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Obesity & Adipokines
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ALX-803-322 Revised 10-Apr-08
Monoclonal Antibody to Collectrin (mouse) (2G5)
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SYNONYMS anti-TMEM27 (mouse) MAb (2G5)
anti-Transmembrane Protein 27 (mouse) MAb (2G5)
anti-Nx17 (mouse) MAb (2G5)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Renin-Angiotensin-Aldosterone System [RAAS] Other Products
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ALX-803-322-C050   50 µg 180.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE: 2G5
ISOTYPE: Mouse IgG1
CONCENTRATION: 0.75mg/ml
PURITY DETAIL: Affinity purified.
FORMULATION: Liquid. In PBS, pH 7.2.
IMMUNOGEN: Synthetic peptide corresponding to aa 29-46 of N-terminal mouse collectrin.
SPECIFICITY: Recognizes mouse collectrin. Detects a band of ~44kDa.
APPLICATION: Immunohistochemistry (paraffin sections) (1:50)
Western Blot (1:500)
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
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Product Specific Literature References
Essential role for collectrin in renal amino acid transport: U. Danilczyk, et al.; Nature 444, 1088 (2006) Abstract
General Information
Collectrin is a catalytically inactive homolog of angiotensin-converting enzyme 2 (ACE2). It binds to SNARE complex by interacting with snapin. Collectrin shows interesting physiological roles related to insulin seccretion, formation of primary cilia, renal cyst formation and amino acid transport. Collectrin is therefore considered as a target for various pathological processes such as diabetes, polycystic kidney disease, hypertension and aminoaciduria.
General Literature References
Collectrin, a collecting duct-specific transmembrane glycoprotein, is a novel homolog of ACE2 and is developmentally regulated in embryonic kidneys: H. Zhang, et al.; J. Biol. Chem. 276, 17132 (2001) Abstract
The HNF-1alpha-SNARE connection: K. Yamagata, et al.; Diabetes Obes. Metab. 9, 40 (2007) Abstract
Collectrin, a homologue of ACE2, its transcriptional control and functional perspectives: Y. Zhang & J. Wada; BBRC 363, 1 (2007), (Review) Abstract
Further Categories Containing This Product:
Insulin & Insulin Receptor/Related ProductsMonoclonal Antibodies
 
 
ALX-803-049 Revised 07-Mar-06
Monoclonal Antibody to C-Peptide (human) (91/1F9)
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SYNONYMS anti-C-Peptide (human) MAb (91/1F9)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Insulin & Insulin Receptor/Related Products
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ALX-803-049-C100   100 µg 300.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: 91/1F9
ISOTYPE: Mouse IgG2b
CONCENTRATION: 0.5mg/ml
PURITY DETAIL: Ammonium sulphate precipitation.
FORMULATION: Liquid. In PBS, pH 7.4, containing 0.9mg/ml sodium azide.
IMMUNOGEN: Human proinsulin.
SPECIFICITY: Recognizes human C-peptide. Cross-reacts with human proinsulin.
APPLICATION: Immunohistochemistry (frozen sections)
Immunoprecipitation
Radioimmunoassay
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year when stored at +4°C.
HANDLING: Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-834 Revised 31-Oct-06
Monoclonal Antibody to CTRP2 (mouse) (Didoo-1)
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SYNONYMS anti-C1q Tumor Necrosis Factor-α-related Protein 2 (mouse) MAb (Didoo-1)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY C1q Tumor Necrosis Factor-alpha-related Proteins [CTRPs]
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ALX-804-834-C100   100 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE: Didoo-1
ISOTYPE: Mouse IgG2b
SOURCE/HOST: Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant mouse CTRP2 (C1q tumor necrosis factor-α-related protein 2) (aa 26-260).
SPECIFICITY: Recognizes mouse CTRP2.
APPLICATION: ELISA
Immunoprecipitation (1:200)
Western Blot (1:1'000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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General Information
Adiponectin is involved in controlling the whole-body metabolism, particularly by increasing insulin sensitivity in muscle and liver, and by increasing fatty acid oxidation in muscle. CTRP2 belongs to a new highly conserved family of adiponectin paralogs designated as C1q tumor necrosis factor-alpha-related proteins (CTRPs) 1-7. CTRP2 (mouse) has been reported to rapidly induce phosphorylation of AMP-activated protein kinase, acetyl-CoA carboxylase, and mitogen-activated protein kinase in C2C12 myotubes, which resulted in increased glycogen accumulation and fatty acid oxidation.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
A family of Acrp30/adiponectin structural and functional paralogs: G.W. Wong, et al.; PNAS 101, 10302 (2004) Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-835 Revised 04-Jan-07
Monoclonal Antibody to CTRP7 (Anna-1)
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SYNONYMS anti-C1q Tumor Necrosis Factor-α-related Protein 7 MAb (Anna-1)
anti-C1qTNF7 MAb (Anna-1)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY C1q Tumor Necrosis Factor-alpha-related Proteins [CTRPs]
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ALX-804-835-C100   100 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE: Anna-1
ISOTYPE: Mouse IgG1
SOURCE/HOST: Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant mouse CTRP7 (C1q tumor necrosis factor-α-related protein 7) (aa 18-290).
SPECIFICITY: Recognizes human and mouse CTRP7.
APPLICATION: ELISA
Immunohistochemistry (paraffin sections)
Immunoprecipitation (1:200)
Western Blot (1:1’000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
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General Information
Adiponectin is involved in controlling the whole-body metabolism, particularly by increasing insulin sensitivity in muscle and liver, and by increasing fatty acid oxidation in muscle. CTRP7 belongs to a new highly conserved family of adiponectin paralogs designated as C1q tumor necrosis factor-alpha-related proteins (CTRPs) 1-7. A member of this family, CTRP2 (mouse) has been reported to rapidly induce phosphorylation of AMP-activated protein kinase, acetyl-CoA carboxylase, and mitogen-activated protein kinase in C2C12 myotubes, which resulted in increased glycogen accumulation and fatty acid oxidation.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
A family of Acrp30/adiponectin structural and functional paralogs: G.W. Wong, et al.; PNAS 101, 10302 (2004) Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-843 Revised 16-Aug-07
Monoclonal Antibody to EDA-A1 (Renzo-1)
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SYNONYMS anti-Ectodysplasin-A1 MAb (Renzo-1)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY EDA & EDAR, Troy/Related Products
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ALX-804-843-C100   100 µg 360.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE: Renzo-1
ISOTYPE: Mouse IgG2b
SOURCE/HOST: Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human EDA-A1 (ectodysplasin-A1) extracellular domain (aa 245-391) (Prod. No ALX-522-038).
SPECIFICITY: Recognizes human and mouse EDA-A1 and EDA-A2.
CROSSREACTIVITY PROTEINS: EDA-A2
APPLICATION: ELISA
Immunohistochemistry (paraffin sections)
Immunoprecipitation (1:100)
Western Blot (1:1‘000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
POSITIVE CONTROL: Prod. No. ALX-522-038
General Information
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Mutations leading to X-linked hypohidrotic ectodermal dysplasia affect three major functional domains in the tumor necrosis factor family member ectodysplasin-A: P. Schneider, et al.; J. Biol. Chem. 276, 18819 (2001) Abstract
Further Categories Containing This Product:
TNF-alpha & TNF Receptors Other ProductsMonoclonal Antibodies
 
