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ALX-803-322
Revised 10-Apr-08
Monoclonal Antibody to Collectrin (mouse) (2G5)
SYNONYMS
anti-TMEM27 (mouse) MAb (2G5)
anti-Transmembrane Protein 27 (mouse) MAb (2G5)
anti-Nx17 (mouse) MAb (2G5)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Renin-Angiotensin-Aldosterone System [RAAS] Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-803-322-C050
50 µg
180.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE:
2G5
ISOTYPE:
Mouse IgG1
CONCENTRATION:
0.75mg/ml
PURITY DETAIL:
Affinity purified.
FORMULATION:
Liquid. In PBS, pH 7.2.
IMMUNOGEN:
Synthetic peptide corresponding to aa 29-46 of N-terminal mouse collectrin.
SPECIFICITY:
Recognizes mouse collectrin. Detects a band of ~44kDa.
APPLICATION:
Immunohistochemistry (paraffin sections) (1:50)
Western Blot (1:500)
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Essential role for collectrin in renal amino acid transport:
U. Danilczyk, et al.; Nature
444
, 1088 (2006)
Abstract
General Information
Collectrin is a catalytically inactive homolog of angiotensin-converting enzyme 2 (ACE2). It binds to SNARE complex by interacting with snapin. Collectrin shows interesting physiological roles related to insulin seccretion, formation of primary cilia, renal cyst formation and amino acid transport. Collectrin is therefore considered as a target for various pathological processes such as diabetes, polycystic kidney disease, hypertension and aminoaciduria.
General Literature References
Collectrin, a collecting duct-specific transmembrane glycoprotein, is a novel homolog of ACE2 and is developmentally regulated in embryonic kidneys:
H. Zhang, et al.; J. Biol. Chem.
276
, 17132 (2001)
Abstract
The HNF-1alpha-SNARE connection:
K. Yamagata, et al.; Diabetes Obes. Metab.
9
, 40 (2007)
Abstract
Collectrin, a homologue of ACE2, its transcriptional control and functional perspectives:
Y. Zhang & J. Wada; BBRC
363
, 1 (2007), (Review)
Abstract
Further Categories Containing This Product:
Insulin & Insulin Receptor/Related Products
•
Monoclonal Antibodies
ALX-803-049
Revised 07-Mar-06
Monoclonal Antibody to C-Peptide (human) (91/1F9)
SYNONYMS
anti-C-Peptide (human) MAb (91/1F9)
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Insulin & Insulin Receptor/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-803-049-C100
100 µg
300.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
91/1F9
ISOTYPE:
Mouse IgG2b
CONCENTRATION:
0.5mg/ml
PURITY DETAIL:
Ammonium sulphate precipitation.
FORMULATION:
Liquid. In PBS, pH 7.4, containing 0.9mg/ml sodium azide.
IMMUNOGEN:
Human proinsulin.
SPECIFICITY:
Recognizes human C-peptide. Cross-reacts with human proinsulin.
APPLICATION:
Immunohistochemistry (frozen sections)
Immunoprecipitation
Radioimmunoassay
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year when stored at +4°C.
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-834
Revised 31-Oct-06
Monoclonal Antibody to CTRP2 (mouse) (Didoo-1)
SYNONYMS
anti-C1q Tumor Necrosis Factor-α-related Protein 2 (mouse) MAb (Didoo-1)
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
C1q Tumor Necrosis Factor-alpha-related Proteins [CTRPs]
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-834-C100
100 µg
320.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE:
Didoo-1
ISOTYPE:
Mouse IgG2b
SOURCE/HOST:
Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION:
1mg/ml
PURITY:
≥95% (SDS-PAGE)
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant mouse CTRP2 (C1q tumor necrosis factor-α-related protein 2) (aa 26-260).
SPECIFICITY:
Recognizes mouse CTRP2.
APPLICATION:
ELISA
Immunoprecipitation (1:200)
Western Blot (1:1'000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C.
