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Obesity & Adipokines
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ALX-201-436 Revised 14-Oct-08 New product
FTO (mouse) (recombinant) (His)
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SYNONYMS Fat Mass and Obesity-associated Protein (mouse) (recombinant) (His)
FATSO (mouse) (recombinant) (His)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Obesity & Diabetes Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-436-C010   10 µg 240.00 USD Add To Cart
ALX-201-436-C050   50 µg 540.00 USD Add To Cart
Product Specification
SOURCE/HOST: Expressed in E. coli. The mature peptide of mouse FTO (aa 2-502) is fused at the N-terminus to a His-tag.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2μm-filtered solution in 55mM TRIS-Cl, pH 8.2, containing 150mM sodium chloride.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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General Information
The FTO (fat mass and obesity-associated) gene is well conserved and found in a single copy in vertebrate species. It is suggested that the FTO protein plays a role in fat cell lipolysis, which may be important in explaining why the FTO gene (and FTO gene variants) is implicated in body weight regulation.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q8BGW1: FTO (mouse)
MANUFACTURER Manufactured by AdipoGen, Inc.
General Literature References
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity: T.M. Frayling, et al.; Science 316, 889 (2007) Abstract
The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase: T. Gerken, et al.; Science 318, 1469 (2007) Abstract
The common rs9939609 gene variant of the fat mass- and obesity-associated gene FTO is related to fat cell lipolysis: K. Wahlen, et al.; J. Lipid. Res. 49, 607 (2007) Abstract
The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain: R. Fredriksson, et al.; Endocrinology 149, 2062 (2008) Abstract
Inverse relationship between obesity and FTO gene expression in visceral adipose tissue in humans: N. Klöting, et al.; Diabetologia 51, 641 (2008) Abstract
Major gender difference in association of FTO gene variant among severely obese children with obesity and obesity related phenotypes: J.A. Jacobsson, et al.; BBRC 368, 476 (2008) Abstract
Regulation of Fto/Ftm gene expression in mice and humans: G. Stratigopoulos, et al.; Am. J. Physiol. Regul. Integr. Comp. Physiol. 294, R1185 (2008) Abstract
Related Products
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • Lipid Metabolism Other Products
 
 
ALX-203-002 Revised 23-Mar-06
ACRP30headless (human) (recombinant)
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SYNONYMS Tail Adiponectin (human) (recombinant)
Tail-Adp (human) (recombinant)
Adipocyte Complement Related Protein of 30kDa headless (human) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Adiponectin [ACRP30] / Related Products
Ordering Information
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ALX-203-002-C010   10 µg 260.00 USD Add To Cart
Product Specification
MW: ~27kDa (SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. The non-homologous (aa 16-45) and collagen domain of human ACRP30 (aa 45-108) are fused at the N-terminus to a FLAG®-tag.
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile water.
APPLICATION: Negative control. When used at 1µg/g body weight in mouse demonstrated no significant bioactivity in terms of reduction of serum glucose compared to wildtype in an in vivo assay. Control compound for rhsMegaAPRIL™ (Prod. No. ALX-522-035) and rhsMegaTNF-α (Prod. No. ALX-522-046).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored as recommended.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
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Product Specific Literature References
Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin: Implications for metabolic regulation and bioactivity: U.B. Pajvani, et al.; J. Biol. Chem. 278, 9073 (2003) Abstract; Full Text
Adiponectin acts in the brain to decrease body weight: Y. Qi, et al.; Nat. Med. 10, 524 (2004) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link Q15848: ACRP30 (human) (precursor)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-203-003 Revised 23-Mar-06
ACRP30headless (mouse) (recombinant)
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SYNONYMS Tail Adiponectin (mouse) (recombinant)
Tail-Adp (mouse) (recombinant)
Adipocyte Complement Related Protein of 30kDa headless (mouse) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Adiponectin [ACRP30] / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-203-003-C010   10 µg 260.00 USD Add To Cart
Product Specification
MW: ~25kDa (SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. The collagen domain of mouse ACRP30 (aa 18-111) is fused at the N-terminus to a linker peptide (8 aa) and a FLAG®-tag.
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
APPLICATION: Negative control. Control compound for rmsMegaOX40L [CD134L]™ (Prod. No. ALX-522-062) and rmsMegaTNF-α™ (Prod. No. ALX-522-047).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored as recommended.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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General Information
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link Q60994: ACRP30 (mouse) (precursor)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-210-105 Revised 28-Sep-06
Polyclonal Antibody to Leptin
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SYNONYMS anti-OB Gene Product PAb
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Leptin / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-105-R050   50 µl 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Sheep
SOURCE/HOST: From rabbit.
CONCENTRATION: 0.7mg/ml
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 25-44 (Q25KVQDDTKTLIKTIVTRIND44) of mouse leptin.
SPECIFICITY: Recognizes human, mouse, rat and sheep leptin.
APPLICATION: Immunocytochemistry (1:1'000)
Immunohistochemistry (frozen sections (1:1'000))
Western Blot (1:4'000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
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Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-117 Revised 24-Feb-05
Polyclonal Antibody to PPAR
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SYNONYMS anti-Peroxisome Proliferator Activated Receptor PAb
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PPAR Antibodies
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ALX-210-117-R100   100 µl 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. Antiserum diluted in PBS containing 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 484-498 (I484KKTETDMSLHPLLQ498) of the C-terminal domain of rat PPARγ2 (peroxisome proliferator activated receptor γ2). This sequence is completely conserved in human, mouse, rat, bovine, chicken and pig PPARγ1, PPARα and NUC1.
