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Obesity & Adipokines
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ALX-522-013 Revised 03-May-07
TNF-R1 (human):Fc (human) (recombinant)
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SYNONYMS TNF-R 60kDa (human):Fc (human) (recombinant)
CD120a (human):Fc (human) (recombinant)
p55 (human):Fc (human) (recombinant)
TNFRSF 1A (human):Fc (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY TNF-R1
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-013-C050   50 µg 360.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
MW: ~60kDa (reducing SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. The extracellular domain of human TNF-R1 (aa 1-211) is fused to the Fc portion of human IgG1.
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or carrier protein.
SPECIFICITY: Binds human and mouse TNF-α (tumor necrosis factor-a).
BIOLOGICAL ACTIVITY: Binds to TNF-R1 and triggers various biological effects (including cell death). rhTNF-R1:Fc fusion protein blocks TNF-α-mediated lysis with a inhibitory activity in a concentration range of 10-50ng/ml.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
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Product Specific Literature References
Development of improved soluble inhibitors of FasL and CD40L based on oligomerized receptors: N. Holler, et al.; J. Immunol. Methods 237, 159 (2000) Abstract
The lymphotoxin-β receptor is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells: I.A. Rooney, et al.; J. Biol. Chem. 275, 13047 (2000) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P19438: TNF-R1 (human) (precursor)
MANUFACTURER Manufactured by Apotech Corporation.
Related Products
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-522-014 Revised 03-May-07
TNF-R2 (human):Fc (human) (recombinant)
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SYNONYMS TNF-R 80kDa (human):Fc (human) (recombinant)
CD120b (human):Fc (human) (recombinant)
p75 (human):Fc (human) (recombinant)
TNFRSF 1B (human):Fc (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY TNF-R2
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-014-C050   50 µg 360.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
MW: ~75kDa (reducing SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. The extracellular domain of human TNF-R2 (aa 1-257) is fused to the Fc portion of human IgG1.
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
SPECIFICITY: Binds human and mouse TNF-α (tumor necrosis factor-α).
APPLICATION: Detection of membrane-bound TNF-α in combination with PAb to human IgG1 (Prod. No. ALX-211-500 (FITC), ALX-211-501 (R-PE), ALX-211-502 (Biotin)).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Specific Literature References
Development of improved soluble inhibitors of FasL and CD40L based on oligomerized receptors: N. Holler, et al.; J. Immunol. Methods 237, 159 (2000) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P20333: TNF-R2 (human) (precursor)
AfCs Signalling Gateway link A002346: TNF-R2 (mouse)
MANUFACTURER Manufactured by Apotech Corporation.
Related Products
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-522-034 Revised 27-Mar-06
LTα3, Soluble (human) (recombinant)
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SYNONYMS TNF-β, Soluble (human) (recombinant)
TNFSF 1, Soluble (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY TNF-alpha & TNF Receptors Other Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-034-C010   10 µg 200.00 USD Add To Cart
ALX-522-034-3010 SuperPack 3x10 µg 410.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
MW: ~25kDa (SDS-PAGE).
SOURCE/HOST: Produced in E. coli. The extracellular domain of human LTα3 (aa 43-205) is fused at the N-terminus to a linker peptide (10 aa) and a FLAG®-tag.
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
SPECIFICITY: Binds to human HVEM and human and mouse TNF-R1 and TNF-R2.
BIOLOGICAL ACTIVITY: Kills human TNF-R1 positive cells.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles.
General Information
Lymphotoxin-α (LTα, TNF-β) is a 25 kDa type II soluble protein belonging to the TNF family. It is expressed as a trimer (LTα3), or with lymphotoxin-β (LTα1β2 or LTα2β1). LTα3 interacts with 3 different members of the TNF-receptor superfamily: HVEM (Prod. No. ALX-522-017), TNF-R1 (Prod. No. ALX-522-013) and TNF-R2 (Prod. No. ALX-522-014). LTα3 is expressed by activated T and B lymphocytes and is a pro-apoptotic cytokine, a pluripotent mediator of inflammtory and immune defense mechanisms, and moreover it plays an important role in regulating the generation of the peripheral lymphoid system.
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link P01374: TNF-β (human) (precursor)
AfCS Signalling Gateway link A001438: TNF-β (mouse)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • HVEM & LIGHT / LT-betaR / DcR3 / Related Products
 
 
ALX-522-038 Revised 27-Mar-08
EDA-A1, Soluble (human) (recombinant)
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SYNONYMS Ectodysplasin-A1, Soluble (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY EDA & EDAR, Troy / Related Products
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ALX-522-038-C010   10 µg 360.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
MW: ~20kDa (SDS-PAGE).
SOURCE/HOST: Produced in E. coli. The extracellular domain of human EDA-A1 (ectodysplasin-A1) (aa 245-391) is fused at the N-terminus to a linker peptide (9 aa) and a FLAG®-tag.
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
SPECIFICITY: Binds to human EDAR (ectodysplasin-A1 receptor).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
Product Specific Literature References
Mutations leading to X-linked hypohidrotic ectodermal dysplasia affect three major functional domains in the tumor necrosis factor family member ectodysplasin-A: P. Schneider, et al.; J. Biol. Chem. 276, 18819 (2001) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q92838: EDA-A1 (human)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • TNF-alpha & TNF Receptors Other Products
 
 
ALX-522-048 Revised 24-Oct-06
EDA-A2, Soluble (human) (recombinant)
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SYNONYMS Ectodysplasin-A2, Soluble (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY EDA & EDAR, Troy / Related Products
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ALX-522-048-C010   10 µg 360.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
MW: ~28kDa (SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. The extracellular domain of human EDA-A2 (ectodysplasin-A2) (aa 245-391) is fused at the N-terminus to a linker peptide (10 aa) and a FLAG®-tag.
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
SPECIFICITY: Binds to human XEDAR (X-linked ectodysplasin-A2 receptor).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
Product Specific Literature References
Mutations leading to X-linked hypohidrotic ectodermal dysplasia affect three major functional domains in the tumor necrosis factor family member ectodysplasin-A: P. Schneider, et al.; J. Biol. Chem. 276, 18819 (2001) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • TNF-alpha & TNF Receptors Other Products
 
 
ALX-522-049 Revised 18-Jul-06
XEDAR (human):Fc (human) (recombinant)
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SYNONYMS X-linked Ectodysplasin-A2 Receptor (human):Fc (human) (recombinant)
EDA-A2 Receptor (human):Fc (human) (recombinant)
EDA2R (human):Fc (human) (recombinant)
TNFRSF27 (human):Fc (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY EDA & EDAR, Troy / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-049-C050   50 µg 360.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
MW: ~47kDa (SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. The cysteine-rich domain of human XEDAR (X-linked ectodysplasin-A2 receptor) (aa 1-133) is fused to the Fc portion of human IgG1.
CONCENTRATION: 1mg/ml after reconstitution
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
SPECIFICITY: Binds human EDA-A2 (ectodysplasin-A2).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
Product Specific Literature References
Mutations leading to X-linked hypohidrotic ectodermal dysplasia affect three major functional domains in the tumor necrosis factor family member ectodysplasin-A: P. Schneider, et al.; J. Biol. Chem. 276, 18819 (2001) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q9HAV5: XEDAR (human)
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors: M. Yan, et al.; Science 290, 523 (2000) Abstract
Related Products
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • TNF-alpha & TNF Receptors Other Products
 
 
ALX-748-003 Revised 04-Mar-05
PPARγ (human) cDNA Probe
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SYNONYMS Peroxisome Proliferator Activator Receptor-γ (human) cDNA Probe
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PPAR cDNA
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ALX-748-003-C002   2 µg 284.00 USD Add To Cart
Product Specification
SOURCE/HOST: Derived from the cDNA library of normal human bone marrow. Has a length of ~1.2kb.
QUANTITY: 2µg of an isolated double-stranded cDNA (coding region)
PURITY: ≥98%
FORMULATION: Solution in 100µl buffer (10mM Tris-HCl, 0.1Mm Na2EDTA, pH 7.5).
APPLICATION: This probe will hybridize with the full length PPARγ sequence (1.85kbp) of most hematopoietic cell lines. The probe may be labelled by radioactive or non-radioactive compounds using random primer labeling or nick translation. For best results avoid repeated freezing and thawing of the probe solution.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
Product Description
Ends: 5' overhang.
Further Categories Containing This Product:
DNA & RNA Probes / Related Products
 
 
ALX-201-201 Revised 20-May-05
Growth Hormone (human) (recombinant)
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SYNONYMS GH (human) (recombinant)
Somatotropin (human) (recombinant)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Growth Hormones / Related Products
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ALX-201-201-C100   100 µg 125.00 USD Add To Cart
Product Specification
MW: ~22.2kDa.
SOURCE/HOST: Produced in E. coli.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. In 88mM mannitol, pH 7.4, containing 5mM phosphate.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • Obesity & Diabetes Other Products
 
 
ALX-201-202 Revised 22-Jan-08
Growth Hormone (20kDa) (human) (recombinant)
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SYNONYMS GH (20kDa) (human) (recombinant)
Somatotropin (20kDa) (human) (recombinant)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Growth Hormones / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-202-C100   100 µg 125.00 USD Add To Cart
Product Specification
MW: ~20kDa.
SOURCE/HOST: Produced in E. coli.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. In 88mM mannitol, pH 7.4, containing 5mM phosphate.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • Obesity & Diabetes Other Products
 
 
ALX-201-421 Revised 03-Jul-08 New product
FTO (human) (recombinant) (His)
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SYNONYMS Fat Mass and Obesity-associated Protein (human) (recombinant) (His)
FATSO (human) (recombinant) (His)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Obesity & Diabetes Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-421-C010   10 µg 230.00 USD Add To Cart
ALX-201-421-C050   50 µg 510.00 USD Add To Cart
Product Specification
SOURCE/HOST: Expressed in E. coli. The mature peptide of human FTP (aa 2-505) is fused at the N-terminus to a His-tag.
CONCENTRATION: 0.5mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2μm-filtered solution in 55mM TRIS, pH 8.2, containing 150mM sodium chloride.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q9C0B1: FATSO (human)
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • Lipid Met