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
Adiponectin is involved in controlling the whole-body metabolism, particularly by increasing insulin sensitivity in muscle and liver, and by increasing fatty acid oxidation in muscle. CTRP2 belongs to a new highly conserved family of adiponectin paralogs designated as C1q tumor necrosis factor-alpha-related proteins (CTRPs) 1-7. CTRP2 (mouse) has been reported to rapidly induce phosphorylation of AMP-activated protein kinase, acetyl-CoA carboxylase, and mitogen-activated protein kinase in C2C12 myotubes, which resulted in increased glycogen accumulation and fatty acid oxidation.
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
A family of Acrp30/adiponectin structural and functional paralogs:
G.W. Wong, et al.; PNAS
101
, 10302 (2004)
Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-835
Revised 04-Jan-07
Monoclonal Antibody to CTRP7 (Anna-1)
SYNONYMS
anti-C1q Tumor Necrosis Factor-α-related Protein 7 MAb (Anna-1)
anti-C1qTNF7 MAb (Anna-1)
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
C1q Tumor Necrosis Factor-alpha-related Proteins [CTRPs]
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-835-C100
100 µg
320.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE:
Anna-1
ISOTYPE:
Mouse IgG1
SOURCE/HOST:
Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION:
1mg/ml
PURITY:
≥95% (SDS-PAGE)
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant mouse CTRP7 (C1q tumor necrosis factor-α-related protein 7) (aa 18-290).
SPECIFICITY:
Recognizes human and mouse CTRP7.
APPLICATION:
ELISA
Immunohistochemistry (paraffin sections)
Immunoprecipitation (1:200)
Western Blot (1:1’000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C.
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
Please click on thumbnails to enlarge.
General Information
Adiponectin is involved in controlling the whole-body metabolism, particularly by increasing insulin sensitivity in muscle and liver, and by increasing fatty acid oxidation in muscle. CTRP7 belongs to a new highly conserved family of adiponectin paralogs designated as C1q tumor necrosis factor-alpha-related proteins (CTRPs) 1-7. A member of this family, CTRP2 (mouse) has been reported to rapidly induce phosphorylation of AMP-activated protein kinase, acetyl-CoA carboxylase, and mitogen-activated protein kinase in C2C12 myotubes, which resulted in increased glycogen accumulation and fatty acid oxidation.
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
A family of Acrp30/adiponectin structural and functional paralogs:
G.W. Wong, et al.; PNAS
101
, 10302 (2004)
Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-843
Revised 16-Aug-07
Monoclonal Antibody to EDA-A1 (Renzo-1)
SYNONYMS
anti-Ectodysplasin-A1 MAb (Renzo-1)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
EDA & EDAR, Troy/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-843-C100
100 µg
360.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE:
Renzo-1
ISOTYPE:
Mouse IgG2b
SOURCE/HOST:
Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION:
1mg/ml
PURITY:
≥95% (SDS-PAGE)
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant human EDA-A1 (ectodysplasin-A1) extracellular domain (aa 245-391) (Prod. No
ALX-522-038
).
SPECIFICITY:
Recognizes human and mouse EDA-A1 and EDA-A2.
CROSSREACTIVITY PROTEINS:
EDA-A2
APPLICATION:
ELISA
Immunohistochemistry (paraffin sections)
Immunoprecipitation (1:100)
Western Blot (1:1‘000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C.
HANDLING:
Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
POSITIVE CONTROL:
Prod. No.
ALX-522-038
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
Mutations leading to X-linked hypohidrotic ectodermal dysplasia affect three major functional domains in the tumor necrosis factor family member ectodysplasin-A:
P. Schneider, et al.; J. Biol. Chem.
276
, 18819 (2001)
Abstract
Related Products
ALX-522-038
EDA-A1, Soluble (human) (recombinant)
ALX-522-048
EDA-A2, Soluble (human) (recombinant)
Further Categories Containing This Product:
TNF-alpha & TNF Receptors Other Products
•
Monoclonal Antibodies
ALX-804-839
Revised 03-May-07
Monoclonal Antibody to EDA-A1 (Renzo-2)
SYNONYMS
anti-Ectodysplasin-A1 MAb (Renzo-2)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
EDA & EDAR, Troy/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-839-C100
100 µg
360.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE:
Renzo-2
ISOTYPE:
Mouse IgG1
SOURCE/HOST:
Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION:
1mg/ml
PURITY:
≥95% (SDS-PAGE)
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant human EDA-A1 (ectodysplasin-A1) extracellular domain (aa 245-391) (Prod. No
ALX-522-038
).
