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ALX-804-854 Revised 29-Oct-07
Monoclonal Antibody to Nesfatin-1 (Nesfaty-1)
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PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Food Intake Modulators Other Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-854-C100   100 µg 360.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
CLONE: Nesfaty-1
ISOTYPE: Mouse IgG1
SOURCE/HOST: Purified from concentrated hybridoma tissue cell culture supernatant.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant rat nesfatin-1 (aa 25-106) (Prod. No. ALX-522-118).
SPECIFICITY: Recognizes mouse and rat nesfatin-1 and precursor nucleobindin-2.
APPLICATION: ELISA
Immunoprecipitation (1:100)
Western Blot (1:1’000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
General Information
Nesfatin-1, a polypeptide produced by cleavage of the NEFA/nucleobindin-2 (NUCB2), is a secreted protein expressed in the appetite-control hypothalamic nuclei. Nesfatin is involved in the regulation of the feeding behaviour. Intracerebroventricular injection of nesfatin-1 reduces body weight in rat by affecting the animal food intake.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Identification of nesfatin-1 as a satiety molecule in the hypothalamus: I.S. Oh, et al.; Nature 443, 709 (2006) Abstract
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Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-522-112 Revised 27-Mar-08
Nesfatin-1 (mouse) (recombinant)
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PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Food Intake Modulators Other Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-112-C010   10 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
MW: ~8kDa
SOURCE/HOST: Recombinant mouse nesfatin-1 (aa 25-106) produced in E. coli.
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 0.2% bovine serum albumin (BSA).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Description
Nesfatin-1, a polypeptide produced by cleavage of the NEFA/nucleobindin-2 (NUCB2), is a secreted protein expressed in the appetite-control hypothalamic nuclei. Nesfatin is involved in the regulation of the feeding behaviour. Intracerebroventricular injection of nesfatin-1 reduces body weight in rat by affecting the animal food intake.
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P81117: Nucleobindin-2 (mouse) [Precursor]
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Identification of nesfatin-1 as a satiety molecule in the hypothalamus: I.S. Oh, et al.; Nature 443, 709 (2006) Abstract
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Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
 
 
ALX-522-114 Revised 27-Mar-08
Nesfatin-1 (mouse) (recombinant) (tagged)
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PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Food Intake Modulators Other Products
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ALX-522-114-C050   50 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
MW: ~35kDa
SOURCE/HOST: Produced in E. coli. Recombinant mouse nesfatin-1 (aa 25-106) is fused at the N-terminus to a GST-tag.
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 0.2% bovine serum albumin (BSA).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Product Description
Nesfatin-1, a polypeptide produced by cleavage of the NEFA/nucleobindin-2 (NUCB2), is a secreted protein expressed in the appetite-control hypothalamic nuclei. Nesfatin is involved in the regulation of the feeding behaviour. Intracerebroventricular injection of nesfatin-1 reduces body weight in rat by affecting the animal food intake.
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P81117: Nucleobindin-2 (mouse) [Precursor]
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Identification of nesfatin-1 as a satiety molecule in the hypothalamus: I.S. Oh, et al.; Nature 443, 709 (2006) Abstract
Related Products
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
 
 
ALX-522-116 Revised 27-Mar-08
Nesfatin-1 (rat) (recombinant)
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PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Food Intake Modulators Other Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-116-C010   10 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
MW: ~8kDa
SOURCE/HOST: Recombinant rat nesfatin-1 (aa 25-106) produced in E. coli.
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 0.2% bovine serum albumin (BSA).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Description
Nesfatin-1, a polypeptide produced by cleavage of the NEFA/nucleobindin-2 (NUCB2), is a secreted protein expressed in the appetite-control hypothalamic nuclei. Nesfatin is involved in the regulation of the feeding behaviour. Intracerebroventricular injection of nesfatin-1 reduces body weight in rat by affecting the animal food intake.
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q9JI85: Nucleobindin-2 (rat) [Precursor]
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Identification of nesfatin-1 as a satiety molecule in the hypothalamus: I.S. Oh, et al.; Nature 443, 709 (2006) Abstract
Related Products
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
 
 
ALX-522-118 Revised 27-Mar-08
Nesfatin-1 (rat) (recombinant) (tagged)
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PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Food Intake Modulators Other Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-118-C050   50 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
MW: ~35kDa
SOURCE/HOST: Produced in E. coli. Recombinant rat nesfatin-1 (aa 25-106) is fused at the N-terminus to a GST-tag.
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 0.2% bovine serum albumin (BSA).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Product Description
Nesfatin-1, a polypeptide produced by cleavage of the NEFA/nucleobindin-2 (NUCB2), is a secreted protein expressed in the appetite-control hypothalamic nuclei. Nesfatin is involved in the regulation of the feeding behaviour. Intracerebroventricular injection of nesfatin-1 reduces body weight in rat by affecting the animal food intake.
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q9JI85: Nucleobindin-2 (rat) [Precursor]
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Identification of nesfatin-1 as a satiety molecule in the hypothalamus: I.S. Oh, et al.; Nature 443, 709 (2006) Abstract
Related Products
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
 
