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Obesity & Adipokines
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ALX-203-003 Revised 23-Mar-06
ACRP30headless (mouse) (recombinant)
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SYNONYMS Tail Adiponectin (mouse) (recombinant)
Tail-Adp (mouse) (recombinant)
Adipocyte Complement Related Protein of 30kDa headless (mouse) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Adiponectin [ACRP30] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-203-003-C010   10 µg 260.00 USD Add To Cart
Product Specification
MW: ~25kDa (SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. The collagen domain of mouse ACRP30 (aa 18-111) is fused at the N-terminus to a linker peptide (8 aa) and a FLAG®-tag.
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
APPLICATION: Negative control. Control compound for rmsMegaOX40L [CD134L]™ (Prod. No. ALX-522-062) and rmsMegaTNF-α™ (Prod. No. ALX-522-047).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored as recommended.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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General Information
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link Q60994: ACRP30 (mouse) (precursor)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-522-059 Revised 02-Mar-07
Adiponectin (mouse) (recombinant)
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SYNONYMS ACRP30 (mouse) (recombinant)
Adipocyte Complement Related Protein of 30kDa (mouse) (recombinant)
AdipoQ (mouse) (recombinant)
apM1 (mouse) (recombinant)
GBP28 (mouse) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Adiponectin [ACRP30] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-059-C050   50 µg 335.00 USD Add To Cart
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Product Specification
SPECIES CROSSREACTIVITY:
Mouse
MW: ~35kDa (SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. Mouse adiponectin (aa 18-247) is fused at the N-terminus to a linker peptide (8 aa) and a FLAG®-tag.
CONCENTRATION: 0.5mg/ml after reconstitution.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile water.
BIOLOGICAL ACTIVITY: Inhibits serum glucose production in mice. Protects mouse hepatocytes from TNF-α-induced cell death in vitro.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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Product Description
Mimics serum adiponectin by forming high molecular weight (HMW) and hexameric species.
Product Specific Literature References
Regulation of T-cell mediated hepatic inflammation by adiponectin and leptin: J.A. Sennello, et al.; Endocrinology 146, 2157 (2005) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link Q60994: Adiponectin (mouse)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Oligomerization state-dependent activation of NF-kappa B signaling pathway by adipocyte complement-related protein of 30 kDa (Acrp30): T.S. Tsao, et al.; J. Biol. Chem. 277, 29359 (2002) Abstract; Full Text
Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity: U.B. Pajvani, et al.; J. Biol. Chem. 279, 12152 (2004) Abstract; Full Text
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-522-063 Revised 28-Aug-07
Adiponectin (human) (recombinant)
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SYNONYMS ACRP30 (human) (recombinant)
Adipocyte Complement Related Protein of 30kDa (human) (recombinant)
AdipoQ (human) (recombinant)
apM1 (human) (recombinant)
GBP28 (human) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Adiponectin [ACRP30] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-063-C050   50 µg 335.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
MW: ~33kDa (SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. Human adiponectin (aa 16-244) is fused at the N-terminus to a linker peptide (14 aa) and a FLAG®-tag.
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 50µl sterile distilled water. Further dilutions should be made with medium containing 5% fetal calf serum or other carrier protein.
BIOLOGICAL ACTIVITY: Activates AMPK.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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Product Description
Mimics serum adiponectin by forming high molecular weight (HMW) and hexameric species.
Product Specific Literature References
Leptin stimulates fatty acid oxidation and peroxisome proliferator-activated receptor alpha gene expression in mouse C2C12 myoblasts by changing the subcellular localization of the alpha2 form of AMP-activated protein kinase: A. Suzuki, et al.; Mol. Cell. Biol. 27, 4317 (2007) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link Q15848: Adiponectin (human) (precursor)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism: A.H. Berg, et al.; Trends Endocrinol. Metab. 13, 84 (2002), (Review) Abstract
Oligomerization state-dependent activation of NF-kappa B signaling pathway by adipocyte complement-related protein of 30 kDa (Acrp30): T.S. Tsao, et al.; J. Biol. Chem. 277, 29359 (2002) Abstract; Full Text
Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity: U.B. Pajvani, et al.; J. Biol. Chem. 279, 12152 (2004) Abstract; Full Text
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-522-088 Revised 08-Dec-06
Adiponectin (Globular Domain) (mouse) (recombinant)
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SYNONYMS ACRP30 (Globular Domain) (mouse) (recombinant)
Adipocyte Complement Related Protein of 30kDa (Globular Domain) (mouse) (recombinant)
AdipoQ (Globular Domain) (mouse) (recombinant)
apM1 (Globular Domain) (mouse) (recombinant)
GBP28 (Globular Domain) (mouse) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Adiponectin [ACRP30] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-088-C050   50 µg 370.00 USD Add To Cart
Product Specification
MW: ~26kDa
SOURCE/HOST: Produced in HEK 293 cells. The globular domain of mouse adiponectin (aa 111-247) is fused at the N-terminus to a linker peptide (8 aa) and a FLAG®-tag.
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: >95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL test; BioWhittaker).
RECONSTITUTION: Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
General Information
Adiponectin, also known as ACRP30 (30kDa adipocyte complement-related protein) is a hormone synthesized and secreted by adipocytes. Expression and plasma levels of adiponectin are decreased in insulin resistance and obesity and synthesis of this adipokine increases when insulin sensitivity is improved and weight is lost.
Adiponectin consists of a carboxyl-terminal globular domain and an amino-terminal collagen-like domain containing 22 Gly-X-Y repeats. The presence of a small amount of a carboxyl-terminal fragment containing the globular domain of adiponectin (gAdiponectin) has been demonstrated in human serum by immunoprecipitation. Adiponectin and gAdiponectin act in the brain to increase energy expenditure and to decrease body weight.
BACKGROUND/TECHNICAL INFORMATION FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice: J. Fruebis, et al.; PNAS 98, 2005 (2001) Abstract; Full Text
Adiponectin, obesity, and cardiovascular disease: M. Fasshauer, et al.; Biochimie 86, 779 (2004) Abstract
Adiponectin acts in the brain to decrease body weight: Y. Qi, et al.; Nat. Med. 10, 524 (2004) Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-338 Revised 18-Mar-08
ANGPTL4 (human) (recombinant)
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SYNONYMS Angiopoietin-like Protein 4 (human) (recombinant)
FIAF (human) (recombinant)
Fasting-induced Adipose Factor (human) (recombinant)
HFARP (human) (recombinant)
Hepatic Fibrinogen/Angiopoietin-related Protein (human) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Angiopoietin-like Proteins [ANGPTLs] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-338-C010   10 µg 295.00 USD Add To Cart
ALX-201-338-C050   50 µg 795.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. Mature human ANGPTL4 (angiopoietin-like protein 4) (aa 26-406) is fused at the C-terminus to a FLAG®-tag.
CONCENTRATION:  
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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General Information
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link Q9BY76: Angiopoietin-related protein 4 (human) [Precursor]