SPECIFICITY: Recognizes mouse and rat PPARγ2. Detects a band of ~55 kDa by Western blot. Cross-reacts with recombinant rat PPARα in Western blot and recombinant mouse PPARγ1 in immunoprecipitation.
APPLICATION: Gel Supershift Assay
Immunoprecipitation
Western Blot (1:2'000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer: P. Tontonoz, et al.; Genes Dev. 8, 1224 (1994) Abstract
Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat: O. Braissant, et al.; Endocrinology 137, 354 (1996) Abstract
MCF-7 and T47D human breast cancer cells contain a functional peroxisomal response: M.W. Kilgore, et al.; Mol. Cell Endocrinol. 129, 229 (1997) Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-166 Revised 13-Dec-04
Polyclonal Antibody to Leptin
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SYNONYMS anti-OB Gene Product PAb
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Leptin / Related Products
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ALX-210-166-R100   100 µl 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Pig
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. Purified IgG in PBS containing 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 91-106 (S91RNVIQIS
NDLENLRD106) of human leptin.
SPECIFICITY: Recognizes human, mouse and pig leptin. Detects a band of ~16kDa by Western blot.
APPLICATION: Western Blot (1:1'000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
General Information
Leptin, the obese (ob) gene product, is a small protein expressed in and secreted from adipose tissue of normal rodents. Studies suggest leptin acts as a circulating hormone capable of regulating body-weight homeostasis and energy balance. One possible target tissue for leptin is the hypothalamus, a proposed control center for satiety and energy expenditure.
Ob knockout mice are characterized by several metabolic abnormalities including, hyperglucocorticoidemia, hyperinsulinemia and insulin resistance, hyperglycemia, altered central nervous system activity, reduced metabolic rate of brown adipose tissue, and a large increase in white adipose tissue. Studies show that the administration of recombinant leptin to ob knockout mice reduces food intake and increases energy expenditure.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-168 Revised 07-May-07
Polyclonal Antibody to Leptin Receptor
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SYNONYMS anti-OB-R PAb
anti-CD295 PAb
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Leptin / Related Products
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ALX-210-168-R100   100 µl 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST: From rabbit.
PURITY DETAIL: Purified IgG.
FORMULATION: Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 577-594 (K577EIQWKTHEVFDAKSKSA594) of the extracellular domain of rat leptin receptor.
SPECIFICITY: Recognizes human, mouse and rat leptin receptor. Detects bands of ~100kDa and ~125kDa by Western blot, representing the short and long forms of leptin receptor. Also detects two unrelated bands of ~31kDa and ~35kDa.
APPLICATION: Western Blot (1:2'000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-161-003.
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Product Specific Literature References
A leptin dose response study in obese (ob/ob) and lean (+/?) mice: R.B.S. Harris, et al.; Endocrinology 139, 8 (1998) Abstract
Related Products
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-190/1 Revised 25-Aug-08
Polyclonal Antibody to PPARα (mouse)
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SYNONYMS anti-Peroxisome Proliferator Activated Receptor α (mouse) PAb
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PPAR Antibodies
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ALX-210-190/1-R100   100 µl 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml.
PURITY DETAIL: Epitope-affinity purified IgG.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 1-18 (M1VDTESPICP
LSPLEADD18) of mouse PPARα
(peroxisome proliferator activated receptor α). A single aa substitution (I8 to L8) exists between the mouse and human protein.
SPECIFICITY: Recognizes mouse PPARα. Detects a band of ~52kDa by Western blot. Does not cross-react with PPARδ or PPARγ.
APPLICATION: Immunocytochemistry (1:100)
Immunoprecipitation
Western Blot (1:1’000)
Functional Application (inhibits PPARα DNA binding)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-165-029.
Related Products
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-191/1 Revised 26-May-08
Polyclonal Antibody to PPARδ
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SYNONYMS anti-Peroxisome Proliferator Activated Receptor δ PAb
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PPAR Antibodies
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ALX-210-191/1-R100   100 µl 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
PURITY DETAIL: Epitope-affinity purified IgG.
FORMULATION: Liquid. Contains 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to  aa 1-14 (M1EQPQEETPE
AREE14) of mouse PPARδ (peroxisome proliferator activated receptor δ). This sequence is ~86% conserved in human PPARδ.
SPECIFICITY: Recognizes mouse and rat PPARδ . Detects a band of ~49kDa by Western blot. Does not cross-react with PPARα or PPARγ.
APPLICATION: Immunocytochemistry (1:100)
Immunohistochemistry (frozen sections (1:200))
Western Blot (1:500)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-165-030.
Related Products
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-192 Revised 12-Oct-05
Polyclonal Antibody to PPARγ2 (mouse)
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SYNONYMS anti-Peroxisome Proliferator Activated Receptor γ2 (mouse) PAb
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PPAR Antibodies
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ALX-210-192-R100   100 µl 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml.
PURITY DETAIL: Epitope-affinity purified IgG.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 1-16 (M1GETLGDSPIDPESDS16) of human PPARγ2 (peroxisome proliferator activated receptor γ2). 
SPECIFICITY: Recognizes mouse PPARγ2. Detects a band of ~56kDa by Western blot. Does not cross-react with PPARα or PPARδ.
APPLICATION: Gel Supershift Assay
Immunohistochemistry (1:500)
Western Blot (1:500)
Functional Application (inhibits PPARγ2 DNA binding)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-165-031.
Product Specific Literature References
Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes: R.M. Lavinsky, et al.; PNAS 95</