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ALX-270-404

Revised 24-Jan-06

Cilostamide
SYNONYMS	N-Cyclohexyl-N-methyl-4-(1,2-dihydro-2-oxo-6-quinolyloxy)butyramide OCP 3689
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Phosphodiesterases/Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-404-M005		5 mg	50.00 USD
ALX-270-404-M025		25 mg	200.00 USD

Product Specification

FORMULA:	C₂₀H₂₆N₂O₃
MW:	342.4
CAS NUMBER:	68550-75-4
PURITY:	≥98%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HANDLING:	Protect from light and oxygen. Packaged under inert gas.

Product Description

Selective inhibitor (IC₅₀=70nM) of phosphodiesterase 3 (PDE3). Reverses the established effects of leptin on food intake and body weight. Blocks the leptin-induced tyrosine phosphorylation of STAT3 at the hypothalamic level.

General Literature References

A phosphatidylinositol 3-kinase phosphodiesterase 3B-cyclic AMP pathway in hypothalamic action of leptin on feeding.: A.Z. Zhao, et al.; Nat. Neurosci. 5, 727 (2002) Abstract

Further Categories Containing This Product:

Obesity & Diabetes Other Products

ALX-270-466

Revised 14-Sep-07

Fluvastatin . sodium salt
PRODUCT LINE	Obesity & Adipokines
PRODUCT CATEGORY	Statins/Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-466-M010		10 mg	48.00 USD
ALX-270-466-M050		50 mg	190.00 USD

Product Specification

FORMULA:	C₂₄H₂₅FNO₄ . Na
MW:	410.5 . 23.0
CAS NUMBER:	93957-54-1
MERCK INDEX:	14: 4218
RTECS:	MJ9675050
SOURCE/HOST:	Synthetic.
PURITY:	≥98%
APPEARANCE:	Off-white to light yellow solid.
SOLUBILITY:	Soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stock solutions are stable for up to 6 months when stored at -20°C.
HANDLING:	Protect from light.
HAZARD:	TOXIC. MAY BE TERATOGENIC.

Product Description

Anticholesterol agent. HMG-CoA reductase inhibitor and antioxidant.

Product Specific Literature References

Folate and carcinogenesis: an integrated scheme: S.W. Choi and J.B. Mason; J. Nutr. 130, 129 (2000) Abstract; Full Text
Effect of fluvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on nitric oxide-induced hydroxyl radical generation in the rat heart: T. Obata, et al.; Biochim. Biophys. Acta 1536, 55 (2001) Abstract
Antioxidative effect of fluvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on peroxidation of phospholipid liposomes: A. Yamamoto, et al.; J. Pharm. Pharmacol. 53, 227 (2001) Abstract

Further Categories Containing This Product:

Obesity & Diabetes Other Products

ALX-201-421

Revised 03-Jul-08

FTO (human) (recombinant) (His)
SYNONYMS	Fat Mass and Obesity-associated Protein (human) (recombinant) (His) FATSO (human) (recombinant) (His)
PRODUCT LINE	Obesity & Adipokines
PRODUCT CATEGORY	Obesity & Diabetes Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-201-421-C010		10 µg	230.00 USD
ALX-201-421-C050		50 µg	510.00 USD

Product Specification

SOURCE/HOST:	Expressed in E. coli. The mature peptide of human FTP (aa 2-505) is fused at the N-terminus to a His-tag.
CONCENTRATION:	0.5mg/ml
PURITY:	≥90% (SDS-PAGE)
FORMULATION:	Liquid. 0.2μm-filtered solution in 55mM TRIS, pH 8.2, containing 150mM sodium chloride.
ENDOTOXIN CONTENT:	<1EU/µg protein (LAL-test).
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING:	After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.

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General Information

BACKGROUND/TECHNICAL INFORMATION	Swiss-Prot link Q9C0B1: FATSO (human)
MANUFACTURER	Manufactured by AdipoGen, Inc.

Further Categories Containing This Product:

Recombinant Proteins/Fusion Proteins • Lipid Metabolism Other Products

ALX-201-202

Revised 22-Jan-08

Growth Hormone (20kDa) (human) (recombinant)
SYNONYMS	GH (20kDa) (human) (recombinant) Somatotropin (20kDa) (human) (recombinant)
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Growth Hormones/Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-201-202-C100		100 µg	125.00 USD

Product Specification

MW:	~20kDa.
SOURCE/HOST:	Produced in E. coli.
CONCENTRATION:	1mg/ml
PURITY:	≥95% (SDS-PAGE)
FORMULATION:	Liquid. In 88mM mannitol, pH 7.4, containing 5mM phosphate.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.

Further Categories Containing This Product:

Recombinant Proteins/Fusion Proteins • Obesity & Diabetes Other Products

ALX-201-201

Revised 20-May-05

Growth Hormone (human) (recombinant)
SYNONYMS	GH (human) (recombinant) Somatotropin (human) (recombinant)
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Growth Hormones/Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-201-201-C100		100 µg	125.00 USD

Product Specification

MW:	~22.2kDa.
SOURCE/HOST:	Produced in E. coli.
CONCENTRATION:	1mg/ml
PURITY:	≥95% (SDS-PAGE)
FORMULATION:	Liquid. In 88mM mannitol, pH 7.4, containing 5mM phosphate.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.