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
Related Products
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-359 Revised 18-Mar-08
ANGPTL3 (human) (recombinant)
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SYNONYMS Angiopoietin-like Protein 3 (human) (recombinant)
Angiopoietin-5 (human) (recombinant)
ANG-5 (human) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Angiopoietin-like Proteins [ANGPTLs] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-359-C010   10 µg 295.00 USD Add To Cart
ALX-201-359-C050   50 µg 795.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. Human ANGPTL3 (angiopoietin-like protein 3) (aa 1-460) is fused at the C-terminus to a FLAG®-tag.
CONCENTRATION:  
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q9Y5C1: Angiopoietin-related protein 3 (human) [Precursor]

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
Related Products
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-368 Revised 04-Apr-07
ANGPTL7 (human) (recombinant)
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SYNONYMS Angiopoietin-like Protein 7 (human) (recombinant)
Cornea-derived Transcript 6 Protein (human) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Angiopoietin-like Proteins [ANGPTLs] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-368-C010   10 µg 295.00 USD Add To Cart
ALX-201-368-C050   50 µg 795.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. Human ANGPTL7 (angiopoietin-like protein 7) (aa 1-346) is fused at the C-terminus to a FLAG®-tag.
CONCENTRATION:   
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
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General Information
Human ANGPTL7 is produced as a secreted glycoprotein with a molecular mass of 45kDa in SDS-PAGE analysis. Human mRNA is expressed in neural tissues, keratoconus cornea, trabecular meshwork, melanotic melanoma and uterus endometrial cancer, while mouse Angptl7 mRNA is expressed in four-cell embryos, synovial fibroblasts, thymus, uterus and testis. ANGPTL7 reduces tumor growth and aberrant blood vessel formation by inducing massive fibrosis in a mouse xenograft model [1]. It was reported that addition of ANGPTL7 results in a further increase in HSC activities. This suggests that ANGPTL7 may activate signal transduction pathways that cannot be activated by SCF, TPO, IGF-2 or FGF-1 [2]. Human ANGPTL7, characterized as potent target gene of WNT/ beta-catenin signalling pathway, is a pharmacogenomics target in the fields of oncology and regenerative medicine [3].
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link O43827: Angiopoietin-related protein 7 (human) [Precursor]

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
General Literature References
[1] The angiopoietin-like factor cornea-derived transcript 6 is a putative morphogen for human cornea: R. Peek, et al.; J. Biol. Chem. 277, 686 (2002) Abstract; Full Text
[2] Angiopoietin-like proteins stimulate ex vivo expansion of hematopoietic stem cells: C.C. Zhang, et al.; Nat. Med. 12, 240 (2006) Abstract
[3] Comparative integromics on Angiopoietin family members: Y. Katoh and M. Katoh; Int. J. Mol. Med. 17, 1145 (2006) Abstract
Related Products
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-373 Revised 18-Mar-08
ANGPTL4 (Coiled-coil Domain) (human) (recombinant)
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SYNONYMS Angiopoietin-like Protein 4 (Coiled-coil Domain) (human) (recombinant)
FIAF (Coiled-coil Domain) (human) (recombinant)
Fasting-induced Adipose Factor (Coiled-coil Domain) (human) (recombinant)
HFARP (Coiled-coil Domain) (human) (recombinant)
Hepatic Fibrinogen/Angiopoietin-related Protein (Coiled-coil Domain) (human) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Angiopoietin-like Proteins [ANGPTLs] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-373-C010   10 µg 295.00 USD Add To Cart
ALX-201-373-C050   50 µg 795.00 USD