ALEXIS Biochemicals: Dlk1 (mouse):Fc (human) (recombinant)

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ALX-270-160

Revised 27-Sep-07

Castanospermine
SYNONYMS	(1S,6S,7R,8R,8aR)-1,6,7,8-Tetrahydroxyoctahydroindolizine
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Other Signal Transduction Pathway Modulators

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-160-M010		10 mg	60.00 USD
ALX-270-160-M050		50 mg	180.00 USD

Product Specification

FORMULA:	C₈H₁₅NO₄
MW:	189.2
CAS NUMBER:	79831-76-8
MERCK INDEX:	14: 1896
SOURCE/HOST:	Isolated from Castanospermum australe seeds.
PURITY:	≥98%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HANDLING:	Protect from moisture.

Product Description

Plant alkaloid. Potent inhibitor of α- and β-glucosidase activity in fibroblast extracts; inhibits the glycoprotein processing cycle. Exhibits antiviral properties. Prevents angiogenesis.

Product Specific Literature References

Castanospermine inhibits the processing of the oligosaccharide portion of the influenza viral hemagglutinin: Y.T. Pan, et al.; Biochemistry 22, 3975 (1983) Abstract
Glycoproteins: their structure, biosynthesis and possible clinical implications: H. Schachter; Clin. Biochem. 17, 3 (1984) Abstract
The effects of processing inhibitors of N-linked oligosaccharides on the intracellular migration of glycoprotein E2 of mouse hepatitis virus and the maturation of coronavirus particles: R. Repp, et al.; J. Biol. Chem. 260, 15873 (1985) Abstract; Full Text
Effects of the anti-inflammatory compounds castanospermine, mannose-6- phosphate and fucoidan on allograft rejection and elicited peritoneal exudates: M.R. Bartlett, et al.; Immunol. Cell Biol. 72, 367 (1994) Abstract
Antiviral activity and metabolism of the castanospermine derivative MDL 28,574, in cells infected with herpes simplex virus type 2: S.P. Ahmed, et al.; BBRC 208, 267 (1995) Abstract
The alpha-glucosidase I inhibitor castanospermine alters endothelial cell glycosylation, prevents angiogenesis, and inhibits tumor growth: R. Pili, et al.; Cancer Res. 55, 2920 (1995) Abstract
Perturbation of free oligosaccharide trafficking in endoplasmic reticulum glucosidase I-deficient and castanospermine-treated cells: C. Durrant & S.E. Moore; Biochem. J. 365, 239 (2002) Abstract

Further Categories Containing This Product:

Natural Products - Antiviral / anti-HIV Agents • Natural Products for Angiogenesis Research • Alkaloids • Glycosidases / Related Products

ALX-380-053

Revised 19-Jun-08

Cerulenin
SYNONYMS	2,3-Epoxy-4-oxo-7,10-dodecadienamide
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics - Apoptosis Inducers & Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-053-M005		5 mg	60.00 USD
ALX-380-053-M010		10 mg	110.00 USD
ALX-380-053-M050		50 mg	420.00 USD

Product Specification

FORMULA:	C₁₂H₁₇NO₃
MW:	223.3
CAS NUMBER:	17397-89-6
MERCK INDEX:	14: 2004
RTECS:	JR1670000
SOURCE/HOST:	Isolated from Cephalosporium caerulens.
PURITY:	≥98%
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in DMSO, dimethyl formamide, dichloromethane, methanol, 100% ethanol or acetone; slighly soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HANDLING:	Protect from light.
HAZARD:	HARMFUL.

Product Description

Antibiotic. Fatty acid synthase (FAS) inhibitor reported to bind in equimolar ratio to β-keto-acyl-ACP synthase, thus inhibiting protein acylation. Produces metabolic effects similar to effects of leptin, but through mechanisms that are independent of, or down-stream from, both leptin and melanocortin receptors. Apoptosis inducer. Inhibitor of bacterial fatty acid synthesis (inhibits FabH, FabB and FabF condensation enzymes).

Product Specific Literature References

Studies on cerulenin, 3. Isolation and physico-chemical properties of cerulenin: Y. Sato, et al.; J. Antibiot. (Tokyo) 200, 344 (1967) Abstract
Effect of cerulenin on the synthesis of very-long-chain fatty acids in microsomes from leek seedlings: F. Schneider, et al.; Biochim. Biophys. Acta 1152, 243 (1993) Abstract
Cerulenin-resistant mutants of Saccharomyces cerevisiae with an altered fatty acid synthase gene: J. Inokashi, et al.; Mol. Gen. Genet. 244, 90 (1994) Abstract
Cerulenin mimics effects of leptin on metabolic rate, food intake, and body weight independent of the melanocortin system, but unlike leptin, cerulenin fails to block neuroendocrine effects of fasting: H. Makimura, et al.; Diabetes 50, 733 (2001) Abstract; Full Text
Key role of mitochondria in cerulenin-mediated apoptosis: S.J. Heiligtag, et al.; Cell Death Differ. 9, 1017 (2002) Abstract
Fatty acid synthase inhibitors cerulenin and C75 retard growth and induce caspase-dependent apoptosis in human melanoma A-375 cells: T.S. Ho, et al.; Biomed. Pharmacother. 61, 578 (2007) Abstract

