anorexia nervosa and controls and relation to insulin sensitivity: M. Misra, et al.; J. Clin. Endocrinol. Metab. 89, 3486 (2004) Abstract; Full Text
Serum leptin, soluble leptin receptor, free leptin index and bone mineral density in patients with primary biliary cirrhosis: F. Szalay, et al.; Eur. J. Gastroenterol. Hepatol. 17, 923 (2005) Abstract
Expression of leptin receptors in mononuclear cells from myelodysplastic syndromes and acute myeloid leukemias: P.C. Tsiotra, et al.; Acta Haematol. 114, 71 (2005) Abstract
General Information
MANUFACTURER Manufactured by BioVendor.
General Literature References
Identification and expression cloning of a leptin receptor: L.A. Tartaglia, et al.; Cell 83, 1263 (1995) Abstract
Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice: H. Chen, et al.; Cell 84, 491 (1996) Abstract
Novel B219/OB receptor isoforms: possible role of leptin in hematopoiesis and reproduction: J.A. Cioffi, et al.; Nat. Med. 2, 585 (1996) Abstract
Abnormal splicing of the leptin receptor in diabetic mice: G.H. Lee; Nature 379, 632 (1996) Abstract
The leptin receptor: L.A. Tartaglia; J. Biol. Chem. 272, 6093 (1997) Abstract
Leptin: J. Auwerx & B. Staels; Lancet 351, 737 (1998), (Review) Abstract
Leptin and its receptors: regulators of whole-body energy homeostasis: K.L. Houseknecht & C.P. Portocarrero; Domest. Anim. Endocrinol. 15, 457 (1998) Abstract
Further Categories Containing This Product:
CD Kits & SetsELISA & EIA Kits
 
 
ALX-340-038 Revised 08-Jul-08
Leukotriene B4
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SYNONYMS LTB4
5,12-Dihydroxy-[S-[R*,S*-(E,Z,Z,E)]]-6,8,10,14-eicosatetraenoic acid
PRODUCT LINE Inflammation
PRODUCT CATEGORY Leukotrienes
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-340-038-C025   25 µg 170.00 USD Add To Cart
Product Specification
FORMULA: C20H32O4
MW: 336.5
CAS NUMBER: 71160-24-2
MERCK INDEX: 14: 5455
PURITY: ≥97%
FORMULATION: Liquid. Solution in ethanol.
SOLUBILITY: Soluble in DMSO or dimethyl formamide; slightly soluble in PBS, pH 7.2 (1mg/ml). Solvents should be free of oxygen, transition metal ions, and redox active compounds.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C. We do not recommend storing aqueous solutions for more than one day.
HANDLING: Protect from light and oxygen.

Product Description
Activator of PPARα. Stimulates a number of leukocyte functions, including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis.
Product Specific Literature References
Leukotriene B4 and inflammatory disease: R.M. McMillan & S.J. Foster; Agents Actions 24, 114 (1988) Abstract
The PPARalpha-leukotriene B4 pathway to inflammation control: P.R. Devchand, et al.; Nature 384, 39 (1996) Abstract
Leukotriene B4: S.W. Crooks & R.A. Stockley; Int. J. Biochem. Cell Biol. 30, 173 (1998), (Review) Abstract
The peroxisome proliferator-activated receptor alpha (PPARalpha) ligand WY 14,643 does not interfere with leukotriene B4 induced adhesion of neutrophils to endothelial cells: M. Heimbürger & J. Palmblad; BBRC 249, 371 (1998) Abstract
Ligand selectivity of the peroxisome proliferator-activated receptor alpha: Q. Lin, et al.; Biochemistry 38, 185 (1999) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION To change the solvent, evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.
Further Categories Containing This Product:
PPAR Agonists
 
 
ALX-201-415 Revised 09-Jul-08 New product
Lipocalin-2 (mouse) (recombinant)
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SYNONYMS NGAL (mouse) (recombinant)
Neutrophil Gelatinase-associated Lipocalin (mouse) (recombinant)
Siderocalin (mouse) (recombinant)
Oncogene 24p3 (mouse) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Adipokines Other Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-415-C010   10 µg 150.00 USD Add To Cart
ALX-201-415-C050   50 µg 320.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. The mature peptide of mouse lipocalin-2 (aa 1-200) is fused to a FLAG®-tag at the C-terminus.
CONCENTRATION: 0.3mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
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General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P11672: Lipocalin-2 (mouse)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
 
 
ALX-201-417 Revised 05-Jun-08 New product
Lipocalin-2 (rat) (recombinant)
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SYNONYMS NGAL (rat) (recombinant)
Neutrophil Gelatinase-associated Lipocalin (rat) (recombinant)
Siderocalin (rat) (recombinant)
Oncogene 24p3 (rat) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Adipokines Other Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-417-C010   10 µg 150.00 USD Add To Cart
ALX-201-417-C050   50 µg 320.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. The mature peptide of rat lipocalin-2 (aa 1-198) is fused to a FLAG®-tag at the C-terminus.
CONCENTRATION: 0.3mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
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General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P30152: Lipocalin-2 (rat)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
 