SPECIFICITY:
Recognizes human and mouse EDA-A1 and EDA-A2.
CROSSREACTIVITY PROTEINS:
EDA-A2
APPLICATION:
ELISA
Immunoprecipitation (1:100)
Flow Cytometry
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C.
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
POSITIVE CONTROL:
Prod. No.
ALX-522-038
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
Mutations leading to X-linked hypohidrotic ectodermal dysplasia affect three major functional domains in the tumor necrosis factor family member ectodysplasin-A:
P. Schneider, et al.; J. Biol. Chem.
276
, 18819 (2001)
Abstract
Related Products
ALX-522-038
EDA-A1, Soluble (human) (recombinant)
ALX-522-048
EDA-A2, Soluble (human) (recombinant)
Further Categories Containing This Product:
TNF-alpha & TNF Receptors Other Products
•
Monoclonal Antibodies
ALX-804-580
Revised 20-Jan-06
Monoclonal Antibody to Growth Hormone (human) (g3H5)
SYNONYMS
anti-GH (human) MAb (g3H5)
anti-Somatotropin (human) MAb (g3H5)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Growth Hormones/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-580-R050
50 µl
195.00 USD
ALX-804-580-R100
100 µl
320.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
g3H5
ISOTYPE:
Mouse IgG2b
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS, pH 7.4, containing 0.1% sodium azide.
IMMUNOGEN:
Recombinant human GH (growth hormone).
SPECIFICITY:
Recognizes human GH.
APPLICATION:
ELISA
Western Blot (1:500-1:1'000)
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for 1 month when stored at +4°C.
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Tumor Markers
•
Obesity & Diabetes Other Products
•
Monoclonal Antibodies
ALX-804-520
Revised 31-Oct-06
Monoclonal Antibody to Leptin (human) (HLEP 55G)
SYNONYMS
anti-OB Gene Product (human) MAb (HLEP 55G)
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Leptin/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-520-C050
50 µg
195.00 USD
ALX-804-520-C100
100 µg
270.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
HLEP 55G
ISOTYPE:
Mouse IgG2b
CONCENTRATION:
1mg/ml.
FORMULATION:
Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN:
Recombinant human leptin.
SPECIFICITY:
Recognizes human leptin.
APPLICATION:
ELISA
(direct and indirect: 1:5'000-1:10'000)
Western Blot
(1:5'000-1:10'000 using ECL. Suggested blocking and dilution buffer is TBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature).
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
Please click on thumbnails to enlarge.
General Information
MANUFACTURER
Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-702
Revised 31-Oct-06
Monoclonal Antibody to Leptin (human) (HLEP 155)
SYNONYMS
anti-OB Gene Product (human) MAb (HLEP 155)
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Leptin/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-702-C050
50 µg
195.00 USD
ALX-804-702-C100
100 µg
270.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
HLEP 155
ISOTYPE:
Mouse IgG1
CONCENTRATION:
1mg/ml
FORMULATION:
Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN:
Recombinant human leptin.
SPECIFICITY:
Recognizes both natural and recombinant human leptin. Detects a band of ~16kDa by Western blot. Does not cross-react with mouse or rat leptin.
APPLICATION:
ELISA
(direct and indirect: 1:5'000-1:10'000).
Western Blot
(1:2'000-1:10'000 using ECL. Suggested blocking and dilution buffer is TBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature).
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles. After receipt, prepare aliquots and store at -20°C.
Product Images
Please click on thumbnails to enlarge.
General Information
MANUFACTURER
Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-701
Revised 31-Oct-06
Monoclonal Antibody to Leptin (rat) (RLEP 227)
SYNONYMS
anti-OB Gene Product (rat) MAb (RLEP 227)
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Leptin/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
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