Further Categories Containing This Product:

Fatty Acid Synthase [FAS] / Related Products

ALX-270-171

Revised 30-Jun-08

Chlorpromazine . hydrochloride
SYNONYMS	2-Chloro-10-(3-dimethylaminopropyl)phenothiazine . HCl
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Calmodulin Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-171-G001		1 g	22.00 USD
ALX-270-171-G005		5 g	66.00 USD

Product Specification

FORMULA:	C₁₇H₁₉ClN₂S . HCl
MW:	318.9 . 36.5
CAS NUMBER:	69-09-0
MERCK INDEX:	14: 2185
RTECS:	SO1750000
PURITY:	≥98% (HPLC)
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in 100% ethanol, methanol or water (50mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
USE/STABILITY:	Not stable in aqueous solution. We strongly recommend always to use freshly prepared solutions.
HANDLING:	Protect from light.
HAZARD:	VERY TOXIC.

Product Description

Inhibits calmodulin stimulation of cyclic nucleotide phosphodiesterase. Dopamine antagonist. D₂antagonist. H₁antagonist. Inhibits TNF-α production. Potent PLA₂inhibitor. Inhibits nitric oxide synthase (NOS) in mouse brain and prevents lipopolysaccharide induction of NOS in mouse lung. Antipsychotic.

Product Specific Literature References

Chlorpromazine as a substitute for ortho-dianisidine and ortho-tolidine in the determination of chlorine, hemoglobin, and peroxidase activity: H.B. Collier; Clin. Biochem. 7, 331 (1974) Abstract
Drug-protein interactions: binding of chlorpromazine to calmodulin, calmodulin fragments, and related calcium binding proteins: D.R. Marshak, et al.; Biochemistry 24, 144 (1985) Abstract
Selective inhibition of group II phospholipase A2 by quercetin: M. Lindahl & C. Tagesson; Inflammation 17, 573 (1993) Abstract
Chlorpromazine inhibits both the constitutive nitric oxide synthase and the induction of nitric oxide synthase after LPS challenge: M. Palacios, et al.; BBRC 196, 280 (1993) Abstract
Protective effect of calmodulin inhibitors against acute cyanide- induced lethality and convulsions in mice: H. Yamamoto; Toxicol. Lett. 66, 73 (1993) Abstract
Pharmacologic inhibitors of tumor necrosis factor production exert differential effects in lethal endotoxemia and in infection with live microorganisms in mice: M.G. Netea, et al.; J. Infect. Dis. 171, 393 (1995) Abstract
Pharmacological regulation of mitochondrial nitric oxide synthase: A. Boveris, et al.; Methods Enzymol. 359, 328 (2002) Abstract
Brain mitochondrial nitric oxide synthase: in vitro and in vivo inhibition by chlorpromazine: S. Lores-Arnaiz, et al.; Arch. Biochem. Biophys. 430, 170 (2004) Abstract

Further Categories Containing This Product:

Phosphodiesterases / Related Products • TNF-alpha & TNF Receptors Other Products • PLA2 Inhibitors • Chemopreventive Agents Other Products • NOS Inhibitors (NOS Induction & Enzyme Activity) • Dopaminergics & Dopamine Receptors / Related Products

ALX-370-009

Revised 26-Jun-06

Cholesterol 3-sulfate . sodium salt
PRODUCT LINE	Obesity & Adipokines
PRODUCT CATEGORY	Cholesterol & Lipid Transport / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-370-009-M005		5 mg	20.00 USD
ALX-370-009-M025		25 mg	45.00 USD

Product Specification

FORMULA:	C₂₇H₄₅O₄S . Na
MW:	465.7 . 23.0
CAS NUMBER:	2864-50-8
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HANDLING:	Protect from light.

Product Description

Activates multiple protein kinase C (PKC) iso-enzymes, especially the ε, η and ζ isoforms.

Product Specific Literature References

Cholesterol sulfate, a novel activator for the eta isoform of protein kinase C: T. Ikuta, et al.; Cell Growth Differentiation 5, 943 (1994) Abstract
Cholesterol sulfate activates multiple protein kinase C isoenzymes and induces granular cell differentiation in cultured murine keratinocytes: M.F. Denning, et al.; Cell Growth Differentiation 6, 1619 (1995) Abstract

Further Categories Containing This Product:

PKC Activators

ALX-270-255

Revised 14-Sep-07

Ciglitazone
SYNONYMS	(±)-5-[4-(1-Methylcyclohexylmethoxy)benzyl]-thiazolidine-2,4-dione U-63287
PRODUCT LINE	DNA Regulation / Transcription
PRODUCT CATEGORY	PPAR Agonists

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-255-M001		1 mg	30.00 USD
ALX-270-255-M005		5 mg	80.00 USD
ALX-270-255-M025		25 mg	310.00 USD

Product Specification

FORMULA:	C₁₈H₂₃NO₃S
MW:	333.5
CAS NUMBER:	74772-77-3
SOURCE/HOST:	Synthetic.
PURITY:	≥98%
APPEARANCE:	Off-white solid.
SOLUBILITY:	Soluble in DMSO or 100% ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
USE/STABILITY:	Stock solutions are stable for up to 3 months when stored at -20°C.

