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Insulin & Insulin Receptor / Related Products
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ALX-270-204 Revised 24-Jun-08
bpV(phen)
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SYNONYMS Potassium bisperoxo (1,10-phenanthroline) oxovanadate (V)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Oxovanadates
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-204-M005   5 mg 53.00 USD Add To Cart
ALX-270-204-M025   25 mg 195.00 USD Add To Cart
Product Specification
FORMULA: K[VO(O2)2C12H8N2] . 3H2O
MW: 350.3 . 54.0
PURITY: ≥98% (51V-NMR)
APPEARANCE: Yellow to orange powder.
SOLUBILITY: Soluble in water (10mM).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
IDENTITY: Identity determined by MS and 51V-NMR (D2O)

Product Description
Potent protein phosphotyrosine phosphatase inhibitor. Also shown to be a potent insulin receptor kinase activator; excellent insulin mimetic in vitro and in vivo.
Product Specific Literature References
Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics: B.I. Posner, et al.; J. Biol. Chem. 269, 4596 (1994) Abstract; Full Text
Selective activation of the rat hepatic endosomal insulin receptor kinase. Role for the endosome in insulin signaling: A.P. Bevan, et al.; J. Biol. Chem. 270, 10784 (1995) Abstract; Full Text
In vivo insulin mimetic effects of pV compounds: role for tissue targeting in determining potency: A.P. Bevan, et al.; Am. J. Physiol. 268, E60 (1995) Abstract
Hypoglycemic effects of peroxovanadium compounds in Sprague-Dawley and diabetic BB rats: J.F. Yale, et al.; Diabetes 44, 1274 (1995) Abstract
A role for tyrosine phosphorylation in both activation and inhibition of the insulin receptor tyrosine kinase in vivo: P.G. Drake, et al.; Endocrinology 137, 4960 (1996) Abstract
Phosphatidylinositol 3'-kinase and p70s6k are required for insulin but not bisperoxovanadium 1,10-phenanthroline (bpV(phen)) inhibition of insulin-like growth factor binding protein gene expression. Evidence for MEK-independent activation of mitogen-activ: C.J. Band & B.I. Posner; J. Biol. Chem. 272, 138 (1997) Abstract; Full Text
Lipopolysaccharide down-regulates the leukotriene C4 synthase gene in the monocyte-like cell line, THP-1: K.J. Serio, et al.; J. Immunol. 170, 2121 (2003) Abstract; Full Text
Further Categories Containing This Product:
Insulin & Insulin Receptor / Related Products
 
 
ALX-201-433 Revised 06-Aug-08 New product
Klotho (Extracellular Domain) (human):Fc (human) (recombinant)
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SYNONYMS KL (Extracellular Domain) (human):Fc (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Fibroblast Growth Factors [FGFs] & Receptors / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-433-C010   10 µg 320.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. The signal peptide and the extracellular domain of human Klotho (aa 1-981) are fused at the C-terminus to the Fc portion of human IgG.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2μm-filtered solution in PBS.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q9UEF7: Klotho (human)
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • Insulin & Insulin Receptor / Related Products
 
 
ALX-201-434 Revised 06-Aug-08 New product
βKlotho (Extracellular Domain) (human):Fc (human) (recombinant)
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SYNONYMS BKL (Extracellular Domain) (human):Fc (human) (recombinant)
Klotho beta-like Protein(Extracellular Domain) (human):Fc (human) (recombinant)
KLB (Extracellular Domain) (human):Fc (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Fibroblast Growth Factors [FGFs] & Receptors / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-434-C010   10 µg 320.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. The extracellular domain of human βKlotho (aa 1-996) is fused at the C-terminus to the Fc portion of human IgG.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2μm-filtered solution in PBS.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
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General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q86Z14: βKlotho (human)
MANUFACTURER Manufactured by AdipoGen, Inc.
General Literature References
BetaKlotho is required for metabolic activity of fibroblast growth factor 21: Y. Ogawa, et al.; PNAS 104, 7432 (2007) Abstract; Full Text
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • Insulin & Insulin Receptor / Related Products
 