 
ALX-201-411 Revised 03-Apr-08 New product
Lipocalin-2 (human) (recombinant)
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SYNONYMS NGAL (human) (recombinant)
Neutrophil Gelatinase-associated Lipocalin (human) (recombinant)
Siderocalin (human) (recombinant)
Oncogene 24p3 (human) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Adipokines Other Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-411-C010   10 µg 150.00 USD Add To Cart
ALX-201-411-C050   50 µg 320.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. The mature peptide of human lipocalin-2 is fused to a FLAG®-tag at the C-terminus.
CONCENTRATION: 0.3mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P80188: Lipocalin-2 (human)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
General Literature References
Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron: T.H. Flo, et al.; Nature 432, 917 (2004) Abstract
The adipokine lipocalin 2 is regulated by obesity and promotes insulin resistance: Q.W. Yan, et al.; Diabetes 56, 2533 (2007) Abstract
Lipocalin 2-mediated growth suppression is evident in human erythroid and monocyte/macrophage lineage cells: K. Miharada, et al.; J. Cell Physiol. 215, 526 (2008) Abstract
The novel role of neutrophil gelatinase-B associated lipocalin (NGAL)/Lipocalin-2 as a biomarker for lupus nephritis: T. Rubinstein, et al.; Autoimmun. Rev. 7, 229 (2008) Abstract
 
 
ALX-430-103 Revised 14-Mar-05
Lovastatin
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SYNONYMS Mevinolin
6-α-Methylcompactin
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Statins/Related Products
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ALX-430-103-M050   50 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C24H36O5
MW: 404.5
CAS NUMBER: 75330-75-5
MERCK INDEX: 14: 5586
PURITY: ≥98%
SOLUBILITY: Soluble in DMSO, chloroform or acetone; sparingly soluble in acetonitrile, methanol or 100 % ethanol; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
Product Description
Inhibitor of HMG-CoA reductase, the rate-limiting enzyme in cholesterol biosynthesis. Induces apoptosis in cancer cells.
Product Specific Literature References
Statins as a newly recognized type of immunomodulator: B. Kwak, et al.; Nat. Med. 6, 1399 (2000) Abstract
Further Categories Containing This Product:
Apoptosis Inducers & Inhibitors Other ProductsUbiquitination Other Products
 
 
ALX-522-034 Revised 27-Mar-06
LTα3, Soluble (human) (recombinant)
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SYNONYMS TNF-β, Soluble (human) (recombinant)
TNFSF 1, Soluble (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY TNF-alpha & TNF Receptors Other Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-034-C010   10 µg 200.00 USD Add To Cart
ALX-522-034-3010 SuperPack 3x10 µg 410.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
MW: ~25kDa (SDS-PAGE).
SOURCE/HOST: Produced in E. coli. The extracellular domain of human LTα3 (aa 43-205) is fused at the N-terminus to a linker peptide (10 aa) and a FLAG®-tag.
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
SPECIFICITY: Binds to human HVEM and human and mouse TNF-R1 and TNF-R2.
BIOLOGICAL ACTIVITY: Kills human TNF-R1 positive cells.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles.
General Information
Lymphotoxin-α (LTα, TNF-β) is a 25 kDa type II soluble protein belonging to the TNF family. It is expressed as a trimer (LTα3), or with lymphotoxin-β (LTα1β2 or LTα2β1). LTα3 interacts with 3 different members of the TNF-receptor superfamily: HVEM (Prod. No. ALX-522-017), TNF-R1 (Prod. No. ALX-522-013) and TNF-R2 (Prod. No. ALX-522-014). LTα3 is expressed by activated T and B lymphocytes and is a pro-apoptotic cytokine, a pluripotent mediator of inflammtory and immune defense mechanisms, and moreover it plays an important role in regulating the generation of the peripheral lymphoid system.
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link P01374: TNF-β (human) (precursor)
AfCS Signalling Gateway link A001438: TNF-β (mouse)

FLAG is a registered trademark of Sigma-Aldrich Co.

MANUFACTURER Manufactured by Apotech Corporation.
 
 
ALX-385-007 Revised 07-Apr-08
Luteolin
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SYNONYMS 3',4',5,7-Tetrahydroxyflavone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavonoids/Related Products
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ALX-385-007-M010   10 mg 15.00 USD Add To Cart
ALX-385-007-M050   50 mg 45.00 USD Add To Cart
Product Specification
FORMULA: C15H10O6
MW: 286.2
CAS NUMBER: 491-70-3
MERCK INDEX: