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Obesity & Adipokines
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ALX-340-039 Revised 05-Feb-05
MEDICA 16
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SYNONYMS 3,3,14,14-Tetramethylhexadecanedioic acid
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Cholesterol & Lipid Transport / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-340-039-M005   5 mg 92.00 USD Add To Cart
Product Specification
FORMULA: C20H38O4
MW: 342.5
CAS NUMBER: 87272-20-6
PURITY: ≥98%
APPEARANCE: Crystalline solid.
SOLUBILITY: 100mg/ml soluble in DMSO, dimethyl formamide or 100% ethanol. Slightly soluble in aqueous buffers.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C

Product Description
Hypolipidemic and antidiabetic agent, shown to reduce adiposity. Induces malic enzyme, mitochondrial glycerol-3-phosphate dehydrogenase, and carnitine palmitoyl transferase I. Inhibitor of citrate lyase and acetyl-CoA carboxylase, expected to disinhibit hepatic fatty acid oxidation while up-regulating electron shuttle mechanism, and thus should stimulate reverse electron transport. Exhibits thyromimetic properties with respect to the modulation of rat liver redox and phosphate potentials.
Product Specific Literature References
Inhibition of lipid synthesis by beta beta'-tetramethyl-substituted, C14-C22, alpha, omega-dicarboxylic acids in the rat in vivo: J. Bar-Tana, et al.; J. Biol. Chem. 260, 8404 (1985) Abstract; Full Text
The hypochylomicronemic effect of beta,beta'-methyl-substituted hexadecanedioic acid (MEDICA 16) is mediated by a decrease in apolipoprotein C-III: B. Frenkel, et al.; J. Biol. Chem. 263, 8491 (1988) Abstract; Full Text
Adipose reduction by beta,beta'-tetramethyl-substituted hexadecanedioic acid (MEDICA 16): R. Tzur, et al.; Int. J. Obes. 13, 313 (1989), Review Abstract
Inhibition of rat liver acetyl-CoA carboxylase by beta, beta'-tetramethyl-substituted hexadecanedioic acid (MEDICA 16): G. Rose-Kahn & J. Bar-Tana; Biochim. Biophys. Acta 1042, 259 (1990) Abstract
Hypolipidemic effect of beta, beta'-tetramethyl hexadecanedioic acid (MEDICA 16) in hyperlipidemic JCR:LA-corpulent rats: J.C. Russell, et al.; Arterioscler. Thromb. 11, 602 (1991) Abstract
Tissue selective modulation of redox and phosphate potentials by beta,beta'-methyl-substituted hexadecanedioic acid: B. Kalderon, et al.; Endocrinology 131, 1629 (1992) Abstract
Mode of action of peroxisome proliferators as hypolipidemic drugs. Suppression of apolipoprotein C-III: R. Hertz, et al.; J. Biol. Chem. 270, 13470 (1995) Abstract; Full Text
Sensitization to insulin induced by beta,beta'-methyl-substituted hexadecanedioic acid (MEDICA 16) in obese Zucker rats in vivo: N. Mayorek, et al.; Diabetes 46, 1958 (1997) Abstract
Mitochondria uncoupling by a long chain fatty acyl analogue: O. Hermesh, et al.; J. Biol. Chem. 273, 3937 (1998) Abstract; Full Text
Development of insulin resistance in the JCR:LA-cp rat: role of triacylglycerols and effects of MEDICA 16: J.C. Russell, et al.; Diabetes 47, 770 (1998) Abstract; Full Text
Peroxisome proliferators as adjuvants for the reverse-electron-transport therapy of obesity: an explanation for the large increase in metabolic rate of MEDICA 16-treated rats: M.F. McCarty; Med. Hypotheses 53, 272 (1999) Abstract
Mitochondrial protonophoric activity induced by a thyromimetic fatty acid analogue: O. Hermesh, et al.; Biochim. Biophys. Acta 1457, 166 (2000) Abstract
Fatty acid cycling in the fasting rat: B. Kalderon, et al.; Am. J. Physiol. Endocrinol. Metab. 279, E221 (2000) Abstract; Full Text
MEDICA 16 inhibits hepatic acetyl-CoA carboxylase and reduces plasma triacylglycerol levels in insulin-resistant JCR: LA-cp rats: L.L. Atkinson, et al.; Diabetes 51, 1548 (2002) Abstract
Genotoxicity of streptozotocin: A.D. Bolzan and M.S. Bianchi; Mutat. Res. 512, 121 (2002), (Review) Abstract
Further Categories Containing This Product:
Antidiabetic Agents / Related Products
 
 
ALX-270-432 Revised 23-May-08
Metformin
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SYNONYMS 1,1-Dimethylbiguanide . hydrochloride
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Antidiabetic Agents / Related Products
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ALX-270-432-G001   1 g 15.00 USD Add To Cart
ALX-270-432-G005   5 g 20.00 USD Add To Cart
Product Specification
FORMULA: C4H11N5 . HCl
MW: 129.2 . 36.5
CAS NUMBER: 1115-70-4
MERCK INDEX: 14: 5938
RTECS: DU1800000
PURITY: ≥97% (Assay)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water (50mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Stock solutions are stable for up to 6 months when stored at -20°C.
HANDLING: Hygroscopic.
HAZARD: IRRITANT.

Product Description
Antidiabetic agent. Reduces the cardiovascular complications of diabetes. Does not induce hypoglycemia.
Product Specific Literature References
Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group: Lancet 352, 854 (1998) Abstract
Starting patients with type 2 diabetes on insulin therapy using once-daily injections of biphasic insulin aspart 70/30, biphasic human insulin 70/30, or NPH insulin in combination with metformin: C. Kilo, et al.; J. Diabetes Complications 17, 307 (2003) Abstract
Effects of metformin and thiazolidinediones on suppression of hepatic glucose production and stimulation of glucose uptake in type 2 diabetes: a systematic review: A. Natali and E. Ferrannini; Diabetologia 49, 434 (2006) Abstract
Insulin-lowering agents inhibit synthesis of testosterone in ovaries of DHEA-induced PCOS rats: T. Misugi, et al.; Gynecol. Obstet. Invest. 61, 208 (2006) Abstract
 
 
ALX-270-343 Revised 30-May-07
3-O-Methyl-N-acetyl-D-glucosamine
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SYNONYMS 3-OMe-GlcNAc
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Carbohydrates
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ALX-270-343-M005   5 mg 190.00 USD Add To Cart
Product Specification
FORMULA: C9H17NO6
MW: 235.2
CAS NUMBER: 94825-74-8
PURITY: ≥98% (1H-NMR)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO (10mg/ml) or water (10mg/ml).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: HARMFUL.

Product Description
Inhibitor of N-acetylglucosamine kinase (Ki=17µM) and N-acetylmannosamine kinase (Ki=80µM). It has been found that 3-OMe-GlcNAc potently inhibits glucose phosphorylation by N-acetylglucosamine kinase whereas glucokinase is not at all affected by this hexosamine.
Product Specific Literature References
Inhibition of N-acetylglucosamine kinase and N-acetylmannosamine kinase by 3-O-methyl-N-acetyl-D-glucosamine in vitro: R. Zeitler, et al.; Eur. J. Biochem. 204, 1165 (1992) Abstract
Utility of 3-O-methyl-N-acetyl-D-glucosamine, an N-acetylglucosamine kinase inhibitor, for accurate assay of glucokinase in pancreatic islets and liver: I. Miwa, et al.; Enzyme Protein 48, 135 (1994) Abstract
Further Categories Containing This Product:
Obesity & Diabetes Other Products • N-Acetylneuraminic Acid / Derivatives
 
 
ALX-270-368 Revised 08-Dec-04
MK-886
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SYNONYMS L-663,536
3-[1-(p-Chlorobenzyl)-5-(isopropyl)-3-t-butylthioindol-2-yl]-2,2-dimethylpropanoic acid, Na
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PPAR Antagonists
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-368-M005   5 mg 60.00 USD Add To Cart
ALX-270-368-M025   25 mg 225.00 USD Add To Cart
Product Specification
FORMULA: C27H33ClNO2S . Na
MW: 471.1 . 23.0
CAS NUMBER: 118414-82-7
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 100% ethanol (25 mg/ml) or DMSO (25 mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
USE/STABILITY: We do not recommend storing solutions for more than one day.

Product Description
Inhibitor of PPARα activation. Inhibits 5-lipoxygenase activating protein (FLAP) and leukotriene biosynthesis (IC50=102nM). Induces apoptosis through the mitochondrial pathway.
Product Specific Literature References
L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2 - dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor: J. Gillard, et al.; Can. J. Physiol. Pharmacol. 67, 456 (1989) Abstract
Inhibition of peroxisome-proliferator-activated receptor (PPAR)alpha by MK886: J.P. Kehrer, et al.; Biochem. J. 356, 899 (2001) Abstract; Full Text
Mitochondria are direct targets of the lipoxygenase inhibitor MK886. A strategy for cell killing by combined treatment with MK886 and cyclooxygenase inhibitors: A. Gugliucci, et al.; J. Biol. Chem. 277, 31789 (2002) Abstract; Full Text
Further Categories Containing This Product:
Apoptosis Inducers & Inhibitors Other Products
 
 
ALX-804-391 Revised 02-Oct-07
Monoclonal Antibody to N-Acetylglucosamine (10D8)
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SYNONYMS anti-GlcNAc MAb (10D8)
PRODUCT LINE Protein Synthesis, Modification & Degradation
PRODUCT CATEGORY Protein Glycosylation
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ALX-804-391-C100   100 µg 453.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
CLONE: 10D8
ISOTYPE: Mouse IgM
PURITY DETAIL: Purified from serum-free cell culture supernatant by subsequent thiophilic adsorption and size exclusion chromatography.
FORMULATION: Lyophilized from 1ml 2x PBS, 0.09% sodium azide, PEG and sucrose.
RECONSTITUTION: Reconstitute with 1ml distilled water (15 min., RT).
IMMUNOGEN: N-Acetylglucosamine.
SPECIFICITY: Recognizes human, mouse and rat N-acetylglucosamine.
APPLICATION: Western Blot (1 µg/ml for AP/BCIP/NBT (MTT) detection; 0.5 µg/ml for HRPO/ECL detection).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Reconstituted antibody is stable for 1 year when stored at -80°C. Thaw aliquots at +37°C. Thawed aliquots may be stored at +4°C for up to 3 months.
HANDLING: After reconstitution, prepare aliquots and freeze in liquid nitrogen. Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-276 Revised 15-Oct-07
Monoclonal Antibody to N-Acetylglucosamine (O-linked) (HGAC85)
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SYNONYMS anti-Glc-NAc (O-linked) MAb (HGAC85)
PRODUCT LINE Protein Synthesis, Modification & Degradation
PRODUCT CATEGORY Protein Glycosylation
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ALX-804-276-C100   100 µg 379.00 USD Add To Cart
Product Specification
CLONE: HGAC85
ISOTYPE: Mouse IgG3
CONCENTRATION: 2mg/ml
FORMULATION: Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN: Heat killed, pepsin treated group A streptococci.
SPECIFICITY: Recognizes β-1,3 linked O-GlcNAc (O-linked N-acetylglucosamine) residues of streptococcal group A carbohydrates as well as O-GlcNAc glycosylated proteins.
APPLICATION: ELISA
Immunocytochemistry (10µg/ml)
Immunoprecipitation
Western Blot (1µg/ml)
Note: Do not use with diluents containing glycosylated proteins!
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Identification of O-linked N-acetylglucosamine modification of ankyrinG isoforms targeted to nodes of Ranvier: X. Zhang & V. Bennett; J. Biol. Chem. 271, 31391 (1996) Abstract; Full Text
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-111 Revised 15-Oct-07
Monoclonal Antibody to N-Acetylglucosamine (O-linked) (RL2)
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SYNONYMS anti-Glc-NAc (O-linked) MAb (RL2)
PRODUCT LINE Protein Synthesis, Modification & Degradation
PRODUCT CATEGORY Protein Glycosylation
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ALX-804-111-R100   100 µl 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
CLONE: RL2
ISOTYPE: Mouse IgG1
CONCENTRATION: 2mg/ml
FORMULATION: Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN: Pore complex-lamina fraction purified from rat liver nuclear envelopes.
SPECIFICITY: Recognizes human, mouse and rat nuclear pore complex (NPC), cytoplasmic and intracellular O-GlcNAc glycosylated proteins. Detects bands of ~210, ~180, ~145, ~100, ~63, ~58, ~54 and ~45kDa by Western blot.
APPLICATION: Immunocytochemistry (1:100)
Immunohistochemistry (paraffin sections (1:200))
Immunoprecipitation