Further Categories Containing This Product:

Recombinant Proteins/Fusion Proteins • Obesity & Diabetes Other Products

ALX-430-023

Revised 11-Mar-05

KN-93
SYNONYMS	2-[N-(2-Hydroxyethyl)-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	CAM Kinase Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-430-023-M001		1 mg	84.00 USD
ALX-430-023-M005		5 mg	336.00 USD

Product Specification

FORMULA:	C₂₆H₂₉ClN₂O₄S
MW:	501.0
CAS NUMBER:	139298-40-1
PURITY:	≥98% (¹H-NMR)
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in DMSO or methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
USE/STABILITY:	Stable for at least 5 years after receipt when stored at +4°C. DMSO stock solutions are stable for 3-4 months when stored at -20°C.
HANDLING:	Protect from light.

Product Description

Selective inhibitor of rat brain Ca²⁺/calmodulin-dependent protein kinase II. Inhibits glucose-induced and forskolin-stimulated insulin release from isolated pancreatic islets. Induces G₁ cell cycle arrest and apoptosis.

Product Specific Literature References

The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells: M. Sumi, et al.; BBRC 181, 968 (1991) Abstract
Inhibition of acid secretion in gastric parietal cells by the Ca2+/calmodulin-dependent protein kinase II inhibitor KN-93: N. Mamiya, et al.; BBRC 195, 608 (1993) Abstract
Presence and possible involvement of Ca/calmodulin-dependent protein kinases in insulin release from the rat pancreatic beta cell: I. Niki, et al.; BBRC 191, 255 (1993) Abstract
G1 cell cycle arrest and apoptosis are induced in NIH 3T3 cells by KN- 93, an inhibitor of CaMK-II (the multifunctional Ca2+/CaM kinase): R.M. Tombes, et al.; Cell Growth Differentiation 6, 1063 (1995) Abstract

Further Categories Containing This Product:

Apoptosis Inducers & Inhibitors Other Products • Obesity & Diabetes Other Products

ALX-430-127

Revised 20-Feb-07

KN-93 (water soluble)
SYNONYMS	KN-93 . hydrogen phosphate 2-[N-(2-Hydroxyethyl)-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine . hydrogen phosphate
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	CAM Kinase Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-430-127-M001		1 mg	90.00 USD
ALX-430-127-M005		5 mg	315.00 USD

Product Specification

FORMULA:	C₂₆H₂₉ClN₂O₄S . H₃PO₄
MW:	501.0 . 98.0
PURITY:	≥98% (¹H-NMR)
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in water.
SHIPPING:	AMBIENT
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 2 years after receipt. Stock solutions are stable for up to 3 months when stored at -20°C.
HANDLING:	Protect from light. Hygroscopic.
HAZARD:	IRRITANT.

Product Description

Product Specific Literature References

The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells: M. Sumi, et al.; BBRC 181, 968 (1991) Abstract
Presence and possible involvement of Ca/calmodulin-dependent protein kinases in insulin release from the rat pancreatic beta cell: I. Niki, et al.; BBRC 191, 255 (1993) Abstract
Inhibition of acid secretion in gastric parietal cells by the Ca2+/calmodulin-dependent protein kinase II inhibitor KN-93: N. Mamiya, et al.; BBRC 195, 608 (1993) Abstract
G1 cell cycle arrest and apoptosis are induced in NIH 3T3 cells by KN-93, an inhibitor of CaMK-II (the multifunctional Ca2+/CaM kinase): R.M. Tombes, et al.; Cell Growth Differ. 6, 1063 (1995) Abstract

Further Categories Containing This Product:

Apoptosis Inducers & Inhibitors Other Products • Obesity & Diabetes Other Products

ALX-270-343

Revised 30-May-07

3-O-Methyl-N-acetyl-D-glucosamine
SYNONYMS	3-OMe-GlcNAc
PRODUCT LINE	Obesity & Adipokines
PRODUCT CATEGORY	Carbohydrates

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-343-M005		5 mg	190.00 USD

Product Specification

FORMULA:	C₉H₁₇NO₆
MW:	235.2
CAS NUMBER:	94825-74-8
PURITY:	≥98% (¹H-NMR)
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in DMSO (10mg/ml) or water (10mg/ml).
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.
HAZARD:	HARMFUL.

Product Description

Inhibitor of N-acetylglucosamine kinase (K_i=17µM) and N-acetylmannosamine kinase (K_i=80µM). It has been found that 3-OMe-GlcNAc potently inhibits glucose phosphorylation by N-acetylglucosamine kinase whereas glucokinase is not at all affected by this hexosamine.