 
ALX-804-839 Revised 03-May-07
Monoclonal Antibody to EDA-A1 (Renzo-2)
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SYNONYMS anti-Ectodysplasin-A1 MAb (Renzo-2)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY EDA & EDAR, Troy/Related Products
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ALX-804-839-C100   100 µg 360.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE: Renzo-2
ISOTYPE: Mouse IgG1
SOURCE/HOST: Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human EDA-A1 (ectodysplasin-A1) extracellular domain (aa 245-391) (Prod. No ALX-522-038).
SPECIFICITY: Recognizes human and mouse EDA-A1 and EDA-A2.
CROSSREACTIVITY PROTEINS: EDA-A2
APPLICATION: ELISA
Immunoprecipitation (1:100)
Flow Cytometry
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
POSITIVE CONTROL: Prod. No. ALX-522-038
General Information
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Mutations leading to X-linked hypohidrotic ectodermal dysplasia affect three major functional domains in the tumor necrosis factor family member ectodysplasin-A: P. Schneider, et al.; J. Biol. Chem. 276, 18819 (2001) Abstract
Further Categories Containing This Product:
TNF-alpha & TNF Receptors Other ProductsMonoclonal Antibodies
 
 
ALX-804-580 Revised 20-Jan-06
Monoclonal Antibody to Growth Hormone (human) (g3H5)
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SYNONYMS anti-GH (human) MAb (g3H5)
anti-Somatotropin (human) MAb (g3H5)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Growth Hormones/Related Products
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ALX-804-580-R050   50 µl 195.00 USD Add To Cart
ALX-804-580-R100   100 µl 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: g3H5
ISOTYPE: Mouse IgG2b
CONCENTRATION: 1mg/ml
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS, pH 7.4, containing 0.1% sodium azide.
IMMUNOGEN: Recombinant human GH (growth hormone).
SPECIFICITY: Recognizes human GH.
APPLICATION: ELISA
Western Blot (1:500-1:1'000)
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for 1 month when stored at +4°C.
HANDLING: Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Tumor MarkersObesity & Diabetes Other ProductsMonoclonal Antibodies
 
 
ALX-804-520 Revised 31-Oct-06
Monoclonal Antibody to Leptin (human) (HLEP 55G)
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SYNONYMS anti-OB Gene Product (human) MAb (HLEP 55G)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Leptin/Related Products
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ALX-804-520-C050   50 µg 195.00 USD Add To Cart
ALX-804-520-C100   100 µg 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: HLEP 55G
ISOTYPE: Mouse IgG2b
CONCENTRATION: 1mg/ml.
FORMULATION: Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN: Recombinant human leptin.
SPECIFICITY: Recognizes human leptin.
APPLICATION: ELISA (direct and indirect: 1:5'000-1:10'000)
Western Blot (1:5'000-1:10'000 using ECL. Suggested blocking and dilution buffer is TBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature).
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
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General Information
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-702 Revised 31-Oct-06
Monoclonal Antibody to Leptin (human) (HLEP 155)
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SYNONYMS anti-OB Gene Product (human) MAb (HLEP 155)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Leptin/Related Products
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ALX-804-702-C050   50 µg 195.00 USD Add To Cart
ALX-804-702-C100   100 µg 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: HLEP 155
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml
FORMULATION: Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN: Recombinant human leptin.
SPECIFICITY: Recognizes both natural and recombinant human leptin. Detects a band of ~16kDa by Western blot. Does not cross-react with mouse or rat leptin.
APPLICATION: ELISA (direct and indirect: 1:5'000-1:10'000).
Western Blot (1:2'000-1:10'000 using ECL. Suggested blocking and dilution buffer is TBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature).
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. After receipt, prepare aliquots and store at -20°C.
Product Images
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General Information
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-701 Revised 31-Oct-06
Monoclonal Antibody to Leptin (rat) (RLEP 227)
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SYNONYMS anti-OB Gene Product (rat) MAb (RLEP 227)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Leptin/Related Products
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