Western Blot (1:1’000)
Note: Do not use with diluents containing glycosylated proteins.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Monoclonal antibodies identify a group of nuclear pore complex glycoproteins: C.M. Snow, et al.; J. Cell. Biol. 104, 1143 (1987) Abstract
Insulin stimulates and diabetes inhibits O-linked N-acetylglucosamine transferase and O-glycosylation of Sp1: G. Majumdar, et al.; Diabetes 53, 3184 (2004) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION By Western blot, ALX-804-111 recognizes up to eight different proteins from the nuclear pore complex (NPC) of approximately 210, 180, 145, 100, 63, 58, 54 and 45 kDa as well as other O-linked glycoproteins outside of the NPC.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-144 Revised 07-Nov-05
Monoclonal Antibody to ACRP30headless (human) (Ne.Na)
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SYNONYMS anti-ACRP30headless (human) MAb (Ne.Na)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Adiponectin [ACRP30] / Related Products
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ALX-804-144-C100   100 µg 320.00 USD Add To Cart
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Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: Ne.Na
ISOTYPE: Mouse IgG1
SOURCE/HOST: Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE).
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human ACRP30headless (tail adiponectin) (Prod. No. ALX-203-002).
SPECIFICITY: Recognizes human ACRP30headless. Does not cross-react with mouse ACRP30headless. Does not cross-react with full length adiponectin.
APPLICATION: ELISA (capture)
Immunoprecipitation
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored as recommended.
HANDLING: Avoid freeze/thaw cycles.
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General Information
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-515 Revised 01-Oct-08
Monoclonal Antibody to Adiponectin (rat) (RADI 06)
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SYNONYMS anti-ACRP30 (rat) MAb (RADI 06)
anti-Adipocyte Complement Related Protein of 30kDa (rat) MAb (RADI 06)
anti-AdipoQ (rat) MAb (RADI 06)
anti-apM1 (rat) MAb (RADI 06)
anti-GBP28 (rat) MAb (RADI 06)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Adiponectin [ACRP30] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-515-C050   50 µg 195.00 USD Add To Cart
ALX-804-515-C100   100 µg 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Rat
CLONE: RADI 06
ISOTYPE: Mouse IgG2
CONCENTRATION: 1mg/ml.
FORMULATION: Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN: Recombinant rat adiponectin.
SPECIFICITY: Recognizes both natural and recombinant rat adiponectin. Does not cross-react with human and mouse adiponectin. Detects a band of ~30kDa by Western blot.
APPLICATION: ELISA (direct and indirect: 1:5’000-1:10’000).
Western Blot (1:2’000-10’000 using ECL. Suggested blocking and dilution buffer is TBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature.)
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
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General Information
BACKGROUND/TECHNICAL INFORMATION
Western Blot Protocol:

1: SDS-PAGE Sample buffer
62.5mM Tris-HCl (pH 6.8), 2% SDS, 10% glycerol, 5% β-mercaptoethanol, 0.1% (w/v) bromophenol blue.

2: Serum preparation
A. 1µl rat serum and 9µl sample buffer after boiling for 5 min.
B. Recombinant rat adiponectin protein: 100ng/µl and 9µl sample buffer after boiling for 5 min.

3: Electrophoresis

4: Transfer
A. Nitrocellulose membrane
B. Constant 30V for 16 hours.

5: Western blotting
A. Blocking: 0.5% skim milk in TBST
B. Secondary IgG: anti-mouse IgG whole molecular (1:5’000)
C. ECL reaction
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-453 Revised 15-Nov-07
Monoclonal Antibody to Adiponectin (human) (HADI 741)
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SYNONYMS anti-ACRP30 (human) MAb (HADI 741)
anti-Adipocyte Complement Related Protein of 30kDa (human) MAb (HADI 741)
anti-AdipoQ (human) MAb (HADI 741)
anti-apM1 (human) MAb (HADI 741)
anti-GBP28 (human) MAb (HADI 741)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Adiponectin [ACRP30] / Related Products
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ALX-804-453-C050