Product Description

Selective PPARγ agonist.

Product Specific Literature References

The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones: T.M. Willson, et al.; J. Med. Chem. 39, 665 (1996) Abstract; Full Text
Detection and functional characterisation of the transcription factor peroxisome proliferator-activated receptor gamma in lutein cells: B. Löhrke, et al.; J. Endocrinol. 159, 429 (1998) Abstract; Full Text
Peroxisome proliferator-activated receptor gamma ligands are potent inhibitors of angiogenesis in vitro and in vivo: X. Xin, et al.; J. Biol. Chem. 274, 9116 (1999) Abstract; Full Text
Thiazolidinediones--the new insulin enhancers: R.J. Jha; Clin. Exp. Hypertens. 21, 157 (1999), (Review) Abstract
The nuclear receptor PPAR gamma and immunoregulation: PPAR gamma mediates inhibition of helper T cell responses: R.B. Clark, et al.; J. Immunol. 164, 1364 (2000) Abstract; Full Text

Further Categories Containing This Product:

Antidiabetic Agents / Related Products

ALX-270-404

Revised 24-Jan-06

Cilostamide
SYNONYMS	N-Cyclohexyl-N-methyl-4-(1,2-dihydro-2-oxo-6-quinolyloxy)butyramide OCP 3689
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Phosphodiesterases / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-404-M005		5 mg	50.00 USD
ALX-270-404-M025		25 mg	200.00 USD

Product Specification

FORMULA:	C₂₀H₂₆N₂O₃
MW:	342.4
CAS NUMBER:	68550-75-4
PURITY:	≥98%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HANDLING:	Protect from light and oxygen. Packaged under inert gas.

Product Description

Selective inhibitor (IC₅₀=70nM) of phosphodiesterase 3 (PDE3). Reverses the established effects of leptin on food intake and body weight. Blocks the leptin-induced tyrosine phosphorylation of STAT3 at the hypothalamic level.

General Literature References

A phosphatidylinositol 3-kinase phosphodiesterase 3B-cyclic AMP pathway in hypothalamic action of leptin on feeding.: A.Z. Zhao, et al.; Nat. Neurosci. 5, 727 (2002) Abstract

Further Categories Containing This Product:

Obesity & Diabetes Other Products

ALX-270-475

Revised 17-Jan-08

Ciprofibrate
SYNONYMS	2-[4-(2,2-Dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid
PRODUCT LINE	Obesity & Adipokines
PRODUCT CATEGORY	Cholesterol & Lipid Transport / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-475-M025		25 mg	50.00 USD
ALX-270-475-M100		100 mg	150.00 USD
ALX-270-475-M250		250 mg	300.00 USD

Product Specification

FORMULA:	C₁₃H₁₄Cl₂O₃
MW:	289.2
CAS NUMBER:	52214-84-3
MERCK INDEX:	14: 2313
RTECS:	UF0880000
PURITY:	≥98% (HPLC)
APPEARANCE:	White to light yellow powder.
SOLUBILITY:	Soluble in DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	TOXIC. MAY BE CARCINOGENIC.

Product Description

Hypolipidemic compound. PPARα (peroxisome proliferator-activated receptor α) agonist.

Product Specific Literature References

Comparison of the effects of various peroxisome proliferators on peroxisomal enzyme activities, DNA synthesis, and apoptosis in rat and human hepatocyte cultures: V. Goll, et al.; Toxicol. Appl. Pharmacol. 160, 21 (1999) Abstract
Phosphorylation of peroxisome proliferator-activated receptor alpha in rat Fao cells and stimulation by ciprofibrate: P. Passilly, et al.; Biochem. Pharmacol. 58, 1001 (1999) Abstract
Differences in cell proliferation in rodent and human hepatic derived cell lines exposed to ciprofibrate: M.C. Clemencet, et al.; Cancer Lett. 222, 217 (2005) Abstract
P450 CYP2C epoxygenase and CYP4A ω-hydroxylase mediate ciprofibrate-induced PPARα-dependent peroxisomal proliferation: A. Gatica, et al.; J. Lipid Res. 48, 924 (2007) Abstract; Full Text

ALX-270-256	Clofibrate
ALX-270-481	Fenofibrate

FORMULA:	C₁₂H₁₅ClO₃
MW:	242.7
CAS NUMBER:	637-07-0
MERCK INDEX:	14: 2377
PURITY:	≥98%
APPEARANCE:	Colorless oil.
SOLUBILITY:	Soluble in DMSO or 100% ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C
USE/STABILITY:	Solutions are stable for up to 6 months when stored at –20°C.