 
APO-54N-036 Revised 19-Jun-08 New product
Nesfatin-1 (mouse/rat) Detection Set [For ELISA Application]
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PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Food Intake Modulators Other Products
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APO-54N-036-KI01   1 Set 630.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
SENSITIVITY: 0.3ng/ml (range 0 to 16ng/ml).
QUANTITY: For 5x96 wells.
KIT/SET CONTAINS: 1 vial Standard (lyophilized) (STD).
1 vial Coating Antibody (COAT).
1 vial Detection Antibody (DET).
APPLICATION: For the quantitative determination of mouse or rat nesfatin-1 from biological samples.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
General Information
Brain hypothalamus expressed several secreted molecules that function in regulating feeding behavior [1]. NUCB2 (NUCB2 also called NEFA for DNA binding /EF-hand /acidic protein) is a hypothalamus-secreted protein containing 396 amino acids that is highly conserved in human, mice and rat [2, 3]. NUCB2 when injected directly into the brain of rats promotes anorexia and decreases body weight [3]. NUCB2 is cleaved posttranslationally by prohormone convertases into a N-terminus-fragment Nesfatin-1 and  two C-terminal peptides, Nesfatin-2 and Nesfatin-3 [3]. Nesfatin-1 possesses all of the anorexigenic property of NUCB2 [4]. The conversion of NUCB2 into Nesfatin-1 is indispensable for its activity in vivo [3].  Nesfatin-1 is found in discrete nuclei of the hypothalamus where it probably activates a leptin-independent melanocortin pathway [3]. Nesfatin-1 crosses the Blood Brain Barrier (BBB) in both the blood-to-brain and brain-to-blood directions by a nonsaturable system [5].  NUCB2 is also expressed in the adipocyte cell line 3T3L1 suggesting other functions of Nesfatin-1 outside brain or peripheral source of Nesfatin-1 affecting brain function [6]. Nesfatin-1 in rat stimulates calcium influx and interacts with a G protein-coupled receptor still to be characterized [7].
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P81117: Nucleobindin-2 (mouse) [Precursor], Q9JI85: Nucleobindin-2 (rat) [Precursor]
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
[1] Hormonal regulation of food intake: S. Stanley, et al.; Physiol. Rev. 85, 1131 (2005) Abstract; Full Text
[2] Isolation, characterization, and primary structure of a calcium-binding 63-kDa bone protein: M. Wendel, et al.; JBC 270, 6125 (1995) Abstract; Full Text
[3] Identification of nesfatin-1 as a satiety molecule in the hypothalamus: S. Oh-I, et al.; Nature 443, 709 (2006) Abstract
[4] Serotonin systems upregulate the expression of hypothalamic NUCB2 via 5-HT2C receptors and induce anorexia via a leptin-independent pathway in mice: K. Nonogaki, et al.; BBRC 372, 186 (2008) Abstract
[5] Permeability of the blood-brain barrier to a novel satiety molecule nesfatin-1: T.O. Price, et al.; Peptides 28, 2372 (2007) Abstract
[6] In-depth analysis of the adipocyte proteome by mass spectrometry and bioinformatics: J. Adachi, et al.; Mol. Cell. Proteomics 6, 1257 (2007) Abstract; Full Text
[7] Nesfatin-1: distribution and interaction with a G protein-coupled receptor in the rat brain: G.C. Brailoiu, et al.; Endocrinology 148, 5088 (2007) Abstract
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Further Categories Containing This Product:
ELISA Sets
 
 
ALX-201-383 Revised 18-Mar-08
Nucleobindin-2 (mouse) (recombinant) (His)
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SYNONYMS NUCB2 (mouse) (recombinant) (His)
DNA-binding Protein NEFA (mouse) (recombinant) (His)
Nesfatin (mouse) (recombinant) (His)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Calcium Signalling (Intracellular) Other Products
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ALX-201-383-C010   10 µg 350.00 USD Add To Cart
ALX-201-383-C050   50 µg 490.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli. Mature human nucleobindin-2 (aa 25-420) is fused at the C-terminus to a His-tag.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS, pH 7.2.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P81117: Nucleobindin-2 (mouse) [Precursor]
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins • Food Intake Modulators Other Products
 
 
ALX-165-052 Revised 04-Mar-05
Peptide YY (3-36) (human)
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PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Food Intake Modulators Other Products
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ALX-165-052-C500   500 µg 130.00 USD Add To Cart
Product Specification
SEQUENCE: H-Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Gln-Arg-Tyr-NH2
FORMULA: C180H279N53O54
MW: 4049.5
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white powder.
FORMULATION: Lyophilized. TFA salt.
SOLUBILITY: 5mg/ml soluble in distilled water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Y2R agonist, inhibiting food intake and reducing weight gain in rats and humans after peripheral injection.
Product Specific Literature References
Gut hormone PYY(3-36) physiologically inhibits food intake: R.L. Batterham, et al.; Nature 418, 650 (2002) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-210-944 Revised 29-Oct-07
Polyclonal Antibody to Nesfatin-1 (AT120)
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PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Food Intake Modulators Other Products
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ALX-210-944-C100   100 µg 360.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
PURITY DETAIL: Protein A-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant rat nesfatin-1 (aa 25-106) (Prod. No.