 
ALX-803-322 Revised 10-Apr-08
Monoclonal Antibody to Collectrin (mouse) (2G5)
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SYNONYMS anti-TMEM27 (mouse) MAb (2G5)
anti-Transmembrane Protein 27 (mouse) MAb (2G5)
anti-Nx17 (mouse) MAb (2G5)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Renin-Angiotensin-Aldosterone System [RAAS] Other Products
Ordering Information
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ALX-803-322-C050   50 µg 180.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE: 2G5
ISOTYPE: Mouse IgG1
CONCENTRATION: 0.75mg/ml
PURITY DETAIL: Affinity purified.
FORMULATION: Liquid. In PBS, pH 7.2.
IMMUNOGEN: Synthetic peptide corresponding to aa 29-46 of N-terminal mouse collectrin.
SPECIFICITY: Recognizes mouse collectrin. Detects a band of ~44kDa.
APPLICATION: Immunohistochemistry (paraffin sections) (1:50)
Western Blot (1:500)
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
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Product Specific Literature References
Essential role for collectrin in renal amino acid transport: U. Danilczyk, et al.; Nature 444, 1088 (2006) Abstract
General Information
Collectrin is a catalytically inactive homolog of angiotensin-converting enzyme 2 (ACE2). It binds to SNARE complex by interacting with snapin. Collectrin shows interesting physiological roles related to insulin seccretion, formation of primary cilia, renal cyst formation and amino acid transport. Collectrin is therefore considered as a target for various pathological processes such as diabetes, polycystic kidney disease, hypertension and aminoaciduria.
General Literature References
Collectrin, a collecting duct-specific transmembrane glycoprotein, is a novel homolog of ACE2 and is developmentally regulated in embryonic kidneys: H. Zhang, et al.; J. Biol. Chem. 276, 17132 (2001) Abstract
The HNF-1alpha-SNARE connection: K. Yamagata, et al.; Diabetes Obes. Metab. 9, 40 (2007) Abstract
Collectrin, a homologue of ACE2, its transcriptional control and functional perspectives: Y. Zhang & J. Wada; BBRC 363, 1 (2007), (Review) Abstract
Further Categories Containing This Product:
Insulin & Insulin Receptor / Related Products • Monoclonal Antibodies
 
 
ALX-803-049 Revised 07-Mar-06
Monoclonal Antibody to C-Peptide (human) (91/1F9)
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SYNONYMS anti-C-Peptide (human) MAb (91/1F9)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Insulin & Insulin Receptor / Related Products
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ALX-803-049-C100   100 µg 300.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: 91/1F9
ISOTYPE: Mouse IgG2b
CONCENTRATION: 0.5mg/ml
PURITY DETAIL: Ammonium sulphate precipitation.
FORMULATION: Liquid. In PBS, pH 7.4, containing 0.9mg/ml sodium azide.
IMMUNOGEN: Human proinsulin.
SPECIFICITY: Recognizes human C-peptide. Cross-reacts with human proinsulin.
APPLICATION: Immunohistochemistry (frozen sections)
Immunoprecipitation
Radioimmunoassay
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year when stored at +4°C.
HANDLING: Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-803-052 Revised 07-Mar-06
Monoclonal Antibody to Viable Rat beta Cells and RIN Cells (K14D10)
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PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Insulin & Insulin Receptor / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-803-052-C100   100 µg 547.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Rat
CLONE: K14D10
ISOTYPE: Mouse IgG2a
CONCENTRATION: 0.5mg/ml
PURITY DETAIL: Ammonium sulphate precipitation.
FORMULATION: Liquid. In PBS, pH 7.4, containing 0.9mg/ml sodium azide.
IMMUNOGEN: Pig proinsulin.
SPECIFICITY: Recognizes surface structure of viable isolated rat beta cells. Does not recognize mouse islet beta cells. Cross-reactivity with human pancreatic beta cells was not detected.
APPLICATION: Flow Cytometry
Immunohistochemistry (frozen sections)
Note: Not recommended for WB and IP.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year when stored at +4°C.
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Influence of target cell preparation on binding of monoclonal islet cell reactive antibodies (mc-ICRA) in cellular enzyme-linked immunosorbent assay (CELISA): M. Schlosser, et al.; J. Immunol. Methods 140, 101 (1991) Abstract
Monoclonal antibody-mediated cytotoxicity against rat beta cells detected in vitro does not cause beta-cell destruction in vivo: B. Ziegler, et al.; Diabetologia 35, 608 (1992) Abstract
Co-culture of pancreatic islets and allogeneic lymphocytes: alterations of responder and stimulator cells: B. Kuttler, et al.; Transplantation 64, 480 (1997) Abstract
Recognition of islet-directed peripheral blood lymphocytes in vitro before rejection of allogeneic grafted islets: B. Kuttler, et al.; Transplantation 69, 1987 (2000) Abstract
Immunomagnetic purification of beta cells from rat islets of Langerhans: V. Hadjivassiliou, et al.; Diabetologia 43, 1170 (2000) Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
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