Product Specific Literature References

Inhibition of N-acetylglucosamine kinase and N-acetylmannosamine kinase by 3-O-methyl-N-acetyl-D-glucosamine in vitro: R. Zeitler, et al.; Eur. J. Biochem. 204, 1165 (1992) Abstract
Utility of 3-O-methyl-N-acetyl-D-glucosamine, an N-acetylglucosamine kinase inhibitor, for accurate assay of glucokinase in pancreatic islets and liver: I. Miwa, et al.; Enzyme Protein 48, 135 (1994) Abstract

Further Categories Containing This Product:

N-Acetylneuraminic Acid/Derivatives • Obesity & Diabetes Other Products

ALX-801-035

Revised 08-Jan-07

Monoclonal Antibody to BSEP (human) (USal-hBSEP-McAb-1)
SYNONYMS	anti-Bile Salt Export Pump (human) MAb (USal-hBSEP-McAb-1) anti-SPGP (human) MAb (USal-hBSEP-McAb-1) anti-Sister of P-glycoprotein (human) MAb (USal-hBSEP-McAb-1) anti-ABCB11 (human) MAb (USal-hBSEP-McAb-1)
PRODUCT LINE	Obesity & Adipokines
PRODUCT CATEGORY	Obesity & Diabetes Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-801-035-C100		100 µg	285.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
CLONE:	USal-hBSEP-McAb-1
ISOTYPE:	Mouse IgG1
CONCENTRATION:	1mg/ml
PURITY DETAIL:	Protein G-affinity purified.
FORMULATION:	Liquid. Contains 100nM sodium azide and 0.7% BSA.
IMMUNOGEN:	Synthetic peptide corresponding to aa 705-718 (Y⁷⁰⁵LVHEPPLAVVDHK⁷¹⁸) of human BSEP (bile salt export pump).
SPECIFICITY:	Recognizes human BSEP. Does not cross-react with human P-glycoprotein.
APPLICATION:	Immunocytochemistry (cytospin preparations) Western Blot (1:50-1:200)
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.

Product Images

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Product Specific Literature References

Expression in Human Trophoblast and Choriocarcinoma Cell Lines, BeWo, Jeg-3 and JAr of Genes Involved in the Hepatobiliary-like Excretory Function of the Placenta: M.A. Serrano, et al.; Placenta 28, 107 (2007) Abstract

General Information

Bile Salts
Bile salts are important physiological agents that serve a number of functions, including absorption, solubilization, transport and secretion of lipids. In the liver, they participate in the generation of bile flow and the secretion of cholesterol and phospholipids, such as phosphatidylcholine. When released into the intestine, they facilitate the uptake of cholesterol, fat-soluble vitamins and other lipids. Moreover, the biosynthesis of bile acids from cholesterol is the most significant pathway for the elimination of cholesterol from the body. However, because of their detergent properties, bile acids are inherently cytotoxic and disruptions in their normal transport or secretion can result in a variety of pathophysiological conditions.

BSEP
Bile formation is an important function of the liver. It is mediated by hepatocytes which generate bile flow within the bile canaliculi by continuous vectorial secretion of bile salts and other solutes across their canalicular (apical) membrane. Bile secretion is mediated by several ATP-binding cassette (ABC) transporters located in the canalicular membrane of hepatocytes. Among these ABC transporters, the bile salt export pump (BSEP or ABCB11) represents the primary, if not sole transport system for the canalicular excretion of bile salts. Bile secretory failure results in cholestasis and progressive familial intrahepatic cholestasis (PFIC) in infancy represents a group of inherited cholestatic diseases that are classified into three subtypes. One of these subtypes, PFIC II, is associated with mutations in the BSEP gene. PFIC patients with mutations in the BSEP gene have normal γ-glutamyltransferase activity, low concentrations of bile salts in bile, and an absence of bile duct proliferation.

Additionally, human obesity is associated with altered cholesterol homeostasis including increased production and turnover, as well as secretion of excess cholesterol from the liver into bile.

BSEP is a multifunctional polypeptide with two homologous halves, each containing a hydrophobic membrane-ancoring domain and an ATP-binding cassette (ABC) domain. The membrane-anchoring domain is composed of six helixes buried in the lipid bilayer of the plasma membrane and the ATP binding ABCs are exposed to the cytosol. The membrane-anchoring domain helixes are thought to form channels spanning the plasma membrane.

Further Categories Containing This Product:

Monoclonal Antibodies

ALX-805-039

Revised 19-May-05

Monoclonal Antibody to CD36 (63)
PRODUCT LINE	Immunology
PRODUCT CATEGORY	CD Antibodies

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-805-039-C100		100 µg	390.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Mouse Rat
CLONE:	63
ISOTYPE:	Mouse IgA
CONCENTRATION:	1mg/ml
FORMULATION:	Liquid. Protein L purified antibody in PBS containing 20% glycerol.
IMMUNOGEN:	Recombinant mouse CD36.
SPECIFICITY:	Recognizes mouse and rat CD36.
APPLICATION:	Flow Cytometry (1:1’000) Immunocytochemistry (1:1’000) Immunoprecipitation (1:1’000) Functional Application (blocks uptake of oxidized LDL by mouse macrophages and prevents foam cell formation in vitro).
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.

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Further Categories Containing This Product:

Obesity & Diabetes Other Products • Monoclonal Antibodies

ALX-804-580

Revised 20-Jan-06

Monoclonal Antibody to Growth Hormone (human) (g3H5)